scholarly journals Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review

2021 ◽  
Vol 6 (1) ◽  
pp. 1318-1323
Author(s):  
Taufik Septiyan ◽  
Gofarana Wilar ◽  
Nasrul Wathoni
Keyword(s):  
Curcuma Longa ◽  
Aloe Vera ◽  
Psidium Guajava ◽  
Recurrent Aphthous Stomatitis ◽  
Persea Americana ◽  
Aphthous Stomatitis ◽  
In Vitro Tests ◽  
Blood Disorders ◽  
Mouth Ulcer

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.

scholarly journals Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 179-187
Author(s):  
Indah Suasani Wahyuni ◽  
Irna Sufiawati ◽  
Wipawee Nittayananta ◽  
Irma Melyani Puspitasari ◽  
Jutti Levita
Keyword(s):  
Oral Mucositis ◽  
Curcuma Longa ◽  
Aloe Vera ◽  
Recurrent Aphthous Stomatitis ◽  
Drug Formulation ◽  
Aphthous Stomatitis ◽  
Licorice Root ◽  
Mucosal Inflammation ◽  
Cochrane Library ◽  
Root Extract

Oral mucosal inflammation is one of the oral diseases causing pain and reducing the quality of human life. The types of oral mucosal inflammation that commonly found were recurrent aphthous stomatitis (RAS) and oral mucositis (OM). Anti-inflammatory drugs, both synthetic and plant-based, have been used to treat RAS and OM. Plant-based drugs have been attracted the attention of some researchers to minimize the side effects of synthetic drugs. However, a comprehensive review addressing the use of plant-based drugs for RAS and OM therapy, including drug formulation and species of plant, has not yet been reported. Here, we reported the article review of 9 publications derived from the databases of PubMed, ScienceDirect, Cochrane Library, and other additional relevant works, in order to find the effectiveness and safety of plant-based drugs for RAS and OM therapy. This review was written by following the PRISMA guidelines, and the risk of bias of the articles was evaluated using the Oxford Quality Scoring System. It was found that the effective and safe drugs for RAS therapy contained acemannan from Aloe vera and curcumin from Curcuma longa, both in an oral gel formulation. For OM therapy, drugs contained curcumin from Curcuma longa; licorice from Glycyrrhiza glabra; Aloe vera and black mulberry from Morus nigra, in soft tablet, mouthwash solution or mucoadhesive film formulation. In conclusion, the most effective and safest plant-based therapy for RAS is Acemannan 0.5% in oral gel, whereas for OM is Licorice root extract 0.18 mg in mucoadhesive film.

scholarly journals EFFECTIVENESS OF THE NATURAL-BASED PRODUCTS AND MUCOADHESIVE FOR RECURRENT APHTHOUS STOMATITIS THERAPY: A SYSTEMATIC REVIEW

2021 ◽  
pp. 7-13
Author(s):  
IIN HELDAYANI ◽  
INDAH SUASANI WAHYUNI
Keyword(s):  
Systematic Review ◽  
Curcuma Longa ◽  
Controlled Trial ◽  
Aloe Vera ◽  
Punica Granatum ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Mucoadhesive Polymers ◽  
Relieve Pain ◽  
Effective Combination

The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) and mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing was based on PRISMA guidelines. The articles published in the last 10 y were selected using PubMed and Google Scholar database carried out during May 2021. The keywords were: natural-based product, mucoadhesive, and Recurrent Aphthous Stomatitis. The risk of bias was assessed using the Oxford Quality Scoring System. Six articles of Randomized Controlled Trial were selected. The NBP were: Aloe vera, Myrrh, Curcuma longa, propolis, ginger, Punica granatum flower, and sesame oil. The drug’s formulation was: gel, film, and spray. The mucoadhesive polymers as vehicles were Hydroxy Propyl Ethyl Cellulose (HPEC), Hydroxy Propyl Methylcellulose (HPMC), Benzocaine, Tragacanth Gum, Carbomer 934, Sodium CMC (carboxymethyl cellulose), and chitosan. Curcuma longa 10 mg/g with HPMC was the most effective to relieve pain, while Punica granatum flower extract with Carbomer 934 and Sodium CMC was the most effective to reduce the ulcer size in RAS. Both of the formulations were in gel form.

scholarly journals Review on in vitro antioxidant activities of Curcuma species commonly used as herbal components in Indonesia

