scholarly journals Evaluation of the relationship between neutrophil-to-lymphocyte ratio and 25-hydroxy vitamin D levels in hemodialysis patients, Isfahan, Iran

2021 ◽  
Vol 6 (2) ◽  
pp. e26-e26
Author(s):  
Azar Baradaran ◽  
Zahra Hoseini ◽  
Parin Hedayati ◽  
Reyhaneh Shirvani
Keyword(s):  
Vitamin D ◽  
Hemodialysis Patients ◽  
Vitamin D Supplementation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Low Grade ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Esrd Patients

Introduction: Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Recently, neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an inflammatory index in many disorders such as CKD. Several studies also have shown the anti-inflammatory effects of vitamin D, and scientists believe that we must prevent vitamin D deficiency in CKD patients. Vitamin D supplementation may decrease mortality and morbidity in end-stage renal disease (ESRD) patients. Objectives: There are few studies on the association between serum 25-hydroxy vitamin D levels and NLR in ESRD patients. Therefore, we tried to evaluate this correlation, hoping to be a key for more researches. Patients and Methods: We enrolled 140 ESRD hemodialysis patients in a cross-sectional study and evaluated the correlation of NLR with serum 25-hydroxy vitamin D levels and some demographic factors in these patients. Results: Our results showed a statistically significant negative correlation between NLR and serum 25-hydroxy vitamin D levels (P=0.010, r= -0.216). However, other variables such as disease duration and age had no correlation with NLR (P=0.649, r= - 0.039 and P=0.781, r= - 0.024, respectively). We also used a linear regression test to check any confounder associated with NLR, and the regression was only significant for serum 25-hydroxy vitamin D levels (P=0.011, B=-0.009). Conclusion: Based on the results, serum 25-hydroxy vitamin D levels can be considered a predictor for NLR in hemodialysis patients.

Demographic Characteristics, Risk Factors, and Presenting Features of Children with Symptomatic Nutritional Rickets: A French Series

2020 ◽  
Vol 93 (5) ◽  
pp. 304-312
Author(s):  
Claire Flot ◽  
Valérie Porquet-Bordes ◽  
Justine Bacchetta ◽  
Anya Rothenbuhler ◽  
Anne Lienhardt-Roussie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Pediatric Population ◽  
Vitamin D Supplementation ◽  
Demographic Characteristics ◽  
Total Serum ◽  
Nutritional Rickets ◽  
Total Serum Calcium ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

<b><i>Aim:</i></b> To describe the demographic characteristics, risk factors, and presenting features of children with symptomatic nutritional rickets in France. <b><i>Methods:</i></b> This is a retrospective study of 38 children diagnosed with nutritional rickets from 1998 to 2019. <b><i>Results:</i></b> We observed a higher frequency of rickets in males (74 vs. 26%), in young children (median age at diagnosis: 23 months; 82% were younger than 5 years), and in children with a non-Caucasian ethnic background (89%). Most children were exclusively breastfed (78%) without adequate vitamin D supplementation (89%). The most common presentations were bowed legs (63%), hypocalcemic seizures (21%), and growth retardation (11%). Approximately half (62%) of the children were hypocalcemic. The children presenting with hypocalcemic seizures were significantly younger (0.8 vs. 2.2 years; <i>p</i> = 0.041) and had lower total serum calcium levels (1.44 vs. 2.17 mmol/L; <i>p</i> &#x3c; 0.0001), higher phosphatemia (1.43 vs. 1.23 mmol/L; <i>p</i> = 0.020), and lower 25-hydroxy vitamin D levels (3 vs. 7 ng/mL; <i>p</i> = 0.020) but similar parathyroid hormone levels (357 vs. 289 ng/mL; <i>p</i> = 0.940) compared to rickets cases who did not experience hypocalcemic seizures. A dilated cardiomyopathy was detected in 14% of the children who had undergone echocardiography. <b><i>Conclusion:</i></b> Nutritional rickets remains endemic in the pediatric population and its most severe forms can have life-threatening sequelae. Health practitioners need to be cognizant of these facts to raise awareness and screen high-risk populations.

