State-of-the-Art Adult Chronic Rhinosinusitis Microbiome: Perspective for Future Studies in Pediatrics

Mixed polymer brushes (MPBs) are composed of two or more disparate polymers covalently tethered to a substrate. The resulting phase segregated morphologies have been extensively studied as responsive “smart” materials, as they can be reversible tuned and switched by external stimuli. Both computational and experimental work has attempted to establish an understanding of the resulting nanostructures that vary as a function of many factors. This contribution highlights state-of-the-art MPBs studies, covering synthetic approaches, phase behavior, responsiveness to external stimuli as well as novel applications of MPBs. Current limitations are recognized and possible directions for future studies are identified.

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Biologics for the treatment of chronic rhinosinusitis with nasal polyps - state of the art

World Allergy Organization Journal ◽

10.1016/j.waojou.2019.100050 ◽

2019 ◽

Vol 12 (8) ◽

pp. 100050 ◽

Cited By ~ 16

Author(s):

Lei Ren ◽

Nan Zhang ◽

Luo Zhang ◽

Claus Bachert

Keyword(s):

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

State Of The Art

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A Review of Subsequence Time Series Clustering

The Scientific World JOURNAL ◽

10.1155/2014/312521 ◽

2014 ◽

Vol 2014 ◽

pp. 1-19 ◽

Cited By ~ 20

Author(s):

Seyedjamal Zolhavarieh ◽

Saeed Aghabozorgi ◽

Ying Wah Teh

Keyword(s):

Time Series ◽

Pattern Recognition ◽

Time Series Data ◽

State Of The Art ◽

Dna Recognition ◽

Series Data ◽

Time Series Clustering ◽

Future Studies ◽

Literature Reviews ◽

Open Issue

Clustering of subsequence time series remains an open issue in time series clustering. Subsequence time series clustering is used in different fields, such as e-commerce, outlier detection, speech recognition, biological systems, DNA recognition, and text mining. One of the useful fields in the domain of subsequence time series clustering is pattern recognition. To improve this field, a sequence of time series data is used. This paper reviews some definitions and backgrounds related to subsequence time series clustering. The categorization of the literature reviews is divided into three groups: preproof, interproof, and postproof period. Moreover, various state-of-the-art approaches in performing subsequence time series clustering are discussed under each of the following categories. The strengths and weaknesses of the employed methods are evaluated as potential issues for future studies.

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SubMito-PSPCP: Predicting Protein Submitochondrial Locations by Hybridizing Positional Specific Physicochemical Properties with Pseudoamino Acid Compositions

BioMed Research International ◽

10.1155/2013/263829 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 13

Author(s):

Pufeng Du ◽

Yuan Yu

Keyword(s):

Physicochemical Properties ◽

Outer Membrane ◽

Acid Composition ◽

State Of The Art ◽

Mitochondrial Protein ◽

Protein Sequences ◽

Online Service ◽

Inner Membrane ◽

Future Studies ◽

General Method

Knowing the submitochondrial location of a mitochondrial protein is an important step in understanding its function. We developed a new method for predicting protein submitochondrial locations by introducing a new concept: positional specific physicochemical properties. With the framework of general form pseudoamino acid compositions, our method used only about 100 features to represent protein sequences, which is much simpler than the existing methods. On the dataset of SubMito, our method achieved over 93% overall accuracy, with 98.60% for inner membrane, 93.90% for matrix, and 70.70% for outer membrane, which are comparable to all state-of-the-art methods. As our method can be used as a general method to upgrade all pseudoamino-acid-composition-based methods, it should be very useful in future studies. We implement our method as an online service: SubMito-PSPCP.

