Multiple Symmetric Lipomatosis: A Cross-Sectional Study to Investigate Clinical Features and Patients’ Quality of Life

Within the subcutaneous adipose tissue diseases, multiple symmetric lipomatosis (MSL) (syn.: Launois Bensaude Syndrome, Morbus Madelung, benign symmetric lipomatosis) is rare. The pathogenesis of MSL remains unclear. We investigated the largest German cohort of MSL patients to obtain anamnestic data and quality of life with a standard questionnaire. Twenty-nine patients with confirmed MSL were included and filled in a questionnaire designed for this study. The questionnaire assessed common anamnestic factors, such as quality of life (EQ-5D-3L) and subjective treatment goals and success (“Patient-Benefit-Index-Lymphedema”, PBI-L). The gender distribution of the patients involved in the study was m/f: 1/4 (male: n = 6 (21%); female n = 23 (79%)). While the exact pathophysiology of MSL remains unclear, a subset of patients’ positive family history suggests a strong genetic factor, sometimes compatible with autosomal dominant inheritance. Patients with MSL showed lower health states (EQ VAS Score: m = 51, sd = 24, range = 0–90) than the German norm population (m = 77). Around two thirds (68%) of patients reported relevant benefits of therapy (liposuction/lipectomy). In our cohort about one third of the patients reported a positive family history for MSL-like features. Additionally, at least in some patients, a strong genetic factor, compatible with autosomal dominant inheritance, seems a possible major driver of MSL development. Alcohol consumption and MSL development has to be regarded as a controversial issue. Patients suffering from MSL have a clear decrease in quality of life and a marked wish for treatment.

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Familial Bell's Palsy: Analysis of 25 Families

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894880976s303 ◽

1988 ◽

Vol 97 (6_suppl3) ◽

pp. 8-10 ◽

Cited By ~ 21

Author(s):

Naoaki Yanagihara ◽

Eiji Yumoto ◽

Toyohiro Shibahara

Keyword(s):

Family History ◽

Autosomal Dominant ◽

Positive Family History ◽

Bell’S Palsy ◽

Autosomal Dominant Inheritance ◽

Dominant Inheritance ◽

Bell's Palsy ◽

History Of ◽

Mode Of Inheritance

Of 625 patients with Bell's palsy, 26 from 25 families (4.0%) had a positive family history of Bell's palsy. Genealogic analysis of the families indicated the mode of inheritance of familial Bell's palsy possibly to be autosomal dominant inheritance with low penetration. The prognosis of familial Bell's palsy was generally favorable. Age, sex, recurrence, and inherited factors are discussed.

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Inherited Bell's Palsy

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947408300309 ◽

1974 ◽

Vol 83 (3) ◽

pp. 343-346 ◽

Cited By ~ 21

Author(s):

Jeffrey W. Willbrand ◽

Joel D. Blumhagen ◽

Mark May

Keyword(s):

Family History ◽

Facial Paralysis ◽

Autosomal Dominant ◽

Positive Family History ◽

Bell’S Palsy ◽

Autosomal Dominant Inheritance ◽

Single Family ◽

Dominant Inheritance ◽

Bell's Palsy ◽

History Of

Twenty-nine cases of Bell's palsy in a single family appear to suggest an autosomal dominant inheritance. In addition, a review of 230 consecutive patients with Bell's palsy revealed a 6% incidence of a positive family history of facial paralysis. These findings implicate inheritance in the etiology of Bell's palsy.

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Mutation screening in theIRF6-gene in patients with apparently nonsyndromic orofacial clefts and a positive family history suggestive of autosomal-dominant inheritance

American Journal of Medical Genetics Part A ◽

10.1002/ajmg.a.32219 ◽

2008 ◽

Vol 146A (6) ◽

pp. 787-790 ◽

Cited By ~ 18

Author(s):

Stefanie Birnbaum ◽

Heiko Reutter ◽

Carola Lauster ◽

Martin Scheer ◽

Gül Schmidt ◽

...

Keyword(s):

Family History ◽

Autosomal Dominant ◽

Mutation Screening ◽

Positive Family History ◽

Autosomal Dominant Inheritance ◽

Dominant Inheritance ◽

Orofacial Clefts

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A clinico-epidemiological study of psoriasis patients with moderate to severe plaque type in tertiary care centre in South India

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20204934 ◽

2020 ◽

Vol 7 (1) ◽

pp. 1

Author(s):

Suganya Sekar ◽

Samuel J. Daniel

Keyword(s):

