Intra-articular injections of autologous platelet concentrates in dogs with surgical reparation of cranial cruciate ligament rupture

2013 ◽  
Vol 26 (04) ◽  
pp. 285-290 ◽  
Author(s):  
J. U. Carmona ◽  
C. M. F. Rezende ◽  
R. F. Silva
Keyword(s):  
Cruciate Ligament ◽  
Reaction Force ◽  
Force Plate ◽  
Treated Group ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Platelet Concentrates ◽  
Cranial Cruciate Ligament ◽  
Replacement Surgery ◽  
Autologous Platelet

Summary Objective The objective of this study was to evaluate by clinical, radiographic, and force plate gait analyses the effect of postsurgical intra-articular injections of autologous platelet concentrates (PC) in a small group of dogs with cranial cruciate ligament (CCL) rupture. Methods The ten dogs used in this study were initially presented with CCL rupture and underwent ligament replacement surgery by fascia lata autograft guided by arthroscopy. Six dogs received three intra-articular injections of PC (PC group); one dose was injected immediately after surgery, and two additional doses were injected at two-week intervals. The remaining four dogs received only nutraceuticals (control group). All dogs were evaluated by clinical examination, serial radiography, and force plate gait analyses at monthly intervals up to 90 days. Results The clinical follow-up of the PC-treated group indicated a better outcome than the control group. Radiographic evaluation was not conclusive. Values of peak vertical reaction force and vertical impulse of the affected limbs were only significantly larger on the 90th postoperative day in the PC group compared to the control group. Clinical significance Our results indicate that autologous PC might improve functional outcome after intra-articular cranial cruciate ligament repair. The effect of PC when using other repair procedures warrants additional studies.

Outcome after Tibial Plateau Levelling Osteotomy and Modified Maquet Procedure in Dogs with Cranial Cruciate Ligament Rupture

2020 ◽  
Vol 33 (03) ◽  
pp. 189-197
Author(s):  
Julia Knebel ◽  
Daniela Eberle ◽  
Stephanie Steigmeier-Raith ◽  
Sven Reese ◽  
Andrea Meyer-Lindenberg
Keyword(s):  
Tibial Plateau ◽  
Cruciate Ligament ◽  
Force Plate ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Cranial Cruciate Ligament ◽  
Surgical Methods ◽  
Significant Difference ◽  
Reaction Forces ◽  
Cranial Cruciate Ligament Rupture

Abstract Objective The aim of this study was to compare outcomes after tibial plateau levelling osteotomy (TPLO) and modified Maquet procedure (MMP) for the treatment of cranial cruciate ligament rupture (CCLR) in dogs using clinical and radiographic evaluation and treadmill-based force plate gait analysis. Study Design This study was a prospective, randomized, controlled study. Materials and Methods Sixty-one dogs (76 joints) with CCLR were treated with TPLO (n = 30 dogs, 41 joints) or MMP (n = 31 dogs, 35 joints) and compared with a control group of 16 healthy Labrador Retrievers. Outcomes after surgery were compared by clinical orthopaedic assessment, radiographic evaluation and force plate gait analysis performed preoperatively, and then at 6 weeks, 3 and 6 months postoperatively. For objective comparison of ground reaction forces, the data were compared with the control group. Major complications were reported. Results A significant improvement in ground reaction forces was reached in all surgically treated dogs. No significant difference was found between the surgical methods at any postoperative re-examination. With regard to peak vertical force (PVF), there were significantly more patients with TPLO within the reference range of healthy dogs at the 3 months re-examination than dogs with MMP. There was no significant difference in mean value comparisons between TPLO and control groups 6 months postoperatively. Compared with the control group, mean values of 93.9% (PVF) and 85.9% (vertical impulse [VI]) were reached by the TPLO group and 89.4% (PVF) and 79.9% (VI) by the MMP group, 6 months postoperatively.No significant differences were found regarding major complications or progression of osteoarthritis. Conclusions Although no significant differences were found between the surgical methods, TPLO patients showed superiority with regard to clinical outcome.