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SWOT METHODOLOGY: A STATE-OF-THE-ART REVIEW FOR THE PAST, A FRAMEWORK FOR THE FUTURE / SSGG METODOLOGIJA: PRAEITIES IR ATEITIES ANALIZĖ

Journal of Business Economics and Management ◽

10.3846/16111699.2011.555358 ◽

2011 ◽

Vol 12 (1) ◽

pp. 24-48 ◽

Cited By ~ 83

Author(s):

Sepehr Ghazinoory ◽

Mansoureh Abdi ◽

Mandana Azadegan-Mehr

Keyword(s):

Literature Review ◽

Future Development ◽

Historical Development ◽

Swot Analysis ◽

State Of The Art ◽

Application Area ◽

Methodological Development ◽

Categorical Analysis ◽

Future Studies ◽

The Past

The SWOT analysis is the process of exploring the internal and external environments of an organization and extracting convenient strategies based on its strengths, weaknesses, opportunities and threats. This paper presents a literature review of SWOT analysis, based on a reference bank of about 557 papers established through searching various databases. This paper reviews papers that have been published up to the end of 2009. The origination and historical development of SWOT are explained first, followed by a survey on trends & classifications in SWOT papers including journals, countries, years, people & contents. Then a categorical analysis is conducted about application area and scope of SWOT. Also a methodological development of SWOT is discussed. Finally, concluding remarks and a few suggestions and challenges are presented for future studies. It is hoped that the paper can serve the needs of researchers and practitioners for easy references of SWOT studies and applications, and hence promote SWOT future development. Santrauka Straipsnyje nagrinejama SSGG metodologijos samprata, apibudinama kaip vidines ir išorines aplinkos tyrimas, pagristas silpnybiu, stiprybiu, galimybiu ir gresmiu identifikavimu. Pateiktoji SSGG analizes literaturos apžvalga yra pagrista 557 straipsniu, pateiktu ivairiose duomenu bazese, analize. Visi nagrineti straipsniai buvo publikuoti 2009 m. Pristatoma SSGG istorine raida, aiškinami tyrimai ir kryptys, klasifikacija, žurnalai, kuriuose publikuojami tokio pobudžio straipsniai, šalys, metai, autoriai, kontekstas, pritaikomumas ir ju sritys. Analizuojama SSGG metodologine raida. Straipsnio pabaigoje pateikiamos išvados ir busimu tyrimu gaires.

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Multilingualism in European workplaces

Multilingua ◽

10.1515/multi-2014-0002 ◽

2014 ◽

Vol 33 (1-2) ◽

Cited By ~ 9

Author(s):

Britt-Louise Gunnarsson

Keyword(s):

State Of The Art ◽

Cross Cultural ◽

Lingua Franca ◽

Discussion Section ◽

Cultural Encounters ◽

Future Studies ◽

Technological Advances ◽

Key Topics ◽

Workplace Discourse ◽

Cultural Networks

AbstractThis state-of-the-art article includes a review of past and recent studies on multilingualism at work in European environments. One aim is to provide the reader with a cross-cultural picture of workplace studies on various languages in Europe, another to discuss both positive and problem-based accounts of multilingualism at work. The overview covers studies on workplace interaction in multilingual regions in Europe, on English as a lingua franca workplaces, on cross-cultural encounters in global businesses, and on workplaces with workforce diversity. The conditions for workplace discourse in Europe have been influenced by a series of changes taking place in recent decades. Globalization and technological advances have created new types of cross-cultural networks, at the same time as political changes and turmoil have led to migration and new and more complex multilingual workplaces throughout Europe. In the discussion section, the scope is enlarged and workplace discourse is related to various contextual frameworks. Finally, some key topics for future studies are sketched.

