Analgesics from the history to contemporary times

Фармацевтический рынок Казахстана растет с каждым годом. Отечественные компании увеличивают внутренне производство ЛС и БАДов, что безусловно вносит свою лепту в решение проблемы импортозамещения. Однако стоит обратить внимание на более простые медикаменты, которыми наши граждане пользуются практически каждый день. К таким относятся ЛФ для рассасывания, которые купируют неприятные симптомы инфекционно - воспалительных заболеваний полости рта и горла, улучшая качество жизни. Стоит обратить внимание на этот сегмент рынка, который насчитывает млн. долларах США. Нами проведен подробный маркетинговый анализ рынка ЛФ для рассасывания Республики Казахстан. Представлены данные касательно лидеров рынка, доли зарубежных и отечественных производителей и объемов рынка за 2019-2020гг. The pharmaceutical market in Kazakhstan is growing every year. Domestic companies increase domestic production of drugs and dietary supplements, which certainly contributes to the problem of import substitution. However, it is worth to pay attention to simpler medicines, which our citizens use practically every day. Such drugs include liquids for resorption, which relieve unpleasant symptoms of infectious and inflammatory diseases of the mouth and throat, improving the quality of life. It is worth paying attention to this market segment, which amounts to millions of U.S. dollars. We have carried out a detailed marketing analysis of the dosage forms market for resorption in Republic of Kazakhstan. The data on the share of foreign and domestic manufacturers and market volumes for 2019-2020 are presented.

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Cross-cultural adaptation of the German version of the Quality of Life in Alzheimer's Disease scale - Nursing Home version (QoL-AD NH)

International Psychogeriatrics ◽

10.1017/s1041610216000107 ◽

2016 ◽

Vol 28 (8) ◽

pp. 1399-1400 ◽

Cited By ~ 6

Author(s):

Martin Nikolaus Dichter ◽

Eva-Maria Wolschon ◽

Gabriele Meyer ◽

Sascha Köpke

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Community Dwelling ◽

Positive Effects ◽

People With Dementia ◽

The Us ◽

Dementia Research ◽

Almost All

Dementia is a chronic and currently incurable syndrome. Therefore, quality of life (QoL) is a major goal when caring for people with dementia (Gibson et al., 2010) and a major outcome in dementia research (Moniz-Cook et al., 2008). The measurement of QoL, especially proxy-rating, is challenging because of the proxy-perspective (Pickard and Knight, 2005), reliability (Dichter et al., 2016), validity (O'Rourke et al., 2015), and responsiveness (Perales et al., 2013). Probably due to these challenges, it has not been possible to show positive effects for QoL in almost all non-pharmacological interventions for people with dementia (Cooper et al., 2012). One recommended (Moniz-Cook et al., 2008) and frequently used instrument is the Quality of Life in Alzheimer's Disease scale (QoL-AD), which was originally developed in the US for community-dwelling people with dementia. The QoL-AD consists of 13 items based on a 4-point Likert scale ranging from “1”=poor to “4”=excellent (Logsdon et al., 1999). The original instrument has been adapted for people living in nursing homes (NH) by Edelmann et al. (2005).

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Sensory profile and its impact on quality of life in patients with painful diabetic polyneuropathy

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.118766 ◽

2013 ◽

Vol 04 (03) ◽

pp. 267-270 ◽

Cited By ~ 3

Author(s):

Kongkiat Kulkantrakorn ◽

Chakraphong Lorsuwansiri

Keyword(s):

