scholarly journals DYNAMICS OF THE VENOUS BLOOD ACID-BASE BALANCE AND RELATIONSHIP BLOOD PH VS TUMOR IN LARYNGEAL CANCER PATIENTS

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
V. A. Kashirin ◽  
O. V. Khorolets ◽  
S. I. Andreev ◽  
A. A. Mikheev
Keyword(s):  
Laryngeal Cancer ◽  
Venous Blood ◽  
Combined Treatment ◽  
Control Group ◽  
Acid Base Balance ◽  
Acid Base ◽  
Tumor Ph ◽  
Blood Ph ◽  
Base Balance ◽  
Group 2

Abstract The characteristic for most solid tumors cells is the intracellular alkalinization and acidification of the extracellular milieu and this pH gradient inversion (pHe < pHi) is associated with tumor proliferation, invasion, metastasis, aggressiveness, and treatment resistance. However is there tumor pH (pHi and/or pHe) changes affect on venous blood plasma pH? Purpose of the study. The venous blood acid-base balance before and after the combined treatment, correlation of the venous blood pH indicators (pHb), relationship neoplasm and blood pH in patients with laryngeal cancer was study. Material and methods. Studies were performed in patients with laryngeal cancer categories T2–3 N0 M0 before and after the combined treatment. The patients were divided into four groups: Group 1 – 25 patients before the start of treatment; Group 2 – 21 patients (from Group 1) after completion of the combined treatment; Group 3 – 14 patients from Group 2 with positive results of treatment and Group 4 – 7 patients from Group 2 with a negative result of treatment (recurrence and/or metastasis of the neoplasm). The control group consisted of 15 practically healthy people (Group C). Examination of venous blood acid-base balance of patients, tumor pH and tumor cells pHi and pHe was carried. Results and discussion. The increase in pCO2 and HCO – concentration will result in decrease in the pH, but if these indicators have a clear correlation in the control group, then in patients groups there was a correlation for pHb & pCO2 and pO2 only. Besides, we marked increase in pCO2, HCO –, K+, while pO decreased in pHb after the combined treatment. It is necessary to point out the differences between some benchmarks and indicators of acid-base balance in the plasma of venous blood in primary patients and patients with recurrent laryngeal cancer. So, if pHb, pO2, and Cl– patients have statistically significant differences from control data, then differences with control pCO2 values are characteristic only for patients of Groups 1 and 3. On the contrary, differences in the HCO – indices are characteristic only for patients of Group 4. There are statistically significant differences from the control indicators K+, Na+, Ca2+, Glu, Lac, mOsm in patients of the first group and Cl– and Lac of patients in the third group. Among the indicators in the third and fourth groups of patients, statistically significant differences were noted in the values of pHb, HCO – and Glu.In patients of groups 1 and 4, the determination of pHt and the calculation of pHi, pHe revealed decrease in pHt and pHe with increasing pHi in patients with recurrence of the neoplasm.The final stage of the study was to determine the relationship (and not correlation) of blood pH and laryngeal tumors and the relationship was noted in the «pHb-tumor» system in primary patients, but in patients in 3 and 4 Groups, that «pHb-tumor» connection is rather contradictory. Conclusion. Acid-base balance indicators obviously cannot be considered as unconditional markers of carcinogenesis, but their monitoring and, in particular, venous blood pH, of patients after special treatment, can help determine the risk group of patients who may develop of a malignant neoplasm recurrence. Keywords: acid-base balance, laryngeal cancer, se, prognosis.

scholarly journals The Alkaline Diet and the Warburg Effect

2021 ◽  
Vol 12 (1) ◽  
pp. 20-39
Author(s):  
Hassan Bahrami ◽  
Ted Greiner
Keyword(s):  
Oxygen Saturation ◽  
Warburg Effect ◽  
Venous Blood ◽  
The Body ◽  
Carbon Dioxide Partial Pressure ◽  
Acid Base Balance ◽  
Acid Base ◽  
Blood Ph ◽  
Effect Theory ◽  
Base Balance

