Peculiarities of immunophysiological shifts in adaptation to climatic and geographical conditions of mountains

2021 ◽  
Author(s):  
N.B. Tyumonbaeva ◽  
A.A. Kazybekova ◽  
N.J. Mamytova ◽  
A.J. Myrzakulova
Keyword(s):  
Immune System ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Immune Complexes ◽  
Mixed Type ◽  
Prolonged Exposure ◽  
Healthy Population ◽  
Natural Factors ◽  
Key Words Adaptation ◽  
Cellular And Humoral Immunity

The functioning of the immune system of people exposed to prolonged exposure to natural factors has been monitored and the main immunity indicators have been studied in practically healthy population of different mountain heights in Chui and Naryn regions. Indicators of specific immunity in the residents of the zone of compensated discomfort is reduced compared with the standards of the zone of relative comfort and refers to the mixed type with suppression of cellular and humoral immunity, apparently, this is associated with the climatic and geographical and environmental characteristics of the region. Key words: adaptation, immune system, T- lymphocytes, B- lymphocytes, immunoglobulins, circulating immune complexes, mountainous conditions.

scholarly journals The influence of thiotriazoline on the change of immune system in the blood of guinea-pigs under the conditions of development of experimental bronchial asthma

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
M. S. Reheda ◽  
М. А. Kolishetska ◽  
V. R. Yurevych
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Blood Plasma ◽  
B Lymphocytes ◽  
Bronchial Asthma ◽  
Functional State ◽  
Immune Complexes ◽  
Guinea Pigs ◽  
Stimulation Of ◽  
Plasma Activity

<p>The aim of our research was to determine the character of the role and functional state of separate indexes<br />of the immune system in blood of guinea-pigs under the conditions of the development of experimental bronchial<br />asthma (BA ) and estimation of thiotriazoline influence on them. Decreasing of T-lymphocytes, stimulation of humoral<br />link of immunity, namely increasing of B-lymphocytes and immunoglobulins of A, M and G, elevation of circulatory<br />immune complexes and slump of complement blood plasma activity had been determined in this research. Immune<br />correcting action of thiotriazoline upon the pointed out indices in case of BA is revealed.</p>

scholarly journals ОСОБЛИВОСТІ ІМУННОГО ГОМЕОСТАЗУ В ДИНАМІЦІ РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНОЇ БРОНХІАЛЬНОЇ АСТМИ

2018 ◽  
Author(s):  
M. S. Reheda ◽  
L. A. Lubinets ◽  
B. F. Shchepanskyi
Keyword(s):  
Immune System ◽  
B Lymphocytes ◽  
Immune Complexes ◽  
Guinea Pigs ◽  
Circulating Immune Complexes ◽  
System Response ◽  
Control Group ◽  
Modeling Process ◽  
Immune System Response

In this paper, it is shown that the modeling process of bronchial asthma (BA ) is accompanied by changes, in comparison with the control group, in the indicators of immune system response: T- & B-lymphocytes, circulating immune complexes in blood of guinea pig males on the 4th, 18th, 25th day of experiment.The aim of the study – determination of some indices of immune system in blood of guinea pigs in the modeling process of BA on 4th, 18th, 25th day of the experiment.Materials and Methods. Experiments were conducted on 40 guinea pigs (males), with body weight 0.25–0.27 kg. Animals were divided into four groups of ten animals in each. Intact guinea pigs were the first group. Animals with experimental BA – the second, third, fourth group respectively on the 4th, 18th, 25th day of the experiment. Experimental BA was reproduced by V. I. Babych method. In blood of intact guinea pigs and animals with experimental BA , the number of T- and B-lymphocytes was determined by the method of E. F. Chernushenko, L. S. Kohosov, determination of the level of circulating immune complexes was carried out by the method of V. Haskova and co-authors. The results of the study were processed by the method of variation statistics using Student's criterion.Results and Discussion. The results of the studies showed unidirectional changes in individual parameters of the immune system, depending on the periods of the formation of BA : an increase in the number of B-lymphocytes and circulating immune complexes, a decrease in the number of T-lymphocytes for all of the studied days of the experiment.Conclusions. The obtained results indicate significant changes in the immune system parameters in the blood of experimental animals with BA and are important for understanding the pathogenesis of BA . These studies provide an opportunity to find the more perfect and effective methods of diagnosis of BA.

