scholarly journals Association between Serum Indoxyl Sulfate Levels and Endothelial Function in Non-Dialysis Chronic Kidney Disease

Toxins ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 589 ◽  
Author(s):  
Chih-Hsien Wang ◽  
Yu-Hsien Lai ◽  
Chiu-Huang Kuo ◽  
Yu-Li Lin ◽  
Jen-Pi Tsai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Linear Regression ◽  
Endothelial Function ◽  
Vascular Reactivity ◽  
Linear Regression Analysis ◽  
Indoxyl Sulfate ◽  
Reactivity Index ◽  
Negatively Associated

Indoxyl sulfate (IS), a product metabolized from tryptophan, is negatively correlated with renal function and cardiovascular diseases in patients with chronic kidney disease (CKD). We investigated the association between serum IS levels and endothelial function in patients with CKD. Fasting blood samples were obtained from 110 patients with stages 3–5 CKD. The endothelial function, represented by vascular reactivity index (VRI), was measured non-invasively using digital thermal monitoring. Serum IS levels were determined using liquid chromatography–mass spectrometry. Twenty-one (19.1%), 36 (32.7%), and 53 (48.2%) patients had poor (VRI < 1.0), intermediate (1.0 ≤ VRI < 2.0), and good (VRI ≥ 2.0) vascular reactivity. By univariate linear regression analysis, a higher prevalence of smoking, advanced age, higher systolic, and diastolic blood pressure (DBP), elevated levels of serum phosphorus, blood urea nitrogen, creatinine, and IS were negatively correlated with VRI values, but estimated glomerular filtration rate negatively associated with VRI values. After being adjusted by using multivariate stepwise linear regression analysis, DBP and IS levels were significantly negatively associated with VRI values in CKD patients. We concluded that IS level associated inversely with VRI values and had a modulating role in endothelial function in patients with stages 3–5 CKD.

P0752THE EXPRESSION AND DIAGNOSTIC VALUE OF URINE ANGIOTENSINOGEN IN CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Qiuyan Huang ◽  
Junzhe Chen ◽  
Ying Tang ◽  
Yanchun Xu ◽  
Anping Xu
Keyword(s):  
Chronic Kidney Disease ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Linear Regression ◽  
Predictive Value ◽  
Linear Regression Analysis ◽  
Diagnostic Value ◽  
Glomerular Sclerosis ◽  
Ckd Stage ◽  
Stage 1

Abstract Background and Aims This article aims to detect the expression of urine angiotensinogen (uAGT) in patients with chronic kidney disease (CKD) and its correlation with clinical and renal pathology. Method Patients who diagnosed with CKD and undergoing renal biopsy for the first visit to Sun Yat-sen Memorial Hospital from March 1st ,2018 to October 1st, 2019 were enrolled. First morning urine samples from CKD patients before renal biopsy and healthy volunteers as controls were collected during the same period. These samples were tested for uAGT by ELISA. Linear regression analysis was used to explore the correlation between uAGT and clinical indicators as well as renal pathology in CKD patients. The receiver operating curve (ROC curve) was used to explore the diagnostic value of uAGT for CKD stage 3 or above and glomerular sclerosis ratio&gt;50%. Results A total of 133 CKD patients with 59 (44.4%) in stage 1, 31 (23.3%) in CKD stage 2, 17 (12.8%) in stage 3, 17 (12.8%) in stage 4 and 9 (6.7%) in stage 5 were included in our study. At the same time, 20 healthy volunteers were included as control. uAGT levels of CKD patients were significantly higher than healthy controls(275.0 vs 774.2,P&lt;0.001). Compared with CKD stage 1-2 patients, uAGT levels in patients with stage CKD 3 or above were significantly increased, and the difference was statistically significant (P&lt;0.001) (Table 1). The result of multivariate linear regression analysis showed that uAGT levels in CKD patients were positively correlated with 24h urine protein (beta = 0.193, P = 0.012) and negatively correlated with eGFR (beta = -0.489, P&lt;0.001) (Table 2). We also demonstrated that uAGT was positively correlated with the ratio of glomerular sclerosis(P = 0.003) (Table 3). Our results showed that the area under the curve (AUC)of uAGT for the diagnosis of renal function with CKD stage 3 or above was 0.789 (Figure 1) with the cut-off value was1959.9pg/ml. The sensitivity and specificity were 51.2% and 97.3% respectively, Furthermore, the positive predictive value (PPV) was 88.0% and negative predictive value (NPV) was 82.95%.The AUC of uAGT for the diagnosis of renal pathological glomerular sclerosis ratio&gt;50% was 0.677 (Figure 2).The cut-off value of uAGT was 2131.8pg/ml.The sensitivity and specificity were 50% and 89.5% respectively. Meanwhile, the PPV was 41.67% and the NPV was 92.25%. Conclusion uAGT was significantly increased in CKD patients, which is closely related with the urinary protein, eGFR, and renal pathology.The specific cut-off value of uAGT can be used as a predictive indicator of advanced CKD stage and severe glomerular sclerosis.

