Effect of propolis extract on clinical parameters and salivary level of matrix metalloproteinase 8 in periodontitis patients: A randomized controlled clinical trial

Background: Periodontitis is bacterial induced inflammation of the tooth-supporting structures. Local antibacterial agents are used as an adjunctive therapy in the treatment of Periodontitis. The aim of this study was to compare the efficacy of subgingivally delivered propolis extract (a resin produced by the honey bees) with chlorhexidine (CHX) mouthwash on clinical parameters and salivary levels of matrix metalloproteinase 8 (MMP-8) in periodontitis patients. Methods: 28 periodontitis patients in stage II or III and grade B were divided in two groups. In control group, patients prescribed 0.2 % CHX mouthwash twice a day for two weeks. In the 20% propolis hydro-alcoholic group, subgingival irrigation was performed twice a week for two weeks. Clinical parameters were measured at baseline and after 2 months. Saliva samples were collected from propolis and control group at baseline and 2 months later to assess MMP-8 levels using the enzyme-linked immunosorbent assay. Additionally, Saliva from 12 periodontally healthy subjects was used to determine the normal levels of MMP-8. Data were analyzed using SPSS, P<0.05 was considered as the level of significance. Results: In the healthy group, the mean salivary levels of MMP-8 were significantly lower than that in control and propolis groups at baseline (P<0.001). The results indicated that there was a significant improvement in clinical parameters (p<0.001) in the propolis group compared to control group, while MMP-8 levels decreased significantly in both groups (P<0.001). Conclusions: Propolis is recommended as an adjunct therapy for periodontitis patients. Clinical trials registration code: IRCT2016122030475N3.

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Efficacy of Herbal Mouthwash with Extracts of Coriandrum Sativum, Mint and Clove in the Treatment of Chronic Gingivitis- A Randomized Controlled Clinical Trial

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i39b32180 ◽

2021 ◽

pp. 59-63

Author(s):

Sneha Puri ◽

Mahvash Fatema ◽

Akhilesh Shewale ◽

Rashmi Bele

Keyword(s):

Test Group ◽

Coriandrum Sativum ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

The Mean ◽

Mechanical Therapy ◽

And Control ◽

Antibiotic Agents ◽

Experimental Group

Introduction: Herbal antiseptic or antibiotic agents are introduced very widely that are effective against plaque microorganisms for the healing of gingival and periodontal tissue. However, none of literature has shown antibacterial effect of coriandrum sativum, clove and mint on the levels of dental plaque when used as a mouthwash. Aim: To assess the efficacy of a newly formulated mouthwash containing Coriandrum sativum, mint and clove to reduce plaque and inflammation to maintain the oral hygiene. Methodology: Twenty systemically healthy patients were randomly allocated to either the test group [G1(coriandrm sativum, mint,clove = 10 patients)] or the control group [G2 (Placebo gel = 10 patients]. Full mouth Gingival Index (GI); Full mouth Plaque Index (PI) was evaluated at baseline and on 14 and 21st day. Result: The mean reduction in PI from 2.28 to 0.85 and 2.13 to 1.21 was noted in the experimental and control groups, respectively. The experimental group (2.21–0.76) comparatively showed better reduction in mean PBI than the control group (2.17–1.29). The results obtained were statistically significant at baseline and 14th and 21st day in all the groups. Remarkable improvement was noted from baseline to 14th and 21st day in all the groups. Conclusion: The encouraging results of our study suggest that the newly formulated mouthwash containing coriandrum Sativum, mint and clove demonstrates anti-inflammatory properties, which may be useful as an adjunctive to mechanical therapy in the prevention and treatment of gingivitis.

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The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

10.21203/rs.3.rs-903099/v1 ◽

2021 ◽

Author(s):

parvaneh sharifipour ◽

Masoomeh Kheirkhah ◽

Mojgan Rajati ◽

hamid haghani

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Childbirth Experience ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

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The effect of distraction techniques on pain and stress during labor: a randomized controlled clinical trial

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2683-y ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA. Results The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: − 0.8 to − 6.0; P = 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P < 0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to − 6.0; P = − 2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P = 0.504), second stage of delivery (P = 0.928), total length of delivery (P = 0.520), Apgar score (P = 1.000) and frequency of oxytocin consumption (P = 0.622). Conclusion According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion. Trial registration IRCT2017042910324N39; Name of registry: Iranian Registry of Clinical Trials; Registered 11 September 2017. URL of registry: https://fa.irct.ir/user/trial/10814/view. Date of enrolment of the first participant to the trial: September 2017.

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The Effect of Distraction Techniques on Pain and Stress during Labor: A Randomized Controlled Clinical Trial

10.21203/rs.2.13303/v2 ◽

2019 ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background: Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods: A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA . Results: The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: -0.8 to -6.0; P= 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P<0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to -6.0; P= -2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P= 0.504), second stage of delivery (P= 0.928), total length of delivery (P= 0.520), Apgar score (P= 1.000) and frequency of oxytocin consumption (P= 0.622). Conclusion: According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion .

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Evaluation of clinical parameters related to methotrexate therapy in lichen planus

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v6i2.29122 ◽

2016 ◽

Vol 6 (2) ◽

pp. 90

Author(s):

Samaresh Chandra Hazra ◽

Agha Masood Choudhury ◽

Lubna Khondker ◽

Md. Shirajul Islam Khan ◽

Muhammad Munir Rashid

Keyword(s):

Clinical Trial ◽

Lichen Planus ◽

Control Group ◽

Controlled Clinical Trial ◽

Clinical Parameters ◽

Morning Dose ◽

Group A ◽

Group B ◽

And Control

Background: For better management of lichen planus a clinical trial of oral methotrexate is necessary in ow· country. Objective: The objective of this study is to evaluate efficacy and safety ofmethotrexate therapy in the treatment of lichen planus.Methods: It was a prospective randomized controlled clinical trial conducted in the department of Dermatology and Venereology, BSMMU, Dhaka, from January 2009 to December 2010. Forty four patients of lichen planus were included in the study. Cases (group-A, n=23) were treated with methotrexate (10 mg) single morning dose and control (group-B, n=21) were treated with mini pulse betamethasone (5mg) single morning dose on 2 consecutive days during the period of 12 weeks. Results: Clinical parameters were measured by follow up clinical examination. Morphological lesion of lichen planus improved 95. 7% in group-A and only 28.6% improved in group-B. At the end of study 82.6% bad no complaints of itching in group-A and 100% had no complaints of itching in group-B. 16(69.6%) patients in group-A were completely cured clinically but 10(47.6%) in group-B. Anemia 3(14.2%) and edema 12(57.1 %) developed in group-B but none in group-A. In group-B, dyspepsia 15(71.4%), acne 10(47.6%),mooning face 8(38.1%), striae 8(38.1%) and hypertrichosis 4(19.0%) developed but none in group-A lntermittenr diarrhoea, headache, nausea and fatigue complained in both groups of patients but the percentage of complaints was higher amog group-8 compared to group-A. Menstrual abnormality developed in group-B 5(71.4%) but none in group-A.Conclusion: The overall adverse effects were less in group-A than group-B. Therefore, methotrexate can be used as an alternative safer option for the treatment of lichen planus.

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The Effect of Distraction Techniques on Pain and Stress during Labor: A Randomized Controlled Clinical Trial

10.21203/rs.2.13303/v1 ◽

2019 ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Randomized Controlled ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background The aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, and length of delivery stages (secondary outcomes). Methods A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two intervention and control groups by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA. Results The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: -0.8 to -6.0; P= 0.01). The mean (SD) of pain intensity was 6.2 (1.4) and 7.5 (1.4) in the intervention and control groups, respectively, which indicated a significant difference between the two groups (P<0.001). Although the mean score of fear in 36th week in the intervention group (29.1) was less than of the control group (39.1), there was no significant difference between the two groups (P= 0.170). Moreover, there was no statistically significant difference between the two groups in terms of the length of the delivery stages (P>0.05). Conclusion According to the results, distraction techniques can reduce the pain and stress of labor, but further studies are needed to reach a decisive conclusion.

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TEACHING READING BY UTILIZING HOT POTATOES SOFTWARE TOWARD STUDENTS’ READING COMPREHENSION OF DESCRIPTIVE TEXT

JEELL (Journal of English Education Linguistics and Literature) ◽

10.32682/jeell.v5i1.927 ◽

2018 ◽

Vol 5 (1) ◽

pp. 26

Author(s):

Abdullah Farih

Keyword(s):

Reading Comprehension ◽

Alternative Hypothesis ◽

T Test ◽

Control Group ◽

Teaching Reading ◽

Post Test ◽

Quasi Experimental ◽

Independent Variable ◽

Level Of Significance ◽

And Control

The objective of this study is to measure whether there is or not significant effect of teaching reading by utilizing Hot Potatoes software toward students’ reading comprehension of descriptive text. The variables used were the teaching treatment of Hot Potatoes Software as the independent variable and the students’ reading comprehension of Descriptive Text as dependent variable. Then, the research designed was Quasi-experimental design and the presentation of data used was quantitative. The data were obtained from the eleventh grade, of which 28 students were taken as sample. The students are divided into two groups; experiment group consisted of 12 students and control group consists of 16 students. To get the data, the pre-test and post-test were applied and then analyzed using t-test formula. The researcher had concluded that there is Significant effect of Hot Potatoes Software toward the students’ reading comprehension achievement. The result showed that mean of students’ post-test was increased. It is proved by the t-test (8.54) which is higher than t-table (2.05) at level of significance 5%. It means that the alternative hypothesis was accepted and it proved that Hot Potatoes Software had significant effect toward students’ reading comprehension of Descriptive Text

