scholarly journals Association between Immunoglobulin G Levels and Adverse Effects Following Vaccination with the BNT162b2 Vaccine among Japanese Healthcare Workers

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1149
Author(s):  
Jun Otani ◽  
Ryuichi Ohta ◽  
Chiaki Sano
Keyword(s):  
Adverse Effects ◽  
Injection Site ◽  
Immunoglobulin G ◽  
Healthcare Workers ◽  
Adverse Reactions ◽  
Community Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Systemic Symptoms ◽  
Self Administered Questionnaire

The purpose of the study was to assess the association between the amount of immunoglobulin G (IgG) and the duration of adverse effects of COVID-19 vaccinations in the Japanese population. This cross-sectional study was conducted from April 2020 to August 2021 among workers at a community hospital. All participants received two doses of the BNT162b2 vaccine (Pfizer-BioNTech) in March and April 2021. Vaccine side effects were measured using a self-administered questionnaire. Serum anti-SARS-CoV-2 IgG was measured 3 months after vaccination. There was a total of 338 participants (mean age: 44.7 years). The incidence of adverse reactions after vaccination was higher in women. Adverse reactions associated with higher IgG levels included: erythema at the injection site after the first dose; induration and inflammation at the injection site; and systemic symptoms, e.g., fever and headache after the second dose. IgG levels were higher in younger participants. These findings could mitigate fears regarding the mild adverse effects of the COVID-19 vaccine and encourage uptake of the BNT162b2 vaccine.

scholarly journals Compliance to albendazole therapy under national deworming day programme at schools in Goa: a questionnaire survey

2017 ◽  
Vol 4 (9) ◽  
pp. 3302
Author(s):  
Nitin Y. Dhupdale ◽  
Jagdish A. Cacodcar ◽  
Purushottam A. Giri ◽  
Vijay S. ◽  
Akshaya Naik
Keyword(s):  
Side Effects ◽  
School Children ◽  
Questionnaire Survey ◽  
Adverse Reactions ◽  
Cross Sectional Study ◽  
Family Welfare ◽  
Sectional Study ◽  
Ministry Of Health ◽  
Cross Sectional ◽  
Self Administered Questionnaire

Background: Ministry of Health and Family Welfare, Government of India observed National Deworming Day (NDD) on February 10, 2016 and second round on August 10, 2016 in all 36 States/UTs of the country. The same initiative was implemented in the state of Goa; the present study was aimed at evaluating this initiative. The objectives of the study were to find the compliance of school children to albendazole tablets and also to find any side effects encountered by the students.Methods: A cross-sectional study was conducted in month of Ocober 2016 amongst total of 266 parents completed a self-administered questionnaire. The Data retrieved from completed questionnaires was entered in EpiDATA and analysed by SPSS version 23. Results: Of the total 65.8% of students received albendazole tablets. The overall compliance to the albendazole was 61.3%. Only 4.1% of students developed minor adverse reactions. Overall 78.9% of the parents were willing to participate in the next round of NDD.Conclusions: The compliance to the albendazole was less than expected. There is a greater need to involve parents and teachers to improve the compliance of students towards albendazole to achieve desired outcomes. 

scholarly journals SAFETY OF HYDROXYCHLOROQUINE FOR COVID-19 PROPHYLAXIS AMONG HEALTHCARE WORKERS: AN OBSERVATIONAL STUDY

2020 ◽  
pp. 55-57
Author(s):  
SANGEETA KHANNA ◽  
NITUL M BEWAL ◽  
AMIT ARORA ◽  
KRISHNA PRASAD G V
Keyword(s):  
Health Care ◽  
Adverse Effects ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Care Staff ◽  
Health Care Staff ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Systemic Examination ◽  
Harmful Effects

Objective: Indian Council of Medical Research recommended hydroxychloroquine (HCQ) for prophylaxis of COVID‐19 for healthcare workers and the Food and Drug Administration approved its use in the treatment and prophylaxis of COVID‐19 disease. Even though HCQ is adequately tolerated in usual circumstances, still questions about the harmful effects of the drug remain a cause for concern in adults treated with HCQ. The objective of this study was to evaluate the major and minor adverse effects of prophylactic HCQ for COVID-19 among healthcare workers. Methods: Our analysis was intended to analyze HCQ’s adverse drug reaction profile for COVID‐19 prophylaxis in prophylactic doses in health-care staff. This was a cross-sectional study carried out among healthcare workers taking HCQ prophylaxis for COVID‑19. The study was carried out over 08 weeks period from April to May 2020. The data were obtained regarding age, sex, comorbidities, and possible adverse effects. A pretested and validated online questionnaire was provided to the participants to assess the harmful effects that they experienced when taking HCQ. Furthermore, pre and post 8 weeks prophylaxis, individuals underwent general and systemic examination, along with ECG and blood sugar level monitoring. Results: The research group comprised 70 previously healthy and health-care staff. In 70 patients, 27 minor adverse effects were reported (18.9%). Headache was the most frequently reported symptoms followed by nausea and vomiting, itching, and skin rashes. There was no statistically relevant variation in harmful effects due to age or number of doses administered. However, none of the adverse effects was serious or debilitating. Conclusion: With adequate pre-prophylaxis evaluation, health education, and regular monitoring, HCQ prophylaxis is safe and devoid of any serious adverse effects in previously healthy individuals.

scholarly journals Adverse effects of COVID‐19 mRNA‐1273 vaccine: A randomized, cross‐sectional study on healthcare workers with detailed self‐reported symptoms

