Halotherapy in the rehabilitation of children in educational institutions

The aim of the study was to assess the impact of halotherapy performed in halocabinets on the health of children who often suffer from acute respiratory diseases. Based on the data obtained, the pronounced anti-inflammatory and sanogenetic effect of the factor was established, and the optimal parameters and halotherapy regimens were determined depending on the presence of symptoms of acute respiratory disease. Follow-up observations have confirmed the durability of the therapeutic effect.

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Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

Marine Drugs ◽

10.3390/md18110570 ◽

2020 ◽

Vol 18 (11) ◽

pp. 570

Author(s):

Kate Summer ◽

Jessica Browne ◽

Lei Liu ◽

Kirsten Benkendorff

Keyword(s):

Respiratory Disease ◽

Respiratory Diseases ◽

Research Priorities ◽

Evidence Base ◽

Chemotherapeutic Agents ◽

Biofilm Inhibition ◽

Traditional Medicines ◽

Chemical Structures ◽

Treatment And Prevention ◽

Anti Inflammatory

Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.

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Improvement in left ventricular mechanics following medical treatment of constrictive pericarditis

Heart ◽

10.1136/heartjnl-2020-317304 ◽

2021 ◽

pp. heartjnl-2020-317304

Author(s):

Kimi Sato ◽

Ayman Ayache ◽

Arnav Kumar ◽

Paul C Cremer ◽

Brian Griffin ◽

...

Keyword(s):

Constrictive Pericarditis ◽

Clinical Symptoms ◽

Heart Association ◽

Left Ventricular ◽

Doppler Imaging ◽

Clinical Resolution ◽

Ventricular Mechanics ◽

Anti Inflammatory ◽

The Impact

ObjectivePatients with constrictive pericarditis (CP) with active inflammation may show resolution with anti-inflammatory therapy. We aimed to investigate the impact of anti-inflammatory medications on constrictive pathophysiology using echocardiography in patients with CP.MethodsWe identified 35 patients with CP who were treated with anti-inflammatory medications (colchicine, prednisone, non-steroidal anti-inflammatory drugs) after diagnosis of CP (mean age 58±13; 80% male). Clinical resolution of CP (transient CP) was defined as improvement in New York Heart Association class during follow-up. We assessed constrictive pathophysiology using regional myocardial mechanics by the ratio of peak early diastolic tissue velocity (e’) at the lateral and septal mitral annulus by tissue Doppler imaging (lateral/septal e’) or the ratio of the left ventricular lateral and septal wall longitudinal strain (LSlateral/LSseptal) by two-dimensional speckle-tracking echocardiography. Longitudinal data were analysed using a mixed effects model.ResultsDuring a median follow-up of 323 days, 20 patients had transient CP, whereas 15 patients had persistent CP. Transient CP had higher baseline erythrocyte sedimentation rates (ESR) (p=0.003) compared with persistent CP. There were no significant differences in LSlateral/LSseptal and lateral/septal e’. During follow-up, only transient CP showed improvement in lateral/septal e’ (p<0.001) and LSlateral/LSseptal (p=0.003), and recovery of inflammatory markers was similar between the two groups. In the logistic model, higher baseline ESR and greater improvement in lateral/septal e’ and LSlateral/LSseptal were associated with clinical resolution of CP using anti-inflammatory therapy.ConclusionsImprovement of constrictive physiology detected by lateral/septal e’ and LSlateral/LSseptal was associated with resolution of clinical symptoms after anti-inflammatory treatment. Serial monitoring of these markers could be used to identify transient CP.

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Age at Vaccination and Timing of Infection Do Not Alter Vaccine-Associated Enhanced Respiratory Disease in Influenza A Virus-Infected Pigs

Clinical and Vaccine Immunology ◽

10.1128/cvi.00563-15 ◽

2016 ◽

Vol 23 (6) ◽

pp. 470-482 ◽

Cited By ~ 12

Author(s):

Carine K. Souza ◽

Daniela S. Rajão ◽

Crystal L. Loving ◽

Phillip C. Gauger ◽

Daniel R. Pérez ◽

...