Quality Of Life ◽

Short Form ◽

Diabetic Polyneuropathy ◽

Sensory Profile ◽

Mcgill Pain Questionnaire ◽

Sharp Pain ◽

Sf 36 ◽

Sensory Score ◽

Almost All

ABSTRACT Context: Painful diabetic polyneuropathy (PDN) is common and causes significant disability. The sensory profile in each patient is different and affects quality of life. Aim: To describe the demographic, details of sensory profile and its impact on quality of life in patients with PDN. Settings and Design: A cross-sectional survey in patients with PDN who were treated in a University Hospital. Materials and Methods: They were interviewed with standard questionnaires, which included neuropathic pain scale (NPS), a short-form McGill Pain Questionnaire (SF-MPQ) and a short form-36 quality of life survey (SF-36). Statistical Analysis Used: Descriptive statistics were used in demographic data. Student′s t test was used to analyze continuous data. Multiple comparisons for proportions and correlations were made using Fisher Exact test and Pearson′s coefficient of correlation, respectively. Results: Thirty three patients were included in this study. In NPS, sharp pain was the most common symptom and itching was the least common. Almost all patients had more than one type of pain. The mean VAS was 53 mm. In SFMPQ, the sensory score, affective score and the present pain score fell in the moderate range. In SF-36, physical functioning was the most affected and social function was the least affected. Conclusions: PDN significantly affects patients′ quality of life, especially physical function and role limitation due to a physical problem. Almost all patients have many types of pain and sharp pain is the most common.

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Quality of Life Philosophy V. Seizing the Meaning of Life and Becoming Well Again

The Scientific World JOURNAL ◽

10.1100/tsw.2003.105 ◽

2003 ◽

Vol 3 ◽

pp. 1210-1229 ◽

Cited By ~ 4

Author(s):

Søren Ventegodt ◽

Niels Jørgen Andersen ◽

Joav Merrick

Keyword(s):

Quality Of Life ◽

Meaning Of Life ◽

Subjective Health ◽

Point Of View ◽

Philosophy Of Life ◽

Life Philosophy ◽

The One ◽

Almost All ◽

Taking Responsibility

This paper presents a positive philosophy of life developed to support and inspire patients to take more responsibility for their own lives and to draw more efficiently on their known or hidden resources. The idea is that everybody can become wiser, use themselves better, and thus improve quality of life, subjective health, and the ability to function.To be responsible means to see yourself as the cause of your own existence and state of being. To be the one who forms your own life to your liking, so that others do not shape it in the way they prefer to see you. Seen this way, taking responsibility in practice is one of the most difficult things to do. One of the greatest and most difficult things to do in this context is to be able to love. To be the one who loves, instead of being the one who demands love, care, awareness, respect, and acceptance from somebody else.Since almost all of us have had parents who maybe loved us too little and mostly conditionally, we all harbor a deep yearning to be loved as we are, unconditionally. A lot of our energy is spent trying to find recognition and acceptance, more or less as we did as children from our parents, who created the framework and defined the rules of the game. But today, reality is different. We have grown up and now life is about shaping our own existence. So we must be the ones who love. This is what responsibility is all about. Taking responsibility is, quite literally, moving the barriers in our lives inside ourselves. Taking responsibility for life means that you are willing to see that the real barriers are not all these external ones, but something that can be found within yourself. Of course there is an outside world that cannot be easily shaped according to your dreams. But a responsible point of view is that although it is difficult, the problem is not impossible; it is your real challenge and task. If there is something you really want, you can achieve it, but whether it happens depends on your wholehearted, goal-oriented, and continuous attempts. This paper describes the philosophy about seizing the meaning of life and becoming well again, even when there is little time left.

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“We have a ticking time bomb”: a qualitative exploration of the impact of canine epilepsy on dog owners living in England

BMC Veterinary Research ◽

10.1186/s12917-020-02669-w ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Amy E. Pergande ◽

Zoe Belshaw ◽

Holger A. Volk ◽

Rowena M. A. Packer

Keyword(s):