Evaluation of Positive Contrast Arthrography in Canine Cranial Cruciate Ligament Disease

1996 ◽  
Vol 09 (01) ◽  
pp. 10-3 ◽  
Author(s):  
D.N. Aron ◽  
R. Roberts ◽  
J. Stallings ◽  
J. Brown ◽  
C.W. Hay
Keyword(s):  
Articular Surface ◽  
Cruciate Ligament ◽  
Positive Contrast ◽  
Joint Effusion ◽  
Radiographic Evaluation ◽  
Cranial Cruciate Ligament ◽  
Joint Pathology ◽  
Meniscal Pathology ◽  
Cranial Cruciate Ligament Disease ◽  
Better Than

SummaryArthrographic and intraoperative evaluations of stifles affected with cranial cruciate disease were compared. Arthrography did not appear to be helpful in predicting cranial cruciate ligament pathology. The caudal cruciate ligament was consistently not visualized in the arthrograms and was normal at surgery. The menisci were visualized consistently in the arthrograms, but conclusions could not be made as to the benefit of arthrography in predicting meniscal pathology. Arthrography was not helpful in predicting joint capsule and femoral articular surface pathology. Survey radiographic evaluation was better than arthrography in evaluating joint pathology. When cruciate injury is suspected, after history and physical examination, survey radiographs are better than positive contrast arthrograms at supporting the diagnosis.Positive contrast arthrography was evaluated as a diagnostic aid in canine cranial cruciate ligament disease. It did not appear to be useful in predicting joint pathology. With arthrography, both menisci could be visualized and evaluated for abnormalities. Joint effusion and presence of osteophytes evaluated on survey radiographs was better than arthrography in evaluating joint pathology.

scholarly journals Surgical model of osteoarthritis secondary to medial patellar luxation in dogs

2011 ◽  
Vol 56 (No. 3) ◽  
pp. 123-130 ◽  
Author(s):  
M.R. Alam ◽  
H.B. Lee ◽  
M.S. Kim ◽  
N.S. Kim
Keyword(s):  
Articular Cartilage ◽  
Cruciate Ligament ◽  
Clinical Signs ◽  
Experimental Period ◽  
Control Group ◽  
Cranial Cruciate Ligament ◽  
Tissue Samples ◽  
Surgical Model ◽  
One Year ◽  
The Right

This study was performed to make a surgical model of osteoarthritis (OA) in the dog. Experimental medial patellar luxation (MPL) was surgically produced in the left stifle (index) of 24 skeletally mature mixed small breed dogs (age two to six years and weight 2.8 to 9 kg). The animals were randomly allocated in 2 groups; sham group (n = 12), where the right stifle was sham operated and control group (n = 12) with intact right stifle. Physical and radiographic examinations of both stifles were performed at 1.5 months intervals over a one-year experimental period. One dog was euthanatized every three months, and both stifles were explored, gross examination was performed and tissue samples from the articular cartilage, cranial cruciate ligament (CCL) and synovium were collected for histomorphology. The clinical signs of OA were obvious in the experimental dogs by 12 weeks of surgical induction of MPL, which was also evidenced in the histopathology of the joint tissues and electron microscopy of the articular cartilage. The radiographic changes of OA were not obvious until remarkable degenerative changes became abvious six months postoperatively. Surgically induced MPL can be a successful tool for experimental induction of OA in dogs.

Does a fabella-tibial suture alter the outcome for dogs with cranial cruciate ligament insufficiency undergoing arthrotomy and caudal pole medial meniscectomy?

2009 ◽  
Vol 22 (04) ◽  
pp. 283-288 ◽  
Author(s):  
E.J. Comerford ◽  
M.R. Owen ◽  
M.S. Tivers
Keyword(s):  
Cruciate Ligament ◽  
Meniscal Tear ◽  
Control Group ◽  
Term Outcome ◽  
Cranial Cruciate Ligament ◽  
Long Term Outcome ◽  
Stifle Joint ◽  
Medial Meniscectomy ◽  
Before And After ◽  
Clinical Records

Summary Objectives: The objective of this study was to evaluate the effects of fabella-tibial suture (FTS) on long-term outcome in dogs with cranial cruciate ligament (CCL) insufficiency and concurrent medial meniscal tear (MMT) that were managed by an open, caudal pole medial meniscectomy (CPMM). Methods: A retrospective review was performed of the clinical records of dogs treated for CCL insufficiency with concurrent MMT by open CPMM, with or without the non-random addition of a nylon FTS according to surgeon preference, during the period of 2001 to 2004. The Bristol Osteoarthritis in Dogs questionnaire was modified for owner assessment of outcome using a visual analogue scale based on several criteria: level of activity, disability, severity of lameness and frequency of lameness before and after surgery. Results: Completed questionnaires from 31 dog owners were received. A FTS was used after CPMM in 22 dogs (FTS group), but in nine dogs (control group) only a CPMM was performed. The median time to follow up was longer in the FTS group (25 months) than the control group (16 months) (P=0.03). There were not any significant differences between the two groups before and after surgery for the following: disability, activity, frequency of lameness, severity of lameness, ability to climb stairs and ability to sit down. Clinical Significance: The placement of a FTS following stifle joint arthrotomy and CPMM in dogs with CCL deficiency and concurrent MMT may not be a significant factor affecting the ultimate surgical outcome, although our study is limited by the non-randomised study design.

