scholarly journals Vitamin D Levels in Children and Adolescents with Cerebral Palsy: Cross-sectional Study / Níveis de Vitamina D em Crianças e Adolescentes com Paralisia Cerebral: Estudo Transversal

2021 ◽  
Vol 4 (3) ◽  
pp. 11938-11949
Author(s):  
Marcela Almeida Linden ◽  
Elizete Aparecida Lomazi ◽  
Gabriel Hessel ◽  
Maria Ângela Bellomo-Brandão
Keyword(s):  
Vitamin D ◽  
Cerebral Palsy ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Food Sources ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Vitamin D Levels

Aim: Tetraparetic Cerebral Palsy (TCP) patients may present risks factors for Vitamin D deficiency such as increased risk of malnutrition and possibly infrequent sun exposure. The present study aimed to compare the vitamin D status in this population of TCP pediatric patients (Case Group) and compare them with healthy children and adolescents (Control Group). Methods: The clinical data obtained were: gender, age, weight, height, nutritional status, consumption of vitamin D food sources, sun exposure and serum levels of vitamin D. Vitamin D deficiency was defined as 20 ng/mL or less of 25(OH)D; “insufficiency” was defined as between 21-29 ng/mL; “sufficiency” was defined as between 30-100 ng/mL.1 Results: Sixty patients aged 3 to 20 years old were divided into two groups: the Control Group (n=30) and the Case Group (n=30) composed of individuals with TCP. Vitamin D levels did not differ between groups; the mean levels were 26.65 ng/mL (SD: 10.51) in the Case Group and, 28.93 ng/mL (SD: 9.26) in the Control Group. Conclusion: There was no difference identified between vitamin D levels among TCP and control patients, and no relationship between risk factors and serum 25(OH)D levels was observed. Even though Brazil is a tropical country with abundant sunshine during most of the year, there is still a considerable number of individuals with vitamin D classifications of insufficiency and deficiency in our study (N= 34/60). This should be alarming for healthcare professionals who work with the pediatric population, which is a population at risk for the development of disability.

scholarly journals Vitamin D levels in children and adolescents with autism

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093463
Author(s):  
Esma Şengenç ◽  
Ertuğrul Kıykım ◽  
Sema Saltik
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Children And Adolescents ◽  
Autism Spectrum ◽  
Control Group ◽  
Healthy Children ◽  
Birth Season ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Calcium Phosphorus

Objective This study aimed to investigate the relationship between autism spectrum disorder (ASD) and vitamin D levels in children and adolescents. Methods We measured serum 25-hydroxyvitamin D (25-OHD) levels in 1529 patients with ASD aged 3 to 18 years, without any additional chronic diseases. Levels of 25-OHD were compared according to sex, age (<11 or ≥11 years), and birth season. Additionally, laboratory parameters (calcium, phosphorus, alkaline phosphatase, and 25-OHD) of 100 selected patients with ASD were compared with those of the healthy control group. Results Vitamin D deficiency or insufficiency was found in approximately 95% of all patients. Levels of 25-OHD in adolescent patients with ASD aged 11 to 18 years were significantly lower than those in patients aged younger than 11 years. In the 100 selected patients with ASD, mean serum 25-OHD levels were significantly lower and alkaline phosphatase levels were higher compared with those in healthy children. Conclusion Our study suggests a relationship between vitamin D and ASD in children. Monitoring vitamin D levels is crucial in autistic children, especially adolescents, to take protective measures and treat this condition early.

scholarly journals Vitamin D Status and Its Determinants in a Paediatric Population in Norway

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1385
Author(s):  
Mads N Holten-Andersen ◽  
Johanne Haugen ◽  
Ingvild Oma ◽  
Tor A Strand
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Children And Adolescents ◽  
Parental Education ◽  
Sun Exposure ◽  
Late Summer ◽  
Paediatric Population ◽  
Vitamin D Supplementation ◽  
Healthy Children ◽  
Vitamin D Levels