Quality Of Life ◽

Lifestyle Changes ◽

Idiopathic Epilepsy ◽

Clinical Aspects ◽

Structured Interviews ◽

Online Groups ◽

Additional Support ◽

Almost All ◽

The Impact

Abstract Background Idiopathic epilepsy is a common neurological condition in dogs. Previous research has focused on clinical aspects of seizure management in dogs with idiopathic epilepsy with little attention given to the emotional and logistical challenges for their owners. The current study aimed to explore the impacts of owning a dog with idiopathic epilepsy on owner quality of life and lifestyle, using qualitative methods. Methods Owners of dogs with idiopathic epilepsy living in England were recruited via social media and word of mouth, and then selected using purposive sampling to participate in face-to-face semi-structured interviews. Epilepsy management was explored through in-depth accounts of owner experiences and influencing factors. Interviews were recorded and transcribed verbatim and thematic analysis was used to construct key themes. Results Twenty-one interviews were completed. Almost all owners had made lifestyle changes in order to care for their dog, including substantial modifications to routines and, in some cases, employment. Many owners discussed a very emotionally close dog-owner bond, and described experiencing frequent feelings of fear, stress and uncertainty regarding their dog’s health. Friends, family and colleagues did not always understand the magnitude of commitment required to care for a dog with idiopathic epilepsy. This, combined with a fear of leaving their dog unsupervised, had social implications in some instances and lead to increased use of the Internet and online groups for peer support. Conclusions The commitment required to care for a dog with idiopathic epilepsy, and the lifestyle changes made by their owners, may be far greater than previously estimated. Further consideration of these factors by veterinary professionals and the friends and families of owners of dogs with idiopathic epilepsy could improve owner quality of life, and facilitate the provision of additional support.

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Current approaches in the treatment of malignant ascites in Germany and Austria.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e20670 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e20670-e20670

Author(s):

Diana Lueftner ◽

Susanne Küpferling ◽

Gülten Oskay-Özcelik ◽

Christian Jehn

Keyword(s):

Quality Of Life ◽

Poor Prognosis ◽

Systemic Chemotherapy ◽

Diuretic Therapy ◽

Treatment Strategies ◽

Healthcare Facility ◽

Malignant Ascites ◽

Almost All ◽

Volume Substitution

e20670 Background: Malignant Ascites (MA) is a common manifestation of advanced cancer associated with a poor prognosis and decreased quality of life. Currently there are no evidence based guidelines for the management of MA and only one agent is approved for its treatment. We conducted a survey with physicians throughout Germany and Austria, to get an overview of current approaches and opinions in the treatment of MA. Methods: 128 medical oncologists (MO), gastroenterologists (GE) and gynecologists (GYN) completed an electronic questionnaire consisting of 33 questions. Answers were evaluated with descriptive statistics. Results: 90% of the physicians were from Germany, 10% from Austria. 48% of those were MO, 30% were GYN and 14% were GE. Most physicians treated an average of 34 pts/year with MA. 26% of these pts suffered from ovarian, 20% from pancreatic, 17% from gastric and 14% from colorectal cancer. The majority of the physicians associated MA with poor prognosis (92%) and significant reduction in quality of life (87%). One third felt MA was a contraindication for full dosing of systemic chemotherapy. Paracentesis (P) was performed in 70% of pts with with symptom relieve and quality of life being the main reasons. Almost half of the pts required 3-5 P, 50% even more than 5 P during the course of their disease. Only 15% of pts needed multiple P per week, the majority (79%) needed the procedure either once a week or every 14 days. In 61% of pts 3-5 l ascites fluid was drained. Only in 8%, 5 l and more were removed. Volume substitution with IV albumin was performed in 40% of pts. Most pts (55%) had to stay 1-3h in a healthcare facility for the procedure. However 21% had to stay > 1 day. While almost all physicians (89%) performed a P at some point in the treatment of MA, 75% felt that a systemic chemotherapy and 55% thought a concomitant diuretic therapy were a necessary adjunct. 7% of the pts received a targeted treatment with catumaxomab. Conclusions: Even though repeated P is the main pillar of treatment of MA, its effect is only temporary, must be performed multiple times, requiring hospital resources. Further treatment strategies have to be evaluated in prospective studies. Targeted therapies like catumaxomab should be integrated into these.

