scholarly journals Krill-Oil-Dependent Increases in HS-Omega-3 Index, Plasma Choline and Antioxidant Capacity in Well-Conditioned Power Training Athletes

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4237
Author(s):  
Franchek Drobnic ◽  
Andreas B. Storsve ◽  
Lena Burri ◽  
Yunpeng Ding ◽  
Montserrat Banquells ◽  
...  
Keyword(s):  
Placebo Group ◽  
Antioxidant Capacity ◽  
Power Training ◽  
Krill Oil ◽  
Omega 3 ◽  
Double Blind ◽  
Post Exercise ◽  
Nutritional Strategy ◽  
Total Antioxidant ◽  
Double Blind Design

There is evidence that both omega-3 polyunsaturated fatty acids (n-3 PUFAs) and choline can influence sports performance, but information establishing their combined effects when given in the form of krill oil during power training protocols is missing. The purpose of this study was therefore to characterize n-3 PUFA and choline profiles after a one-hour period of high-intensity physical workout after 12 weeks of supplementation. Thirty-five healthy power training athletes received either 2.5 g/day of Neptune krill oilTM (550 mg EPA/DHA and 150 mg choline) or olive oil (placebo) in a randomized double-blind design. After 12 weeks, only the krill oil group showed a significant HS-Omega-3 Index increase from 4.82 to 6.77% and a reduction in the ARA/EPA ratio (from 50.72 to 13.61%) (p < 0.001). The krill oil group showed significantly higher recovery of choline concentrations relative to the placebo group from the end of the first to the beginning of the second exercise test (p = 0.04) and an 8% decrease in total antioxidant capacity post-exercise versus 21% in the placebo group (p = 0.35). In conclusion, krill oil can be used as a nutritional strategy for increasing the HS-Omega-3 Index, recover choline concentrations and address oxidative stress after intense power trainings.

scholarly journals Impact of Fatty Acid Supplementation on Cognitive Performance among United States (US) Military Officers: The Ranger Resilience and Improved Performance on Phospholipid-Bound Omega-3’s (RRIPP-3) Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1854
Author(s):  
Bernadette P. Marriott ◽  
Travis H. Turner ◽  
Joseph R. Hibbeln ◽  
Jill C. Newman ◽  
Marcie Pregulman ◽  
...  
Keyword(s):  
United States ◽  
Controlled Trial ◽  
The United States ◽  
Military Officers ◽  
Krill Oil ◽  
Omega 3 ◽  
Double Blind ◽  
Significant Group ◽  
Intention To Treat ◽  
Improved Performance

Studies have assessed omega-3 fatty acids and cognitive decline among older adults and cognitive development among children, although less is known about cognitive or neurological effects among young adults. We examined whether omega-3 supplementation from krill oil could improve cognition and resilience among young military officers compared to a control. This double-blind, placebo-controlled trial enrolled 555 officers (mean age 23.4 ± 2.8, 98.6% male) entering the United States (US) Army Infantry Basic Officer Leaders Course (IBOLC) with the intention to complete the US Ranger Course. Volunteer participants consumed eight dietary supplements daily of krill oil containing 2.3 g omega-3 or control (macadamia nut oil) over an approximate 20-week period. Cognitive functioning, resilience, and mood were assessed during a well-rested period at approximately 14 weeks and after a battlefield simulation at 16 weeks. Blood spot samples were collected to monitor compliance and dietary intake was assessed. All hypotheses were tested using both ‘Intention to Treat’ (ITT) and ‘As Per Protocol’ (APP) approaches. Of the 555 randomized individuals, 245 (44.1%) completed the study. No statistically significant group-by-time interactions indicating treatment effect were found on any outcomes. Poor compliance was indicated by lower than expected omega-3 elevations in the treatment group, and may have contributed to a failure to detect a response.

scholarly journals Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 823
Author(s):  
Chien-Chang Ho ◽  
Po-Sheng Chang ◽  
Hung-Wun Chen ◽  
Po-Fu Lee ◽  
Yun-Chi Chang ◽  
...  
Keyword(s):  
Placebo Group ◽  
Glycemic Control ◽  
Antioxidant Capacity ◽  
Controlled Trial ◽  
Controlled Study ◽  
Model Assessment ◽  
Glycemic Profile ◽  
Homeostatic Model Assessment ◽  
Total Antioxidant ◽  
Double Blinded

