The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity

Overweight and obesity in childhood and adolescence represent major public health problems of our century, and account for increased morbidity and mortality in adult life. Irisin and Fibroblast Growth Factor 21 (FGF-21) have been proposed as prognostic and/or diagnostic biomarkers in subjects with obesity and metabolic syndrome, because they increase earlier than other traditional biomarkers. We determined the concentrations of Irisin and FGF-21 in children and adolescents with overweight and obesity before and after one year of a life-style intervention program of diet and physical exercise and explored the impact of body mass index (BMI) reduction on the concentrations of Irisin, FGF-21 and other cardiometabolic risk factors. Three hundred and ten (n = 310) children and adolescents (mean age ± SD: 10.5 ± 2.9 years) were studied prospectively. Following one year of the life-style intervention program, there was a significant decrease in BMI (p = 0.001), waist-to-hip ratio (p = 0.024), waist-to-height ratio (p = 0.024), and Irisin concentrations (p = 0.001), and an improvement in cardiometabolic risk factors. There was no alteration in FGF-21 concentrations. These findings indicate that Irisin concentrations decreased significantly as a result of BMI reduction in children and adolescents with overweight and obesity. Further studies are required to investigate the potential role of Irisin as a biomarker for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors.

Download Full-text

Prevalence of Overweight and Obesity in Adolescents and Their Association with Cardiometabolic Risk Factors and Life-style

Hygiena ◽

10.21101/hygiena.a1446 ◽

2016 ◽

Vol 61 (3) ◽

pp. 100-107 ◽

Cited By ~ 1

Author(s):

Katarína Hirošová ◽

Zora Gerová ◽

Martin Samohýl ◽

Daniela Krajčová ◽

Diana Vondrová ◽

...

Keyword(s):

Risk Factors ◽

Life Style ◽

Cardiometabolic Risk ◽

Overweight And Obesity ◽

Cardiometabolic Risk Factors

Download Full-text

Physical fitness as a moderator in the relationship between adiposity and cardiometabolic risk factors in children and adolescents

The Journal of Sports Medicine and Physical Fitness ◽

10.23736/s0022-4707.20.11130-7 ◽

2020 ◽

Vol 60 (12) ◽

Author(s):

Caroline Brand ◽

Ana P. Sehn ◽

Anelise R. Gaya ◽

Jorge Mota ◽

Javier Brazo-Sayavera ◽

...

Keyword(s):

Risk Factors ◽

Physical Fitness ◽

Children And Adolescents ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

The Relationship

Download Full-text

Psychologic Profiles as Predictors of Success in a Cardiovascular Risk Factors Life-style Intervention Program

Southern Medical Journal ◽

10.1097/00007611-199610000-00007 ◽

1996 ◽

Vol 89 (10) ◽

pp. 971-976

Author(s):

WILLIAM A. BANKS ◽

SHEILA A. CORRIGAN ◽

JEFFREY A. WEST ◽

PATRICIA P. WILLHOIT ◽

PATRICIA RYDER

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Life Style ◽

Intervention Program ◽

Predictors Of Success ◽

Life Style Intervention

Download Full-text

Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0479 ◽

2017 ◽

Vol 30 (9) ◽

Cited By ~ 4

Author(s):

Nalan Hakime Nogay

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Strong Correlation ◽

Cardiometabolic Risk ◽

Density Lipoprotein ◽

Cardiometabolic Risk Factors ◽

Atherogenic Index ◽

Fasting Period ◽

Atherogenic Index Of Plasma ◽

The Mean

AbstractBackground:Most of the studies investigating the correlation between the atherogenic index of plasma (AIP) and cardiometabolic risk factors have been conducted with adults, while only a limited number of related studies that involved children and adolescents has been conducted. The purpose of this study is to assess the correlation between the AIP and other cardiometabolic risk factors in adolescents.Methods:This study was conducted with 310 girls and 90 boys who were between the ages of 6 and 18 years. After a 10-h fasting period, the biochemical values of the participants were measured in the morning. The anthropometric measurements of the participants were also taken. The AIP was calculated as Log10 (triglycerides/high density lipoprotein-cholesterol; TG/HDL-C).Results:In adolescents between the ages of 12 and 18, the mean AIP of the group with TG ≥130 mg/dL was significantly higher than that of the groups with TG of 90–129 mg/dL and <90 mg/dL. There was a strong correlation between TG and AIP for both boys and girls among the children and adolescents, while there was a strong correlation between the TG/HDL-C ratio and TG only in the boys who were within the 6–11-year-old age group.Conclusions:An increase in AIP is associated with cardiovascular risk factors in children and adolescents other than those seen in adults. Based on the TG/HDL-C ratio, the AIP may be superior as a complementary index in the assessment of cardiometabolic risks in children and adolescents.

Download Full-text

The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

Journal of Pediatrics Review ◽

10.32598/jpr.9.2.950.1 ◽

2021 ◽

Vol 9 (2) ◽

pp. 167-174

Author(s):

Motahar Heidari-Beni ◽

◽

Roya Riahi ◽

Fatemeh Mohebpour ◽

Majid Khademian ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Waist Circumference ◽

Children And Adolescents ◽

Serum Uric Acid ◽

Cardiometabolic Risk ◽

Population Based ◽

Cardiometabolic Risk Factors ◽

Potential Association ◽

Iranian Children

Context: There has been an increasing interest in epidemiological and clinical studies concerning the role of uric acid in cardiometabolic diseases, especially in children and adolescents. However, these potential relationships remain undiscovered; accordingly, its pathophysiological mechanisms remain unrecognized. This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Objectives: This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Methods: The data of 595 individuals aged 7-18 years were assessed in this research. Anthropometric measurements and laboratory tests were performed according to standardized protocols. Results: The Mean±SD age of the 595 explored students was 12.39±3.07 years. The overall Mean±SD SUA level of the study participants was measured as 4.22±1.13 mg/dL, with significant gender-wise differences (4.04±0.97 mg/dL vs 4.38±1.24 mg/dL, respectively; P<0.05). The prevalence of hyperuricemia based on the 90th percentile of SUA levels was equal to 10.6%. There was a positive association between SUA levels and abdominal obesity (waist circumference: ≥90th percentile) [Odds Ratio (OR): 1.54; 95% Confidence Interval (CI): 1.26 to 1.86] and general obesity [gender-specific Body Mass Index (BMI) for >95th percentile] (OR: 2.32; 95% CI: 1.74 to 3.11). Conclusions: This study suggested BMI and waist circumference as cardiometabolic risk factors, i.e. significantly associated with SUA levels in children and adolescents.

Download Full-text