Quality Of Life ◽

Family History ◽

Age Of Onset ◽

Tertiary Care ◽

Positive Family History ◽

Severe Psoriasis ◽

Tertiary Care Centre ◽

Plaque Type ◽

The Mean

Background: Psoriasis is a chronic disorder with the most common manifestation being the plaque-type. Nearly 20% of the plaque type suffer from a disease of moderate to severe intensity with immense effect on the quality of life. Aim was to study the clinical, socio-economic and demographic characteristics of patients with moderate to severe plaque type of psoriasis.Methods: This was an observational study conducted in about fourty patients diagnosed with moderate to severe plaque type of psoriasis based upon the clinical history, morphology of the lesions and assessed using psoriasis area and severity index (PASI), dermatology life quality index (DLQI) scoring and for comorbidities. Data was compiled and analyzed with statistical package for social science (SPSS) Version 20.0.Results: Mean age was 37.43±10.1 years. 22 were males (55%) and 18 were females (45%). The mean duration was 8.93 years and 15% had family history. The mean age of onset was earlier in the females (20.23 years) with a positive family history, as compared to males (25.36 years). About 62.5% had moderate psoriasis and 37.5% had severe psoriasis. At the baseline the PASI score was 31.98±6.08 and DLQI score was 36. About 67.5% had nail changes and 10% had psoriatic arthritis. Almost in half (47.5%) the duration of the disease was 1 to 5 years and scalp (32.5%) the most common initial site of involvement. Various comorbidities were documented, 72% in moderate psoriasis and 73.33% in severe psoriasis with dyslipidemia (67.5%) being commonest.Conclusions: Patients with moderate to severe psoriasis mostly have a low quality of life with multiple significant co-morbidities that increases the risk for morbidity and mortality.

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Factors associated with undiagnosed type II diabetes mellitus, undiagnosed impaired fasting glucose and these patients’ quality of life in Lebanon

Journal of Public Health ◽

10.1093/pubmed/fdz051 ◽

2019 ◽

Vol 42 (3) ◽

pp. 550-560 ◽

Cited By ~ 1

Author(s):

Souheil Hallit ◽

Sylvia Saade ◽

Rouba Karen Zeidan ◽

Katia Iskandar ◽

Nelly Kheir ◽

...

Keyword(s):

Quality Of Life ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Positive Family History ◽

Knowledge Score ◽

Type Ii Diabetes Mellitus ◽

Diabetes Knowledge ◽

Cross Sectional ◽

Family History Of Diabetes

Abstract Objective To assess the association between undiagnosed impaired fasting glucose (UIFG) and diabetes (UD), their risk factors and the patients’ knowledge about diabetes and their quality of life (QOL). Methods A cross-sectional study was conducted between May and September 2017 in four laboratories enrolling 495 patients. We used the Diabetes Knowledge and SF-12 questionnaires to assess the patients’ knowledge about diabetes and QOL. This study meets the Wilson and Jungner criteria for disease screening. Results A higher knowledge score (ORa = 0.85) was significantly associated with the absence of diabetes compared to UPD, whereas an increased age (ORa = 1.2) and a positive family history of diabetes (ORa = 1.81) were significantly associated with higher odds of UPD. An increased knowledge score (ORa = 0.55) was significantly associated with an absence of diabetes compared to UD, whereas an increased BMI (ORa = 1.40) and an increased age (ORa = 1.07) were associated with increased odds of having UD. UD (Beta = −5.799) was significantly associated with decreased total physical component QOL score, whereas increased diabetes knowledge score (Beta = 0.415) was significantly associated with increased physical QOL. A higher diabetes knowledge score (Beta = 0.459) were associated with increased mental QOL. Conclusion Seeing the relatively high percentage of UD and UIFG, we propose that screening should be considered and subject to proper assessment in the light of the findings of this study.

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Investigation of the Risk Factors and Associated Co-Morbid Conditions among Patients with Colorectal Cancer in Trinidad

Gastrointestinal Disorders ◽

10.3390/gidisord2030020 ◽

2020 ◽

Vol 2 (3) ◽

pp. 193-201

Author(s):

Vijay Kumar Chattu ◽

Priya Gopie ◽

Rajiv K. Singh ◽

Kimberly Singh ◽

Sachin Singh ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Risk Factors ◽

Family History ◽

Medical Records ◽

Demographic Data ◽

Comorbid Condition ◽

Cross Sectional ◽

The Third

Colorectal cancer (CRC) is the third most common cancer, and the fourth most common cause of cancer mortality worldwide. In Trinidad and Tobago, it is the third most common type of cancer in both sexes. Since there is scanty research on the risk factors associated with CRC, this study was conducted to determine the correlation between risk factors, including associated comorbid conditions, and CRC in Trinidad. A cross-sectional study was conducted amongst diagnosed CRC patients (>18 years) using a pre-tested questionnaire consisting of sections on demographic data, lifestyle before diagnosis, quality of life, and depression status. Additional information such as recurrence of cancer, Body Mass Index (BMI), Hypertension (HT), blood glucose levels and family history of cancer were collected from the medical records. Of the total participants, the majority were males (58%), and the mean age of diagnosis in both sexes was 65 years. The retrospective chart review showed that 68% were found to have a comorbid condition (Diabetes or HT). Upon review of the medical records, 93.2% of the subjects did not have a familial history. However, the questionnaire data showed that 73% of subjects had a family history. Around 50% of CRC patients were alcohol consumers and 30% were cigarette smokers prior to their cancer diagnosis. Interestingly, a majority of patients (91%) had never been screened for CRC prior to their diagnosis. Subjects with CRC displayed minimal depression, indicating that being diagnosed with CRC did not have a grave impact on their state of mind or quality of life. Our findings showed that prevalence of CRC was higher in males and amongst individuals of African descent. However, larger prospective studies may be warranted to fully demonstrate this effect.

