scholarly journals Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4041
Author(s):  
Huijuan Jia ◽  
Ya Wen ◽  
Wanping Aw ◽  
Kenji Saito ◽  
Hisanori Kato
Keyword(s):  
Rheumatoid Arthritis ◽  
Tricarboxylic Acid Cycle ◽  
Folk Medicine ◽  
Complementary Therapy ◽  
Muscle Weight ◽  
Initial Stage ◽  
Rheumatoid Cachexia ◽  
Medicinal Properties ◽  
Gastrocnemius Muscles

Coriander is a commonly used vegetable, spice, and folk medicine, possessing both nutritional and medicinal properties. Up to two-thirds of patients with rheumatoid arthritis (RA) exhibit loss of body mass, predominately skeletal muscle mass, a process called rheumatoid cachexia, and this has major effects of the quality of life of patients. Owing to a lack of effective treatments, the initial stage of cachexia has been proposed as an important period for prevention and decreasing pathogenesis. In the current study, we found that cachexia-like molecular disorders and muscle weight loss were in progress in gastrocnemius muscle after only 5 days of RA induction in rats, although rheumatoid cachexia symptoms have been reported occurring approximately 45 days after RA induction. Oral administration of coriander slightly restored muscle loss. Moreover, iTRAQ-based quantitative proteomics revealed that coriander treatment could partially restore the molecular derangements induced by RA, including impaired carbon metabolism, deteriorated mitochondrial function (tricarboxylic acid cycle and oxidative phosphorylation), and myofiber-type alterations. Therefore, coriander could be a promising functional food and/or complementary therapy for patients with RA against cachexia.

Role of the motor nerve in activity-induced enzymatic adaptation in skeletal muscle

1982 ◽  
Vol 242 (5) ◽  
pp. C272-C277 ◽  
Author(s):  
J. Henriksson ◽  
H. Galbo ◽  
E. Blomstrand
Keyword(s):  
Skeletal Muscle ◽  
Gastrocnemius Muscle ◽  
Tricarboxylic Acid Cycle ◽  
Motor Nerve ◽  
Oxidative Capacity ◽  
Control Group ◽  
Marker Enzyme ◽  
Muscle Weight ◽  
Enzymatic Adaptation ◽  
Gastrocnemius Muscles

The sciatic nerve was cut on one side in 11 male cats, and a piece of the nerve was removed. The cats were then divided at random into two groups, a stimulation group (S) of five cats and a control group (C) of six cats. Bilateral electrical stimulation (2 Hz) of the gastrocnemius muscle (directly or via the motor nerve) was carried out in the S cats 4 h/day, 3 days/wk for 4 wk. The voltage delivered was adjusted in each cat so that both gastrocnemius muscles lifted identical loads the same distance. The activity of the tricarboxylic acid cycle marker enzyme succinate dehydrogenase (SDH) per unit of muscle weight more than doubled in response to stimulation both in the intact and the denervated gastrocnemius muscle. Stimulation did not affect the activity of the glycolytic marker enzyme 6-phosphofructokinase (PFK) or muscle capillarization. Denervation resulted in pronounced (approx 50%) fiber atrophy, which was not prevented by the stimulation. It is concluded that the presence of the motor nerve per se is not necessary for an activity-induced adaptation of the oxidative capacity of skeletal muscle.

scholarly journals OBTENÇÃO E CARACTERIZAÇÃO DE EXTRATO BRUTO DE CAVALINHA PARA FINS MEDICINAIS

2019 ◽  
Vol 10 (2) ◽  
pp. 75
Author(s):  
Andreza Ribeiro Simioni ◽  
Tábada Maria Sales Pereira ◽  
Alexandro Da Silva Abreu ◽  
Janicy Arantes Carvalho ◽  
Ana Valéria de Moraes ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Crude Extracts ◽  
Equisetum Hyemale ◽  
The Family ◽  
Medicinal Properties ◽  
Uv Visible ◽  
Thermal Influence ◽  
Chemical Influence