scholarly journals PSVI-22 Immunity indicators of calves obtained from cows with ketosis during the treatment process

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 199-199
Author(s):  
Sergey Kovalev ◽  
Anastasia Nikitina ◽  
Polina Anipchenko ◽  
Anatoly Stekolnikov ◽  
Pavel Kiselenko ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Treatment Process ◽  
Absolute Number ◽  
Relative Content ◽  
Newborn Calves ◽  
Cellular And Humoral Immunity

Abstract The purpose of these studies was to determine the indicators of cellular and humoral immunity of calves. Compared to calves obtained from untreated cows, the number of T-lymphocytes in young calves born from cows treated with Timolin increased the level of T-cells to 32.9%, while using Timosplenin 45%. As a result of the use of immunomodulators in treating cows with ketosis in mothers, the relative content of T-lymphocytes in the blood of calves born from them increased when using the drug Leucogen by 1.7 times, Timosplenin by 2.3 times, Timalin in 2.2 times. The use of Leucogen for cows with ketosis contributed to an increase in the percentage of B cells in the blood of calves born by 23%, Timosplenin 83%, and Timalin 42%. At the same time, the absolute number of B-lymphocytes in the treatment of “Leucogen” increased 1.9 times and reached the level of healthy calves, in the treatment with the preparations “Timosplenin” and “Timalin” - the increase was, respectively, 3.0 and 2.3 times and was higher this indicator in young animals born from healthy calves. Thus, the inclusion of dry immunomodulators in the treatment regimen of patients with ketosis leads not only to normalization of metabolism, but is also accompanied by an increase in the level of cellular immunity factors in calves born from them. Under the influence of “Leucogen,” the percentage of lymphocytes was normalized, whereas with the introduction of “Timalin” and “Timosplenin,” the content of this type of cells in newborn calves even exceeded those in healthy young.

scholarly journals State of the immune system in women using the “Provag” probiotic

2020 ◽  
Vol 22 (4) ◽  
pp. 785-790
Author(s):  
V. A. Kozlov ◽  
A. G. Borisov ◽  
A. A. Savchenko ◽  
A. E. Kondakov ◽  
I. V. Kudryavtsev
Keyword(s):  
Immune System ◽  
Blood Serum ◽  
Lactobacillus Plantarum ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Lactobacillus Fermentum ◽  
Passive Hemagglutination ◽  
Specific Antibodies ◽  
Lactobacillus Gasseri ◽  
Healthy Women

Lactobacilli are  widely used  in clinical  practice as probiotics, biologically  active  additives  and probiotic products for functional nutrition. Some  probiotics can  be considered as bacterial vaccines  due  to induction of immune response, accompanied by production of specific antibodies. The aim of the present study was to evaluate  the state of cellular and humoral immunity in women  by using probiotic strains of lactobacilli. The  study  included 31 healthy  women  aged  25-45  years.  As a source  of probiotic lactobacterial complex, we used  the  “Provag” preparation (RU  77.99.11.003.E.003746.02.11 of 11.02.2011, 1 capsule  contains 109 Lactobacillus  gasseri 57C,  Lactobacillus  fermentum  57A и Lactobacillus  plantarum  57B).  The  drug  was used for 30 days, at a rate  of one  capsule  per day. The  immune system was examined twice: before  administering the drug and after 30 days of treatment. The study of blood  lymphocyte populations and subpopulations was performed by flow cytometry using direct immunofluorescence technique. The concentration of IgA, IgM, IgG in blood serum was determined using enzyme  immunoassay. To determine specific antibodies, we used passive hemagglutination reaction with erythrocyte diagnosticum. The complex of probiotic lactobacilli Lactobacillus gasseri, Lactobacillus  fermentum  and  Lactobacillus  plantarum corresponding to the “Provag” preparation was used as a source  of antigen. It has been revealed  that  the number of T and B lymphocytes in peripheral blood increased after  30 days  of treatment with  the  probiotic preparation “Provag” in  healthy  women. Elevated contents of T cells was due to the T helper  cell fraction. Increased levels of T helpers and B lymphocytes were associated with stimulation of humoral immunity, as evidenced by increasing concentration of IgA and  IgG in blood  serum.  By means  of passive hemagglutination reaction, we have found  that  90% of healthy  women showed increased concentrations of specific IgA in blood after 30 days of treatment with “Provag” preparation.