scholarly journals Inflammatory activity and vitamin D levels in an MS population treated with rituximab

2019 ◽  
Vol 5 (1) ◽  
pp. 205521731982659 ◽  
Author(s):  
Johan Linden ◽  
Gabriel Granåsen ◽  
Jonatan Salzer ◽  
Anders Svenningsson ◽  
Peter Sundström
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Magnetic Resonance ◽  
Vitamin D Supplementation ◽  
Inflammatory Activity ◽  
T2 Lesions ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Multiple Sclerosis Patients

Background Most multiple sclerosis patients on disease-modifying treatment at Umeå University Hospital are treated with rituximab and the prevalence of vitamin D supplementation has increased over time. Follow-up studies of these off-label treatments are needed. Objective To study inflammatory activity and adverse effects in rituximab-treated multiple sclerosis patients, and associations with 25-hydroxy-vitamin D levels. Methods Retrospectively collected data on repeated estimates of relapses, disability, side effects, magnetic resonance imaging, laboratory measures including 25-hydroxy-vitamin D levels and self-perceived health. Results In 272 multiple sclerosis patients with a mean follow-up of 43 months, we identified seven possible relapses during active rituximab treatment. On magnetic resonance imaging examination, new T2 lesions were seen in 1.3% (10 out of 792 scans), and 0.25% (two out of 785 scans) showed contrast enhancement. Adjusted 25-hydroxy-vitamin D levels in samples drawn close to all magnetic resonance images with new T2 lesions were lower compared to the remainder (62 vs. 81 nmol/l; P = 0.030). Levels of 25-hydroxy-vitamin D were associated with self-perceived health ( r = 0.18, P = 0.041, n = 130) and C-reactive protein ( r = –0.13, P = 0.042) but not with the risk of side effects. Conclusion The inflammatory activity in this rituximab-treated multiple sclerosis population that increasingly used vitamin D supplementation was extremely low. Higher 25-hydroxy-vitamin D levels were associated with beneficial outcomes.

TO STUDY THE PREVALENCE OF VITAMIN D3 DEFICIENCY IN NEPHROTIC SYNDROME

2021 ◽  
pp. 22-23
Author(s):  
Neharika Gupta ◽  
Kirandeep Sodhi ◽  
R. Narayan ◽  
Gauri Chauhan ◽  
A.K Bhardwaj
Keyword(s):  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Venous Blood ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Female Ratio ◽  
Vitamin D Levels ◽  
Study Population ◽  
Frequent Relapsers ◽  
A Prospective Study

Background: Cross-sectional studies of children with Nephrotic Syndrome have shown deciency of Vitamin D due to its loss in urine, bound to Vitamin D binding protein and through various other mechanisms. Therefore, this study was taken up to study the prevalence of Vitamin D deciency in Children with Nephrotic syndrome. A prospective study of children with Methods: Nephrotic syndrome at the time of hospital admission to Department of Paediatrics, MMIMSR, Mullana, Ambala, was undertaken. 2ml venous blood of the child was collected for assessment of 25(OH)D. A total of 50 chil Results: dren were enrolled in this study. Mean age was 6.4 years. Male to female ratio was 16:9. Vitamin D levels < 20ng/ml were seen in 76% children in the study population; with 28% patients having Vitamin D deciency while 48% had insufciency. Also, frequent relapsers and children with initial episode had lower levels of vitamin D as compared to infrequent relapsers. Children with Nephrotic Syndrome should have routine measurement of Conclusion: 25(OH)D and they will benet from vitamin D supplementation, if having decient/ insufcient levels. Individualized Vitamin D treatment strategy can be devised for each child.

scholarly journals Characterizing the Assessment and Management of Vitamin D Levels in Patients with Osteoporosis in Clinical Practice: A Chart Review Initiative

