scholarly journals Clinical efficacy of the affinity purified antibodies to the protein S100 in the complex rehabilitation of the infants with acute obstructive bronchitis affected by perinatal pathology of central nervous system

2019 ◽  
pp. 42-46
Author(s):  
Yu. L. Mizernitskiy ◽  
I. M. Melnikova ◽  
V. A. Pavlenko ◽  
V. N. Volovenko ◽  
N. M. Kondrashova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Efficacy ◽  
Recurrent Events ◽  
Vegetative State ◽  
Bronchial Obstruction ◽  
Perinatal Pathology ◽  
Active Medication ◽  
Short Course ◽  
The Central Nervous System

Objective: The objective is to assess the clinical efficacy of the inclusion of release-active medication of affinity purified antibodies to protein S100 in complex rehabilitation of infants with old acute obstructive bronchitis affected by perinatal pathology of central nervous system of hypoxic genesis.Methods: 210 infants aged from 2–36 months, who suffered events of acute obstructive bronchitis, were examined. Along with clinical methods of examination, a computer bronchophonography and assessment of heart rate variability were performed.Results: Additional inclusion of release-active medication ‘Tenoten for children’ in the complex of rehabilitation of these patients had a positive effect on autonomic balance and autonomic component of bronchial obstruction. At the same time, the short course of Tenoten (1 month) did not prevent recurrent events of bronchial obstruction.Conclusions: Probably, patients with recurrent events of acute bronchial obstruction in combination with pronounced functional disorders of vegetative state require longer courses of release-active medication which normalized the activity of the central nervous system.

scholarly journals Association Between Medications Acting on the Central Nervous System and Fall-Related Injuries in Community-Dwelling Older Adults: A New User Cohort Study

2019 ◽  
Vol 75 (5) ◽  
pp. 1003-1009 ◽  
Author(s):  
Shelly L Gray ◽  
Zachary A Marcum ◽  
Sascha Dublin ◽  
Rod Walker ◽  
Negar Golchin ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Injury Risk ◽  
Cox Proportional Hazards ◽  
Community Dwelling ◽  
Active Medication ◽  
Increased Risk ◽  
The Central Nervous System ◽  
Community Dwelling Older Adults

Abstract Background It is well established that individual medications that affect the central nervous system (CNS) increase falls risk in older adults. However, less is known about risks associated with taking multiple CNS-active medications. Methods Employing a new user design, we used data from the Adult Changes in Thought study, a prospective cohort of community-dwelling people aged 65 and older without dementia. We created a time-varying composite measure of CNS-active medication exposure from electronic pharmacy fill data and categorized into mutually exclusive categories: current (within prior 30 days), recent (31–90 days), past (91–365 days), or nonuse (no exposure in prior year). We calculated standardized daily dose and identified new initiation. Cox proportional hazards models examined the associations between exposures and the outcome of fall-related injury identified from health plan electronic databases. Results Two thousand five hundred ninety-five people had 624 fall-related injuries over 15,531 person-years of follow-up. Relative to nonuse, fall-related injury risk was significantly greater for current use of CNS-active medication (hazard ratio [HR] = 1.95; 95% CI = 1.57–2.42), but not for recent or past use. Among current users, increased risk was noted with all doses. Risk was increased for new initiation compared with no current use (HR = 2.81; 95% CI = 2.09–3.78). Post hoc analyses revealed that risk was especially elevated with new initiation of opioids. Conclusions We found that current use, especially new initiation, of CNS-active medications was associated with fall-related injury in community-dwelling older adults. Increased risk was noted with all dose categories. Risk was particularly increased with new initiation of opioids.

scholarly journals Modern Physical Rehabilitation Technologies for Children with Perinatal Lesions of the Central Nervous System

2021 ◽  
Vol 20 (4) ◽  
pp. 57-64
Author(s):  
Maya A. Khan ◽  
Maria S. Petrova ◽  
Maria G. Degtyareva ◽  
Natalya A. Mikitchenko ◽  
Olga U. Smotrina ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Physical Rehabilitation ◽  
Medical Rehabilitation ◽  
Psychomotor Development ◽  
Cochrane Library ◽  
Rehabilitation Team ◽  
Perinatal Pathology ◽  
Wide Range ◽  
The Central Nervous System

