O impacto da ingestão de medicamentos e vitaminas sintéticas no sistema digestivo devido aos novos métodos nutricionais / The impact of the intake of synthetic drugs and vitamins on the digestive system due to new nutritional methods

2021 ◽  
Vol 4 (2) ◽  
pp. 8599-8607
Author(s):  
Lucas Ferreira Nery Santiago ◽  
Maria Eduarda Ribeiro Coutinho Da Franca ◽  
Letícia Queiroz de Almeida Maciel ◽  
Alysson Kennedy Pereira De Souza ◽  
Daniela Heitzmann Amaral Valentin De Souza ◽  
...  
Keyword(s):  
Digestive System ◽  
Synthetic Drugs ◽  
The Impact

scholarly journals Immunosuppression-lipid Metabolism Interplay and Medicinal Plants in Atherosclerosis: A Review

2018 ◽  
Vol 24 (24) ◽  
pp. 2789-2793 ◽  
Author(s):  
Fahimeh Moradi ◽  
Robert D.E Sewell ◽  
Zahra Lorigooini ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Critical Role ◽  
Arterial Disease ◽  
Toxic Substances ◽  
Synthetic Drugs ◽  
Related Quality ◽  
Health Related ◽  
Negative Side Effects ◽  
Atherosclerosis Development ◽  
The Impact

Atherosclerosis is a chronic arterial disease responsible for the majority of vascular-related deaths throughout the world. Immune cells and inflammation in conjunction with hyperlipidemia play a key role in atherosclerosis development. Regarding the low efficacy of the synthetic drugs and also the associated negative side effects which can adversely influence health-related quality of life, looking for natural, affordable and non-toxic substances seem necessary. Plant-derived natural products play a critical role in the prevention and treatment of atherosclerosis. In this review, we aimed to outline the most important medicinal herbs effective for atherosclerosis through the impact on immune system.

Fitoterapia i suplementacja diety w chorobach górnego odcinka przewodu pokarmowego

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Krzysztof Błecha
Keyword(s):  
Natural Products ◽  
Gastrointestinal Tract ◽  
Digestive System ◽  
Raw Materials ◽  
Main Role ◽  
Plant Raw Materials ◽  
Synthetic Drugs ◽  
Physiological Processes ◽  
Anti Inflammatory ◽  
Materials Used

Prevention and therapy of gastrointestinal tract diseases should take into account as minimal as possible intervention physiological processes which take place in digestive system. Digestive disorders, which are often caused by synthetic drugs, can generate more complicated diseases. Herbs should be a preventive or complementary way of action. They can also play the main role in therapy of less complicated diseases. Natural products are used in therapy of gastrointestinal tract diseases because they have anti-inflammatory, antibacterial, coating, digestion improving and relaxative properties. They are helpful in gastro-oesophageal reflux, dyspepsia, gastritis and ulcers. Natural products, especially plant raw materials, used in the therapy of digestive system diseases, according to their leading activity, can be divided into the following groups: anti-inflammatory and protective, facilitating digestion, sedative and antimicrobial. It should be emphasized that plant raw materials act in multidirectional way and therefore not always may be classified strictly within such groups of curing activity.

scholarly journals The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Ewa Matuszczak ◽  
Marta Diana Komarowska ◽  
Wojciech Debek ◽  
Adam Hermanowicz
Keyword(s):  
Bisphenol A ◽  
Reproductive System ◽  
Food Packaging ◽  
Digestive System ◽  
Personal Hygiene ◽  
Review Of The Literature ◽  
Testicular Dysgenesis Syndrome ◽  
Human Fertility ◽  
Dental Sealants ◽  
The Impact