The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study. Thirty-one well-trained college athletes were randomly assigned to ubiquinone (300 mg/d, n = 17) or placebo group (n = 14). The glycemic profile [fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], plasma and erythrocyte malondialdehyde (MDA), total antioxidant capacity (TAC), and ubiquinone status were measured. After supplementation, the plasma ubiquinone concentration was significantly increased (p < 0.05) and the level of erythrocyte MDA was significantly lower in the ubiquinone group than in the placebo group (p < 0.01). There was a significant correlation between white blood cell (WBC) ubiquinone and glycemic parameters [HbA1c, r = −0.46, p < 0.05; HOMA-IR, r = −0.67, p < 0.01; QUICKI, r = 0.67, p < 0.01]. In addition, athletes with higher WBC ubiquinone level (≥0.5 nmol/g) showed higher erythrocyte TAC and QUICKI and lower HOMA-IR. In conclusion, we demonstrated that athletes may show a better antioxidant capacity with higher ubiquinone status after 12 weeks of supplementation, which may further improve glycemic control.

Treatment of neuroleptic-induced akathisia with the 5-HT2 antagonist mianserin

1999 ◽  
Vol 174 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Michael Poyurovsky ◽  
Marina Shardorodsky ◽  
Camil Fuchs ◽  
Michael Schneidman ◽  
Abraham Weizman
Keyword(s):  
Placebo Group ◽  
Low Dose ◽  
Rating Scales ◽  
Therapeutic Option ◽  
Response To Treatment ◽  
Double Blind ◽  
Log Odds ◽  
Double Blind Design ◽  
To Receive ◽  
Barnes Akathisia Scale

BackgroundSerotonin (5-HT): dopamine imbalance may underlie neuroleptic-induced akathisia.AimTo evaluate the efficacy of the 5-HT2 antagonist, mianserin in neuroleptic-induced akathisia.MethodsThirty neuroleptic-treated patients with schizophrenia were randomly allocated in a double-blind design to receive either mianserin (15 mg/day) or placebo for five days. Patients were assessed at baseline and on Days 3 and 5 by the Barnes Akathisia Scale (BARS), as well as by other relevant clinical rating scales.ResultsCompared with the placebo group, the mianserin-treated patients showed a significant reduction in all four BARS subscales by Day 5, with mean reductions in the BARS global score of 9.9% and 52.2%, respectively (P=0.006). Response to treatment (a reduction of at least two points on the BARS global subscale), was noted in six patients (40%) in the mianserin group and only one patient (9.1%) in the placebo group (P=0.04, log odds ratio 2.23).ConclusionsMianserin at a low dose may be a promising therapeutic option for patients with acute neuroleptic-induced akathisia.

Comparison of clomipramine and fluoxetine treatment of dogs with tail chasing

2010 ◽  
Vol 38 (05) ◽  
pp. 295-299 ◽  
Author(s):  
E. Yalcin
Keyword(s):  
Placebo Group ◽  
Clinical Signs ◽  
Response To Treatment ◽  
German Shepherd ◽  
Double Blind ◽  
Behavioral History ◽  
Fluoxetine Treatment ◽  
Double Blind Design ◽  
Hydro Chloride ◽  
Better Than

Summary Objective: The aim of the study was to determine the response to treatment with clomipramine and fluoxetine in dogs with tail chasing. Material and methods: Twenty-five client owned dogs with tail chasing were included in this study. Diagnosis of tail chasing was made on the basis of the dog’s behavioral history, clinical signs, and results of laboratory parameters. The study had a randomized, placebo-controlled, double-blind design. Dogs were allocated to three groups. During 12 weeks, dogs of one group were given 2 mg/kg clomipramine hydro-chloride orally, dogs of the second group received 1 mg/kg fluoxetine orally and placebo was administered to control dogs. Changes in signs of tail chasing were weekly reported by the owners. Treatment was assessed in four intervals: weeks 1–3, 4–6, 7–9, and weeks 10–12, respectively. Results: German shepherd dogs and Anatolian sheepdogs were overrepresented. In all four intervals improvement of tail chasing did not differ significantly between clomipramine and fluoxetine (p > 0.05). Improvement of behavior in the clomipramine group was significantly better than in the placebo group between weeks 1–3 and 4–6 and between weeks 7–9 and 10–12 (p < 0.05). Furthermore, there was a significantly better improvement in the fluoxetine group between weeks 7–9 and weeks 10–12 when compared to the placebo group (p < 0.05). Conclusion and clinical relevance: Clomipramine and fluoxetine seem to be equally effective in the treatment of tail chasing. Treated dogs responded well to the drugs and both drugs did not show superiority over each other.

scholarly journals Effect of 1 Year Krill Oil Supplementation on Cognitive Achievement of Dutch Adolescents: A Double-Blind Randomized Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1230 ◽  
Author(s):  
Inge S.M. van der Wurff ◽  
Clemens von Schacky ◽  
Trygve Bergeland ◽  
Roeslan Leontjevas ◽  
Maurice P. Zeegers ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Repeated Measurements ◽  
Krill Oil ◽  
Omega 3 ◽  
Double Blind ◽  
Neurocognitive Tests ◽  
Neurocognitive Test ◽  
Intervention Trials ◽  
One Year ◽  
And Function