scholarly journals Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 532
Author(s):  
Bang-Gee Hsu ◽  
Chih-Hsien Wang ◽  
Yu-Hsien Lai ◽  
Jen-Pi Tsai
Keyword(s):  
Chronic Kidney Disease ◽  
Endothelial Dysfunction ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Vascular Reactivity ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Reactivity Index ◽  
Enzyme Linked Immunosorbent Assay ◽  
Galectin 3

Galectin-3, which is a novel biomarker of cardiovascular stress and related to inflammation, could predict adverse cardiovascular events. However, its relationship with endothelial function in patients with chronic kidney disease (CKD) remains inconclusive. This study aimed to investigate the association between serum galectin-3 levels and endothelial function in patients with stages 3–5 CKD. Fasting blood samples were obtained from 130 patients. Serum galectin-3 levels were determined using the enzyme-linked immunosorbent assay. The endothelial function, demonstrated as a vascular reactivity index (VRI), was measured noninvasively through digital thermal monitoring test. Then, we sorted the patients into poor, intermediate, and good vascular reactivity (VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0), accounting for 24 (18.5%), 44 (33.8%), and 62 (47.7%) patients, respectively. As the VRI decreased, the serum galectin-3 and C-reactive protein (CRP) levels significantly increased. The galectin-3 value positively correlated with the CRP value but negatively correlated with estimated glomerular filtration rate. In multivariable stepwise linear regression analysis, serum log-transformed galectin-3 level and log-transformed CRP were significantly negatively associated with VRI values. Therefore, galectin-3 together with CRP is associated with VRI values and is a potential endothelial function modulator and a valuable biomarker of endothelial dysfunction in patients with CKD.

scholarly journals Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Metabolites ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 159 ◽  
Author(s):  
Tai-Li Chen ◽  
Ming-Che Lee ◽  
Ching-Chung Ho ◽  
Bang-Gee Hsu ◽  
Jen-Pi Tsai
Keyword(s):  
Fatty Acid ◽  
Endothelial Function ◽  
Kidney Transplant ◽  
Vascular Reactivity ◽  
Fatty Acid Binding Protein ◽  
Reactivity Index ◽  
Thermal Monitoring ◽  
Fatty Acid Binding ◽  
Negatively Associated ◽  
Acid Binding Protein

Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (KT) patients. Fasting blood samples were obtained from 80 KT patients. Serum A-FABP levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0–1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. There were 12 (15.0%), 30 (37.5%), and 38 (47.5%) KT patients categorized as having poor, intermediate, and good vascular reactivity, respectively. Increased serum levels of alkaline phosphatase (p = 0.012), γ-glutamyltranspeptidase (GGT; p = 0.032), and A-FABP (p < 0.001) were associated with decreased vascular reactivity. Multivariable forward stepwise linear regression analysis revealed that age (β = −0.283, adjusted R2 change = 0.072; p = 0.003) and serum log-A-FABP level (β = −0.514, adjusted R2 change = 0.268; p < 0.001) were significantly associated with VRI values in KT patients. We concluded that serum fasting A-FABP level is negatively associated with VRI values and plays a role in endothelial dysfunction of KT patients.

scholarly journals Correlates of sedentary behaviour among adolescents and adults with hazardous, harmful or dependent drinking in South Africa

2019 ◽  
Vol 25 ◽  
Author(s):  
Karl Peltzer ◽  
Nancy Phaswana-Mafuya ◽  
Supa Pengpid
Keyword(s):  
Regression Analysis ◽  
Alcohol Use ◽  
Linear Regression ◽  
Sedentary Behaviour ◽  
Linear Regression Analysis ◽  
Alcohol Use Disorders ◽  
Older Age ◽  
Problem Drinkers ◽  
Negatively Associated ◽  
Adolescents And Adults