Recommendations for sufficient vitamin D intake in children were recently revised in Norway. However, optimal levels of vitamin D are still debated and knowledge on supplementation and vitamin D levels in healthy children in Norway is scarce. Therefore, we measured the plasma-concentration of 25-hydroxyvitamin D (25(OH)D) in children and adolescents attending the outpatient paediatric clinics in Innlandet Hospital Trust, Norway during two consecutive years (2015–2017). We recruited 301 children and adolescents aged 5 months to 18 years (mean 7.8, SD 4.4 years) for the study and obtained sample material for 25(OH)D measurements from 295 (98%). Information on diet, vitamin D supplementation, sun exposure, ethnicity, parental education and general health was collected by questionnaire. 25(OH)D levels were analysed and determinants for 25(OH)D were estimated by linear regression. 1.0% of the children had deficient levels (25(OH)D < 25 nmol/L) and 21.0% had insufficient levels (25–50 nmol/L). 25(OH)D levels ranging from 50 to 75 nmol/L were found among 38.3%, while 39.7% had levels above 75 nmol/L. The mean 25(OH)D level was 70.0 nmol/L (SD 23.4, range 17–142 nmol/L) with a significant seasonal variation with lowest levels in mid-winter and highest in late summer. In addition to seasonal variation independent determinants for 25(OH)D-levels were age of the child, parental ethnicity, vitamin D supplementation and soda consumption. Along with parental ethnicity other than Nordic, age was the strongest determinant of 25(OH)D, with adolescents having the lowest levels.

scholarly journals Vitamin D levels in epileptic children on long-term anticonvulsant therapy

2015 ◽  
Vol 55 (3) ◽  
pp. 164
Author(s):  
Fathy Pohan ◽  
Aryono Hendarto ◽  
Irawan Mangunatmadja ◽  
Hartono Gunardi
Keyword(s):  
Vitamin D ◽  
Valproic Acid ◽  
Vitamin D Deficiency ◽  
Anticonvulsant Therapy ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
The Mean

Background Long-term anticonvulsant therapy, especially with enzyme inducers, has been associated with low 25-hydroxyvitamin D [25(OH)D] levels and high prevalence of vitamin D deficiency. However, there have been inconsistent results in studies on the effect of long-term, non-enzyme inducer anticonvulsant use on vitamin D levels.Objective To compare 25(OH)D levels in epileptic children on long-term anticonvulsant therapy and non-epileptic children. We also assessed for factors potentially associated with vitamin D deficiency/insufficiency in epileptic children.Methods This cross-sectional study was conducted at two pediatric neurology outpatient clinics in Jakarta, from March to June 2013. Subjects in the case group were epileptic children, aged 6-11 years who had used valproic acid, carbamazepine, phenobarbital, phenytoin, or oxcarbazepine, as a single or combination therapy, for at least 1 year. Control subjects were non-epileptic, had not consumed anticonvulsants, and were matched for age and gender to the case group. All subjects’ 25(OH)D levels were measured by enzyme immunoassay.Results There were 31 epileptic children and 31 non-epileptic control children. Their mean age was 9.1 (SD 1.8) years. Most subjects in the case group were treated with valproic acid (25/31), administered as a monotherapy (21/31). The mean duration of anticonvulsant consumption was 41.9 (SD 20) months. The mean 25(OH)D level of the epileptic group was 41.1 (SD 16) ng/mL, lower than the control group with a mean difference of 9.7 (95%CI 1.6 to 17.9) ng/mL. No vitamin D deficiency was found in this study. The prevalence of vitamin D insufficiency in the epileptic group was higher than in the control group (12/31 vs. 4/31; P=0.020). No identified risk factors were associated with low 25(OH)D levels in epileptic children.Conclusion Vitamin D levels in epileptic children with long-term anticonvulsant therapy are lower than that of non-epileptic children, but none had vitamin D deficiency.