The changing diets accompanying our modern life style have increased the content of foods that form acidic metabolic waste residues in the body. Wastes from these metabolic processes are released into the interstitial fluids and the blood, slightly changing their pH temporarily. This link may in turn have an impact on the incidence of non-communicable diseases (NCDs). According to Warburg effect theory, an acidic cellular and circulatory environment may cause various specific health problems such as hypoxia and cancer, whereas an oxygen-rich optimum-alkaline environment could retain healthy cells. However, the mechanisms by which the diet may be influential on blood pH-related parameters and on health have remained largely unknown. This paper begins with a detailed presentation of the concepts, issues and the existing evidence regarding alkaline and acid forming diets, and summarizes the three main mechanisms by which the diet influences the acid-base balance in the body. It then presents the findings of a small exploratory study in which one author (HB) followed diets traditionally thought to produce alkaline or acidic residues. After each diet period of one month (with a two-month wash out period), pH, oxygen saturation, and carbon dioxide partial pressure were measured for arterial and for venous blood.   The resulting data indicated that the diets followed changed blood pH-related parameters in the expected directions according to the acid-base theory of health. Increased intake of acid-forming foods resulted in a slightly lower pH level, but a significant reduction of oxygen saturation in the blood, whereas increased consumption of alkaline forming foods maintained the high oxygen saturation in the blood that, according to Warburg effect theory, may, if maintained, reduce the incidence of NCDs. Further cross-over research of this kind is needed, utilizing large samples and testing various dietary modifications.

Effects of dietary supplementation of calcified seaweed extract with different levels of salt on performance, acid–base balance, and meat quality of growing lambs

2020 ◽  
Vol 60 (4) ◽  
pp. 553
Author(s):  
I. A. Alhidary ◽  
M. M. Abdelrahman
Keyword(s):  
Meat Quality ◽  
Seaweed Extract ◽  
Control Group ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Group 2 ◽  
Different Levels ◽  
Added Salt

Sixty 4-month-old male Awassi lambs were used in a 70-day trial to evaluate the effects of supplemental AcidBuf (calcified seaweed extract; Celtic Sea Minerals, Carrigaline, County Cork, Ireland) with different levels of salt on the productive performance, acid–base status, and meat quality of growing lambs. Animals were randomly divided into six groups of 10 lambs each. The dietary treatments were (1) no added supplemental AcidBuf or salt (control group), (2) 0.4% added AcidBuf (A+S0.0), (3) 0.4% added AcidBuf + 0.4% added salt (A+S0.4), (4) 0.4% added AcidBuf + 0.8% added salt (A+S0.8), (5) 0.4% added AcidBuf + 0.1.2% added salt (A+S1.2), and (6) 0.4% added AcidBuf + 1.6% added salt (A+S1.6). Feed intake was measured weekly, and all lambs were weighed every week for evaluation of the productive parameters. Blood samples were collected from all lambs for measurement of biochemical and acid–base variables. At the end of experiment, eight lambs from each treatment were slaughtered for evaluation of carcass characteristics and meat quality. Lambs fed the AcidBuf-0.4% and 0.8% salt diet had greatest ADG (P = 0.03) and G:F (P = 0.02) respectively. The addition of AcidBuf to the diets increased (P &lt; 0.05) the serum K concentration and reduced urea N and total CO2 concentrations in serum compared with the control group. The addition of AcidBuf and salt at level of 0.4% resulted in increases in hot (P = 0.03) and cold carcass weights (P = 0.04) compared with the control group. Overall, these data indicate that AcidBuf and salt supplementation improved weight gain and carcass weight in lambs.

Effects of monensin and yeast supplementation on blood acid-base balance in finishing feedlot steers fed a high-grain, high-protein diet

2006 ◽  
Vol 82 (5) ◽  
pp. 653-659 ◽  
Author(s):  
C. Castillo ◽  
J. Hernández ◽  
J. Méndez ◽  
P. García-Partida ◽  
V. Pereira ◽  
...  
Keyword(s):  
Venous Blood ◽  
Lactate Production ◽  
High Protein Diet ◽  
Study Groups ◽  
Control Group ◽  
Yeast Culture ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Parameters ◽  
Base Balance