Background: There is lack of information on the correlates of sedentary behaviour among persons with alcohol use disorders. The study aimed to examine socio-demographic and health correlates among adolescents and adults with hazardous, harmful or probable dependent alcohol use (= problem drinking).Method: Data from the cross-sectional South African National Health and Nutrition Examination Survey (SANHANES-1) 2011–12 were analysed. From a total sample of 15 085 persons aged 15 years and older, 2849 adolescents and adults (mean age = 37.1 years, standard deviation [s.d.] = 15.1) were identified as problem drinkers, based on the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Multivariable logistic and linear regression were used to determine the associations between socio-demographic characteristics, health variables and high sedentary behaviour (≥8 h/day) and total minutes of sedentary behaviour a day.Results: The prevalence of high sedentary behaviour (≥ 8 h/day) was 11.9% overall (11.9% among men and 12.1% among women), and the mean (s.d.) duration of sedentary behaviour was 263 (169) min/day. In bivariate analysis, older age, population group, functional disability, cognitive impairment, having hypertension, having had a stroke and posttraumatic symptoms were correlated with high sedentary behaviour. In adjusted logistic regression analysis, older age and being Indian or Asian were positively, and having been diagnosed with angina was negatively, associated with high sedentary behaviour. In linear regression analysis, older age, not employed and having had a stroke were positively, and being of mixed race and having angina were negatively, associated with total minutes (up to 960 min/day) of sedentary behaviour in a day.Conclusion: The study provides socio-demographic and health correlates of sedentary behaviour among problem drinkers. This information can guide possible future interventions in reducing sedentary behaviour among problem drinkers.

Abstract 188: Long-Term Coffee Consumption Is Associated with Improved Endothelial Function in Elderly Individuals: Ikaria Study

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Evangelos Oikonomou ◽  
Gerasimos Siasos ◽  
Christina Chrysohoou ◽  
Dimitrios Tousoulis ◽  
Marina Zaromitidou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Linear Regression ◽  
Endothelial Function ◽  
Linear Regression Analysis ◽  
Antioxidant Properties ◽  
Coffee Consumption ◽  
Elderly Subjects ◽  
Elderly Individuals

Background: Acute coffee consumption is associated with impaired endothelial function, though its long term impact on endothelial function is controversial. We evaluated the association between chronic coffee intake and endothelial function, in elderly residents of Ikaria Island, as the inhabitants of this island show increased longevity and low rates of cardiovascular mortality. Methods: The study was conducted on a subgroup population of IKARIA study consisted of 175 elderly subjects (aged 65-91 yrs), inhabitants of Ikaria Island. Endothelial function was evaluated by ultrasound measurement of flow-mediated-dilatation (FMD). Dietary habits (including coffee consumption in cups per week and in ml per week) were assessed through a food frequency questionnaire. Results: Among elderly subjects, 28% had diabetes mellitus, 29% had hypercholesterolemia, 37% had a BMI>30 kg/m2, and 72% were defined as hypertensives. Moreover, 97% of the study group consumed boiled, Greek type of coffee. There was no difference between hypertensives and normotensives concerning age (75±6 years vs. 73±5 years, p=NS), male sex (51% vs. 56%, p=NS) and coffee consumption [328(120-360) ml/day vs. 346(120-360) ml/day, p=NS]. Linear regression analysis after adjustment for confounders such as age, sex, the presence of cardiovascular disease, hypercholesterolemia, diabetes mellitus and hypertension revealed that elderly individuals who consume less that 7 cups of coffee per week had significant worse FMD compared to those consume 7 to 14 cups of coffee [B=1.37, 95%C.I.: (-0.005, 2.748), p=0.05]. Furthermore, linear regression analysis in hypertensive elderly individuals, after adjustment for the aforementioned confounders, revealed that coffee consumption in ml per week was associated with increased FMD, [B=0.003, 95%C.I.: (0.000, 0.005) p=0.039]. Conclusion: Long term consumption of boiled, Greek type of coffee, with its antioxidant properties, is associated with improved endothelial function in elderly individuals. The beneficial effects of coffee are consisted even in hypertensive individuals, illustrating another cardio-protective dietary pattern of elderly inhabitants in Ikaria Island.