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Quality of Life in Children with Epilepsy in Wah Cantt, Pakistan: A Cross-sectional Study

Journal of Rawalpindi Medical College ◽

10.37939/jrmc.v24i2.1232 ◽

2020 ◽

Vol 24 (2) ◽

pp. 128-133

Author(s):

Shahzad Haider ◽

Tahir Mahmood ◽

Sajjad Hussain ◽

Sajid Nazir ◽

Sidra Shafiq ◽

...

Keyword(s):

Quality Of Life ◽

Family History ◽

Cross Sectional Study ◽

Age Group ◽

Cross Sectional ◽

Co Morbidity ◽

Female Children ◽

History Of ◽

History Of Epilepsy

Objective: To assess the Quality Of Life (QOL) in children with epilepsy using modified QOLCE-55 questionnaire. Material and Methods: We consecutively enrolled children aged 4 to 16 years who were under treatment for childhood epilepsy. Basic demographic and clinical details including type of epilepsy, developmental history, family history of epilepsy and any co-morbidity were recorded in a predesigned Performa. QOL was evaluated by using modified QOLCE-55 (39 items) from parents. Results: A total of 54 children were enrolled in the study, 42 (78%) were males and 12(22%) were female children with epilepsy. Eight children got good QOLCE score, while 24 children had average and 22 children got a poor score. The good score was mostly seen in 4-8 years (40%) of age while the poor score was seen in 12-16 years (70%) age group. Age of the patients (p=<0.001), gender (p=<0.001), associated co-morbidities (p=0.003) and family history of epilepsy (p=0.011) showed a significant effect on the QOLCE score. Type of epilepsy (p= 0.825) and development of a child (p=0.109) did not affect the QOLCE score significantly. Conclusion: The study showed that Children with co-morbidities, family history of epilepsy and female children of older age group (12-16 years) had poor QOL. Types of seizures and development of the child did not significantly alter the QOLCE score.

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Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽

10.1024/1662-9647/a000207 ◽

2019 ◽

Vol 32 (3) ◽

pp. 125-134

Author(s):

Mechthild Niemann-Mirmehdi ◽

Andreas Häusler ◽

Paul Gellert ◽

Johanna Nordheim

Keyword(s):

Quality Of Life ◽

Patient Autonomy ◽

Positive Association ◽

Well Being ◽

Negative Association ◽

Significant Positive Association ◽

Cross Sectional ◽

People With Dementia ◽

Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

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Glittre ADL test in eutrophic, overweight and obese elderly

Fisioterapia Brasil ◽

10.33233/fb.v21i1.3244 ◽

2020 ◽

Vol 21 (1) ◽

pp. 49

Author(s):

Augusto Baumhardt Guidoti ◽

Ângelo Pereira Cattani ◽

Cintia Laura De Araujo ◽

Fernanda Beatriz Costa Delacoste ◽

Guilherme Scotta Hentschke ◽

...

Keyword(s):

Quality Of Life ◽

Functional Capacity ◽

Elderly Women ◽

Handgrip Strength ◽

Exercise Intolerance ◽

World Health ◽

Chronic Obstructive ◽

Cross Sectional ◽

World Health Organization Quality

The Glittre ADL-test (TGlittre) has been designed and validated to measure functional capacity during daily living activities in patients with chronic obstructive pulmonary disease (COPD) but is now used in several other situations. The aim of this study was to evaluate the applicability of TGlittre in a sample of overweight and obese eutrophic elderly. This was an experimental and cross-sectional study, which included 21 elderly women, allocated by BMI, in eutrophic (n = 8), overweight (n = 6) and obese (n = 7) groups. They were assessed for functional capacity (TGlittre and 6MWT), quality of life (QOL) with the questionnaire World Health Organization Quality of Life for Older People (WHOQOL-OLD) and handgrip strength (HGS). TGlittre correlated with age (p = 0.0040) and with 6MWT (p = 0.0086), but no statistical difference was found in TGlittre's performance time and the distance covered in 6MWT between groups. TGlittre did not correlate with HGS (p = 0.1493) and WHOQOL-Old (p = 0.0905). The data obtained in the present study corroborate that TGlittre is used as a functional measurement variable in the elderly population.Keywords: aged, obesity, exercise intolerance.

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