scholarly journals Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

2021 ◽  
Vol 14 ◽  
pp. 117863882110187
Author(s):  
Hedyeh Saneifard ◽  
Marjan Shakiba ◽  
Ali Sheikhy ◽  
Leila Baniadam ◽  
Fatemeh Abdollah Gorji ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Tanner Stage ◽  
Additional Risk Factor ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

scholarly journals Vitamin D deficiency during pregnancy and its associated factors among third trimester Malaysian pregnant women

2019 ◽  
Author(s):  
Fui Chee Woon ◽  
Yit Siew Chin ◽  
Intan Hakimah Ismail ◽  
Marijka Batterham ◽  
Amir Hamzah Abdul Latiff ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Associated Factors ◽  
Sun Exposure ◽  
Food Sources ◽  
Third Trimester ◽  
Supplement Use ◽  
Vitamin D Intake ◽  
Vitamin D Levels

AbstractBackgroundDespite perennial sunshine, vitamin D deficiency is prevalent among Malaysian especially pregnant women.ObjectiveTo determine the vitamin D status and its associated factors among third trimester pregnant women attending government health clinics in Selangor and Kuala Lumpur, Malaysia.MethodsInformation on socio-demographic characteristics, obstetrical history, vitamin D intake, supplement use, and sun exposure were obtained through face-to-face interviews. Serum 25-hydroxyvitamin D concentration was measured and classified as deficient (< 30 nmol/L), insufficient (30-50 nmol/L), and sufficient (≥ 50 nmol/L).ResultsOf the 535 pregnant women recruited, 42.6% were vitamin D deficient. They consumed an average of 8.7 ± 6.7 μg of vitamin D daily. A total of 80.4% of the vitamin D were obtained from the food sources, while 19.6% were from dietary supplements. Fish and fish products showed the highest contribution to vitamin D intake (35.8%). The multivariate generalized linear mixed models, with clinic as a random effect, indicates that higher intake of vitamin D is associated with lower risk of vitamin D deficiency among pregnant women (OR = 0.96; 95% CI = 0.93-0.99). Non-Malay pregnant women had lower odds of having vitamin D deficiency (OR = 0.13; 95% CI = 0.04-0.37) compared to Malays. No associations were found between age, educational level, monthly household income, work status, gravidity, parity, pre-pregnancy body mass index, total hours of sun exposure, total percentage of body surface area, and sun exposure index per day with vitamin D deficiency.ConclusionsVitamin D deficiency is prevalent among Malaysian pregnant women. Considering the possible adverse obstetric and fetal outcomes of vitamin D deficiency during pregnancy, antenatal screening of vitamin D levels and nutrition education should be emphasised by taking into consideration ethnic differences.

scholarly journals Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110660
Author(s):  
Di Che ◽  
Li Yu ◽  
Yong Guo ◽  
Hai-jin Ke ◽  
Cui Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Bone Metabolism ◽  
Vitamin D Deficiency ◽  
Cow’S Milk ◽  
Control Group ◽  
Healthy Children ◽  
Serum Calcitonin ◽  
Cow's Milk ◽  
Vitamin D Levels

Objective Research is limited regarding biochemical markers of bone metabolism among children with cow’s milk protein allergy (CMPA). We aimed to determine differences in vitamin D and bone metabolism markers between infants with CMPA and healthy infants and explore relationships between these in a cross-sectional study. Methods In total, we included 41 children diagnosed with CMPA and under systematic medical and nutritional care at our center, and 50 healthy children as a control group. We reviewed demographic and clinical characteristics and measured serum biomarkers. Results We found that serum 25-hydroxyvitamin D (25(OH)D) levels among infants in the CMPA group were significantly lower than those in the control group, and levels of bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin were reduced. Pearson correlation analysis showed that serum 25(OH)D concentrations in the CMPA group were negatively correlated with parathyroid hormone but not significantly correlated with calcitonin and BALP. Logistic regression showed that CMPA was a risk factor for vitamin D deficiency. Conclusions Our study indicated that CMPA was associated with disturbances in bone metabolism. Levels of vitamin D in children with CMPA were lower than those in healthy children. CMPA was a risk factor for vitamin D deficiency.