MO423PROENKEPHALIN AS A BIOMARKER OF KIDNEY FILTRATION IN ACUTE KIDNEY INJURY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Camila Lima ◽  
Etienne Macedo
Keyword(s):  
Acute Kidney Injury ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Linear Regression ◽  
Serum Creatinine ◽  
Linear Regression Analysis ◽  
Kidney Injury ◽  
Multivariate Linear Regression Analysis ◽  
Serum Cystatin ◽  
Blood Samples

Abstract Background and Aims In the last decades, clinical research biomarker (BM) to improve assessment of kidney function have been intensive, and proenkephalin (PENK) has been identified as a new BM of filtration. We hypothesized whether PENK would have a better accuracy for the diagnosis of severe AKI than serum cystatin (CYS) and the serum creatinine (Scr). We evaluate patient in the peri op of liver transplant (LT). Method Blood samples were collected during the pre and post (until 48 hours) operative (op.) period of LT in 57 eligible patients. Where was analyzed PENK (Sphingotest®), CYS (Milipex) and Scr (Quimioluminence). AKI diagnosis was based on the Kidney Disease International Global Outcomes (KDIGO) criteria using Scr. KDIGO 1 was subclassified according to the International Club of Ascites (ICA). Results Of the 57 patients undergoing LT, 50 (88%) developed AKI according to the KDIGO criteria in the first week after LT. Twenty-one patients without AKI and with KDIGO 1-A (37%) were summarized as the no AKI/mild AKI group, whereas 36 patients with KDIGO 1-B, 2 and 3 (63%) were summarized as the severe AKI group. Before the intra - operative insult only PENK was significantly higher in patients that developed severe AKI, median 55 [P25-75(44,25 – 94,55)] in no AKI/mild AKI versus 90,16 [P25-75(64,70 – 135,76)] pmol/l in severe AKI p 0,021, an AUC 0,685 (CI 0,536 – 0,833), with a cutoff 55 pmol/l, sensibility of 0,86 and specificity 0,52, accuracy 0,75 to severe AKI. Scr levels in pre-op. were non- significantly higher in severe AKI; p=0,088. The CYS in the pre-op was similar within the groups. Pos-operative 48 hours after LT, PENK was significantly higher in severe AKI, median 81 [P25-75(61,25 – 101,50)] versus 161,45 [P25-75(122,85 – 294,03)] in severe AKI - p &lt;0,0001 an AUC 0,83 (CI 0,72 - 0,94) with a cutoff 119,05 pmol/l, sensibility of 0,80 and specificity 0,90, accuracy 0,84 to severe AKI. Scr levels in post-op achieve an AUC 0,77 (CI 0,63 - 0,92) with a cutoff 1,49mg/dl, sensibility of 0,94, specificity 0,67 and accuracy 0,82. In a multivariate linear regression analysis adjusted for age, anestesia time, urine output and fluid balance, the PENK only was independently associated of severe AKI in pre-op. with OR 4,40 (CI 1,40 – 13,88) – p0,001 and the post-op. with OR 44,64 (CI 5,40 – 368,5) – p&lt;0,0001. Conclusion PENK is a promisor filtration biomarker and showed a better acuracy to severe AKI in pre-operative than standard AKI diagnostic by Scr. Prediction of severe AKI in pre-operative period by PENK can help the management of these patients in the future.

scholarly journals Performance of Bioelectrical Impedance and Anthropometric Predictive Equations for Estimation of Muscle Mass in Chronic Kidney Disease Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Natália Tomborelli Bellafronte ◽  
Lorena Vega-Piris ◽  
Guillermina Barril Cuadrado ◽  
Paula Garcia Chiarello
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Linear Regression Analysis ◽  
Bioelectrical Impedance ◽  
Fat Free Mass ◽  
Predictive Equation ◽  
Predictive Equations

Background: Patients with chronic kidney disease (CKD) are vulnerable to loss of muscle mass due to several metabolic alterations derived from the uremic syndrome. Reference methods for body composition evaluation are usually unfeasible in clinical settings.Aims: To evaluate the accuracy of predictive equations based on bioelectrical impedance analyses (BIA) and anthropometry parameters for estimating fat free mass (FFM) and appendicular FFM (AFFM), compared to dual energy X-ray absorptiometry (DXA), in CKD patients.Methods: We performed a longitudinal study with patients in non-dialysis-dependent, hemodialysis, peritoneal dialysis and kidney transplant treatment. FFM and AFFM were evaluated by DXA, BIA (Sergi, Kyle, Janssen and MacDonald equations) and anthropometry (Hume, Lee, Tian, and Noori equations). Low muscle mass was diagnosed by DXA analysis. Intra-class correlation coefficient (ICC), Bland-Altman graphic and multiple regression analysis were used to evaluate equation accuracy, linear regression analysis to evaluate bias, and ROC curve analysis and kappa for reproducibility.Results: In total sample and in each CKD group, the predictive equation with the best accuracy was AFFMSergi (men, n = 137: ICC = 0.91, 95% CI = 0.79–0.96, bias = 1.11 kg; women, n = 129: ICC = 0.94, 95% CI = 0.92–0.96, bias = −0.28 kg). AFFMSergi also presented the best performance for low muscle mass diagnosis (men, kappa = 0.68, AUC = 0.83; women, kappa = 0.65, AUC = 0.85). Bias between AFFMSergi and AFFMDXA was mainly affected by total body water and fat mass. None of the predictive equations was able to accurately predict changes in AFFM and FFM, with all ICC lower than 0.5.Conclusion: The predictive equation with the best performance to asses muscle mass in CKD patients was AFFMSergi, including evaluation of low muscle mass diagnosis. However, assessment of changes in body composition was biased, mainly due to variations in fluid status together with adiposity, limiting its applicability for longitudinal evaluations.