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Urine Leukotriene E4: Implications as a Biomarker in Chronic Rhinosinusitis

Otolaryngology ◽

10.1177/01945998211011060 ◽

2021 ◽

pp. 019459982110110

Author(s):

Garret Choby ◽

Christopher M. Low ◽

Joshua M. Levy ◽

Janalee K. Stokken ◽

Carlos Pinheiro-Neto ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Disease Severity ◽

State Of The Art ◽

Cochrane Central Register ◽

Diagnostic Biomarker ◽

Ovid Medline ◽

Potential Marker ◽

Cochrane Database ◽

Central Register

Objective To provide a comprehensive state-of-the-art review of the emerging role of urine leukotriene E4 (uLTE4) as a biomarker in the diagnosis of chronic rhinosinusitis (CRS), aspirin-exacerbated respiratory disease (AERD), and asthma. Data Sources Ovid MEDLINE(R), Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus. Review Methods A state-of-the-art review was performed investigating the role of uLTE4 as a diagnostic biomarker, predictor of disease severity, and potential marker of selected therapeutic efficacy. Conclusions uLTE4 has been shown to be a reliable and clinically relevant biomarker for CRS, AERD, and asthma. uLTE4 is helpful in ongoing efforts to better endotype patients with CRS and to predict disease severity. Implications for Practice Aside from being a diagnostic biomarker, uLTE4 is also able to differentiate aspirin-tolerant patients from patients with AERD and has been associated with objective disease severity in patients with CRS with nasal polyposis. uLTE4 levels have also been shown to predict response to medical therapy, particularly leukotriene-modifying agents.

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STATE OF THE ART OF SCIENTIFIC LITERATURE ON Hancornia speciosa: TRENDS AND GAPS

Revista Brasileira de Fruticultura ◽

10.1590/0100-29452016869 ◽

2016 ◽

Vol 38 (4) ◽

Cited By ~ 3

Author(s):

LUCIANE MADUREIRA DE ALMEIDA ◽

CÁSSIA APARECIDA NOGUEIRA ◽

PEDRO PAULINO BORGES ◽

ANGÉLICA DAIANE LEMOS DO PRADO ◽

PABLO JOSÉ GONÇALVES

Keyword(s):

Experimental Approach ◽

Scientific Literature ◽

State Of The Art ◽

Scientific Productivity ◽

Natural Compounds ◽

Future Studies ◽

Conservation Projects ◽

Pharmacological Potential ◽

Hancornia Speciosa ◽

Management And Conservation

ABSTRACT The economic and scientific interest in Hancornia speciosa (mangabeira) has been growing in recent years, mainly due to the marketing of fruit and extraction of natural compounds with high pharmacological potential. In this study, a scientometric survey about mangabeira was carried out in order to promote and direct future studies on the species. As a result, low scientific productivity associated with this species was found, with only 131 articles published in the last 69 years. In addition, this study identified some trends in bibliographic production on mangabeira, among them: the increasing number of articles over the years; scientific dissemination in nationwide journals; the main focus of this study is associated with agronomic studies; the experimental approach is more frequent and usually associated with populations of restricted geographical distribution; and the scientific production is mainly from education institutions. Furthermore, this study also allowed the identification of some gaps in knowledge about mangabeira, among them the difficulty in describing and characterizing botanical lines; lack of analysis of the genetic diversity of widely distributed populations; lack of management and conservation projects for the species; lack of description of cultivation, collection and preservation techniques of fruits; and lack of identification of natural compounds responsible for its pharmacological activity. It is expected that the data generated in this study will serve to direct future studies on H. speciosa.

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Analysis of Tug of War Competition: A Narrative Complete Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph19010003 ◽

2021 ◽

Vol 19 (1) ◽

pp. 3

Author(s):

Ruth Cayero ◽

Valentín Rocandio ◽

Asier Zubillaga ◽

Ignacio Refoyo ◽

Julio Calleja-González ◽

...