Bisphenol A (BPA) has been used since the 1950s, in food packaging, industrial materials, dental sealants, and personal hygiene products. Everyone is exposed to BPA through skin, inhalation, and digestive system. BPA disrupts endocrine pathways, because it has weak estrogenic, antiandrogenic, and antithyroid activities. Despite the rapid metabolism, BPA can accumulate in different tissues. Many researchers proved the impact of BPA on human development, metabolism, and finally reproductive system. There is increasing evidence that BPA has impact on human fertility and is responsible for the reproductive pathologies, e.g., testicular dysgenesis syndrome, cryptorchidism, cancers, and decreased fertility in male and follicle loss in female.

scholarly journals A Review of the Impact of Selected Anthropogenic Chemicals from the Group of Endocrine Disruptors on Human Health

Toxics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 146
Author(s):  
Katarzyna Goralczyk
Keyword(s):  
Human Health ◽  
Endocrine Disruptors ◽  
Digestive System ◽  
Meta Analysis ◽  
Holistic Approach ◽  
Public Healthcare ◽  
Endocrine Activity ◽  
Daily Lives ◽  
Food Packages ◽  
The Impact

Background: The aim of the study was to review data on the impact of anthropogenic chemicals (endocrine disruptors) on various diseases, which, consequently, may facilitate their prevention and be used as a tool for managing public healthcare. Every day, humans are exposed to chemicals, including xenoestrogens, which are similar to female hormones. Methods: This manuscript was prepared based on a meta-analysis of research on the impacts of selected EDCs on human health. Results: Special attention should be paid to bisphenol A (BPA), benzo-α-pyrene, and phthalates due to their proven endocrine activity and presence in our daily lives. Xenoestrogens are absorbed by human organisms through the digestive system since they can migrate to food from food packages and drinks as well as from plastic products used daily. The presence of these chemicals in human organisms is considered a potential cause for some diseases commonly referred to as ‘diseases of civilization’. Conclusions: The biomonitoring of xenoestrogens, which are chemicals with unfavorable impacts on human health, is a crucial tool for assessing the risk from the pollution of the environment. The novelty is a holistic approach to assessing the occurrence of risk factors for civilization diseases.

scholarly journals Impact of photoperiod on circadian sucrose and sucrase rhythms in the digestive system of silkworm, Bombyx mori.

2013 ◽  
Vol 5 (1) ◽  
pp. 230-241
Author(s):  
E. Bhuvaneswari ◽  
B. Sailaja ◽  
S. Sivaprasad
Keyword(s):  
Bombyx Mori ◽  
Digestive System ◽  
Continuous Light ◽  
Sucrose Uptake ◽  
Gut Content ◽  
Dark Cycle ◽  
The Impact ◽  
Silkworm Bombyx Mori

The impact of photoperiod on circadian sucrose and sucrase rhythms were analyzed in the digestive system of Bombyx mori under 12 hr light-dark cycle (LD), continuous light (LL) and continuous dark (DD). The rhythmic changes were interpreted as synthetic cycles in gut wall and release or uptake cycles in gut lumen. The gut wall comprised 6 sucrose synthetic cycles (SS cycles) under LD, LL and 5 under DD. The 24 hr rhythm of LD and LL was clock shifted to 28.8 hr under DD. In gut content, the sucrose rhythm showed 7 sucrose uptake cycles (SUcycles) under LD, 6 under LL and 5 under DD and the 24 hr rhythm of LD was clock shifted to 28.0 hr under LL and 34 hr under DD. In the gut wall sucrase rhythm maintained 7 SES cycles under LD and DD and 9 cycles under LL and its 24-hr rhythm is advanced to 18.2 hr. In the gut lumen 5 SER cycles under LD, 8 under LL and 6 under DD and its rhythm is advanced to 15 hr under LL and 20 hr under DD. Further analysis of data showed that LD favoured both synthesis and uptake of sucrose while LL, favoured the sucrase synthesis and its release.

scholarly journals Targeted anti-inflammatory therapy effect on various indicators of the psoriatic arthritis activity: Moscow Unified Arthritis Registry (MUAR) data