O uso de plantas medicinais para o tratamento de doenças está associado à medicina popular de diferentes partes do mundo. A cavalinha, pertencente à família Equisetaceae, é amplamente distribuída na região sul do Brasil. Possui propriedades medicinais, tais como diurética, hemostática, anti-inflamatória, cicatrizante, dentre outros princípios ativos intrínsecos. O presente trabalho teve por objetivo a obtenção de extratos brutos da planta Equisetum hyemale por uso de dois métodos extrativos diferentes, a caracterização dos extratos por meio de suas propriedades e potencialidades medicinais e avaliação do efeito da temperatura em ambos os extratos. Os resultados permitiram a comparação de ambos os métodos extrativos, por influência térmica (Soxhlet) e influência química (Maceração), utilizando técnicas como espectroscopia no Uv-visível e na região do Infravermelho, que permitiram a quantificação de clorofila e da atividade antioxidante. O cultivo celular em monocamadas como modelo biológico permitiu avaliar a citotoxicidade dos extratos brutos. Tendo em vista a carência de pesquisas científicas sobre o mecanismo de extração de ativos de origem vegetal, este trabalho contribui para a área de produtos naturais, os quais são utilizados para a melhoria da qualidade de vida.Palavras-chave: Extração. Caracterização. Cavalinha.ABSTRACTThe use of medicinal plants for the treatment of diseases is associated with folk medicine from different parts of the world. The “cavalinha”, belonging to the family Equisetaceae, is widely distributed in southern Brazil. It has medicinal properties such as diuretic, hemostatic, anti-inflammatory, healing, among other intrinsic active ingredients. The objective of the present work was to obtain crude extracts from the Equisetum hyemale plant by using two different extractive methods, the characterization of the extracts by their medicinal properties and potentialities and the evaluation of the temperature effect on both extracts. The results allowed the comparison of both extractive methods, by thermal influence (Soxhlet) and chemical influence (Maceration), using techniques such as UV-visible and Infrared spectroscopy, which allowed the quantification of chlorophyll and antioxidant activity. Cell culture in monolayers as a biological model allowed to evaluate the cytotoxicity of crude extracts. Given the lack of scientific research on the mechanism of extraction of plant-based assets, this work contributes to the area of natural products, which are used to improve the quality of life.Keywords: Extraction. Characterization. Cavalinha.

scholarly journals PHYTOCHEMICAL PURIFICATION OF ACTIVE CONSTITUENTS ISOLATED FROM ROOT OF THE MEDICINAL HERB, CARALLUMA QUADRANGULA

2020 ◽  
Author(s):  
Jamal AN. Al-Mahweety ◽  
Ammer Al-Fadaly ◽  
Waled Abdo Ahmed
Keyword(s):  
Peer Review ◽  
Folk Medicine ◽  
Phytochemical Analysis ◽  
Initial Stage ◽  
Unique System ◽  
Pure Compounds ◽  
Phytochemical Compounds ◽  
Review Reports ◽  
E Mail

Objective: Present study aim for the purification of quantitative phytochemical compounds from roots of  Caralluma quadrangula belongs to the family Asclepiadaceae. This type of plants can be use as folk medicine  to take care of wide diversity of health  and diseases situation. Methods: Preliminary phytochemical analysis for different type of chemical compounds by using various  chromatographic techniques. The phytochemical characterizations were evaluated by nuclear magnetic resonance and mass spectrometry. Results: The quantitative phytochemical analysis of this species exhibited the presence four pure compounds,  hydroxyoplopan-4-one (4.5 mg), dihydroxyeudesm-4(15)-ene (5.0 mg), and quercetin- rhamnopyranosyl-D-glucopyranose (Rutin) (7.0 mg). Conclusion: From this study, it can be concluded that the species found four pure compounds from C. quadrangula. Peer Review History: Received 25 July 2020; Revised 10 August; Accepted 28 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Name: Marwa  A. A. Fayed Affiliation: Faculty of Pharmacy, University of Sadat City, Egypt E-mail: [email protected]   Name: Dr. Ali Gamal Ahmed Al-kaf Affiliation: Sana'a university, Yemen E-mail: [email protected]   Name: Ahmad Najib Affiliation: Department of Pharmacognosy-Phytochemystry Universitas Muslim Indonesia-Indonesia E-mail: [email protected]   Comments of reviewer(s): Similar Articles: A STUDY OF PHYTOCHEMICAL CONSTITUENTS IN CARALLUMA QUADRANGULA PHARMACOGNOSTIC EVALUATION OF GOMPHRENA SERRATA ROOT

scholarly journals Benefits of Exercise in Rheumatoid Arthritis

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Jennifer K. Cooney ◽  
Rebecca-Jane Law ◽  
Verena Matschke ◽  
Andrew B. Lemmey ◽  
Jonathan P. Moore ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Exercise Training ◽  
Functional Limitation ◽  
Routine Care ◽  
Systemic Autoimmune Disease ◽  
Resistance Exercise Training ◽  
Beneficial Effects ◽  
Rheumatoid Cachexia ◽  
Joint Health