Food Research ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 286-293 ◽  
Author(s):  
Abdul Rohman ◽  
H. Widodo ◽  
E. Lukitaningsih ◽  
M. Rafi ◽  
Nurrulhidayah A.F. ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Curcuma Longa ◽  
Radical Scavenging ◽  
Thiobarbituric Acid ◽  
Natural Antioxidants ◽  
In Vitro Tests ◽  
Antioxidant Power ◽  
Ferric Thiocyanate ◽  
Herbal Components

Free radicals, reactive nitrogen species (RNS) and reactive oxygen species (ROS) have been known to contribute several degenerative diseases such as cardiovascular diseases, aging, certain types of cancers, rheumatoid arthritis, neurodegenerative, and diabetes mellitus. In order to overcome the negative effects of these radicals, some scientists have explored some natural antioxidants from plants and it's by-products. The antioxidant can be defined as any substances or samples capable of inhibiting free radical reactions in the oxidation reaction. Due to curcuminoids contained, Curcuma species such as Curcuma longa, Curcuma heyneana, Curcuma mangga, and Curcuma xanthorriza were commonly used for herbal components in some traditional medicine. Several in vitro tests been introduced and used to measure antioxidant activities, namely radical scavenging assay using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6 -sulfonic acid) (ABTS•+), ferric reducing antioxidant power (FRAP), ferric-thiocyanate, phosphomolybdenum method, cupric ion reducing antioxidant capacity, metal chelating power, beta-carotene bleaching linoleic-ferric-thiocyanate, and thiobarbituric acid methods. This review highlighted the antioxidant activities in vitro of C. longa, C. heyneana, C. mangga, and C. xanthorriza through several tests. To perform this review, several repute databases were analyzed and used. From this review, it can be stated that Curcuma species have powerful antioxidant activities, therefore they could be potential sources of natural antioxidants and can be used as food supplements.

scholarly journals JENIS DAN PEMANFAATAN TANAMAN OBAT DI DESA BUDI MUKTI SULAWESI TENGAH DAN PENGEMBANGANNYA SEBAGAI MEDIA PEMBELAJARAN

2018 ◽  
Vol 9 (1) ◽  
pp. 11-19
Author(s):  
Ni Made Mega Hariani
Keyword(s):  
Cocos Nucifera ◽  
Aloe Vera ◽  
Zingiber Officinale ◽  
Psidium Guajava ◽  
Persea Americana ◽  
Apium Graveolens ◽  
Piper Betle ◽  
Syzygium Aromaticum ◽  
Cordyline Fruticosa ◽  
Cocos Nucifera L

Penelitian ini bertujuan untuk mengidentifikasi jenis dan cara pemanfaatan tanaman obat yang dimanfaatkan sebagai bahan obat-obatan tradisional oleh masyarakat di Desa Budi Mukti Sulawesi Tengah dan pengembangannya sebagai media pembelajaran. Metode yang digunakan adalah metode survei dimana sampel diambil secara acak. Analisis pemanfaatan tanaman sebagai obat dilakukan dengan wawancara secara terbuka dengan masyarakat di sekitar lokasi penelitian. Hasil penelitian diperoleh 36 species tanaman yang berkhasiat obat, tergolong dari 29 familia yaitu: Cordyline fruticosa L. (andong), Pluchea indica L. (beluntas), Cocos nucifera L. (kelapa), Andrographis paniculata Ness. (sambiloto), Annona muricata L. (sirsak), Amaranthus hybridus L. (bayam), Apium graveolens L. (seledri), Ipomea reptans L. (kangkung), Ipmoea batatas L. (ubi jalar), Mamordica charantia L. (pare), Carica papaya L. (pepaya), Euphorbia tirucalli L. (petikan kebo), Orthosiphoon staminues Benth. (kumis kucing), Persea Americana Mill. (alpukat), Michelia alba (cempaka putih), Hibiscus rosasinensis L. (kembang sepatu), Cyclea barbata Miers. (cincau), Leucaena leucocephala L. (lantoro), Moringa oleifera (kelor), Psidium guajava L. (jambu biji), Syzygium aromaticum L. (cengkeh), Averrhoa bilimbi L. (belimbing wuluh), Pandanus amaryllifolius Roxb. (pandan wangi), Cymbopogon citratus L. (sere), Imperata cylindrical L. (alang-alang), Piper betle L. (daun sirih), Morinda citriffolia L. (mengkudu), Citrus aurantifolia L. (jeruk nipis), Manilkara kauki L. (sawo), Physalis angulate (ciplukan), Aloe vera L. (lidah buaya), Zingiber officinale Rosc. (jahe), Cucurma xanthorrhiza Roxb. (temulawak), Curcuma domestica Val. (kunyit), Zingiber purpureum Roxb. (bangle), dan Kaempferia galangal L. (kencur). Bagian tumbuhan yang dimanfaatkan untuk pengobatan antara lain; akar, batang, daun, bunga, buah, biji, kulit batang dan seluruh bagian tumbuhan dengan cara penggunaan yang berbeda-beda. Penelitian ini menghasilkan produk berupa buku saku sebagai media pembelajaran Biologi.  