Keyword(s):

Respiratory Disease ◽

Influenza A Virus ◽

Influenza A ◽

Control Groups ◽

Swine Industry ◽

Vaccine Component ◽

Live Attenuated Influenza Virus ◽

And Control ◽

The Impact

ABSTRACTWhole inactivated virus (WIV) vaccines are widely used in the swine industry to reduce clinical disease against homologous influenza A virus (IAV) infection. In pigs experimentally challenged with antigenically distinct heterologous IAV of the same hemagglutinin subtype, WIV vaccinates have been shown to develop vaccine-associated enhanced respiratory disease (VAERD). We evaluated the impact of vaccine valency, age at vaccination, and duration between vaccination and challenge on the development of VAERD using vaccine containing δ1-H1N2 and challenge with pandemic H1N1 (pH1N1) virus. Pigs were vaccinated with monovalent WIV MN08 (δ1-H1N2) and bivalent (δ1-H1N2–H3N2 or δ1-H1N2–pH1N1) vaccines and then were challenged with pH1N1 at 3 weeks postboost (wpb). Another group was vaccinated with the same monovalent WIV and challenged at 6 wpb to determine if the time postvaccination plays a role in the development of VAERD. In a follow-up study, the impact of age of first WIV vaccination (at 4 versus 9 weeks of age) with a boost 3 weeks later (at 7 versus 12 weeks of age) was evaluated. A monovalent live-attenuated influenza virus (LAIV) vaccine administered at 4 and 7 weeks of age was also included. All mismatched WIV groups had significantly higher lung lesions than the LAIV, bivalent MN08-CA09, and control groups. Age of first vaccination or length of time between booster dose and subsequent challenge did not alter the development of VAERD in WIV-vaccinated pigs. Importantly, the mismatched component of the bivalent MN08-CA09 WIV did not override the protective effect of the matched vaccine component.

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EFFECTIVENESS OF FIXED COMBINATION OF FORMULATIONS FOR COUGHING

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.20.4.45 ◽

2020 ◽

Vol 20 (4) ◽

pp. 45-48

Author(s):

V. M. Zhdan ◽

Н. S. Khaimenova ◽

M. Yu. Babanina ◽

O.A. Kyrian ◽

I. V. Ivanitskiy

Keyword(s):

Respiratory Disease ◽

Respiratory Diseases ◽

Comparison Group ◽

Clinical Symptoms ◽

Fixed Combination ◽

Pathological Process ◽

Efficacy And Safety ◽

Bronchial Secretion ◽

Acute Respiratory Diseases ◽

The Difference

There are many respiratory diseases, which despite the difference in aetiology, pathogenesis, the peculiarities in progression may have some common features, resulting in the localization of the pathological process in the respiratory systems. These common signs include changes in bronchial secretion that ultimately leads to mucostasis and burdens the course of any respiratory disease. There are very few combined formulations capable of impacting several mechanisms of mucostasis at once. One of them is Ascoril possessing a double effect of bronchodilator and expectorant. The aim of this study was to evaluate the clinical efficacy and safety of Ascoril therapy for patients with acute respiratory diseases. The study included 105 patients aged 25 ± 0.5 to 55 ± 1.6 years with mild or moderate acute respiratory disease, who had acute respiratory diseases with cough due to laryngitis, pharyngitis, tracheitis, bronchitis. Patients of the 1st group (75 patients, the main group) received the treatment with Ascoril, the patients of the 2nd group (30 patients, the comparison group) received Bromhexine. The patients in both groups were comparable by age and sex. The patients treated with Ascoril showed the disappearance of cough symptoms 3 – 4 days earlier than the patients in the comparison group (p < 0.05). The total score assessment of clinical symptoms during the treatment demonstrated the administration of Ascoril promoted the effectiveness of therapy, which was found significantly higher than in the 2nd group (p < 0.05). We can conclude Ascoril reduces the duration of the disease, cut down the need in antibiotics, lowers the manifestations of bronchial hyper reactivity, and promotes faster clinical recovery, the last but not the least, it is safe.

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Nursing patients with respiratory problems

Oxford Handbook of Adult Nursing ◽

10.1093/med/9780199231355.003.0006 ◽

2009 ◽

pp. 99-134

Keyword(s):

Respiratory Disease ◽

Respiratory Diseases ◽

Oxygen Therapy ◽

Respiratory Infections ◽

Acute Respiratory Disease ◽

Nursing Assessment ◽

Surgical Interventions ◽

Chronic Respiratory Diseases ◽

Respiratory Problems

Nursing assessment of patients with respiratory problems 100 Common respiratory nursing problems 102 Oxygen therapy 104 Tests and investigations 108 Respiratory infections 110 Chronic respiratory diseases: innate 112 Chronic respiratory diseases: acquired 114 Acute respiratory disease 118 Common respiratory surgical interventions 120 Respiratory equipment 122...