The subject of this publication is the medical rehabilitation of children with perinatal lesions of the central nervous system. Currently, the main methodological principles of stage-by-stage medical rehabilitation of newborns, mainly children with the consequencesof perinatal damage to the nervous system, have been determined. Special attention should be paid to the issue of minimal use of medicines in children with perinatal pathology, in this regard, an importanttask is the development and scientific justification of new non-drug technologies of medical rehabilitation, especially in childrenunder 1 year. Medical rehabilitation sets itself the following tasks: stimulation of blood circulation in the brain tissues, improvement of muscle toneby affecting the central nervous system and the peripheral nervous system, activation of neuromuscular transmission processes andimprovement of psychomotor development of a child with perinatal pathology of the central nervous system. Medical rehabilitationof children with perinatal lesions of the central nervous system begins at the earliest possible time and is carried out by specialists ofa multidisciplinary rehabilitation team based on an individual medical rehabilitation program. Aim. To study the results of research conducted by Russian and foreign authors on the issues of physical rehabilitation of children withperinatal damage to the central nervous system and to conduct an analysis of the effectiveness of the proposed technologies. Material and methods. The literature review for this article was conducted from the elibrary, PubMed, Cochrane Library databaseswith a search depth of 10 years. The selection of publications was carried out using keywords: non-drug technologies, perinatal damageto the central nervous system; perinatal hypoxic-ischemic encephalopathy, kinesotherapy, neurodevelopmental therapy, massage,thin finger training method, dry immersion, fitball gymnastics, V. Voit therapy; Bobat therapy. Conclusion. Currently, a wide range of non-drug technologies of medical rehabilitation of children with the consequences of perinataldamage to the central nervous system is used such as therapeutic gymnastics, massage, kinesiotherapy with a neuroreflex locomotionaccording to Vojta’s method, Bobath-therapy, massage, etc. The analysis of publications has shown that kinesotherapy and massagein in the complex of rehabilitation measures for children with perinatal lesions allows to increase the effectiveness of rehabilitationmeasures, reduce the severity of motor disorders, and can help reduce the frequency of formation of cerebral palsy.

scholarly journals Pathogenesis of perinatal pathology in newborns developing under conditions of chronic hypoxia with placental insufficiency

2004 ◽  
Vol 53 (2) ◽  
pp. 26-29
Author(s):  
I. I. Evsyukova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Hypoxia ◽  
Scientific Research ◽  
Placental Insufficiency ◽  
Intrauterine Development ◽  
Functional Systems ◽  
Perinatal Pathology ◽  
Priority Direction ◽  
The Central Nervous System

The study of the pathogenetic aspects of disorders in the formation of the functions of the central nervous system and other vital functional systems of the child's body under unfavorable conditions of its intrauterine development has always been a priority direction of scientific research by the employees of the Department of Physiology and Pathology of Newborns of the N.I. BEFORE. Otta RAMS.

Physical rehabilitation of children with perinatal lesion of the central nervous system

2021 ◽  
pp. 29-39
Author(s):  
M.A. Khan ◽  
Prikuls V.F. Prikuls V.F. ◽  
N.A. Mikitchenko ◽  
O.Yu. Smotrina ◽  
Filatova E.V. Filatova E.V.
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Muscle Tone ◽  
Medical Rehabilitation ◽  
Psychomotor Development ◽  
Rehabilitation Team ◽  
Perinatal Pathology ◽  
Wide Range ◽  
The Central Nervous System ◽  
Rehabilitation Measures