scholarly journals Порушення імунного гомеостазу в ранній період розвитку виразкової хвороби шунка на тлі експериментальної пневмонії

2017 ◽  
Author(s):  
L. O. Furdychko
Keyword(s):  
Gastric Ulcer ◽  
Immune System ◽  
T Lymphocytes ◽  
B Lymphocytes ◽  
Immune Complexes ◽  
Experimental Studies ◽  
Early Period ◽  
Circulating Immune Complexes ◽  
Immune Homeostasis ◽  
Experimental Pneumonia

Introduction. The article adduces the obtained results of the indices of immune homeostasis in the development of combined pathology (experimental pneumonia (EP) and gastric ulcer (GU) of the stomach). The immune system is characterized by the number of T-lymphocytes since they are the basis of the cellular component of the immuneresponse and the concentration of b-lymphocytes and circulating immune complexes (CIC), which are responsible for cellular immunity.The aim of the study – the content of T-lymphocytes, CEC to assess the immune system in the development of EP and GU.Materials and Methods. This experimental study was conducted on 39 guinea pigs-males. Experimental pneumonia caused by the method of V. N. Shliapnikova, T. L. Solodova [et al.] Gastric ulcer of the stomach wassimulated by the method of V. I. Komarova. We determined the content of T- and B-lymphocytes (SD3 and SD19) in the blood by the method of E. F. Chernushenko, L. S. Kohosova. The level of circulating immune complexes (CIC) in the blood by the method of Haskova V., Kaslik J..Results and Discussion. The results of experimental studies established that early period of development (4th and 8th day) of gastric ulcer and pneumonia is characterized by the following changes of immune homeostasis: decrease in the level of T-lymphocytes and elevated levels of lymphocytes and circulating immune complexes in the blood of Guinea pigs.Conclusion. A depression of cell growth and humoral types of immunity in terms of experimental pneumoniaand gastric ulcer was revealed.  

scholarly journals The influence of the Selenium and Germanium on humoral immunity content in quails

2020 ◽  
pp. 88-95
Author(s):  
A. Yemelyanenko ◽  
S. Shmayun ◽  
M. Nishmenenko ◽  
O. Yemelyanenko ◽  
O. Poroshinska ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Immune System ◽  
Key Words ◽  
Humoral Immunity ◽  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
Low Molecular Weight ◽  
Main Indicator ◽  
Ig G

The results of the studies on the infl uence of Selenium and Germanium nanoacqualates complex on the content of immunoglobulins and circulating immune complexes in quail’s are presented in the article. It was found that the level of immunoglobulins is the main indicator of the state of humoral immunity. According to the results of the studies the content of immunoglobulins A, M, G in the quail’s serum was 0.80 ± 0.03 mg/ml, 0.30 ± 0.01 mg/ml, and 5.82 ± 0 , 06 mg/ml, accordingly. That are 31.1%, 20.0% and 6.0%, respectively, comparing with data of the control group. Inthe serum of fi ve days old quail’s Ig A content was 0.84 ± 0.02 mg/ml, Ig M 0.54 ± 0.03 mg/ml and Ig G 6.87 ± 0.04 mg/ml, that consisted 29.2%, 42.1% and 5.0%, respectively, comparing with the control group. The content of circulating immune complexes (CEC) in theblood serum of one- and fi ve-days old quails was 1.5 and 1.6 times, respectively lower than in the birds of the control group. The content of low molecular weight CECs in the serum of one- and fi ve-days old quail, decreased signifi cantly in both groups(in 2 and 1.1 times, respectively). This probably characterizes the overall effi cacy and balance of the immune system's responses in quails exposed to Selenium and Germanium nanoacqualates at used doses of 0.05 μg/kg and 5.0 μg/kg, respectively. We consider that as a positive eff ect on the immunity of quails in the early post-embryonic period. Therefore, the use of Selenium and Germanium nanoacqualates complex has a complementary eff ect and helps to increase the immunoreactivity of young animals by maintaining the activity of the immune system. Key words: Selenium nanoacquachelate, Germanium nanoacquachelate, quails, immunoglobulins, immunity.