scholarly journals Force plate gait analysis to assess limb function after tibial tuberosity advancement in dogs with cranial cruciate ligament disease

2008 ◽  
Vol 21 (03) ◽  
pp. 243-249 ◽  
Author(s):  
D. Damur ◽  
T. Guerrero ◽  
M. Haessig ◽  
P. Montavon ◽  
K. Voss
Keyword(s):  
Functional Outcome ◽  
Cruciate Ligament ◽  
Force Plate ◽  
Tibial Tuberosity ◽  
Ground Reaction Forces ◽  
Cranial Cruciate Ligament ◽  
Reaction Forces ◽  
Vertical Ground ◽  
Vertical Ground Reaction Forces

Summary Objective: To assess functional outcome in dogs with cranial cruciate ligament (CrCL) disease after tibial tuberosity advancement (TTA) using force plate gait analysis, and to evaluate parameters potentially influencing outcome. Study design: Prospective clinical study. Animals: Consecutive clinical patients (n=37) with CrCL-deficient stifles (n=40). Methods: The stifle joints were examined arthroscopically prior to TTA. Meniscal release was not performed if the medial meniscus was intact. Open medial arthrotomy and partial meniscectomy were performed in the presence of meniscal tears. Vertical ground reaction forces were measured preoperatively and at follow-up examinations four to 16 months postoperatively (mean: 5.9 months). The ground reaction forces of a group of 65 healthy dogs were used for the comparison. The potential effects of clinical parameters on functional outcome were evaluated statistically. Results: Complete CrCL rupture was identified in 28 joints, and partial CrCL rupture in 12 joints. The medial meniscus was damaged in 21 stifles. Vertical ground reaction forces were significantly higher at follow-up (P<0.01), but remained significantly lower than those of control dogs (P<0.01). Complications were identified in 25% of joints, and the dogs with complications had significantly lower peak vertical forces at follow-up than the dogs without complications (P=0.04). Other clinical parameters did not influence outcome. Conclusions: Tibial tuberosity advancement significantly improved limb function in dogs with CrCL disease, but did not result in complete return to function. Complications adversely affected functional outcome. Clinical significance: A return to a function of approximately 90% of normal can be expected in dogs with CrCL disease undergoing TTA.

scholarly journals Evaluation of the Use of Neuro Muscular Taping (NMT) in the Treatment of Postoperative Edema in Acute ACL Repair Surgery

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Andrea Del Duca
Keyword(s):  
Statistical Tests ◽  
Cruciate Ligament ◽  
Surgical Techniques ◽  
Standard Of Care ◽  
Treated Group ◽  
Rehabilitation Program ◽  
Control Group ◽  
Acl Repair ◽  
Percentage Decrease ◽  
Experimental Group

Background: Surgical techniques for the treatment of Anterior Cruciate Ligament (ACL) injuries are exponentially improved in the past few decades. Nevertheless, edema and pain commonly accompany post-surgical procedures and when excessive, can adversely affect the healing course. In recent years, Neuro Muscular Taping (NMT) has been proposed as a new technique for the treatment of post-operative edema. Objective: In this study, we aimed to investigate the effects Neuro Muscular Taping (NMT) in the treatment of edema in the acute and post-acute postoperative phases of ACL repair surgery. Methods: Thirty patients (19 M, 11F; mean age: 27 y/o) with ACL injury were randomly assigned to two groups for the rehabilitation program: (1) An experimental group to receive a NMT treatment; or (2) A control group which underwent the standard-of-care rehabilitation protocols. Both groups where weekly monitored for 4 weeks after the surgery. Swelling was assessed through measurement of the limb circumference; post-operative pain was evaluated with VAS. After collection, data were processed by means of the Mann-Whitney and Wilcoxon statistical tests, through which we evaluated the percentage decrease in knee swelling of the operated limb. Results: In comparison to the control group, the experimental group showed significant improvements in swelling and pain. The circumference of the operated limb registered was: -2.4% ±0.1 in the NMT-treated group and + 0.3% ±0.2 in the control group in the first week (p = 0.030), -3.7% ±0.1 in the NMT-treated group and -0.63% ±0.3 in the control group in the second week (p = 0.038), -4.5% ±0.1 in the NMT-treated group and -1.2% ±0.3 in the control group in the third week (p = 0.019), -5.8% ±0.1 in the NMT-treated group and -2.4% ±0.3 in the control group in the fourth week (p = 0.019). VAS in the first week was 3.11 ±01.05 in NTM-treated group and 4.67 ±0.71 in the control group (p = 0.006). Our data showed a statistically significant reduction of the mean circumference of the lower limb at each time point and the reduction of mean VAS at the first week treated with NMT compared to the control group (p < 0.05). Conclusion: Our results revealed that NMT technique applied in the acute rehabilitation program of ACL surgery is effective in the treatment of postoperative edema.