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Clinical effectiveness of conventional influenza vaccination in asthmatic children

Epidemiology and Infection ◽

10.1017/s0950268801006574 ◽

2002 ◽

Vol 128 (2) ◽

pp. 205-211 ◽

Cited By ~ 41

Author(s):

A. J. SMITS ◽

E. HAK ◽

W. A. B. STALMAN ◽

G. A. VAN ESSEN ◽

A. W. HOES ◽

...

Keyword(s):

Influenza Vaccination ◽

Respiratory Disease ◽

Acute Otitis Media ◽

Experimental Studies ◽

Clinical Effectiveness ◽

Acute Respiratory Disease ◽

Older Children ◽

Asthmatic Children ◽

Primary Care Practices ◽

The Impact

Influenza immunization rates among young asthmatics remain unsatisfactory due to persistent concern about the impact of influenza and the benefits of the vaccine. We assessed the effectiveness of the conventional inactivated trivalent sub-unit influenza vaccine in reducing acute respiratory disease in asthmatic children. We conducted a two-season retrospective cohort study covering the 1995–6 and 1996–7 influenza outbreaks in 22 computerized primary care practices in the Netherlands. In total, 349 patients aged between 0 and 12 years meeting clinical asthma-criteria were included; 14 children were lost to follow-up in the second season. The occurrence of physician-diagnosed acute respiratory disease episodes including influenza-like illness, pneumonia, bronchitis, bronchiolitis, asthma exacerbation and acute otitis media in vaccinated and unvaccinated children were compared after adjustments for age, prior health care and medication use. The occurrence of acute respiratory disease in unvaccinated children was 28% and 24% in the 1995–6 and 1996–7 season, respectively, and was highest in children under 6 years of age (43%). The overall pooled clinical vaccine effectiveness was 27% (95% confidence interval −7 to 51%, P = 0·11) after adjustments. A statistically higher vaccine protectiveness of 55% (95% CI 20–75%, P = 0·01) was observed among asthmatics under 6 years of age compared with −5% in older children (95% CI −81 to 39%). The occurrence of acute respiratory disease among asthmatic children during influenza epidemics is very high, notably in the youngest. Influenza vaccination may reduce morbidity in asthmatic infants and pre-school children. However, larger, preferably experimental, studies are needed to establish the benefits of vaccination, notably in older asthmatic children.

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Increased Mortality of Respiratory Diseases, Including Lung Cancer, in the Area with Large Amount of Ashfall from Mount Sakurajima Volcano

Journal of Environmental and Public Health ◽

10.1155/2012/257831 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 8

Author(s):

Kenta Higuchi ◽

Chihaya Koriyama ◽

Suminori Akiba

Keyword(s):

Lung Cancer ◽

Respiratory Disease ◽

Respiratory Diseases ◽

Volcanic Ash ◽

Chronic Respiratory Disease ◽

Chronic Respiratory Diseases ◽

Disease Mortality ◽

The World ◽

Acute Respiratory Diseases ◽

Standardized Mortality Ratios

Objectives. Mount Sakurajima in Japan is one of the most active volcanoes in the world. This work was conducted to examine the effect of volcanic ash on the chronic respiratory disease mortality in the vicinity of Mt. Sakurajima.Methods. The present work examined the standardized mortality ratios (SMRs) of respiratory diseases during the period 1968–2002 in Sakurajima town and Tarumizu city, where ashfall from the volcano recorded more than 10.000 g/m2/yr on average in the 1980s.Results. The SMR of lung cancer in the Sakurajima-Tarumizu area was 1.61 (95% CI = 1.44–1.78) for men and 1.67 (95% CI = 1.39–1.95) for women while it was nearly equal to one in Kanoya city, which neighbors Tarumizu city but located at the further position from Mt. Sakurajima, and therefore has much smaller amounts of ashfall. Sakurajima-Tarumizu area had elevated SMRs for COPDs and acute respiratory diseases while Kanoya did not.Conclusions. Cristobalite is the most likely cause of the increased deaths from those chronic respiratory diseases since smoking is unlikely to explain the increased mortality of respiratory diseases among women since the proportion of smokers in Japanese women is less than 20%, and SPM levels in the Sakurajima-Tarumizu area were not high. Further studies seem warranted.