scholarly journals Disease Burden of Chronic Kidney Disease Due to Hypertension From 1990 to 2019: A Global Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Aiming Chen ◽  
Minjie Zou ◽  
Charlotte Aimee Young ◽  
Weiping Zhu ◽  
Herng-Chia Chiu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Linear Regression ◽  
Socioeconomic Factors ◽  
Multiple Linear Regression ◽  
Disease Burden ◽  
Global Analysis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Model ◽  
Stepwise Multiple Linear Regression

Background: Although it is widely known that hypertension is an important cause of chronic kidney disease (CKD), little detailed quantitative research exists on the burden of CKD due to hypertension.Objective: The objective of the study is to estimate the global disease burden of CKD due to hypertension and to evaluate the association between the socioeconomic factors and country-level disease burden of CKD due to hypertension.Methods: We extracted the disability-adjusted life-year (DALY) numbers, rates, and age-standardized rates of CKD due to hypertension from the Global Burden of Disease Study 2019 database to investigate the time trends of the burden of CKD due to hypertension from 1990 to 2019. Stepwise multiple linear regression analysis was performed to evaluate the correlations between the age-standardized DALY rate and socioeconomic factors and other related factors obtained from open databases.Results: Globally, from 1990 to 2019, DALY numbers caused by CKD due to hypertension increased by 125.2% [95% confidential interval (CI), 124.6 to 125.7%]. The DALY rate increased by 55.7% (55.3 to 56.0%) to 128.8 (110.9 to 149.2) per 100,000 population, while the age-standardized DALYs per 100,000 population increased by 10.9% (10.3 to 11.5%). In general, males and elderly people tended to have a higher disease burden. The distribution disparity in the burden of CKD due to hypertension varies greatly among countries. In the stepwise multiple linear regression model, inequality-adjusted human development index (IHDI) [β = −161.1 (95% CI −238.1 to −84.2), P &lt; 0.001] and number of physicians per 10,000 people [β = −2.91 (95% CI −4.02 to −1.80), P &lt; 0.001] were significantly negatively correlated with age-standardized DALY rate when adjusted for IHDI, health access and quality (HAQ), number of physicians per 10,000 people, and population with at least some secondary education.Conclusion: Improving the average achievements and equality of distribution in health, education, and income, as well as increasing the number of physicians per 10,000 people could help to reduce the burden of CKD due to hypertension. These findings may provide relevant information toward efforts to optimize health policies aimed at reducing the burden of CKD due to hypertension.

scholarly journals The Association Between Related Party Transaction And Tax Avoidance In Indonesia

2020 ◽  
Vol 4 (02) ◽  
pp. 117
Author(s):  
Putra Aryotama ◽  
Amrie Firmansyah
Keyword(s):  
Regression Analysis ◽  
Panel Data ◽  
Linear Regression ◽  
Quantitative Method ◽  
Linear Regression Analysis ◽  
Tax Avoidance ◽  
Corporate Tax ◽  
Negatively Associated ◽  
Related Party Transactions ◽  
Related Party Transaction

<p>This study aims to examine the association between related party transaction and tax avoidance in Indonesia’ Non-Financial Companies. Related-party transactions, as its name implies, are transactions conducted by companies with its related parties. Meanwhile, tax avoidance is a reduction in corporate tax liability, which is conducted by the company legally. This study employs a quantitative method using linear regression analysis and uses panel data of companies listed under the Indonesia Non-Financial Companies on IDX from 2014 to 2017. The result of this study suggests that related party transaction is negatively associated with tax avoidance.</p>

Sign in / Sign up

Export Citation Format

Share Document