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Jonathan D. Adachi ◽  
Jacques P. Brown ◽  
George Ioannidis
Keyword(s):  
Vitamin D ◽  
Clinical Practice ◽  
Bone Health ◽  
Chart Review ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Vitamin D Supplements

Though vitamin D is important for bone health, little is known about the monitoring and management of vitamin D levels in patients with osteoporosis in clinical practice—a deficit this chart review initiative aimed to remedy. A total of 52 physicians completed profiles for 983 patients being treated for osteoporosis between November 2008 and April 2009. Information collected included demographics; fracture risk factors; availability and level of serum vitamin D measurements; and information on osteoporosis medications and calcium and vitamin D supplementation. Physicians also evaluated patients’ current regimens and detailed proposed changes, if applicable. Nearly 85% of patients were prescribed calcium and vitamin D supplements. Serum 25-hydroxy vitamin D levels were available for 73% of patients. Of these patients, approximately 50% had levels less than 80 nmol/L, which contrasts with the 37% thought to have “unsatisfactory” vitamin D levels based on physician perceptions. Physicians felt 26% of patients would benefit from additional vitamin D supplementation. However, no changes to the osteoporosis regimen were suggested for 48% of patients perceived to have “unsatisfactory” vitamin D levels. The results underscore the importance of considering vitamin D status when looking to optimize bone health.

Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status

2016 ◽  
Vol 30 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Nicole A. Slater ◽  
Michelle L. Rager ◽  
Dawn E. Havrda ◽  
Arthur F. Harralson
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Variant Alleles

This cross-sectional study enrolled 180 patients at a private family practice in Virginia. Total serum vitamin D concentrations were obtained weekly from January 30, 2013, through March 30, 2013, in consecutive patients regularly scheduled for laboratory work at the practice. Patients were categorized into 2 groups and analyzed for variant alleles in vitamin D receptor ( VDR; rs2228570), cytochrome P450 2R1 ( CYP2R1; rs10741657), 7-dehydrocholesterol reductase ( DHCR7; rs12785878), and group-specific component ( GC; rs2282679) to determine whether variants of those alleles influenced total serum 25(OH)D concentrations. One-hundred and eighty patients were enrolled, with 40 (22%) being sufficient, 25-hydroxy vitamin D level 25(OH)D ≥ 30 ng/mL, and 140 (78%) being insufficient, 25(OH)D < 30 ng/mL. Of the 4 genes, 2 genes, CYP2R1 (rs10741657) and GC (rs2282679), demonstrated a significant association related to vitamin D status. Subjects with 1 or more variant alleles at rs10741657 were almost 3.7 (odds ratio [OR] 3.67; 95% confidence interval [CI]: 1.35-9.99) times more likely be insufficient in vitamin D and subjects with 1 or more variant alleles at rs2282679 were about half (OR 0.42; 95% CI: 0.18-0.93) as likely to be insufficient in vitamin D. Allelic variations in CYP2R1 (rs10741657) and GC (rs2282679) affect vitamin D levels, but variant alleles on VDR (rs2228570) and DHCR7 (rs12785878) were not correlated with vitamin D deficiency, 25(OH)D < 30 ng/mL.

scholarly journals Changes in vitamin D levels and depressive symptoms in later life in England

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giorgio Di Gessa ◽  
Jane P. Biddulph ◽  
Paola Zaninotto ◽  
Cesar de Oliveira
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Later Life ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Representative Study ◽  
Increased Risk ◽  
Vitamin D Levels

AbstractInadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient < 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels < 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms.

scholarly journals Study of the relationship between neutrophil-to-lymphocyte ratio and parathyroid hormone levels in patients undergoing hemodialysis, Isfahan, Iran