scholarly journals The Effect of External Focus Attention Exercise On the Kinetic Risk Factors Associated With ACL Injury

2021 ◽  
Vol 10 (3) ◽  
pp. 470-485
Author(s):  
Nazanin Dalvandpour ◽  
◽  
Mostafa Zarei ◽  
Behrouz Abdoli ◽  
Hamed Abbasi ◽  
...  
Keyword(s):  
Injury Prevention ◽  
Ground Reaction Force ◽  
Cruciate Ligament ◽  
Reaction Force ◽  
Acl Injury ◽  
Control Group ◽  
External Focus ◽  
Time To Stabilization ◽  
Internal Focus ◽  
Anterior Cruciate

Background and Aims One of the most common and dangerous injuries in sports is an Anterior Cruciate Ligament (ACL) injury. Today, despite the ACL injury prevention programs, the prevalence of this injury remains high. Most of the instructions used in injury prevention programs are based on internal focus, while studies have shown that using external focus can improve performance in individuals. The purpose of this study was to investigate the effect of focus of attention on eight weeks of anterior cruciate ligament injury prevention training on landing skill kinetic variables in soccer players. Methods The current methodology included 35 players from 3 premier league teams in Tehran province. The teams were randomly divided into three groups of Prevent injury and Enhance Performance (PEP) exercises based on the External Focus (EF) (12 people), Internal Focus (IF) (12 people), and control group (11 people). In the pretest of ground reaction force, rate of loading, and time to stabilization during landing skill. The training groups performed pep injury prevention exercises for eight weeks and related instructions instead of warm-up exercises. Control group players were performing the regular activities. ANOVA with repeated measures and one-way ANOVA and Tukey post hoc tests were used to evaluate changes Results The test results showed significant changes in vertical, anterior-posterior ground reaction force and rate of loading in the external focus group (P≤0.05). But there was no critical difference in time to stabilization and internal-external ground reaction force. Conclusion According to the results, external focus instruction has positive effects on kinetic components. Therefore, it is recommended that exercises based on these instructions be used to reduce the risk of ACL injury and to repair this injury.

scholarly journals A Comparative Study of the Effects of Platelet-Rich Fibrin, Concentrated Growth Factor and Platelet-Poor Plasma on the Healing of Tooth Extraction Sockets in Rabbits

2022 ◽  
Author(s):  
Siying Li ◽  
Hongyi Yang ◽  
Qinyu Duan ◽  
Hongyu Bao ◽  
Aodi Li ◽  
...  
Keyword(s):  
New Zealand ◽  
Growth Factor ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Control Group ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Bone Absorption ◽  
Autologous Platelet ◽  
Over Time

Abstract Background：Autologous platelet concentrate has been widely used to encourage the regeneration of hard and soft tissues. Up to now, there are three generations of autologous platelet concentrates. Many studies have shown that different autologous platelet concentrates have different healing effects. However, these differences still need to be further verified and discussed. The purpose of this study was to explore and compare the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in New Zealand rabbits. Methods：A total of 24 healthy male New Zealand white rabbits aged 8-12 weeks were selected. The experimental animals were randomly divided into four groups: three experimental groups were respectively implanted with PPP, CGF and PRF gel after bilateral mandibular anterior teeth were extracted, and the control group did not implant any material. The alveolar bone of the mandibular anterior region was taken at 2, 4 and 8 weeks after operation. The height and width of the extraction wound were detected by CBCT, the growth of the new bone was observed by HE and Masson staining, and the expression of osteogenic genes was detected by real-time PCR. Data were analyzed using IBM SPSS statistical package 22.0.Results: The radiological results showed that alveolar bone absorption in all groups gradually increased over time. However, the experimental groups showed lower amounts of bone absorption. The histological results showed that new bone formation was observed in all groups. Over time, the new bone trabeculae of the CGF group became closely aligned while those in the PPP and PRF groups remained scattered. PCR results showed that the expression of BMP-2 and ALP was higher in the experimental groups than the control group.Conclusion: In conclusion, the application of PRF, CGF and PPP in tooth extraction sockets effectively promoted bone regeneration. CGF showed more effective bone induction and tissue regeneration ability in the long term.

