Feasibility Study of Precise Balloon Catheter Tracking and Visualization with Fast Photoacoustic Microscopy

Correct guiding of the catheter is a critical issue in almost all balloon catheter applications, including arterial stenosis expansion, coronary arterial diseases, and gastrointestinal tracking. To achieve safe and precise guiding of the balloon catheter, a novel imaging method with high-resolution, sufficient depth of penetration, and real-time display is required. Here, we present a new balloon catheter guiding method using fast photoacoustic microscopy (PAM) technique for precise balloon catheter tracking and visualization as a feasibility study. We implemented ex vivo and in vivo experiments with three different medium conditions of balloon catheter: no air, air, and water. Acquired cross-sectional, maximum amplitude projection (MAP), and volumetric 3D PAM images demonstrated its capability as a new imaging guiding tool for balloon catheter tracking and visualization.

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Fabrication of Coaxial and Confocal Transducer Based on Sol-Gel Composite Material for Optical Resolution Photoacoustic Microscopy

Diagnostics ◽

10.3390/diagnostics10010006 ◽

2019 ◽

Vol 10 (1) ◽

pp. 6

Author(s):

Masayuki Tanabe ◽

Tai Chieh Wu ◽

Makiko Kobayashi ◽

Che Hua Yang

Keyword(s):

Ex Vivo ◽

Photoacoustic Imaging ◽

Sol Gel ◽

Optical Resolution ◽

Maximum Amplitude ◽

Photoacoustic Signal ◽

Center Frequency ◽

Photoacoustic Microscopy ◽

3 Dimensional ◽

Pulse Echo

We have newly developed coaxial and confocal optical-resolution photoacoustic microscopy based on sol-gel composite materials. This transducer contains a concave-shaped piezoelectric layer with a focus depth of 5 mm and a hole with a diameter of 3 mm at the center to pass a laser beam into a phantom. Therefore, this system can directly detect an excited photoacoustic signal without prisms or acoustic lenses. We demonstrate the capability of the system through pulse-echo and photoacoustic imaging experiments. The center frequency of the fabricated transducer is approximately 7 MHz, and its relative bandwidth is 86%. An ex-vivo experiment is conducted, and photoacoustic signals are clearly obtained. As a result, 2- and 3-dimensional maximum amplitude projection images are reconstructed.

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The Urological Dyna-CT: ex vivo feasibility study of interventional cross-sectional imaging in the endourological operation room

World Journal of Urology ◽

10.1007/s00345-012-0951-9 ◽

2012 ◽

Vol 32 (1) ◽

pp. 277-280 ◽

Cited By ~ 8

Author(s):

M. S. Michel ◽

M. Ritter ◽

H. Wertz ◽

S. Schönberg ◽

A. Häcker ◽

...

Keyword(s):

Feasibility Study ◽

Ex Vivo ◽

Cross Sectional ◽

Operation Room ◽

Cross Sectional Imaging ◽

Sectional Imaging

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TO EVALUATE THE EFFECTIVENESS OF CONDOM BALLOON CATHETER IN TREATING INTRACTABLE POSTPARTUM HEMORRHAGE AT KONTUM PROVINCIAL HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2018.6.24 ◽

2018 ◽

Vol 8 (6) ◽

pp. 178-183

Author(s):

Dinh Nguyen Gia ◽

Thanh Cao Ngoc

Keyword(s):

Maternal Death ◽

Postpartum Hemorrhage ◽

Medical Management ◽

Balloon Catheter ◽

Uterine Atony ◽

Cross Sectional ◽

Common Cause ◽

Provincial Hospital ◽

Balloon Tamponade ◽

Condom Catheter

Background: Postpartum hemorrhage (PPH) remains a significant contributor to maternal morbility and mortality and accounts for 31% of maternal death in Vietnam. The most common cause of PPH is uterine atony. Recently, uterine tamponade using intrauterine condom appears to be an effective tool in the management of intractable PPH. Objectives: To evaluate the success of condom as a tamponade to arrest intractable PPH due to uterine atony in patients not responding to medical management. Materials and Methods: The study was designed as a cross-sectional and descriptive, included 32 patients who underwent condom balloon tamponade at Kontum Provincial Hospital from 1/2012 to 8/2016. Results: 32 women (mean age 25.71 ± 6.45 years range, 16 - 39) underwent condom balloon tamponade for PPH controls. 29 patients (90.62%) successfully responded the tamponade therapy by the use of condom catheter. Three patients (9.37%) required hysterectomy. Conclusions: Condom catheter balloon effectively controls the intractable PPH due to uterine atony. Key words: PPH (Pospartum hemorrhage), Tamponade, Condom catheter balloon, Uterine atony

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The Influence of Force Direction on the Fracture Pattern and Fracture Resistance of Canine Teeth in Dogs

Journal of Veterinary Dentistry ◽

10.1177/0898756417705229 ◽

2017 ◽

Vol 34 (1) ◽

pp. 8-17 ◽

Cited By ~ 2

Author(s):

Stephanie Goldschmidt ◽

Catherine Zimmerman ◽

Caitlyn Collins ◽

Scott Hetzel ◽

Heidi-Lynn Ploeg ◽

...

