scholarly journals How Asymmetries Evolved: Hearts, Brains, and Molecules

Symmetry ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 914
Author(s):  
Michael C. Corballis
Keyword(s):  
Molecular Level ◽  
Great Apes ◽  
Genetic Associations ◽  
Sense Organs ◽  
Internal Organs ◽  
Trade Off ◽  
Symmetrical Body ◽  
The Right ◽  
Manual Manipulation ◽  
The Brain

Humans belong to the vast clade of species known as the bilateria, with a bilaterally symmetrical body plan. Over the course of evolution, exceptions to symmetry have arisen. Among chordates, the internal organs have been arranged asymmetrically in order to create more efficient functioning and packaging. The brain has also assumed asymmetries, although these generally trade off against the pressure toward symmetry, itself a reflection of the symmetry of limbs and sense organs. In humans, at least, brain asymmetries occur in independent networks, including those involved in language and manual manipulation biased to the left hemisphere, and emotion and face perception biased to the right. Similar asymmetries occur in other species, notably the great apes. A number of asymmetries are correlated with conditions such as dyslexia, autism, and schizophrenia, and have largely independent genetic associations. The origin of asymmetry itself, though, appears to be unitary, and in the case of the internal organs, at least, may depend ultimately on asymmetry at the molecular level.

scholarly journals On the casuistry of progressive paralysis (several cases with acute and prolonged course)

2021 ◽  
Vol XII (2) ◽  
pp. 197-208
Author(s):  
G. A. Dedov
Keyword(s):  
Dura Mater ◽  
Great Difficulty ◽  
Pathological Changes ◽  
Serous Fluid ◽  
Pia Mater ◽  
Internal Organs ◽  
Inner Surface ◽  
Cortical Substance ◽  
The Right ◽  
The Brain

28 / VII. The patient died at 6.30 am. Opening 28 / VII. Great emaciation; stiffness is poorly expressed; on the sacrum and on the right trochanter bedsores. The bones of the cranial vault are thickened, diple is almost absent. Dura mater is spliced ​​in some places with the inner surface of the vault and with the pia mater. The last one is thickened, cloudy (milky stripes), it is removed from the surface of the brain with great difficulty. Brain weight 1397.0; its substance is edematous; the cortical substance is anemic, atrophied; the lateral ventricles are dilated with a large amount of serous fluid. In the internal organs, except for the expansion of the lower lobes of both lungs, no pathological changes were noted.

scholarly journals PLACE OF METAPHOR IN NEUROPHYSIOLOGY AND THEORY OF ARTIFICIAL INTELLIGENCE

2020 ◽  
Keyword(s):  
Artificial Intelligence ◽  
Right Hemisphere ◽  
Technical Object ◽  
Internal Organs ◽  
Integral Element ◽  
Creative Self ◽  
The Right ◽  
Spatially Oriented ◽  
The Brain ◽  
Control Interaction

The article analyzes metaphor through the prism of neurophysiological approach and theory of artificial intelligence. Also the most important concepts for management of technical object are considered: condition, algorithm and adaptation. Metaphor is an integral element of creative process, its necessary tool, it is metaphorical element in thinking, among others that promotes interaction of logical thinking with insight. Perception of an object means gaining "access" to those programs which control interaction with the object, i.e. through perception that is irrational, relative and limited in humans (and also limited in the robot), is a transition to the rational side of the brain where logical decisions are made. Metaphor and analogy, the abstract operate in the right hemisphere, which is the "producer" of creativity. Thus metaphor is extremely close to creativity and is one of the mechanisms of creative self-realization. Human brain evolved from the brain of animal that interacted with the environment without the help of language and which also has hemispheres of brain. If we consider language as one of the elements of brain improvement, it jeopardizes the approach of many psychologists who believe that language is primary. Animal does not use metaphor when it "communicates" with other animals: it gives signals and signs in its "direct" meaning, while man reinterprets some words through other ones where the spiritual is intertwined with the material. The vestibular apparatus, located in the temporal bone, controls the position of body in space and accelerates its movements, that is why language is spatially oriented, and hence metaphor is. Interestingly, the receptors are also present in the internal organs, such as those that control blood circulation or digestion. Existence of such receptors can explain existence of “occasional” metaphors based not on five known feelings.