scholarly journals α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

2019 ◽  
Vol 9 (23) ◽  
pp. 5235 ◽  
Author(s):  
Nasrul Wathoni ◽  
Nia Yuniarsih ◽  
Arief Cahyanto ◽  
Muhctaridi Muhctaridi
Keyword(s):  
In Vitro Release ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Fickian Diffusion ◽  
Garcinia Mangostana ◽  
Scanning Calorimetry ◽  
Main Compound ◽  
Discovery Studio ◽  
Hydrogel Film

Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan–alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan–alginate have the potential as carriers of α-M for RAS therapy.

scholarly journals Efeito in vitro de compostos de plantas sobre o fungo Colletotrichum gloeosporioides Penz: isolado do maracujazeiro

2009 ◽  
Vol 33 (spe) ◽  
pp. 1853-1860 ◽  
Author(s):  
André Costa da Silva ◽  
Nilza de Lima Pereira Sales ◽  
Alisson Vinícius de Araújo ◽  
Cecílio Frois Caldeira Júnior
Keyword(s):  
Manihot Esculenta ◽  
Colletotrichum Gloeosporioides ◽  
Curcuma Longa ◽  
Psidium Guajava ◽  
Cymbopogon Citratus ◽  
Lippia Citriodora ◽  
Eclipta Alba ◽  
Lippia Sidoides ◽  
Solanum Sisymbriifolium

Neste trabalho, objetivou-se avaliar o efeito de extratos e óleos essenciais de quatorze plantas medicinais e ou nativas, conhecidas popularmente no Norte de Minas Gerais, sobre a germinação de esporos e crescimento micelial do fungo Colletotrichum gloeosporioides. Foram utilizados no teste de inibição do crescimento micelial, os extratos aquosos de alecrim (Rosmarinus officinalis), erva baleeira (Cordia verbenacea), joá (Solanum sisymbriifolium), quebra-pedra (Phyllanthus corcovadensis), erva botão (Eclipta alba) e açafrão da índia (Curcuma longa) obtidos por meio do processo de infusão; óleo essencial de alecrim de vargem (Família Lamiaceae), alecrim pimenta (Lippia sidoides), alfavaca cravo (Ocimum gratissimum), lippia (Lippia citriodora), goiaba branca (Psidium guajava), capim santo (Cymbopogon citratus); óleo resina de copaíba (Copaifera langsdorffi); hidrolatos de alecrim de vargem, goiaba vermelha (Psidium guajava), lippia, capim santo, goiaba branca, alfavaca cravo; manipueira de (Manihot esculenta). Também foram testados esses mesmos hidrolatos e os óleos essenciais na germinação dos esporos do fungo. Todos os tratamentos foram realizados in vitro, cultivando-se o fungo em meio de cultura BDA acrescido de 100μL dos compostos vegetais. No teste de inibição da germinação, todos os óleos essenciais impediram a germinação do fungo. No entanto, os hidrolatos não tiveram esse efeito. No teste de crescimento micelial, os óleos essenciais de todas as plantas inibiram completamente o crescimento do fungo, exceto o óleo da goiaba branca. Os extratos aquosos, a manipueira, o óleo resina e os hidrolatos, também não foram eficientes sobre o crescimento do patógeno. Esses resultados indicam o potencial antifúngico de alguns óleos essenciais de plantas medicinais.

scholarly journals Control of root rot (Phytophthora cinnamomi) in avocado (Persea Americana) with bioagents