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The Influence of External Factors on the Morbidity of Military Personnel

Journal of New Medical Technologies ◽

10.12737/17030 ◽

2015 ◽

Vol 22 (4) ◽

pp. 83-88 ◽

Cited By ~ 1

Author(s):

Гуревич ◽

K. Gurevich ◽

Каражелясков ◽

O. Karazhelyaskov

Keyword(s):

Military Personnel ◽

Respiratory Diseases ◽

Weather Conditions ◽

External Factors ◽

Public Order ◽

High Incidence ◽

Acute Respiratory Diseases ◽

The Russian Federation ◽

The Impact ◽

Hygienic Conditions

In the article the authors characterize the relevance of the study of morbidity in military personnel with acute respiratory diseases, as well as the study of their risk factors and causes. The purpose is to assess the impact of external factors on the morbidity of military personnel at the call. The object of the study is the incidence of internal troops of the Ministry of internal Affairs of the Russian Federation from 2012 to 2014 in accordance with changing weather conditions. 62 soldiers living in the barracks were evaluated. A large significance of the temperature factor on acute diseases and on ʺdelayed morbidityʺ communityacquired pneumonia was established by means of factor analysis. It was shown the impact the cubic capacity of the air in the barracks and the dryer temperature for clothing on the high incidence of communityacquired pneumonia hygienic conditions in the barracks. It was revealed the significant correlation with features of service on protection of a public order.

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Dose-response associations of cardiorespiratory fitness with all-cause mortality and incidence and mortality of cancer and cardiovascular and respiratory diseases: the UK Biobank cohort study

British Journal of Sports Medicine ◽

10.1136/bjsports-2018-099093 ◽

2019 ◽

Vol 53 (21) ◽

pp. 1371-1378 ◽

Cited By ~ 16

Author(s):

Lewis Steell ◽

Frederick K Ho ◽

Anne Sillars ◽

Fanny Petermann-Rocha ◽

Hiu Li ◽

...

Keyword(s):

Colorectal Cancer ◽

Respiratory Disease ◽

Cardiorespiratory Fitness ◽

Respiratory Diseases ◽

Dietary Factors ◽

Uk Biobank ◽

Circulatory Disease ◽

Incidence And Mortality ◽

All Cause Mortality

ObjectiveTo investigate the association of cardiorespiratory fitness with all-cause mortality, and cardiovascular disease (CVD), respiratory disease, chronic obstructive pulmonary disease (COPD) and cancer mortality and incidence.DesignProspective population-based study.SettingUK Biobank.ParticipantsOf the 5 02 628 (5.5% response rate) participants recruited by UK Biobank, we included 73 259 (14.6%) participants with available data in this analysis. Of these, 1374 participants died and 4210 developed circulatory diseases, 1293 respiratory diseases and 4281 cancer, over a median of 5.0 years (IQR 4.3–5.7) follow-up.Main outcome measuresAll-cause mortality and circulatory disease, respiratory disease, COPD and cancer (such as colorectal, lung, breast and prostate) mortality/incidence. Fitness was estimated using a submaximal cycle ergometer test.ResultsThe HR for all-cause mortality for each metabolic equivalent of task (MET) higher fitness was 0.96 (95% CI 0.93 to 0.98). Similar results were observed for incident circulatory disease (HR 0.96 [0.95 to 0.97]), respiratory disease (HR 0.96 [0.94 to 0.98]), COPD (HR 0.90 [0.86 to 0.95) and colorectal cancer (HR 0.96 [0.92 to 1.00]). Nonlinear analysis revealed that a high level of fitness (>10METs) was associated with a greater incidence of atrial fibrillation (HR 1.24 [1.07 to 1.44]) and prostate cancer (HR 1.16 [1.02 to 1.32]) compared with average fitness. All results were adjusted for sociodemographic, lifestyle and dietary factors, body composition, and morbidity at baseline and excluded events in the first 2 years of follow-up.ConclusionsHigher cardiorespiratory fitness was associated with lower risk of premature mortality and incidence of CVD, respiratory disease and colorectal cancer.

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