scholarly journals #DeathToFreedomOfSpeech

2019 ◽  
Vol 2 (2(4)) ◽  
pp. 135-145
Author(s):  
Dominik Stosik
Keyword(s):  
World Wide ◽  
Freedom Of Speech ◽  
The Internet ◽  
National Elections ◽  
Trade Off ◽  
Privacy Law ◽  
Psychological Warfare ◽  
The World ◽  
The Right ◽  
The Brain

In this analysis the author sets out to examine the concept of freedom of speech on the internet, drawing upon the development of the World Wide Web, the Big-Data-Trade-Off-Dilemma and the nothing-to-hide argument fallacy. A key finding is the observation of a multitude of emerging challenges in the field of ethics, privacy, law and security. Furthermore the most recent exertion of influence on the freedom of speech, that is to say astroturfing should adduce as an instance to demonstrate the possibilities of manipulating public opinion. Further on, the analysis of governmental military enhancement programmes and the example of a recent entertainment programme production shall serve as a visualisation that the research on unprecedented signal resolution and datatransfer bandwidth between the brain and electronics might be far more close to reality than one might be expecting. The results suggest that the freedom of speech is preceded by the freedom of thinking. Its manipulation on a bigger scale (e.g. national elections) could serve as a new way of psychological warfare and therefore the freedom of thinking, or the right to a free mind should remain unviolated.

Elucidation of the brain correlates of cognitive empathy and self-awareness

2002 ◽  
Vol 25 (1) ◽  
pp. 40-41 ◽  
Author(s):  
Julian Paul Keenan ◽  
Mark A. Wheeler
Keyword(s):  
Perspective Taking ◽  
Right Hemisphere ◽  
Great Apes ◽  
Cognitive Empathy ◽  
Higher Order ◽  
Self Awareness ◽  
Language Lateralization ◽  
Brain Correlates ◽  
The Right ◽  
The Brain

Self-awareness is thought to be tied to processes of higher-order perspective taking including empathy. These abilities appear to be reserved for humans, great apes, and possibly, dolphins. Recent examinations reveal that both self-awareness and empathy may have origins in the right hemisphere. It is possible that, as in language, lateralization plays a key role in the development of higher-order perspective taking and self-awareness.

The brain structure and neurosecretory cells of noctuid moth Anadevidia peponis: Noctuidae

1990 ◽  
Vol 48 (3) ◽  
pp. 436-437
Author(s):  
M. Sato ◽  
Y. Ogawa ◽  
M. Sasaki ◽  
T. Matsuo
Keyword(s):  
Biological Clock ◽  
Virgin Female ◽  
Basic Structure ◽  
Fixed Time ◽  
Neurosecretory Cells ◽  
Nerve Cells ◽  
Noctuid Moth ◽  
The Right ◽  
20 Nm ◽  
The Brain

A virgin female of the noctuid moth, a kind of noctuidae that eats cucumis, etc. performs calling at a fixed time of each day, depending on the length of a day. The photoreceptors that induce this calling are located around the neurosecretory cells (NSC) in the central portion of the protocerebrum. Besides, it is considered that the female’s biological clock is located also in the cerebral lobe. In order to elucidate the calling and the function of the biological clock, it is necessary to clarify the basic structure of the brain. The observation results of 12 or 30 day-old noctuid moths showed that their brains are basically composed of an outer and an inner portion-neural lamella (about 2.5 μm) of collagen fibril and perineurium cells. Furthermore, nerve cells surround the cerebral lobes, in which NSCs, mushroom bodies, and central nerve cells, etc. are observed. The NSCs are large-sized (20 to 30 μm dia.) cells, which are located in the pons intercerebralis of the head section and at the rear of the mushroom body (two each on the right and left). Furthermore, the cells were classified into two types: one having many free ribosoms 15 to 20 nm in dia. and the other having granules 150 to 350 nm in dia. (Fig. 1).

