scholarly journals Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3718
Author(s):  
Fernanda Rosa ◽  
Boris L. Zybailov ◽  
Galina V. Glazko ◽  
Yasir Rahmatallah ◽  
Stephanie Byrum ◽  
...  
Keyword(s):  
Human Milk ◽  
Protein Profile ◽  
Abundant Species ◽  
Host Protein ◽  
Milk Formula ◽  
Microbiota Composition ◽  
Milk Diet ◽  
Formula Diet ◽  
Neonatal Piglets ◽  
Cecal Microbiota

The metaproteome profiling of cecal contents collected from neonatal piglets fed pasteurized human milk (HM) or a dairy-based infant formula (MF) from postnatal day (PND) 2 to 21 were assessed. At PND 21, a subset of piglets from each group (n = 11/group) were euthanized, and cecal contents were collected for further metaproteome analysis. Cecal microbiota composition showed predominantly more Firmicutes phyla and Lachnospiraceae family in the lumen of cecum of HM-fed piglets in comparison to the MF-fed group. Ruminococcus gnavus was the most abundant species from the Firmicutes phyla in the cecal contents of the HM-fed piglets at 21 days of age. A greater number of expressed proteins were identified in the cecal contents of the HM-fed piglets relative to the MF-fed piglets. Greater abundances of proteins potentially expressed by Bacteroides spp. such as glycoside enzymes were noted in the cecal lumen of HM-fed piglets relative to the MF. Additionally, lyases associated with Lachnospiraceae family were abundant in the cecum of the HM group relative to the MF group. Overall, our findings indicate that neonatal diet impacts the gut bacterial taxa and microbial proteins prior to weaning. The metaproteomics data were deposited into PRIDE, PXD025432 and 10.6019/PXD025432.

A Retrospective Analysis of the Effects of an Exclusively Human Milk Protein Diet on Neonatal Feeding Tolerance

2020 ◽  
Author(s):  
Jessica Wickland ◽  
Christine Wade ◽  
Becky Micetic ◽  
Keith Meredith ◽  
Gregory Martin
Keyword(s):  
Birth Weight ◽  
Human Milk ◽  
Milk Protein ◽  
Very Low Birth Weight ◽  
Bovine Milk ◽  
Milk Diet ◽  
Vlbw Infants ◽  
Key Points ◽  
Human Milk Protein ◽  
Feeding Tolerance

Objective This study was aimed to evaluate the effect of human milk protein fortifier (HMPF) versus bovine milk protein fortifier (BMPF) on feeding tolerance defined as the time to reach full feeds and necrotizing enterocolitis (NEC) in premature very low birth weight (VLBW) infants. Study Design A retrospective review using the BabySteps Database included 493 infants born ≤33 weeks of gestational age and ≤1,250 g (g) birth weight. A total of 218 infants fed a human milk diet (HMD) with BMPF were compared with 275 infants fed an HMD with HMPF. Results Full feeds were reached significantly sooner in the HMPF group (median: 14 vs. 16 days, p = 0.04). Weight at full feeds was significantly lower in the HMPF group (1,060 vs. 1110 g, p = 0.03). Conclusion Using HMPF to provide an exclusively HMD allowed VLBW infants to achieve full feeds sooner, but did not affect rate of NEC compared with using a BMPF with an HMD. Key Points

THE RELATIONSHIP OF THE SODIUM, POTASSIUM, AND CHLORIDE CONCENTRATION OF THE FEEDING TO THE WEIGHT GAIN OF PREMATURE INFANTS

PEDIATRICS ◽  
1962 ◽  
Vol 30 (6) ◽  
pp. 909-916
Author(s):  
Herbert I. Goldman ◽  
Samuel Karelitz ◽  
Hedda Acs ◽  
Eli Seifter
Keyword(s):  
Weight Gain ◽  
Sodium Chloride ◽  
Human Milk ◽  
Premature Infants ◽  
Chloride Concentration ◽  
The Other ◽  
Milk Formula ◽  
Sodium Potassium ◽  
Relationship Of ◽  
The Relationship