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The Effect of Applying POSSE (Predict- Organize-Search-Summarize-Evaluate) on the Students’ Reading Comprehension

GENRE Journal of Applied Linguistics of FBS Unimed ◽

10.24114/genre.v2i1.725 ◽

2013 ◽

Vol 2 (1) ◽

Cited By ~ 1

Author(s):

Eka Rejeki Maha ◽

Berlin Sibarani

Keyword(s):

Reading Comprehension ◽

Experimental Design ◽

Null Hypothesis ◽

Alternative Hypothesis ◽

Choice Test ◽

Control Group ◽

Multiple Choice Test ◽

Level Of Significance ◽

And Control ◽

Experimental Group

This study was aimed at finding out The Effect of Applying POSSE (Predict-Organize-Search-Summarize-Evaluate) Strategy on the Students’ Reading Comprehension. This study used the experimental design. The population of this study was the students of SMA Negeri 2 Medan. There were sixty students taken as the sample of the research. This study was conducted with two randomized groups namely experimental and control group. The experimental group was taught by applying POSSE strategy while control group was taught without applying POSSE strategy. The instrument of collecting the data was multiple choice test which consists of 40 items. To obtain the reliability of the test, the researcher used Kuder-Richardson (KR-21). The calculation shows the reliability was 0.81(high). The data were analyzed by using t-test. The calculation shows that t-observed (4.76) is higher than t-table (2.00) at the level of significance (α) 0.05 with the degree of freedom (df) 58. Therefore, the null hypothesis (Ho) is rejected and alternative hypothesis (Ha) is accepted. It means that there was a significant effect of applying POSSE strategy on the students’ reading comprehension. Keywords: POSSE Strategy, Reading Comprehension.

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The Effect of Applying Learning Together Method on the Students’ Reading Comprehension

GENRE Journal of Applied Linguistics of FBS Unimed ◽

10.24114/genre.v1i2.744 ◽

2012 ◽

Vol 1 (2) ◽

Author(s):

Haryato Siregar ◽

Elia Masa Ginting

Keyword(s):

Reading Comprehension ◽

Alternative Hypothesis ◽

Choice Test ◽

Control Group ◽

Teaching Reading ◽

Multiple Choice Test ◽

Level Of Significance ◽

And Control ◽

Experimental Group ◽

Learning Together

This study was aimed at finding out the effect of applying Learning Together Method on the students’ reading comprehension. This study used the experimental design. The population of this study was the students of SMP Negeri 1 Muara. There were sixty students of eighth class as the sample of the research. This study was conducted with two randomized groups namely experimental and control group. The experimental group was taught by applying Learning Together Method while control group was taught without applying Learning Together Method. The instrument of collecting the data was multiple choice test which consists of 20 items. To obtain the reliability of the test, the researcher used Kuder-Richardson (KR-21) formula. The calculation shows the reliability was 0.82(high). The data were analyzed by using t-test. The calculation shows that t-observed (4.9) is higher than t-table (2.00) at the level of significance (α) 0.05 with the degree of freedom (df) 58. Therefore, the null hypothesis (Ho) is rejected and alternative hypothesis (Ha) is accepted. It means that teaching reading comprehension by applying Learning Together Method significantly affect reading comprehension. Keywords: Learning Together Method, Reading Comprehension

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THE EFFECT OF RAP (READ, ASK, PARAPHRASE) STRATEGY ON STUDENTS’ READING COMPREHENSION IN READING ANALYTICAL EXPOSITION TEXT

10.24114/reg.v4i3.5244 ◽

2015 ◽

Vol 4 (3) ◽

Author(s):

Veronika N. And Lince Sihombing

Keyword(s):

Reading Comprehension ◽

Experimental Design ◽

T Test ◽

Control Group ◽

Multiple Choice Tests ◽

Choice Tests ◽

Second Year ◽

Level Of Significance ◽

And Control ◽

Experimental Group

This study focused on finding out the effect of applying RAP (Read, Ask,Paraphrase) Strategy on students’ reading comprehension in reading analyticalexposition text. This study was conducted in experimental design. The populationof this research was the second year of students in SMA Swasta Katolik BudiMurni 2 Medan. There were seventy students of the second year senior highschool students as the sample of the research. This study was conducted with tworandomized groups namely Experimental Group and Control Group. Theexperimental group was taught by applying RAP Strategy, while the control groupwas taught by applying conventional strategy. The instrument of collecting thedata was multiple choice tests which consisted of 25 items. The data wereanalyzed by using t-test formula. The calculation shown that t-observed (5.36)was higher than t-table (1.994) at the level of significance (α) 0.05 with the degreeof freedom (df) 68. It means that there was a significant effect of applying RAPStrategy on students’ reading comprehension in reading analytical exposition text.

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