2021 ◽  
Vol 5 (2) ◽  
pp. 78-83
Author(s):  
K.A. Lytkina ◽  
◽  
G.V. Lukina ◽  
E.N. Koltsova ◽  
E.I. Shmidt ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Certolizumab Pegol ◽  
Genetically Engineered ◽  
Targeted Drugs ◽  
Biological Drugs ◽  
Synthetic Drugs ◽  
Das 28 ◽  
Therapy Effect ◽  
Anti Inflammatory ◽  
The Impact

Background: the number of genetically engineered biological drugs and targeted synthetic drugs for the treatment of psoriatic arthritis (PA) is rapidly increasing. Data on their comparative efficacy is limited. The results of individual studies suggest that the drugs may show different efficacy concerning different disease manifestations (arthritis, spondylitis, entesitis, cutaneous and nail lesions). Aim: to compare the effect of targeted drugs on the results achieved in different PA domains in real clinical practice. Patients and Methods: the data were taken from the Moscow Unified Arthritis Registry (MUAR). We analyzed treatment episodes in which there was a completed visit no earlier than 6 months from therapy initiation with targeted drug (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, tofacitinib, ustekinumab). Drug comparison was carried out according to the achieved values of the DAS-28, BASDAI, MASES, LEI, DLQI, PASI and BSA indices. The most significant confounders (factors that characterize the patient and are significantly related to the studied indicator) were established for each group of indicators to eliminate the impact of differences between patients who received different drugs. The comparisons were adjusted for confounders. Results: the analysis included 184 treatment episodes with targeted drugs in 156 patients with PA. There were no significant differences between the drugs in their effect on the following domains: «joints» domain (DAS-28), «spine/entheses» domain (BASDAI, MASKS, LEI), «skin» domain (DLQI, PASI, BSA). Conclusion: the achieved values of activity indicators concerning the involvement of joint, spine, entheses and skin in patients with PA didn’t significantly differ when treated with various targeted drugs. KEYWORDS: psoriatic arthritis, enthesitis, spondylitis, sacroiliitis, targeted therapy, treatment efficacy, confounder. FOR CITATION: Lytkina K.A., Lukina G.V., Koltsova E.N. et al. Targeted anti-inflammatory therapy effect on various indicators of the psoriatic arthritis activity: Moscow Unified Arthritis Registry (MUAR) data. Russian Medical Inquiry. 2021;5(2):78–83. DOI: 10.32364/2587-6821- 2021-5-2-78-83.

scholarly journals Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Feng Zhao ◽  
Chan Li ◽  
Yun Wu ◽  
Jianling Xia ◽  
Ming Zeng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Digestive System ◽  
Meta Analysis ◽  
Tissue Growth ◽  
Node Metastasis ◽  
The Impact

Aim. A meta-analysis was conducted to estimate the impact of connective tissue growth factor (CTGF) on outcomes in patients with digestive system cancers. Methods. A systemic literature survey was performed by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of CTGF on outcomes in patients with digestive system cancers. Hazard ratios and 95% confidence intervals were calculated for prognostic factors, overall and recurrence-free survival using RevMan 5.3 software. Results. This meta-analysis was conducted to evaluate a total of 11 studies that included 1730 patients. The results showed that elevated CTGF expression was significantly correlated with advanced age, larger tumor size, multiple tumors, and vascular invasion. Subgroup analysis by cancer type revealed increased risk for lymph node metastasis and advanced tumor node metastasis (TNM) stage in gastric cancer, compared with colorectal cancer. An unfavorable effect of elevated CTGF levels on overall survival was found in patients with hepatocellular carcinoma and patients with gastric cancer, while survival was improved in colorectal cancer patients with high CTGF expression, compared to those with normal levels of CTGF. Conclusions. Elevated CTGF expression may be a novel biomarker for disease status and predicted survival outcomes in patients with specific digestive system cancers.

Sign in / Sign up

Export Citation Format

Share Document