Evaluation of an intracapsular technique for the treatment of cranial cruciate ligament rupture

2000 ◽  
Vol 13 (04) ◽  
pp. 197-203 ◽  
Author(s):  
J. K. Roush ◽  
J. J. Hoskinson ◽  
R. M. McLaughlin ◽  
J. J. Geels
Keyword(s):  
Surgical Repair ◽  
Cruciate Ligament ◽  
Force Plate ◽  
Plain Film ◽  
Clinical Results ◽  
Cranial Cruciate Ligament ◽  
Plain Film Radiography ◽  
Bone Scans ◽  
Plate Analysis

SummaryTreatment of cranial cruciate ligament (CCL) rupture using fascial replacement techniques have yielded good clinical results, with 85% to 93% of dogs returning to clinical soundness or intermittent lameness as evaluated by surgeons or owners, but have not been evaluated by force plate analysis long-term. The purpose of this study is to document the long-term clinical and radiographic outcome of dogs having CCL rupture stabilized with an underand- over fascial graft technique by owner assessment, clinical examination, force plate analysis, plain film radiography, and scintigraphy. Twenty dogs with previously repaired unilateral CCL rupture were used for the study. Although client satisfaction was high, force plate analysis revealed significantly lower vertical forces and impulses in the operated versus unoperated limbs. Radiographs and bone scans revealed significant bony changes and synovitis in the operated stifle relative to the unoperated stifle at a median of 17.5 months following repair. Lameness persists in dogs having undergone CCL repair using the under-and-over fascial graft technique; whether this lameness is secondary to progression of osteoarthritis or is a result of surgical repair is unknown.The under-and-over fascial strip technique for stabilization of cranial cruciate ligament-deficient stifles has been evaluated using force plate analysis and nuclear scintigraphy. A median of 17.5 months following surgery, dogs are bearing less weight on the operated limbs as compared to the unoperated limbs. Significant synovitis and bony changes are present when compared to the unoperated limb as evaluated by scintigraphy. Despite these changes, clients are satisfied with the results of surgical repair.

scholarly journals Neurophysiological correlates of motor planning and movement initiation in ACL-reconstructed individuals: a case–control study

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e023048 ◽  
Author(s):  
Florian Giesche ◽  
Tobias Engeroff ◽  
Jan Wilke ◽  
Daniel Niederer ◽  
Lutz Vogt ◽  
...  
Keyword(s):  
Visual Information ◽  
Spectral Power ◽  
Ecological Validity ◽  
Cruciate Ligament ◽  
Statistical Significance ◽  
Reaction Force ◽  
Force Plate ◽  
Motor Planning ◽  
Current Evidence ◽  
Movement Initiation

IntroductionCurrent evidence suggests that the loss of mechanoreceptors after anterior cruciate ligament (ACL) tears might be compensated by increased cortical motor planning. This occupation of cerebral resources may limit the potential to quickly adapt movements to unforeseen external stimuli in the athletic environment. To date, studies investigating such neural alterations during movement focused on simple, anticipated tasks with low ecological validity. This trial, therefore, aims to investigate the cortical and biomechanical processes associated with more sport-related and injury-related movements in ACL-reconstructed individuals.Methods and analysisACL-reconstructed participants and uninjured controls will perform repetitive countermovement jumps with single leg landings. Two different conditions are to be completed: anticipated (n=35) versus unanticipated (n=35) successful landings. Under the anticipated condition, participants receive the visual information depicting the requested landing leg prior to the jump. In the unanticipated condition, this information will be provided only about 400 msec prior to landing. Neural correlates of motor planning will be measured using electroencephalography. In detail, movement-related cortical potentials, frequency spectral power and functional connectivity will be assessed. Biomechanical landing quality will be captured via a capacitive force plate. Calculated parameters encompass time to stabilisation, vertical peak ground reaction force, and centre of pressure path length. Potential systematic differences between ACL-reconstructed individuals and controls will be identified in dependence of jumping condition (anticipated/ unanticipated, injured/uninjured leg and controls) by using interference statistics. Potential associations between the cortical and biomechanical measures will be calculated by means of correlation analysis. In case of statistical significance (α<0.05.) further confounders (cofactors) will be considered.Ethics and disseminationThe independent Ethics Committee of the University of Frankfurt (Faculty of Psychology and Sports Sciences) approved the study. Publications in peer-reviewed journals are planned. The findings will be presented at scientific conferences.Trial statusAt the time of submission of this manuscript, recruitment is ongoing.Trial registration numberNCT03336060; Pre-results.

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