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Efficacy and safety of two Ayurvedic dosage forms for Allergic rhinitis: Study protocol for an open-label randomized controlled trial

10.21203/rs.2.13359/v2 ◽

2019 ◽

Author(s):

JM Dahanayake ◽

Pathirage Kamal Perera ◽

P Galappaththy ◽

D Samaranayake

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Controlled Trial ◽

Dosage Forms ◽

Efficacy And Safety ◽

Open Label ◽

Randomized Controlled ◽

Nasal Symptoms ◽

Freeze Dried

Abstract Background: Allergic rhinitis (AR) is an immune response of the nasal mucosa to airborne allergens and involves nasal congestion, watery nasal discharge, itching of the nose and sneezing. The symptoms of allergic rhinitis may significantly affect a patient’s quality of life and can be associated with conditions such as fatigue, headache, cognitive impairment and sleep disturbances. Various complementary and alternative medicine treatments have been used for this condition in clinical practice. The Ayurveda system of medicine is the most common complementary medicine system practiced in Sri Lanka. The aim of this study is to examine the efficacy and safety of a decoction used in traditional Ayurveda for allergic rhinitis and it’s ready to use freeze dried formulation in comparison to an antihistamine over a period of 4 weeks on relief of symptoms in allergic rhinitis. Study design: This is a three arm, open label, non-inferiority, randomized controlled clinical trial enrolling patients with AR. Tamalakyadi decoction containing 12 ingredients (TMD12), used in traditional Ayurveda and its freeze dried formulation are the test products. The efficacy and safety of the two Ayurvedic dosage forms will be tested against the antihistamine loratidine Patients with symptoms of AR will be allocated randomly into the 3 arms after a 1 week run-in period and the medications will be given orally for 28 days. Total Nasal symptom Score (TNSS) of the patients will be used as the primary efficacy endpoint. TNSS will be recorded and compared between the 3 arms prior to visit 1, at the end of 28 days, end of the and second months of follow up. Symptom scores of daytime nasal symptoms, night time nasal symptoms, non-nasal symptoms and Health Related Quality of Life questionnaire are used as secondary end points. Discussion: This clinical trial will be able to provide evidence based scientific data on Ayurvedic dosage form, TMD12 and the freeze-dried formulation in the treatment of allergic rhinitis. This trial is expected to develop capacity to scientifically evaluate various Ayurvedic treatments that are claimed to have efficacy in treatment of various disease conditions. Trial registration:ISRCTN18149439 (06 May 2019) Keywords: Allergic rhinitis, Ayurvedic dosage forms, Tamalakyadi decoctions, Randomized controlled trial

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Types of urethral stricture and their recurrence rates post urological treatments

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20212347 ◽

2021 ◽

Author(s):

Wedyan Salem Basaif ◽

Husam Hamad Alamri ◽

Hind Waleed Mousa ◽

Raghad Abdulelah Alsayed ◽

Abdullah Mohammed Almohammadi ◽

...

Keyword(s):

Quality Of Life ◽

Current Evidence ◽

Internal Urethrotomy ◽

Recurrence Rates ◽

Current Management ◽

Urethral Strictures ◽

Common Causes ◽

Almost All ◽

Anastomotic Urethroplasty

Urethral strictures can significantly impact the quality of life for patients because it can be associated with significant complications such as fistulas, bladder calculi, infections and sepsis. Additionally, it might even lead to renal failure. The worldwide prevalence of urethral strictures is high, with an estimated rate of 229-627 patients per 100,000 population. In this literature review, the aim was to discuss the types and etiology of urethral strictures and the recurrence rates following the different management modalities. Studies that were included in this review were published between January 2005 until May 2021. The results support the current evidence that the idiopathic and iatrogenic bulbar strictures are the most common types while penile strictures, the iatrogenic and inflammatory are the most common causes. Recurrence rates are reported after management with almost all of the current management modalities, indicating the need for better interventions to enhance the outcomes and alleviate the quality of care. The recurrence rate of strictures after treatment with internal urethrotomy and direct vision internal urethrotomy by three years is 65%. Other studies reported that the rate of recurrence was estimated to be around 14 after 6 months from internal urethrotomy and up to 27% after 12 months. The rate of complications and recurrence following treatment with anastomotic urethroplasty was estimated to be less than 5%. Detailed information and discussion were provided in the study manuscript.