Keyword(s):

Fracture Resistance ◽

Ex Vivo ◽

Testing Machine ◽

Fracture Pattern ◽

Hard Tissue ◽

Canine Tooth ◽

Cross Sectional ◽

Significant Difference ◽

Force Direction ◽

Testing Group

Biomechanical studies of the elongated canine tooth of animals are few, and thus our understanding of mechanical and physical properties of animal teeth is limited. The objective of the present study was to evaluate the influence of force direction on fracture resistance and fracture pattern of canine teeth in an ex vivo dog cadaver model. Forty-five extracted canine teeth from laboratory beagle dogs were standardized by hard tissue volume and randomly distributed among 3 force direction groups. The teeth were secured within a universal testing machine and a load was applied at different directions based on testing group. The maximum force to fracture and the fracture pattern classification were recorded for each tooth. After correcting for hard tissue cross-sectional area in a multivariate analysis, no significant difference in the amount of force required for fracture was apparent between the different force direction groups. However, the influence of force direction on fracture pattern was significant. The results of this study may allow the clinician to educate clients on possible causal force directions in clinically fractured teeth and, thus, help prevent any contributing behavior in the future.

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Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

Applied Physics B ◽

10.1007/s00340-021-07586-w ◽

2021 ◽

Vol 127 (4) ◽

Author(s):

S. Skruszewicz ◽

S. Fuchs ◽

J. J. Abel ◽

J. Nathanael ◽

J. Reinhard ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Near Infrared ◽

Extreme Ultraviolet ◽

Infrared Light ◽

Imaging Method ◽

Optical Coherence ◽

Axial Resolution ◽

Cross Sectional ◽

X Ray ◽

Broad Bandwidth

AbstractWe present an overview of recent results on optical coherence tomography with the use of extreme ultraviolet and soft X-ray radiation (XCT). XCT is a cross-sectional imaging method that has emerged as a derivative of optical coherence tomography (OCT). In contrast to OCT, which typically uses near-infrared light, XCT utilizes broad bandwidth extreme ultraviolet (XUV) and soft X-ray (SXR) radiation (Fuchs et al in Sci Rep 6:20658, 2016). As in OCT, XCT’s axial resolution only scales with the coherence length of the light source. Thus, an axial resolution down to the nanometer range can be achieved. This is an improvement of up to three orders of magnitude in comparison to OCT. XCT measures the reflected spectrum in a common-path interferometric setup to retrieve the axial structure of nanometer-sized samples. The technique has been demonstrated with broad bandwidth XUV/SXR radiation from synchrotron facilities and recently with compact laboratory-based laser-driven sources. Axial resolutions down to 2.2 nm have been achieved experimentally. XCT has potential applications in three-dimensional imaging of silicon-based semiconductors, lithography masks, and layered structures like XUV mirrors and solar cells.

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A Multilayer Functionalized Drug-Eluting Balloon for Treatment of Coronary Artery Disease

Pharmaceutics ◽

10.3390/pharmaceutics13050614 ◽

2021 ◽

Vol 13 (5) ◽

pp. 614

Author(s):

Hak-Il Lee ◽

Won-Kyu Rhim ◽

Eun-Young Kang ◽

Bogyu Choi ◽

Jun-Hyeok Kim ◽

...

Keyword(s):

Coronary Artery ◽

Ex Vivo ◽

Multilayer Coating ◽

Balloon Catheter ◽

Transition Time ◽

Coating Materials ◽

Drug Transfer ◽

Coated Materials ◽

Drug Loss ◽

Drug Eluting

Drug-eluting balloons (DEBs) have been mostly exploited as an interventional remedy for treating atherosclerosis instead of cardiovascular stents. However, the therapeutic efficacy of DEB is limited due to their low drug delivery capability to the disease site. The aim of our study was to load drugs onto a balloon catheter with preventing drug loss during transition time and maximizing drug transfer from the surface of DEBs to the cardiovascular wall. For this, a multilayer-coated balloon catheter, composed of PVP/Drug-loaded liposome/PVP, was suggested. The hydrophilic property of 1st layer, PVP, helps to separate drug layer in hydrophilic blood vessel, and the 2nd layer with Everolimus (EVL)-loaded liposome facilitates drug encapsulation and sustained release to the targeted lesions during inflation time. Additionally, a 3rd layer with PVP can protect the inner layer during transition time for preventing drug loss. The deionized water containing 20% ethanol was utilized to hydrate EVL-loaded liposome for efficient coating processes. The coating materials showed negligible toxicity in the cells and did not induce pro-inflammatory cytokine in human coronary artery smooth muscle cells (HCASMCs), even in case of inflammation induction through LPS. The results of hemocompatibility for coating materials exhibited that protein adsorption and platelet adhesion somewhat decreased with multilayer-coated materials as compared to bare Nylon tubes. The ex vivo experiments to confirm the feasibility of further applications of multilayer-coated strategy as a DEB system demonstrated efficient drug transfer of approximately 65% in the presence of the 1st layer, to the tissue in 60 s after treatment. Taken together, a functional DEB platform with such a multilayer coating approach would be widely utilized for percutaneous coronary intervention (PCI).

