scholarly journals A Hypericin Delivery System Based on Polydopamine Coated Cerium Oxide Nanorods for Targeted Photodynamic Therapy

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1025 ◽  
Author(s):  
Yang Wang ◽  
Yu Zhang ◽  
Ming Jin ◽  
Yinghua Lv ◽  
Zhichao Pei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cerium Oxide ◽  
Delivery System ◽  
Targeted Delivery ◽  
Oxide Nanorods ◽  
Alkaline Conditions ◽  
Targeting Ability ◽  
Human Hepatoma Hepg2 Cells ◽  
Will Self ◽  
Targeted Photodynamic Therapy

Photodynamic therapy (PDT) as a non-aggressive therapy with fewer side effects has unique advantages over traditional treatments. However, PDT still has certain limitations in clinical applications, mainly because most photosensitizers utilized in PDT are hydrophobic compounds, which will self-aggregate in the aqueous phase and cause undesirable effects. In order to resolve this, we utilized the self-polymerization of dopamine molecules under alkaline conditions to coat cerium oxide nanorods (CeONR) with a dense polydopamine (PDA) film. Thereafter, thiolated galactose (Gal-SH) and hypericin (Hyp) were modified and loaded onto the surface to construct CeONR@PDA-Gal/Hyp, respectively, which can be used for targeted photodynamic therapy of human hepatoma HepG2 cells. CeONR@PDA-Gal/Hyp was characterized by transmission electron microscope (TEM), Zeta potential, Ultraviolet-visible (UV-Vis), and fluorescence spectroscopy, respectively. This hypericin delivery system possesses good biocompatibility and specific targeting ability, where the galactose units on the surface of CeONR@PDA-Gal/Hyp can specifically recognize the asialo-glycoprotein receptors (ASGP-R), which overexpress on HepG2 cell membrane. Furthermore, Hyp will detach from the surface of CeONR@PDA-Gal/Hyp after the nanorods enter cancer cells, and shows excellent PDT effect under the irradiation of light with a wavelength of 590 nm. Our work exemplifies a novel targeted delivery of hydrophobic photosensitizers for cancer treatment.

scholarly journals Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1967
Author(s):  
Ziwen Dai ◽  
Juan Li ◽  
Yongfang Lin ◽  
Zhigang Wang ◽  
Yang Huang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Dna Aptamers ◽  
Dna Nanostructures ◽  
Dna Strands ◽  
Targeting Ability

We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease.

scholarly journals Dual function of lectins — new perspectives in targeted photodynamic therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1241-1250 ◽  
Author(s):  
Vanya Bogoeva ◽  
Lidiya Petrova ◽  
Julie Bouckaert ◽  
Anna Yordanova ◽  
Ivan Ivanov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Dual Function ◽  
Tumor Tissues ◽  
Potential Applications ◽  
Specific Antigens ◽  
Imaging Detection ◽  
New Perspective ◽  
Targeted Photodynamic Therapy

Porphyrins and phthalocyanines are photosensitizers (PS) that are used in clinical imaging, detection of cancer cells and are particularly applied in photodynamic therapy (PDT). Many scientists have been focused on the design of different porphyrin compounds. However, similar to other anti-cancer agents, they cannot selectively recognize tumor tissues. Scientists are seeking new methods to overcome this problem and to find appropriate targeted delivery strategies. Plant lectins are especially suitable molecules for such targeting as they preferentially recognize specific antigens on the glycosylated cancer cells. This review will give more detailed information about the dual function of lectins and their interactions with PSs, which is a new perspective in targeted PDT. The implications and potential applications of such studies will also be discussed.

Cyclometalated iridium(iii) complex nanoparticles for mitochondria-targeted photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 14061-14067 ◽  
Author(s):  
Huan Lu ◽  
Xinpeng Jiang ◽  
Yanyan Chen ◽  
Ke Peng ◽  
Yiming Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
White Light ◽  
Breast Cancer Cells ◽  
Water Solubility ◽  
Targeting Ability ◽  
Targeted Photodynamic Therapy ◽  
Mitochondria Targeting ◽  
Mcf 7

Ir(tiq)2ppy nanoparticles are prepared to achieve water solubility and mitochondria-targeting ability with high PDT efficiency to MCF-7 breast cancer cells under white light irradiation.

A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

2019 ◽  
Vol 55 (90) ◽  
pp. 13518-13521 ◽  
Author(s):  
Xuejiao Guo ◽  
Roy C. H. Wong ◽  
Yimin Zhou ◽  
Dennis K. P. Ng ◽  
Pui-Chi Lo
Keyword(s):  
Photodynamic Therapy ◽  
Targeted Delivery ◽  
Site Specific ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

A sequential “tag-and-click” process for targeted delivery of photosensitisers for photodynamic therapy.

Hypericin Delivery System Based on P84 Copolymeric Micelles Linked with N-(3-Aminopropyl)-2-pyrrolidone for Melanoma-Targeted Photodynamic Therapy

2020 ◽  
Vol 2 (4) ◽  
pp. 1692-1701 ◽  
Author(s):  
R. S. Gonçalves ◽  
G. Braga ◽  
A. C. V. de Oliveira ◽  
G. B. César ◽  
T. T. Tominaga ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Targeted Photodynamic Therapy

Scavenger-Receptor Targeted Photodynamic Therapy¶

2000 ◽  
Vol 72 (4) ◽  
pp. 533 ◽  
Author(s):  
Michael R. Hamblin ◽  
Jaimie L. Miller ◽  
Bernhard Ortel
Keyword(s):  
Photodynamic Therapy ◽  
Scavenger Receptor ◽  
Targeted Photodynamic Therapy

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

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