scholarly journals Evaluation of Oxidative Changes in Polycystic Ovary Syndrome Rats with Hypothyroidism Induced by Propylthiouracil

2021 ◽  
Vol 6 (3) ◽  
pp. 105-110
Author(s):  
Sara Khodabandeh ◽  
Homayoun Khazali ◽  
Abdolkarim Hosseini ◽  
Vahid Azizi
Keyword(s):  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Metabolic Disorders ◽  
Polycystic Ovary ◽  
The Body ◽  
Estradiol Valerate ◽  
Ovary Syndrome ◽  
Severity Of The Disease ◽  
The Relationship ◽  
Different Doses

Introduction: More than 186 million people suffer to infertility worldwide. Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation and infertility. PCOS is known as an endocrine disorder in women of marriageable age and is associated with metabolic disorders and dysfunction of the reproductive system. There is also a clear link between fertility and hypothyroidism, which is often associated with ovulation disorders. In recent years, an increasing zest has been witnessed in conducting more research into PCOS and hypothyroidism. So, recognizing the relationship between these two diseases can help for a better understanding of infertility.Methods: In line with such calls for more research, the present study is aimed at investigating the levels of oxidants and antioxidants in the blood of rats with PCOS induced by estradiol valerate (2 mg/kg of body weight) for 60 days and then received oral propylthiouracil in different doses (1,2 and 4 mg/kg of body weight) to induce hypothyroidism. Results: Results showed an increase in catalase (CAT), superoxide dismutase (SOD) and nitric oxide (NO) in PCOS rats. The results also indicated a significant increase in NO (P < 0.05) and a significant decrease in SOD and CAT (P < 0.05) after hypothyroidism in rats with PCOS. That is, as the severity of the disease increased, these indicators also showed significant alterations. Conclusion: Hence, hypothyroidism following PCOS exacerbates oxidant and antioxidant imbalances in the body, which can eventually result in tissue damage.

scholarly journals The link between metabolic features and TSH levels in polycystic ovary syndrome is modulated by the body weight: an euglycaemic–hyperinsulinaemic clamp study

2016 ◽  
Vol 175 (5) ◽  
pp. 433-441 ◽  
Author(s):  
Valeria Tagliaferri ◽  
Daniela Romualdi ◽  
Maurizio Guido ◽  
Antonio Mancini ◽  
Simona De Cicco ◽  
...  
Keyword(s):  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
The Body ◽  
Oral Glucose ◽  
Ovary Syndrome ◽  
Insulin Metabolism ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp ◽  
Tsh Levels

Objective To evaluate the link among thyroid function, glucose/insulin metabolism and steroid hormones in women with polycystic ovary syndrome (PCOS), and to verify if the body mass index (BMI) might influence the interplay between PCOS features and subclinical hypothyroidism (SCH). Study design Case–control study conducted from January to December 2014. Methods One-hundred fifty-four young women with PCOS, according to Rotterdam criteria, and 88 controls were enrolled in an academic research environment. Anthropometric evaluation, hormonal and lipid assays, oral glucose tolerance test (OGTT) and euglycaemic–hyperinsulinaemic clamp were performed. Hirsutism was assessed with the Ferriman–Gallwey (FG) score. Main results SCH was found in 14% of PCOS subjects and in 1% of controls (P < 0.01). In PCOS women, TSH levels were directly correlated with fasting glycaemia, but not with other hormonal and metabolic parameters. When PCOS patients were classified on the basis of BMI, TSH levels significantly correlated with insulin secretion, insulin resistance, DHEAS and cortisol levels in obese PCOS women. Inverse correlations were found between TSH and both oestradiol and SHBG in the same group. In nonobese PCOS patients, only waist-to-hip ratio values were correlated with TSH. The prevalence of SCH was not different between nonobese and obese PCOS groups (14 and 15% respectively). However, SCH was associated with higher levels of insulin, DHEAS, cortisol and FG score only in the obese subgroup. Conclusions Our data confirm that the prevalence of SCH is increased in PCOS women. The presence of SCH is associated with endocrine and metabolic imbalances of PCOS, and the excessive body weight seems to promote this interplay.

scholarly journals Polycystic ovary syndrome: clinical and pathogenetic aspects of a multidisciplinary problem

2021 ◽  
Vol 2 ◽  
pp. 7-14
Author(s):  
V.G. Syusyuka ◽  
M.Y. Sergienko ◽  
G.I. Makurina ◽  
O.A. Yershova ◽  
A.S. Chornenka
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Disorders ◽  
Polycystic Ovary ◽  
Clinical Manifestations ◽  
Reproductive Function ◽  
Point Of View ◽  
The Body ◽  
Cardiovascular Risks ◽  
Ovary Syndrome ◽  
The Impact