Keyword(s):

State Of The Art ◽

Sport Activity ◽

Relative Strength ◽

Anthropometric Parameters ◽

Future Studies ◽

The Usa ◽

Pulling Force ◽

High Degree ◽

Indoor And Outdoor ◽

Drop Phase

Tug-of-war (TOW) is an internationally played activity including professional and amateur athletes, defined as early as 4000 years ago (as a rope-less version) in the artwork on Egyptian tomb engravings, and is played as per the rules laid out by TWIF, which has 73 member countries and administrative headquarters in the USA. Typically, two teams of “pullers” participate and apply enormous contra directional forces on the pulling rope. Originally, two types of competition are used: knockout and points. This narrative review describes the scientific state of the art of TOW. To the best of the authors’ knowledge, no previous information has been published on this topic. Anthropometric parameters for competitors are near 83.6, lean body mass 69.4, and body fat 16. The VO2MAX is 55.8 mL/kg/min. In terms of relative strength, the dynamic leg power is 4659.8 N. Endurance TOW elicits minimal muscle damage. Injured strains and sprains comprised over half of all injuries: back (42%), shoulder–upper limb (23%) and knee (17%). Pulling movement in TOW contests can be divided into three phases, namely the “drop”, “hold” and “drive” phases. The maximal pulling force was 1041.6 ± 123.9 N. The percentage of dynamic pulling force in the static maximal pulling force was 75.5 ± 14.4% and the dynamic ranged from 106.4 to 182.5%. There are two gripping styles: indoor and outdoor. The friction characteristics between surface and shoe in TOW is important in determining a suitable shoe for indoor TOW. A waist belt might be a useful piece of equipment for TOW sport. The EMG technique in TOW entails a high degree of dorsal muscle activity during the pulling. The factor of force vanishing was the coordination among athletes. The force vanishing percentage goes from 8.82 ± 5.59 for two contenders to 19.74 ± 2.22 for eight athletes, 6.4% in the sum of two pullers. However, in the drop phase, for female elite TOW team, only the 0.5% of the pulling force was wasted. Future studies are need in order to understand better this historical sport activity.

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Thrombin Generation and Cirrhosis: State of the Art and Perspectives

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0040-1715102 ◽

2020 ◽

Vol 46 (06) ◽

pp. 693-703

Author(s):

Aurélien Lebreton ◽

Thomas Sinegre ◽

Thomas Lecompte ◽

Laurie Talon ◽

Armand Abergel ◽

...

Keyword(s):

Protein C ◽

Thrombin Generation ◽

State Of The Art ◽

Thrombotic Risk ◽

Future Studies ◽

Promising Tool ◽

Increased Risk ◽

Hemorrhagic Events ◽

Coagulation Inhibitors ◽

Main Determinants

AbstractEpidemiological and laboratory studies performed in the last decades have changed our understanding of coagulopathy in cirrhosis, from a condition at increased risk of hemorrhagic events to one at higher thrombotic risk. However, it is not clear whether the decrease in factors that promote (except factor [F] VIII) versus inhibit coagulation in patients with cirrhosis results in a rebalanced state or in a hypercoagulable phenotype. This issue can be partially addressed using thrombin generation assays (TGA), which unlike routine clotting tests (prothrombin time or activated partial thromboplastin time) are sensitive to both procoagulant factors and coagulation inhibitors. However, many preanalytical issues and variable analytical methodologies used in TGAs complicate data analysis and interlaboratory comparisons. The introduction of TGAs in which activators of the protein C pathway (particularly soluble forms of thrombomodulin [TM]) are added has allowed detection of a reduced anticoagulant effect of TM or even a hypercoagulable phenotype as judged by endogenous thrombin potential. However, inter- and intra-assay variability may be greater with this TGA variant compared with “standard” TGAs. TGAs also allowed identifying main determinants of the hypercoagulability phenotype in the presence of TM: acquired antithrombin and protein C deficiencies, and elevated FVIII levels. The aim of this narrative review is to summarize the preanalytical and methodological variables of TGAs and also the findings of the main studies that have evaluated TGAs in patients with cirrhosis. The review also provides some propositions for future studies and outlines some perspectives on the potential implementation of this promising tool in clinical practice for the study of coagulation in patients with cirrhosis.

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