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Ex Vivo assessment of competent strut coverage after coronary stenting by optical coherence tomography

European Heart Journal ◽

10.1093/ehjci/ehaa946.2471 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

R Bhoite ◽

H Jinnouchi ◽

F Otsuka ◽

Y Sato ◽

A Sakamoto ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Predictive Value ◽

Ex Vivo ◽

High Sensitivity ◽

Optical Coherence ◽

Cross Sectional ◽

Neointimal Thickness ◽

Stent Strut ◽

Oct Imaging ◽

Definition Of

Abstract Background In many studies, struts coverage is defined as >0 mm of tissue overlying the stent struts by optical coherence tomography (OCT). However, this definition has never been validated using histology as the “gold standard”. The present study sought to assess the appropriate cut-off value of neointimal thickness of stent strut coverage by OCT using histology. Methods OCT imaging was performed on 39 human coronary arteries with stents from 25 patients at autopsy. A total of 165 cross-sectional images from 46 stents were co-registered with histology. The optimal cut-off value of strut coverage by OCT was determined. Strut coverage by histology was defined as endothelial cells with at least underlying two layers of smooth muscle cells. Considering the resolution of OCT is 10–20 μm, 3 different cut-off values (i.e. at ≥20, ≥40, and ≥60 μm) were assessed. Results A total of 2235 struts were evaluated by histology. Eventually, 1216 struts which were well-matched struts were analyzed in this study. By histology, uncovered struts were observed in 160 struts and covered struts were observed in 1056 struts. The broadly used definition of OCT-coverage which does not consider neointimal thickness yielded a poor specificity of 37.5% and high sensitivity 100%. Of 3 cut-off values, the cut-off value of >40 μm was more accurate as compared to >20 and >60 mm [sensitivity (99.3%), specificity (91.0%), positive predictive value (98.6%), and negative predictive value (95.6%)] Conclusion The most accurate cut-off value was ≥40 μm neointimal thickness by OCT in order to identify stent strut coverage validated by histology. Funding Acknowledgement Type of funding source: None

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How one treats lateral epicondylitis – a survey among Brazilian orthopedists

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04445-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Rafael Fuchs Lazarini ◽

Renato Arouca Zan ◽

João Carlos Belloti ◽

Ildeu Afonso de Almeida Filho ◽

Luiz Fernando Sartori Centenaro ◽

...

Keyword(s):

Surgical Treatment ◽

Tennis Elbow ◽

Lateral Epicondylitis ◽

Hand Surgery ◽

Initial Therapy ◽

Cross Sectional Study ◽

Imaging Method ◽

Cross Sectional ◽

Imaging Tool ◽

Management Protocol

Abstract Background Lateral epicondylitis (LE), also known as tennis elbow, is the most common painful elbow condition. It affects approximately 1–3% of adults. There are various possible treatments described in the literature, but evidence to support a gold standard management protocol is lacking. Therefore, the objective of this study was to evaluate how Brazilian orthopaedists diagnose and treat lateral epicondylitis and compare these results with the available evidence. Methods This is an observational, analytical, cross-sectional study. A questionnaire was prepared to obtain information from the participants with eight specific questions (2 on diagnosis and 6 on treatment). These questions were answered voluntarily by participants at 3 major congresses of orthopaedists in Brazil in 2018. The results were analysed in accordance with the overall number of responses and were evaluated among groups according to subspecialty. Results We obtained a total of 501 questionnaires. Of these, 33 were excluded. The mean age was 38.67 years. The majority of respondents (91%) were male. We obtained 26.7% from specialists in hand surgery (Hand group), 36.5% from subspecialists in shoulder and elbow (Shoulder and Elbow group), and 36.8% from generalists in orthopaedics or from other subspecialties (General Orthopaedists group). For diagnosis, 24.4% did not initially request any imaging method. The most requested exam was ultrasonography (54.9%). The most prominent indication for initial treatment was physical therapy. For refractory cases, 78.3% of the respondents preferred doing a local infiltration. The most commonly used substance for local infiltrations was corticosteroids (89.6%). With respect to the surgical treatment option, 75.8% of those who recommend it prefer open techniques, and 24.2% prefer arthroscopic treatment. Of the total respondents, 12.8% did not recommend surgical treatment for LE. Conclusion Among Brazilian orthopaedists, the Cozen test is most frequently chosen, and ultrasound is the most commonly used imaging tool. Nonsurgically, oral nonsteroidal anti-inflammatory drugs (NSAIDs) plus physiotherapy is the most popular initial therapy, and corticosteroids are the most popular type of infiltration agent. Most surgeons recommended surgery after 6 months of nonsurgical treatment, and 75.8% preferred the open technique.

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