One hundred four healthy premature infants, of birth weight 1,000 to 1,800 gm, were fed one of five feedings: (1) human milk; (2) human milk plus 13 meq/l of sodium chloride; (3) human milk plus 13 meq/l of sodium chloride and 18 meq/l of potassium chloride; (4) a half-skimmed cows milk formula; and (5) a partially-skimmed vegetable oil, cows milk formula. The infants fed any of the three human milk formulas gained weight at a slower rate than the infants fed either of the two cows milk formulas. Infants whose diets were changed from unmodified human milk to the half-skimmed cows milk gained large amounts of weight, and at times were visibly edematous. Infants whose diets were changed from the human milks with added sodium chloride, to the half-skimmed cows milk, gained lesser amounts of weight and did not become edematous. The infants fed the two cows milk diets gained similar amounts of weight, although one diet provided 6.5 gm/kg/day, the other 3.1 gm/kg/day of protein.

Gastroduodenal Motility in Neonates: Response to Human Milk Compared With Cow's Milk Formula

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 434-438
Author(s):  
T. Tomomasa ◽  
P. E. Hyman ◽  
K. Itoh ◽  
J. Y. Hsu ◽  
T. Koizumi ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
High Amplitude ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Wave Form ◽  
Fasting State ◽  
Cow's Milk ◽  
Gastroduodenal Motility

It is known that breast milk empties more quickly from the stomach than does infant formula. We studied the difference in gastroduodenal motility between neonates fed with human milk and those fed with infant formula. Twenty-four five-to 36-day-old neonates were fed with mother's breast milk or with a cow's milk-based formula. Postprandlial gastroduodenal contractions were recorded manometrically for three hours. Repetitive, high-amplitude nonmigrating contractions were the dominant wave form during the postprandial period. The number of episodes, duration, amplitude, and frequency of nonmigrating contractions were not different following the different feedings. The migrating myoelectric complex, which signals a return to the interdigestive (fasting) state, appeared in 75% of breast milk-fed infants but only 17% of formula-fed infants (P < .05) within the three-hour recording period. Because contractions were similar following the two meals, but a fasting state recurred more rapidly in breast-fed infants, we conclude that factors other than phasic, nonpropagated antroduodenal contractions were responsible for the differences in gastric emptying between breast milk and formula.

Human milk mycobiota composition: relationship with gestational age, delivery mode, and birth weight

2020 ◽  
Vol 11 (2) ◽  
pp. 151-162 ◽  
Author(s):  
M. Dinleyici ◽  
V. Pérez-Brocal ◽  
S. Arslanoglu ◽  
O. Aydemir ◽  
S. Sevuk Ozumut ◽  
...  
Keyword(s):  
Human Milk ◽  
Gestational Age ◽  
Caesarean Delivery ◽  
Abundant Species ◽  
Large For Gestational Age ◽  
Delivery Mode ◽  
Mature Milk ◽  
Milk Samples ◽  
Delivery Term ◽  
Spontaneous Delivery

Intestinal and human milk microbiota studies during infancy have shown variations according to geographical location, delivery mode, gestational age, and mother-related factors during pregnancy. In this study, we performed metagenomic mycobiota analyses of 44 transient and mature human milk among five different groups: mothers of normal spontaneous delivery-term (NS-T), caesarean delivery-term (CS-T), premature (PT), small for gestational age (SGA), and large for gestational age (LGA) infants. Fungi were detected in 80 out of the 88 samples. Regarding the number of observed fungal species, the NS-T group was more homogeneous (less variable) comparing the other groups (P<0.05). In the transient human milk samples, the most abundant species were Saccharomyces cerevisiae (33.3%) and Aspergillus glaucus (27.4%). While A. glaucus (33.7%) was second most abundant species in mature milk, S. cerevisiae disappeared (P<0.01) and Penicillium rubens became the most abundant species (35.5%) (P<0.05). Among the NS-T group, the most abundant species was Malassezia globosa in both transient and mature milk. In contrast, S. cerevisiae was the most abundant species in transient human milk (45.0%) in the CS-T group, but it disappeared in mature milk (P<0.01). In transient milk, M. globosa was only represented 6.0-9.0% of taxa in the PT, SGA, and LGA groups (P<0.05). In transient and mature milk in the PT, SGA and LGA groups, the most abundant species were A. glaucus and P. rubens. In mature milk samples, P. rubens is more abundant in CS-T group, PT group and LGA group, than the NS-T groups (P<0.05 for all). Although fungi constitute only a very small part of the human milk microbiome, we observed some changes that the human milk mycobiota composition varies in caesarean delivery, premature, SGA and LGA groups, comparing the normal spontaneous delivery, as well as differences between transient and mature human milk.

Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet

2018 ◽  
Vol 33 (5) ◽  
pp. 671-678 ◽  
Author(s):  
Robert K. Huston ◽  
Andrea M. Markell ◽  
Elizabeth A. McCulley ◽  
Stuart K. Gardiner ◽  
Sean L. Sweeney
Keyword(s):  
Human Milk ◽  
Milk Diet

COMPARATIVE HEMATOLOGIC RESPONSE TO IRON FORTIFICATION OF A MILK FORMULA FOR INFANTS

PEDIATRICS ◽  
1959 ◽  
Vol 24 (3) ◽  
pp. 404-412
Author(s):  
A. Marsh ◽  
H. Long ◽  
E. Stierwalt
Keyword(s):  
Premature Infants ◽  
Serum Iron ◽  
Iron Supplementation ◽  
Full Term ◽  
Milk Intake ◽  
Milk Formula ◽  
Iron Fortification ◽  
Milk Diet ◽  
Iron Supplement ◽  
Growth Development

Seventy-four full-term and 42 premature infants were studied from birth to 9 months of age in relation to intake of iron. All were maintained on a vitamin-supplemented milk diet, and approximately a third had iron supplementation of 12 mg in 32 fluid ounces of milk intake. Significant differences between groups as regards growth, development or number of illnesses were not apparent. The infants fed supplemental iron had higher values for hemoglobin, hematocrit and serum iron, after 3 to 3½ months of age, and these values continued to be significantly higher throughout the 9-month period of observation. Among the infants who received no iron supplement, 2 full-term and 16 premature infants developed evidence of anemia, which responded quickly when the infants were changed to the iron-fortified formula. No signs of toxicity or difficulty were noted in the iron-supplemented group, nor of lack of acceptability by the infants of any formula used in the study.

scholarly journals Early fortification of enteral feedings for infants <1250 grams birth weight receiving a human milk diet including human milk based fortifier

2020 ◽  
Vol 13 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Robert Huston ◽  
Martin Lee ◽  
Evelyn Rider ◽  
Melissa Stawarz ◽  
Dawn Hedstrom ◽  
...  
Keyword(s):  
Birth Weight ◽  
Human Milk ◽  
Milk Diet ◽  
Enteral Feedings

scholarly journals Consumption of breast milk, formula and other non-human milk by children aged under 2 years: analysis of eighty-six low- and middle-income countries

2020 ◽  
pp. 1-9
Author(s):  
Paulo AR Neves ◽  
Aluísio JD Barros ◽  
Phillip Baker ◽  
Ellen Piwoz ◽  
Thiago M Santos ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Breast Feeding ◽  
Milk Formula ◽  
Milk Consumption ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Low And Middle Income ◽  
Economic Inequalities

Abstract Objective: To investigate the prevalence and socio-economic inequalities in breast milk, breast milk substitutes (BMS) and other non-human milk consumption, by children under 2 years in low- and middle-income countries (LMIC). Design: We analysed the prevalence of continued breast-feeding at 1 and 2 years and frequency of formula and other non-human milk consumption by age in months. Indicators were estimated through 24-h dietary recall. Absolute and relative wealth indicators were used to describe within- and between-country socio-economic inequalities. Setting: Nationally representative surveys from 2010 onwards from eighty-six LMIC. Participants: 394 977 children aged under 2 years. Results: Breast-feeding declined sharply as children became older in all LMIC, especially in upper-middle-income countries. BMS consumption peaked at 6 months of age in low/lower-middle-income countries and at around 12 months in upper-middle-income countries. Irrespective of country, BMS consumption was higher in children from wealthier families, and breast-feeding in children from poorer families. Multilevel linear regression analysis showed that BMS consumption was positively associated with absolute income, and breast-feeding negatively associated. Findings for other non-human milk consumption were less straightforward. Unmeasured factors at country level explained a substantial proportion of overall variability in BMS consumption and breast-feeding. Conclusions: Breast-feeding falls sharply as children become older, especially in wealthier families in upper-middle-income countries; this same group also consumes more BMS at any age. Country-level factors play an important role in explaining BMS consumption by all family wealth groups, suggesting that BMS marketing at national level might be partly responsible for the observed differences.

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