The article presents data from guidelines, consensus and literature sources on the modern point of view regarding to the pathogenesis, diagnosis and principles of treatment of women with polycystic ovary syndrome. It is a systemic pathology that occurs in women of any age, from puberty to menopause, involving almost all systems of the body in the process. The work focuses on the variability of the clinical manifestations of this syndrome, which is characterized by menstrual irregularities, infertility, polycystic changes in the ovaries according to ultrasound, dermatopathies and metabolic disorders. The main purpose of diagnosing the syndrome is to determine the severity of clinical manifestations, the sources and pathogenesis of androgen hyperproduction, the impact on reproductive function, as well as the assessment of metabolic and cardiovascular risks. Given the multifaceted clinical manifestations, the management of women with polycystic ovary syndrome requires a multidisciplinary approach, and pathogenetic therapy should include normalization of the hormonal profile and menstrual function, treatment of dermatopathies, correction of metabolic disorders, treatment of infertility (if pregnancy is relevant), etc.

scholarly journals THE EFFECT OF METFORMIN ON BODY WEIGHT IN POLYCYSTIC OVARY SYNDROME PATIENTS

2014 ◽  
Vol 2 (3) ◽  
pp. 33-39
Author(s):  
Yasser El-Shabrawy ◽  
Alaa Alhaboby ◽  
Nageeb Abdulgaleel Hassan ◽  
Sameer Issa Bloukh ◽  
Moayad Jamal Shahwan
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
The Body ◽  
Online Questionnaire ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Positive Effect

Polycystic Ovary Syndrome (PCO) is an endocrine disease that is characterized by a set of symptoms including irregular menstruation, subfertility, skin changes, hirsutism and weight gain. The pathogenesis of PCO is mostly related to increase androgens and insulin resistance. Treatment is mostly symptomatic hence metformin is being used due to its effect in decreasing gluconeogenesis and by increasing peripheral utilization of glucose, in addition to its lowering effects on androgen. Thus, Metformin role in PCO treatment ranges between managing insulin resistance, promoting ovulation and treating hirsutism to some extent. Some studies showed that Metformin is effective in lowering body weight in PCO patients, yet it is not being indicated officially for this purpose. Background: Metformin is expected to have an effect of weight reduction in PCO patients This is the scope of this research which intends to explore this action. Method: The Study design is cross sectional study using online questionnaire. Open and closed ended questions were included.  Results: Based on the results the majority shows decrease in the weight, while only one reported increase in their weight and only one had the same weight during and after treatment with metformin. Conclusions:  Metformin generally showed positive effect regarding reducing the body weight of the females diagnosed with polycystic ovarian syndrome when used alone.

scholarly journals The role of body weight reduction and treatment with metformin in the recovery of the menstrual function in women presenting with polycystic ovary syndrome and excessive body weight

2011 ◽  
Vol 57 (2) ◽  
pp. 14-18
Author(s):  
P V Popova ◽  
E M Riazantseva ◽  
I E Zazerskaia ◽  
L I Ivanova ◽  
E N Grineva
Keyword(s):  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Life Style ◽  
Polycystic Ovary ◽  
The Body ◽  
Ovary Syndrome ◽  
Menstrual Function ◽  
Excessive Body Weight ◽  
Group 3 ◽  
Group 2

A total of 40 women presenting with polycystic ovary syndrome (PCOS) and excessive body weight/obesity were randomly allocated to 3 groups. The patients in group 1 were advised to change the life style (including consumption of a low-calory diet and regular physical exercises), those making up group 2 had to change the life style and take metformin (850 mg twice daily), the patients of group 3 used metformin without modifying their life style. Thirty three patients completed the study. Those in groups 1 (n=14) and 2 (n=10) experienced a similar significant reduction of both the body weight and the HOMA index. In group 3 (n=9), these characteristics remained virtually unaltered. The fraction of women displaying the positive menstrual response during the treatment was not significantly different in groups 1 and 2 (50 and 60% respectively; p=0.77) whereas none of the patients in group 3 showed the positive menstrual response (the difference between this and the two previous groups was significant; p=0.035). A significant decrease in the testosterone level was documented in the women of group 2. The authors conclude that it was the reduction of the body weight rather than regular intake of metformin at a daily dose of 1700 mg that contributed to the improvement of the menstrual function in women with PCOS and the excessive body weight.

scholarly journals Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zora Lazúrová ◽  
Jana Figurová ◽  
Beáta Hubková ◽  
Jana Mašlanková ◽  
Ivica Lazúrová
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Bisphenol A ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Suppressive Effect ◽  
Human Reproduction ◽  
Control Group ◽  
Ovary Syndrome ◽  
Ovarian Steroidogenesis ◽  
The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

scholarly journals The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome

2021 ◽  
Vol 9 ◽  
pp. 100079
Author(s):  
Abu Saleh Md Moin ◽  
Thozhukat Sathyapalan ◽  
Stephen L. Atkin ◽  
Alexandra E. Butler
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Neuropilin 1 ◽  
Relationship Of ◽  
The Relationship
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