scholarly journals Parameters of homocystein and features of the immune status in persons working in the chemical industry

2006 ◽  
Vol 5 (4) ◽  
pp. 52-56
Author(s):  
T. T. Radzivil ◽  
I. V. Krat ◽  
I. V. Oradovskaya
Keyword(s):  
Risk Factor ◽  
Immune System ◽  
Humoral Immunity ◽  
Chemical Industry ◽  
Independent Risk Factor ◽  
Immune Status ◽  
Cellular And Humoral Immunity ◽  
Increased Activity

The indices of the immune status and homocystein in persons working in the chemical industry are studied. As a result, the laboratory indications of activation of the immune system are revealed, as well as the increased activity of cellular and humoral immunity. Moderate homocysteinemia is found among men aging of 56—65 with an idiopathic hypertensia. Homocystein appears to be an independent risk factor of coronary, cerebral and peripheral vessels diseases.

scholarly journals Features of immune status in athletes specializing in rowing and handball

2015 ◽  
Vol 22 (1) ◽  
pp. 65-67
Author(s):  
V. S. Vasilenko ◽  
N. D. Mamiev
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Immune Status ◽  
Relative Number ◽  
Lymphocyte Apoptosis ◽  
Cellular And Humoral Immunity ◽  
Immunoglobulin Levels ◽  
Over Time

The work is perfromed at the department of the hospital therapy GPMU, laboratory of llergiology and immunology of the research-practical Center of Dental faculty of SpbGMU named after I. Р. Pavlov. State of cellular and humoral immunity at the beginning and at the end of the training year of 15-17 years old young sportsmen of the first level and candidates masters of sports involved in an academic rowing and handball was studied. The athletes of both groups showed significant improvements as compared to the persons not involved in sports, lymphocyte apoptosis inducers (CD95+), the natural killer cells (CD16 + ) and B-lymphocytes (CD20 + ). Over time, in the athletes, regardless the sport, unidirectional changes are detected, encompassing the enhancing of the relative number of CD25+ with receptors for IL2, and immunoglobulin levels.

The effect of ozone on human cellular and humoral immunity: Characterization of T and B lymphocytes by rosette formation

1978 ◽  
Vol 15 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Anthony Savino ◽  
Mirzda L. Peterson ◽  
Dennis House ◽  
Alvis G. Turner ◽  
Harvey E. Jeffries ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Humoral Immunity ◽  
Rosette Formation ◽  
T And B Lymphocytes ◽  
Cellular And Humoral Immunity

scholarly journals CHARACTERISTICS OF IMMUNE RESPONSE UNDER EXPERIMENTAL MODELS OF ACID BURNS OF THE ESOPHAGUS

2016 ◽  
Vol 72 (2) ◽  
pp. 52-55
Author(s):  
T. Koval ◽  
T. Ischuk ◽  
Ya. Raetska
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Experimental Model ◽  
Humoral Immunity ◽  
Immune Complexes ◽  
Healing Process ◽  
Experimental Models ◽  
Circulating Immune Complexes ◽  
Burn Wounds

It is well known that the immune system is actively involved in the regeneration and healing process of burn wounds. However, unanswered questions remain about the role of humoral immunity in the mechanisms of healing and complications of burn wounds. We have developed an experimental model of the acid burns of the esophagus (ABE) corresponding esophageal burns in children 1-8 years. We studied the features of humoral immunity in rats with AВE, with the observed reduction of IgG and increase levels of medium and low circulating immune complexes (CIC) on the first day after the burn of the esophagus. On the 21st day after the burn, we observed an increase in the concentration of IgG and a slight accumulation of medium- and low-CIC. Studied indicators can be used for the differentiation of ABE.

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