Long-chain polyunsaturated fatty acids (LCPUFA) are important for brain development and function, maybe especially during adolescence. Observational studies have demonstrated an association between fish consumption (a source of LCPUFA) and cognition in adolescents, but intervention trials are lacking. The goal of the current study was to investigate the effect of one year of krill oil (a source of LCPUFA) supplementation on the cognitive performance of adolescents with a low Omega-3 Index (O3I ≤ 5%). A double-blind, randomized, and placebo-controlled supplementation trial with repeated measurements (baseline (T0), three months (T1), six months (T2), and 12 months (T3)) in adolescents (267 randomized) was executed. Participants were randomized to 400 mg eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day in Cohort I or placebo and 800 mg EPA + DHA per day in Cohort II or placebo. O3I was monitored by a finger prick at all time points. At T0, T2, and T3, participants executed a neurocognitive test battery. Covariate corrected mixed models were run with either condition (krill or placebo) or O3I as predictors. Krill oil supplementation led to a small but significant increase in mean O3I, but few participants increased to the intended O3I range (8–11%). There was no significant effect of supplementation on the neurocognitive tests, nor a relationship between O3I and neurocognitive test scores. The increase in O3I was small in most participants, probably due to non-compliance. Possibly the increase in O3I was too small to demonstrate an effect. More research on the influence of LCPUFAs on cognition in adolescents is needed.

scholarly journals Verbal Behaviour Changes with Depression Treatment

1969 ◽  
Vol 14 (5) ◽  
pp. 503-508 ◽  
Author(s):  
G. Marjerrison ◽  
P. C. Deza ◽  
J. C. K. Silzer
Keyword(s):  
Molecular Structure ◽  
Placebo Group ◽  
Treatment Period ◽  
Depression Treatment ◽  
Double Blind ◽  
Depressed Patients ◽  
Verbal Behaviour ◽  
Double Blind Design ◽  
Behaviour Changes ◽  
Verbal Responsiveness

Imipramine, amitriptyline and their two desmethylated analogues were compared to a placebo and to each other in terms of serial changes in molecular structure over a four-week treatment period in a double-blind design. Twelve acutely depressed patients were randomly assigned to each drug and to the placebo group. Clinical psychiatric ratings and a measure of verbal responsiveness to selective reinforcement in interviews both showed the active drugs to produce greater change than the placebo. Suggestive differences between the drugs favoured the imipramine-desmethylimipramine series over the amitriptyline-nortriptyline, while desmethylation also appeared to favour the change with treatment towards increased interpersonal responsiveness.

scholarly journals Effects of antioxidant supplementation on oxidative stress balance in young footballers– a randomized double-blind trial

2021 ◽  
Author(s):  
Błażej Stankiewicz ◽  
Mirosława Cieślicka ◽  
Sławomir Kujawski ◽  
Elżbieta Piskorska ◽  
Tomasz Kowalik ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Antioxidant Capacity ◽  
Venous Blood ◽  
Thiobarbituric Acid ◽  
Double Blind ◽  
Before And After ◽  
Total Antioxidant ◽  
Double Blinded ◽  
And Control ◽  
Chokeberry Juice

Abstract Background: The intensive physical exercise in which athletes take part in competitive sports can negatively affect the pro-oxidative–antioxidant balance. The use of compounds with high antioxidant potential, which certainly should include chokeberry, can prevent these adverse changes. Methods: The study was conducted as a double blinded randomized trial on a group of football players (mean age=15.8), who underwent 7 weeks of supplementation with 200 ml chokeberry juice per day. The players were randomly assigned to the experimental (supplemented, FP-S; n = 12) and control (placebo, FB-C; n = 8) groups. Before and after the supplementation period, participants performed an beep test . Venous blood was taken for serum isolation before, immediately after, 3 h, 24 h after the test Level of thiobarbituric acid reactive products (TBARS), hydroxy-2'-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC), iron (Fe), hepcidin, ferritin, myoglobin, albumin and morphological parameters (RBC, HGB, HCT, MCV, MCH, MCHC and lactic acid) were measured.Results: There were no significant impact of the supplementation intervention in response to the physical exercise test in the studied groups.. The post-hoc test showed no effect of chokeberry juice supply on any of the morphological, biochemical or performance parameters analysed.Conclusions: The supplementation of Chokeberry juice shows no effects on measured parameters in studied populations. It may indicate Such results may indicate insufficient antioxidant capacity of the supplemented juice.

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