The article is dedicated to non-pharmacological rehabilitation of children with perinatal lesions of the central nervous system. Currently, the main methodological principles of the staged medical rehabilitation of newborns, mainly children with consequences of perinatal damage to the nervous system, have been determined. Special attention should be paid to the issue of the minimum use of drugs in children with perinatal pathology. In this regard, an important task is to develop and scientifically substantiate new non-drug technologies for medical rehabilitation, especially in children under 1 year of age. Medical rehabilitation has the following aims: stimulation of blood circulation in the tissues of the brain, improvement of muscle tone by acting on the central nervous system and the peripheral nervous system, activation of the processes of neuromuscular transmission and improvement of the psychomotor development of a child with perinatal pathology of the central nervous system. Medical rehabilitation of children with perinatal lesions of the central nervous system begins at the earliest possible date and is carried out by specialists of a multidisciplinary rehabilitation team based on an individual medical rehabilitation program. At present, a wide range of non-drug technologies for medical rehabilitation of children with the consequences of perinatal damage to the central nervous system is used: therapeutic gymnastics, massage, kinesitherapy with a neuroreflex component according to the V. Vojta’s method, Bobath therapy. The analysis of publications presented in the review has shown that the inclusion of modern technologies of kinesitherapy and massage in the complex of rehabilitation measures in children with perinatal lesions can increase the effectiveness of rehabilitation measures, reduce the severity of movement disorders, and decrease the incidence of cerebral palsy.

Neurophysiological Characteristics and Methods of Correcting Somatic Dysfunctions in Sensory Auditory System in Children with Perinatal Pathology of the Central Nervous System

2015 ◽  
pp. 50-58
Author(s):  
L. . Vygovskaya ◽  
A. . Samigullina ◽  
Y. . Efendiev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Child Development ◽  
Auditory System ◽  
Development Stage ◽  
Health Condition ◽  
Hearing Disorders ◽  
Perinatal Pathology ◽  
The Central Nervous System

The study showed how the severe health condition at birth has influence on manifestation rate of the peripheral and central hearing disorders in patients with perinatal pathology of the central nervous system. The algorithm for correcting somatic dysfunctions reduces frequency and degree of neurosensory hearing disorders at the earliest child development stage, thereby promoting the integration of these patients into society.

scholarly journals Myocysticercosis as a Rare Cause of Hand Swelling involving Thenar Group of Muscles: A Case Report

2020 ◽  
Vol 58 (228) ◽  
Author(s):  
Saugat KC ◽  
Gaurav Neupane ◽  
Anand Regmi ◽  
Sujit Shrestha
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Skeletal Muscles ◽  
Taenia Solium ◽  
Surgical Excision ◽  
Endemic Region ◽  
Diagnostic Dilemma ◽  
Short Course ◽  
Subcutaneous Tissues ◽  
The Central Nervous System

Larval form of Taenia solium causes cysticercosis that commonly involves the central nervous system. Other sites of manifestation are eye, gastrointestinal system, skeletal muscles and subcutaneous tissues. Isolated muscular involvement is rare with only a handful of cases reported in the literature. We present this case of an isolated symtomatic hand swelling due to Myocysticercosis which pose diagnostic dilemma. This should be considered in differential diagnosis in our developing nation and especially in endemic region. High resolution ultrasound of the hand (thenar region) helped in the diagnosis and is often diagnostic like in our case. The treatment of choice of an isolated symptomatic lesion without involvement of central nervous system is surgical excision which we did followed by short course of antiheminthic and anti-inflammatory medication for two weeks.

scholarly journals Perinatal Factors Affect in Development of Somatic Dysfunctions in Patients with Neurosensory Disorders and Perinatal Pathology of the Central Nervous System

2015 ◽  
pp. 59-65
Author(s):  
A. . Samigullina ◽  
L. . Vygovskaya ◽  
Y. . Efendiev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Perinatal Period ◽  
Anatomical Landmarks ◽  
Perinatal Factors ◽  
Adverse Conditions ◽  
Birth Injuries ◽  
Perinatal Pathology ◽  
The Central Nervous System ◽  
Main Factors

Chronic placental insufficiency and birth injuries are the main factors in the development of neurosensory disorders and somatic dysfunctions in patients with perinatal pathology of the central nervous system. Each category of patients born in the adverse conditions of the perinatal period has a certain set of somatic dysfunctions due to the influence of the pathogenetic mechanisms on the relevant anatomical landmarks

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