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“We have a ticking time bomb”: A qualitative exploration of the impact of canine epilepsy on dog owners living in England

10.21203/rs.3.rs-39029/v1 ◽

2020 ◽

Author(s):

Amy Eliza Pergande ◽

Zoe Belshaw ◽

Holger A Volk ◽

Rowena M A Packer

Keyword(s):

Quality Of Life ◽

Lifestyle Changes ◽

Idiopathic Epilepsy ◽

Clinical Aspects ◽

Structured Interviews ◽

Online Groups ◽

Additional Support ◽

Almost All ◽

The Impact

Abstract Background Idiopathic epilepsy is a common neurological condition in dogs. Previous research has focused on clinical aspects of seizure management in dogs with idiopathic epilepsy with little attention given to the emotional and logistical challenges for their owners. The current study aimed to explore the impacts of owning a dog with idiopathic epilepsy on owner quality of life and lifestyle, using qualitative methods. Methods Owners of dogs with idiopathic epilepsy living in England were recruited via social media and word of mouth, and then selected using purposive sampling to participate in face-to-face semi-structured interviews. Epilepsy management was explored through in-depth accounts of owner experiences and influencing factors. Interviews were recorded and transcribed verbatim and thematic analysis was used to construct key themes. Results Twenty-one interviews were completed. Almost all owners had made lifestyle changes in order to care for their dog, including substantial modifications to routines and, in some cases, employment. Many owners discussed a very emotionally close dog-owner bond, and described experiencing frequent feelings of fear, stress and uncertainty regarding their dog’s health. Friends, family and colleagues did not always understand the magnitude of commitment required to care for a dog with idiopathic epilepsy. This, combined with a fear of leaving their dog unsupervised, had social implications in some instances and lead to increased use of the Internet and online groups for peer support. Conclusions The commitment required to care for a dog with idiopathic epilepsy, and the lifestyle changes made by their owners, may be far greater than previously estimated. Further consideration of these factors by veterinary professionals and the friends and families of owners of dogs with idiopathic epilepsy could improve owner quality of life, and facilitate the provision of additional support.

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Resilience and Quality of Life in Breast Cancer Patients

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2015.128 ◽

2015 ◽

Vol 3 (4) ◽

pp. 727-731 ◽

Cited By ~ 20

Author(s):

Gordana Ristevska-Dimitrоvska ◽

Izabela Filov ◽

Domnika Rajchanovska ◽

Petar Stefanovski ◽

Beti Dejanova

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Future Perspective ◽

Psychological Resilience ◽

Breast Cancer Patients ◽

Global Quality Of Life ◽

Eortc Qlq ◽

Almost All

BACKGROUND: Many studies have shown that a relationship exists between quality of life (QoL) and resilience in breast cancer patients, but few studies present information on the nature of this relationship of resilience on QoL. Our aim was to examine the relationship between resilience and quality of life in breast cancer patients.METHODS: QoL was measured in 218 consequent breast cancer patients, with EORTC - QLQ Core 30 questionnaire, and EORTC QLQ-BR23. The resilience was measured with Connor Davidson Resilience Scale.RESULTS: The global quality of life was positively correlated with the levels of resilience (R = 0.39 p < 0.001). All functional scales (physical, role, emotional, cognitive and social functioning was in a positive correlation with resilience. The symptoms severity (fatigue, nausea and vomitus, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea, financial difficulties) was in negative correlation with resilience. Less resilient breast cancer patients reported worse body image and future perspective and suffered from more severe adverse effects of systemic therapy, and arm/breast symptoms. CONCLUSION: Our findings show that psychological resilience affects different aspects of health-related quality of life. More resilient patients have significantly better quality of life in almost all aspects of QoL.

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