ASSESSMENT OF PHYSIOLOGICAL PARAMETERS OF THE TRIGEMINAL AND COCHLEOVESTIBULAR SYSTEMS IN TEMPOROMANDIBULAR JOINT PAIN DYSFUNCTION

2020 ◽  
Vol 17 (2) ◽  
pp. 110-120
Author(s):  
N.D. Sorokina ◽  
◽  
L.R. Shahalieva ◽  
S.S. Pertsov ◽  
L.V. Polma ◽  
...  
Keyword(s):  
Nervous System ◽  
Evoked Potentials ◽  
Temporomandibular Joint ◽  
Differential Diagnostics ◽  
Autonomous Nervous System ◽  
Dental Diseases ◽  
Grade Ii ◽  
The Right ◽  
Distal Occlusion ◽  
The Brain

One of the most common causes of chronic pain in the facial region, including in the trigeminal nerve link, which is not associated with dental diseases, is pain dysfunction of the temporomandibular joint. At the same time, there is evidence in the literature that there are relationships between pain dysfunction of the temporomandibular joint, abnormal occlusion, cervical-muscular tonic phenomena, postural disorders, dysfunction of the Autonomous nervous system and cochleovestibular manifestations. At the same time, neurophysiological indicators of functional disorders in the maxillofacial region and intersystem interactions in pain dysfunction of the temporomandibular joint are insufficiently studied.Goal. The aim of the work is to evaluate the neurophysiological features of trigeminal afferentation in terms of trigeminal somatosensory evoked potentials (TSWP) and the auditory conducting system of the brain in terms of acoustic stem evoked potentials (ASVP) in distal occlusion of the dentition with pain dysfunction of the temporomandibular joint (TMJ) in comparison with physiological occlusion in students 18-21 years old. Material and methods. The main study included 41 students with distal occlusion (21 girls and 20 boys), (grade II Engl, symmetrically right and left in 14 people, and grade II Engl on the left and grade I on the right in 12 people, grade I on the left and grade II on the right in 15 people). All respondents with distal occlusion and who were practically healthy signed an informed consent to participate in the study. We used complex orthodontic methods of examination, subjective degree of severity and intensity of pain in the TMJ, assessment of the Autonomous nervous system (samples and tests), and neurophysiological methods for assessing TSVP and ASVP. Results. Significant differences in ASEP parameters were found in the group of respondents with distal occlusion in the form of a decrease in the latency period of peak I, III, and V compared to physiological occlusion, that correlated with the subjective assessment (in points) of cochleovestibular disorders. According to the TSVP study, a decrease in the duration of latent periods was found, which indicates an increased excitability of non-specific brain stem structures at the medullo-ponto-mesencephalic level compared to the control group. Conclusions. The results obtained are supposed to be used for differential diagnostics, including such dental diseases as TMJ pain dysfunction, occlusion abnormalities accompanied by pain syndrome. Additional functional diagnostics of multi-modal VP of the brain (acoustic evoked potentials, trigeminal evoked potentials) can be performed in conjunction with indicators of autonomic nervous system dysfunction, with parameters of severity of clinical symptoms of cochleovestibular disorders, musculoskeletal dysfunction the maxillofacial area, with indicators of pain, which will determine the tactics and effectiveness of subsequent treatment.

Defending Virtuous Motivation

2018 ◽  
Author(s):  
Joshua May
Keyword(s):  
Framing Effects ◽  
Moral Behavior ◽  
Situational Factors ◽  
Key Factors ◽  
Trade Off ◽  
Moral Hypocrisy ◽  
Debunking Arguments ◽  
Self Interest ◽  
Mood Effects ◽  
The Right

This chapter considers remaining empirical challenges to the idea that we’re commonly motivated to do what’s right for the right reasons. Two key factors threaten to defeat claims to virtuous motivation, self-interest (egoism) and arbitrary situational factors (situationism). Both threats aim to identify defective influences on moral behavior that reveal us to be commonly motivated by the wrong reasons. However, there are limits to such wide-ranging skeptical arguments. Ultimately, like debunking arguments, defeater challenges succumb to a Defeater’s Dilemma: one can identify influences on many of our morally relevant behaviors that are either substantial or arbitrary, but not both. The science suggests a familiar trade-off in which substantial influences on many morally relevant actions are rarely defective. Arriving at this conclusion requires carefully scrutinizing a range of studies, including those on framing effects, dishonesty, implicit bias, mood effects, and moral hypocrisy (vs. integrity).