2020 ◽  
Vol 46 (3) ◽  
pp. 205-211
Author(s):  
Ciro Hideki Sumida ◽  
Lucas Henrique Fantin ◽  
Karla Braga ◽  
Marcelo Giovanetti Canteri ◽  
Martin Homechin
Keyword(s):  
Biological Control ◽  
Root Rot ◽  
Phytophthora Cinnamomi ◽  
Persea Americana ◽  
Field Conditions ◽  
In Vitro Tests ◽  
Trichoderma Spp ◽  
Maize Cultivation ◽  
Antagonistic Potential

ABSTRACT Despite the favorable edaphoclimatic conditions for avocado production in Brazil, diseases such as root rot caused by the pathogen Phytophthora cinnamomi compromise the crop. With the aim of managing root rot in avocado, the present study aimed to evaluate chemical and biological control with isolates of Trichoderma spp. and Pseudomonas fluorescens. Thus, three assays were conducted to assess: (i) mycelial inhibition of P. cinnamomi by isolates of Trichoderma spp. and P. fluorescens from different crop systems; (ii) effect of autoclaved and non-autoclaved metabolites of P. fluorescens, and (iii) chemical or biological treatment of avocado seedlings on the control of root rot under field conditions. The isolates of Trichoderma spp. from maize cultivation soil and the commercial products formulated with Trichoderma presented greater antagonism (p <0.05) to the pathogen P. cinnamomi in the in vitro tests. Similarly, non-autoclaved metabolites of P. fluorescens presented antagonistic potential to control P. cinnamomi. Under field conditions, the fungicide metalaxyl and the bioagents showed effectiveness in controlling P. cinnamomi, as well as greater root length and mass. Results demonstrated potential for the biological control of avocado root rot with Trichoderma spp. and P. fluorescens.

scholarly journals In-vitro potential of crude extracts of selected garden herbs for mastitis management in Zambia

2021 ◽  
Vol 5 (1) ◽  
pp. 49-62
Author(s):  
Joshua Ngwisha ◽  
◽  
Mulemba T. Samutela ◽  
Mbawe Zulu ◽  
Wizaso Mwasinga ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Ethyl Acetate ◽  
Curcuma Longa ◽  
Bovine Mastitis ◽  
Aloe Vera ◽  
Field Isolates ◽  
Herbal Formulation ◽  
Crude Extracts ◽  
Agar Dilution

Introduction: The advent of bovine mastitis associated antimicrobial resistance has necessitated development of alternative herbal remedies. In this study, we tested, in-vitro, the antimicrobial efficacy of three crude extracts: (1) aqueous, (2) ethanol and (3) ethyl acetate extracts of Zambian cultivated Aloe barbadensis Miller (Aloe vera) and Curcuma longa (Turmeric) and also made comparisons to synthetic anti-mastitis formulations. Methods: The active compounds of these herbs were obtained as crude extracts using water, ethanol and ethyl acetate as solvents. The test microbes comprised of ten standard controls including Escherichia coli and Pseudomonas aeruginosa and 84 field isolates (all gram positive bacteria) from clinical and subclinical mastitis milk samples from selected districts of the Southern Province of Zambia belonging to the genera Staphylococcus, Streptococcus, Bacillus and Lactobacillus. The agar dilution method was used to determine the antimicrobial activity by observing the sensitivity which was graded as sensitive, intermediate or resistant. Commercial synthetic anti-mastitis preparations served as positive controls and their sensitivity was compared to that of the herbal preparations. The Minimum Inhibitory Concentrations (MIC) of the herbal formulation was also determined using two-fold serial dilutions. Results: The agar dilution test results of the field isolates indicated 18.8% resistance, 25.3% intermediate and 56% sensitivity for the herbal extracts, while the synthetic anti-mastitis preparation averaged 16.8% resistance, 4.75% intermediate and 78.5% sensitivity. The gram negative controls tested were generally resistant. On average, the agar dilution trials revealed; 41.8% resistance, 13% intermediate and 45.3% sensitivity for the herbal formulation while the synthetic antimicrobials produced 23.5% resistance, 5.2% intermediate and 71.3% sensitivity. Mean MIC was 11.5mg/ml at the 5% serial dilution for the herbal extract compared to the Cephalexin (semi-synthetic antimicrobial) MIC for S. aureus at 0.5mg/L or 0.0005mg/ml. Conclusion: The herbs Aloe vera and Curcuma longa from Zambia showed antimicrobial efficacy on bovine mastitis causing microbes and may be used as a cheaper alternative to synthetic anti-mastitis preparations and as an aid to fight antimicrobial resistance to the benefit of the most affected and resource limited small-scale dairy farmers.

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