This paper aims to highlight the importance of exercise in patients with rheumatoid arthritis (RA) and to demonstrate the multitude of beneficial effects that properly designed exercise training has in this population. RA is a chronic, systemic, autoimmune disease characterised by decrements to joint health including joint pain and inflammation, fatigue, increased incidence and progression of cardiovascular disease, and accelerated loss of muscle mass, that is, “rheumatoid cachexia”. These factors contribute to functional limitation, disability, comorbidities, and reduced quality of life. Exercise training for RA patients has been shown to be efficacious in reversing cachexia and substantially improving function without exacerbating disease activity and is likely to reduce cardiovascular risk. Thus, all RA patients should be encouraged to include aerobic and resistance exercise training as part of routine care. Understanding the perceptions of RA patients and health professionals to exercise is key to patients initiating and adhering to effective exercise training.

Psychosomatic Features, Compliance and Complementary Therapies in Rheumatoid Arthritis

2020 ◽  
Vol 16 (3) ◽  
pp. 215-223
Author(s):  
Rostislav A. Grekhov ◽  
Galina P. Suleimanova ◽  
Andrei S. Trofimenko ◽  
Liudmila N. Shilova
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Interpersonal Relationships ◽  
Behavioral Therapy ◽  
Current Data ◽  
Psychotherapeutic Interventions ◽  
And Coping ◽  
Regulation Of Emotion ◽  
The Impact

This review highlights the issue of psychosomatic conditions in rheumatoid arthritis, paying special attention to new researches and trends in this field. Emerging concepts in all the major parts of the problem are covered consecutively, from the impact of chronic musculoskeletal pain on the emotional state to disease influence over quality of life, socio-psychological, and interpersonal relationships. Chronic pain is closely related to emotional responses and coping ability, with a pronounced positive effect of psychotherapeutic interventions, family and social support on it. Psychosexual disorders, anxiety, depression also commonly coexist with rheumatoid arthritis, leading to further decrease in quality of life, low compliance, and high suicide risk. Influence of psychosomatic conditions on the overall treatment effect is usually underestimated by rheumatologists and general practitioners. Psychosomatic considerations are of great importance for up-to-date management of rheumatoid arthritis, as they strongly influence the quality of life, compliance, and thereby disease outcomes. Two major approaches of psychological rehabilitation exist, both coping with pain through the regulation of emotion and psychotherapeutic intervention, which not only helps patients in coping with the disease, but also aimed at improving the overall adaptation of the patient. It includes techniques of relaxation, cognitive-behavioral therapy, and biofeedback therapy. Current data about the efficacy of the additional correcting therapies for patients with rheumatoid arthritis, both emerging and common ones, are discussed in the review.

Evaluating the efficacy of intra-articular injections of platelet rich plasma (PRP) in rheumatoid arthritis patients and its impact on inflammatory cytokines, disease activity and quality of life.

2020 ◽  
Vol 16 ◽  
Author(s):  
Dalia S. Saif ◽  
Nagwa N. Hegazy ◽  
Enas S. Zahran
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Inflammatory Cytokines ◽  
Platelet Rich Plasma ◽  
Joint Inflammation ◽  
Monthly Interval ◽  
Post Injection ◽  
Tnf Α

Background: Among rheumatoid arthritis patients (RA), general disease activity is well regulated by diseasemodifying anti-rheumatic medications (DMARDS), but sometimes local inflammation still persists among a few joints. Adjuvant modern molecular interventions as Platelet Rich Plasma (PRP) with a suggested down regulating effect on inflammatory mediators has a proven effect in management of RA. We aim to evaluate the therapeutic effect of intra-articular PRP versus steroid in RA patients and their impact on inflammatory cytokines IL1B , TNF α, local joint inflammation, disease activity and quality of life (QL). Methods: Open labeled parallel randomized control clinical trial was carried out on 60 RA patients randomly divided into 2 groups, Group 1: included 30 patients received 3 intra-articular injections of PRP at monthly interval, Group 2: included 30 patients received single intra-articular injection of steroid. They were subjected to clinical, laboratory, serum IL1B and TNF α assessment at baseline and at 3, 6 months post injection. Results: Patients of both groups showed improvements in their scores of evaluating tools at 3months post injection and this improvement was persistent in the PRP group up to 6 months post injection while it was continued only for 3 months in the steroid group. Conclusions: PRP is a safe, effective and useful therapy in treating RA patients who had insufficient response and persistent pain and inflammation in just one or two joints through its down regulating effect on inflammatory cytokines IL1B, TNF α with subsequent improvement of local joint inflammation, disease activity and QL.

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