scholarly journals Noni fruit’s water spot appearance on the second day of harvest: a trade-off between resistance and energy

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Tian Wu ◽  
Danyan Hu ◽  
Qingfen Wang
Keyword(s):  
Statistical Analysis ◽  
Molecular Level ◽  
Morinda Citrifolia ◽  
Transcriptome Data ◽  
Trade Off ◽  
Kegg Pathways ◽  
Available Energy ◽  
Climacteric Fruit ◽  
The Relationship ◽  
Insight Into

Abstract Background Noni (Morinda citrifolia Linn.) is a tropical tree that bears climacteric fruit. Previous observations and research have shown that the second day (2 d) after harvest is the most important demarcation point when the fruit has the same appearance as the freshly picked fruit (0 d); however, they are beginning to become water spot appearance. We performed a conjoint analysis of metabolome and transcriptome data for noni fruit of 0 d and 2 d to reveal what happened to the fruit at the molecular level. Genes and metabolites were annotated to KEGG pathways and the co-annotated KEGG pathways were used as a statistical analysis. Results We found 25 pathways that were significantly altered at both metabolic and transcriptional levels, including a total of 285 differentially expressed genes (DEGs) and 11 differential metabolites through an integrative analysis of transcriptomics and metabolomics. The energy metabolism and pathways originating from phenylalanine were disturbed the most. The upregulated resistance metabolites and genes implied the increase of resistance and energy consumption in the postharvest noni fruit. Most genes involved in glycolysis were downregulated, further limiting the available energy. This lack of energy led noni fruit to water spot appearance, a prelude to softening. The metabolites and genes related to the resistance and energy interacted and restricted each other to keep noni fruit seemingly hard within two days after harvest, but actually the softening was already unstoppable. Conclusions This study provides a new insight into the relationship between the metabolites and genes of noni fruit, as well as a foundation for further clarification of the post-ripening mechanism in noni fruit.

scholarly journals RONC-26. A CASE OF RADIATION NECROSIS OF THE CEREBELLUM 16 YEARS AFTER CHEMORADIOTHERAPY FOR MEDULLOBLASTOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii460-iii460
Author(s):  
Mayuko Miyata ◽  
Masahiro Nonaka ◽  
Akio Asai
Keyword(s):  
Radiation Necrosis ◽  
Tumor Resection ◽  
Pathological Examination ◽  
Secondary Cancer ◽  
Brain Necrosis ◽  
Cerebellar Medulloblastoma ◽  
Cerebellar Peduncle ◽  
The Right ◽  
The Brain

Abstract BACKGROUND If new lesions are observed during follow-up of the malignant tumor after treatment, it is difficult to distinguish whether the tumor is a recurrent lesion, secondary cancer, or radiation necrosis of the brain. We have encountered a patient with symptomatic radiation necrosis of the cerebellum 16 years after treatment of medulloblastoma. CASE PRESENTATION: A 24-year-old man who had received a tumor resection and chemoradiotherapy for cerebellar medulloblastoma at the age of 8 presented with dizziness. For the past 16 years, there was no recurrence of the tumor. He subsequently underwent MRI scan, and T1-Gd image showed enhanced lesion in the right cerebellar peduncle. Cerebrospinal fluid cytology analysis was negative for tumor. We suspected tumor reccurence or secondary cancer, and performed lesion biopsy. The result of the pathological examination was radiation necrosis of the cerebellum. DISCUSSION: The interval of radiation necrosis of the brain and radiotherapy can vary from months to more than 10 years. So, whenever a new lesion is identified, radiation brain necrosis must be envisioned. According to guidelines in Japan, there is no absolute examination for discriminating tumor recurrence from radiation brain necrosis and diagnosis by biopsy may be required. CONCLUSION We experienced a case of symptomatic radiation necrosis of the cerebellum 16 years after treatment. In patients showing new lesion after long periods of time, the possibility of radiation necrosis to be considered.

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