scholarly journals Determining the Predictive Power of Vitamin D Levels in Iron Deficiency Anemia

2019 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Sorush Niknamian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Levels ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Vitamin D Levels

Background:Iron deficiency anemia is one of the most common hypochromic microcytic anemias and nutritional disorders in today’s world. Vitamin D is an important steroid hormone for the metabolism of serum calcium and phosphorus and plays a major role in the function of various body systems. Evidence suggests that vitamin D deficiency is associated with iron deficiency anemia. We aimed to compare the serum level of vitamin D between children with iron deficiency anemia and healthy ones. Methods: This case-control study was conducted on 60 patients with iron deficiency anemia and 60 healthy ones who did not suffer from iron deficiency anemia. Patients participated in the study voluntarily. Vitamin D levels were measured using HPLC and ferritin by RIA method. To estimate the predictive value of vitamin D levels in iron deficiency anemia, ROC curve analysis was used.  Results: In this study, 120 children aged 6-144 months with mean age of 30.2±31.4 months were analyzed; 49.2% of them were boys and 50.8% were girls. Vitamin D levels varied from 4.8 to 63.2 ng/ml with a mean of 23.87±12.57 ng/ml in all patients (19.25±9.15 ng/ml in the case group and 28.48±13.84 ng/ml in the control group (P<0.001). In other words, patients with a vitamin D level <23.6 ng/ml should be investigated for iron deficiency anemia, and sufficient vitamin D had a protective effect on iron deficiency anemia and each unit increase in vitamin D decreased the chance of iron deficiency anemia by 7.8%. Conclusion: The prevalence of simultaneous iron deficiency anemia and vitamin D deficiency is very high in children and there is a significant relationship between serum levels of 25(OH)D and hemoglobin.

scholarly journals Vitamin D status in children with cerebral palsy

2017 ◽  
Vol 4 (2) ◽  
pp. 615
Author(s):  
Sowjan Manohar ◽  
Rajakumar Ponnandai Gangadaran
Keyword(s):  
Vitamin D ◽  
Cerebral Palsy ◽  
Vitamin D Deficiency ◽  
Tamil Nadu ◽  
Total Serum ◽  
Case Group ◽  
Vitamin D Status ◽  
Feeding Difficulties ◽  
Vitamin D Levels ◽  
Children With Cerebral Palsy

Background: The aim of the study was to find the prevalence of vitamin D status - vitamin D deficiency and insufficiency in children with cerebral palsy and to compare them with normal children. To identify the risk factors associated with vitamin D deficiency in these children.Methods: A prospective case control study was done in 200 children in Shri Sathya Sai Medical College and Research Institute, Ammapettai, Thiruporur, Tamil Nadu, India over a period of one year from December 2014 to December 2015 after obtaining approval from institutional ethical committee. Study group contained 100 children with cerebral palsy. 100 Age and sex matched children were taken as controls. Children included in the study were between 1 to 12 years. All children were subjected to the following investigations: serum calcium-total, serum phosphorus, serum alkaline phosphatase (SAP) levels. These were determined by an automated analyzer. The 25OH vitamin D levels were estimated by CLIA (chemi luminescence immunoassay) method. Results: Vitamin D deficiency was observed in 32 (32%) and insufficiency in 61 (61%) of children with cerebral palsy in case group. Similarly, vitamin D status studied in control children was found that majority of them 49 (49%) was normal. While 38 (38%) were vitamin D insufficient, 13 (13%) showed deficient levels (p <0.0000001).Conclusions: The presence of feeding difficulties, poor sunlight exposure, poor nutritional status, and the use of antiepileptic drugs, type of CP and the functional grade of CP had statistically significant association with Vitamin D deficiency in these children.  

Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

2016 ◽  
Vol 9 (6) ◽  
pp. 3544-3548
Author(s):  
Aya Hallak ◽  
Malhis Mahmoud ◽  
Yaser Abajy Mohammad
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Coronary Syndrome ◽  
Normal Individuals ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

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