2021 ◽  
Vol 6 (1) ◽  
pp. e19-e19
Author(s):  
Azar Baradaran ◽  
Sayed Mohsen Hosseini ◽  
Reyhaneh Shirvani ◽  
Parin Hedayati ◽  
Zahra Hoseini
Keyword(s):  
Parathyroid Hormone ◽  
Small Sample Size ◽  
Female Gender ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Small Sample ◽  
Neutrophil To Lymphocyte Ratio ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Lymphocyte Ratio

Introduction: Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health (1). Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with end-stage renal disease (ESRD). Systemic inflammation is correlated with cardiovascular disease. Furthermore, parathyroid hormone (PTH) causes releasing of IL-6 from liver and osteoblast. IL-6 increases lifetime and activity of neutrophils. Therefore, PTH may have a direct correlation with neutrophil-to-lymphocyte ratio (NLR). Objectives: In this study, we aimed to determine the performance of NLR in hemodialysis and its possible correlation with PTH. Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and also Ca×P products (mg2 /dL2 ) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and also patients with or without chronic hypertensive disease. Results: This study consisted of 136 hemodialysis patients. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P>0.05). In addition, we test their correlation in other subgroups including hypertensive and normotensive, diabetic and non-diabetics, and male versus female patients. We found no significant correlation between iPTH and NLR in the mentioned subgroups, too. Conclusion: Observed correlation between PTH and NLR in hemodialysis patients may be due to our small sample size. Therefore, further studies on this subject are suggested.

scholarly journals Correlation of Vitamin D Serum Level of Mothers and Their Newborns

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Hassan Boskabadi ◽  
Elahe Heidari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
High Rate ◽  
Cross Sectional ◽  
Maternal Vitamin ◽  
Premature Newborns ◽  
Vitamin D Levels

Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

scholarly journals Prevalence of vitamin D deficiency in various regions of the Russian Federation: results of the first stage of the multicenter cross-sectional randomized study

2021 ◽  
Vol 23 (4) ◽  
pp. 4-12
Author(s):  
Ekaterina A. Pigarova ◽  
Liudmila Y. Rozhinskaya ◽  
Nino N. Katamadze ◽  
Alexandra A. Povaliaeva ◽  
Ekaterina A. Troshina
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Russian Federation ◽  
Randomized Study ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
The Russian Federation

Background. A vitamin D deficiency is a global wide health problem. Inadequate vitamin D status leads to serious medical, social and economic consequences and requires timely diagnosis and adequate correction.Aim: to assess the incidence of vitamin D deficiency among the population living in regions of the Russian Federation located at latitudes from 45° to 70° and to study its relationship to various factors (demographic, socio-economic, geographical, etc.).Materials and methods. A multicenter, cross-sectional, randomized study of individuals of both sexes aged 18 to 50 years. The study of 25ОНD level in the blood serum was carried out by INVITRO LLC laboratories using chemilumescent analysis in two stages: in the period from March to May 2020 and from October to November 2020. The first stage of the study involved 500 volunteers (77% women, 23% men). Demographic and socioeconomic characteristics, factors associated with vitamin D levels, were assessed using a specially designed questionnaire.Results. In this article we present the results of the first stage. A countrywide high prevalence of vitamin D deficiency (56.4%) and insufficiency (27.9%) was revealed, that is, 84.3% of the population aged 18–50 years requires cholecalciferol supplementation. The lowest vitamin D status was found in St. Petersburg, Arkhangelsk, Kyzyl and Rostov-on-Don (over 90% of participants had inadequate levels). A decrease in the level of 25ОНD was observed to a greater extent in men than in women (p <0.05), as well as in young people aged 18–25 years (p <0.05). No major association of vitamin D status with anthropometric parameters, the number of days of disability, were not found. However, those who went to tanning beds or were in direct sunlight for at least 30 days a year had higher levels of 25ОНD, and those using sunscreens had lower levels.Conclusion. The data obtained confirms the widespread prevalence of vitamin D deficiency and insufficiency in the country (84.3% of participants), generally not related to the geographical latitude of residence, which indicates the need for vitamin D supplementation in a significant part of the population.

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