2021 ◽  
Author(s):  
Renuka Ananth Kalyan Kadali ◽  
Ravali Janagama ◽  
Sharanya Peruru ◽  
Viswanath Gajula ◽  
Rajasekhar R. Madathala ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Reported healthcare workers knowledge and practices of hand hygiene in specialist hospitals of Kano, Northwest Nigeria

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Auwal Umar Gajida ◽  
Usman Muhammad Ibrahim ◽  
Rabiu Ibrahim Jalo ◽  
Musa Muhammad Bello ◽  
Amole Taiwo Gboluwaga ◽  
...  
Keyword(s):  
Hand Hygiene ◽  
Healthcare Workers ◽  
Healthcare Providers ◽  
Cross Sectional Study ◽  
Formal Training ◽  
Drug Resistant ◽  
Improve Hand Hygiene ◽  
Cross Sectional ◽  
Hygiene Practices ◽  
Self Administered Questionnaire

Compliance with recommended hand hygiene among healthcare providers is important in the prevention of morbidity and mortality associated with hospitalacquired infections including drug resistant microorganisms. This study aimed to determine the reported knowledge and hand hygiene practices among healthcare workers in Specialist Hospitals in Kano, Nigeria. Descriptive cross-sectional study design was used to study 302 healthcare workers in the specialist hospitals in Kano. Data was collected using semi-structured self-administered questionnaire and analyzed at univariate, bivariate and multivariate levels using IBM SPSS version 22. The age of the respondents ranged from 18 to 59 years with a mean of 31.4±9 years. Up to onethird (36.1%) of the respondents had poor knowledge despite the reported hand hygiene practice of 78%. Use of Alcohol Based Hand Rub and soap and water constituted 26.7% and 15.7% respectively. There was statistically significant association between working in MMSH, working in Pediatrics wards, CHEW cadre, and attendance of hand hygiene training in the last 3 years and having good knowledge of hand hygiene. Hand hygiene training was found to improve hand hygiene knowledge [AOR=1.58, 95% CI= (1.01-2.5)] and practice [AOR=1.12 95%CI= (0.64-1.99)]. Reported knowledge of hand hygiene was poor but the practices were encouraging and associated with formal training of healthcare workers on hand hygiene. Therefore, Hospital management should ensure regular hand hygiene training and re-training among healthcare workers.

EFFICACY OF TREATMENT OF H.PYLORI EARDICATION WITH STANDARD TRIPLE THERAPY IN PEPTIC ULCER PATIENTS

2011 ◽  
pp. 122-129
Author(s):  
Quang Di Bui ◽  
Phuoc Lam Nguyen
Keyword(s):  
Peptic Ulcer ◽  
Adverse Effects ◽  
Triple Therapy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Intention To Treat ◽  
Standard Triple Therapy

Objectives: The aim of study is to evaluate the efficacy, tolerability and adverse effects of a standard triple therapy including Rabeprazole, Clarithromycin and Amoxicilline at Sai gon Hoan My hospital in order to consider treatment H.pylori for patients who have not yet eradicated before or need to be undertaked by alternative regimens. Methods: By descriptive cross-sectional study, the authors have examined 116 patients sufferring from peptic ulcer received 10-day therapy including Rabe (20mg b.d) plus Clari(500mg b.d) plus Amoxi(1g b.d). Eradication is confirmed with endoscopy after 4 weeks from completing of treatment. Results and Discussion: 100% of patients were initially included and noboby was dropped out of the follow-up satges. The mean age was 49 in which 62% was male, 73(62,9%) presented duodenal ulcer, 28(24,1%) gastric ulcer and 15(13%) simultaneous gastric and duodenal ulcers. All patients took medications correctly. Per-protocol and intention to treat eradication rates were both 75%(95% CI=73,4-78,3). Additionally, 62(53,4%) patients had at least one risky factor for peptic ulcer disease, smoking being the most common one 44(37,9%).The adverse effects were reported overall in 67% of the patients, mainly including changed taste, very bitter, tired 49%, trouble sleeping 12% and diarrhea 5%. Conclusion: this ten-day standard triple therapy used in this study is ineffective with high adverse effects.The first line eradication with new regimens should be alternative.

Psychosocial Impact of Covid-19 Pandemic on Frontline Healthcare Workers in Pakistan: A Cross-Sectional Study

2020 ◽  
Author(s):  
Quratul-Ain Zafar
Keyword(s):  
Data Collection ◽  
Emotional Distress ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Psychosocial Impact ◽  
Control Group ◽  
Study Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Frontline Healthcare Workers

Objective: The purpose of this study was to evaluate the impact of the COVID-19 pandemic on frontline healthcare workers in Pakistan in terms of psychological factors emotional distress, insomnia, and burnout. Study Design: Observational cross-sectional study. Place and Duration of Study: This study was conducted at different hospitals across Pakistan and data collection was carried out from 15th June 2020 till 15th August 2020. Material and Methods: This was a questionnaire-based study aiming to compare the levels of burnout and emotional distress between frontline COVID-19 and non-COVID-19 healthcare workers. Any physician, nurse, and other healthcare workers were recruited from emergency care units and Covid-19 care units (target group), and non-COVID-19 care units (control group). Participation was voluntary and participants had to complete self-reported questionnaires and scales. A mixed-mode data collection was carried out, either in paper or web-based form to ensure maximum participation. Results: The independent t-test showed a statistically significant difference between the two groups regarding depression, stress, and insomnia. The study group showed higher scores for these factors than the control group. Chi-square test of association revealed significant scores of burnout and professional fulfillment in both groups. There was a higher prevalence of burnout in the study group than in the control group. Conclusion: This study concludes that there was a significant psychosocial impact of the Covid-19 pandemic in the frontline healthcare workers measured in terms of emotional distress, insomnia, and burnout.

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