Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans

Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between −10 and −20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.

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Bioceramic Drug Delivery System for Cancer Treatment and Regenerative Medicine

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.696.245 ◽

2016 ◽

Vol 696 ◽

pp. 245-249

Author(s):

Ahmed El-Ghannam

Keyword(s):

Drug Delivery ◽

Growth Factors ◽

Bone Regeneration ◽

Critical Size ◽

Release Kinetics ◽

Drug Binding ◽

Calvarial Defect ◽

Ceramic Composition ◽

Delivery Platform ◽

Kinetics Of

Silica-calcium-phosphate composite (SCPC) is a drug delivery platform that has successfully demonstrated the ability to bind and release several therapeutics including antibiotics, peptides, anticancer drugs, and growth factors. It has successfully demonstrated a unique capacity for bone regeneration. The present studies address the effect of the phosphate and silicate functional groups on drug binding and controlled release kinetics of Cisplatin (Cis). Moreover, the roles of ceramic composition and resorbability on rhBMP2 release kinetics and bone regeneration in a critical size calvarial defect in rabbit is presented.

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Zero-Order or First-Order Release Kinetics of Water-in-Oil-in-Water(W/O/W) Multiple Emulsions of Lipiodol Dependent on the Types of Surfactants.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.40.2860 ◽

1992 ◽

Vol 40 (10) ◽

pp. 2860-2863 ◽

Cited By ~ 4

Author(s):

Shan-Yang LIN ◽

Wing-Yiu LUI

Keyword(s):

Release Kinetics ◽

Zero Order ◽

First Order ◽

Multiple Emulsions ◽

Oil In Water ◽

Order Release ◽

Kinetics Of

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Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery

Journal of Engineering and Science in Medical Diagnostics and Therapy ◽

10.1115/1.4048481 ◽

2020 ◽

Vol 3 (4) ◽

Author(s):

Maher Amer ◽

Roland K. Chen

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Release Kinetics ◽

Therapeutic Index ◽

Ocular Drug Delivery ◽

Release Profile ◽

Drug Release Profile ◽

Sustained Drug Release ◽

Sustained Drug Delivery ◽

Kinetics Of

Abstract Microneedles (MNs) provide a minimally invasive alternative to intravitreal injections and a promising means to sustainable ocular drug delivery. To optimize the sustained drug release profile and to ease the administration of the MN array to the eye, the number of MNs in an MN array and their layout need to be carefully selected. In this study, the drug release kinetics of MN arrays with varying numbers of MNs (8, 12, and 16) is studied over a four-week period. The MN arrays show a much more uniform drug release profile than the single injections. Only the 16-needle MN array fully released all the amount of loaded drug at the end of the 4-week period. Both 8- and 12-needle arrays showed a steady release rate over the 4-week period, which is the longest sustained release duration that has been reported. Zero-order models are created to predict drug release profiles for the three MN arrays. It is estimated that the MN array with 8 needles can deliver the drug for up to 6 weeks. The models can be used to design MN arrays with a given targeted therapeutic index for sustained drug delivery.

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Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽

10.3390/molecules25030742 ◽

2020 ◽

Vol 25 (3) ◽

pp. 742 ◽

Cited By ~ 4

Author(s):

Thashini Moodley ◽

Moganavelli Singh

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Drug Delivery Vehicles ◽

Biological Compatibility ◽

Delivery Vehicles ◽

Efficient Loading ◽

Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

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