AbstractThe aim of this study was to evaluate the effects of two dietary supplements (monensin and a live yeast culture) on acid-base balance in steers maintained in a commercial feedlot system, considering effects over the finishing productive cycle. Steers (no. =42) were allotted randomly to one of the three study groups: (1) control group (no supplementation, C), (2) monensin supplementation (MON), and (3) live Saccharomyces cerevisiae strain 47 supplementation (SACC). Venous blood samples were collected for the measurement of acid-base parameters and l-lactate. Production parameters were also used as a complementary tool for understanding the internal changes associated with supplementation. During the finishing period, MON steers tended to gain more efficiently than C and SACC steers. In the C group, the finishing-period diet caused a progressive decline in blood bases, in line with the high-grain diet consumption. In contrast, supplemented animals did not show this trend, although lower HCO3− and base excess values were registered in SACC steers than in MON, indicating that ionophore supplementation is less effective for reducing blood base consumption than yeast supplementation. In our study, the lack of the expected response to yeast supplementation may be attributable to the high crude protein content of the ration, a common feature of commercial feedlot industries.

scholarly journals Clinical assessment of acid-base balance in Netherland Dwarf rabbit

2020 ◽  
Author(s):  
J. M. Chapel ◽  
J. L. Benedito ◽  
J. Hernández ◽  
P. Famigli-Bergamini ◽  
C. Castillo
Keyword(s):  
Reference Values ◽  
Venous Blood ◽  
Meat Production ◽  
Acid Base Balance ◽  
Acid Base ◽  
Sodium Potassium ◽  
Mean Values ◽  
Base Balance ◽  
Biochemical Profiles ◽  
Made In

Abstract Pet rabbits have increased their popularity in a lot of countries. However, most of the laboratory profiles in rabbit medicine come from the observations made in rabbit as biomodels or meat production. So that further researches are necessary to obtain reference values for hematology and biochemical profiles in pet rabbits and the different breeds, especially, in relation to acid-base balance. The aim of this report was to offer the mean values of the main parameters connected with acid-base profile in Netherland Dwarf breed. Thirty-five healthy rabbits (15 males and 20 females) were studied. Venous blood sample from lateral saphenous vein was analyzed to measure: haematocrit, haemoglobin, blood urea nitrogen, glucose, blood pH, partial pressure of CO2 (pCO2), total CO2, ions bicarbonate, chloride, sodium, potassium, base excess and anion Gap. Results showed a shorter range that those reported by different researchers. Moreover, differences between genders were showed in pCO2, its values were higher in males. It may be associated with a greater cellular metabolism. Values obtained in this research should be taken into account by veterinary clinicians for this breed in their clinical assessments. Besides, these values provide new results in parameters with few reference values.

scholarly journals Effects of a new intravenous electrolyte solution for veterinary therapy on the electrolyte and acid-base balances of healthy horses

2016 ◽  
Vol 46 (8) ◽  
pp. 1479-1485 ◽  
Author(s):  
Priscilla Fajardo Valente Pereira ◽  
José Antonio Bessegatto ◽  
Gabriela de Castro Bregadioli ◽  
Stéfany Lia Oliveira Camilo ◽  
Nathali Adrielli Agassi de Sales ◽  
...  
Keyword(s):  
Electrolyte Solution ◽  
Fluid Therapy ◽  
Repeated Measures ◽  
Venous Blood ◽  
Isotonic Saline ◽  
Acid Base Balance ◽  
Acid Base ◽  
Before And After ◽  
Base Balance ◽  
Clinical Changes

ABSTRACT: The effects of a new intravenous electrolyte solution for veterinary therapy on electrolyte and acid-base balances of horses were evaluated, assessing the potential of the use of this solution as a rational alternative in fluid therapy. Eight healthy adult horses, including 4 males and 4 females, received two treatments in a cross-over design: isotonic saline solution (IS) and a test solution (TS) containing 145mEq of Na+, 5mEq of K+, 4mEq of Ca++, 2mEq of Mg++, 96mEq of Cl-, 60mEq of lactate, 50g of dextrose, and 4mg of cyanocobalamin per liter. Solutions were IV infused in a volume corresponding to 5% of BW, over 3 hours. Venous blood samples were taken 5 times before and after the infusion (at 0, 3, 6, 9 e 24h), for pHv, pCO2v, HCO3 -v, BEv, Na+, K+, Cl-, Ca++, Ca, P, Mg, glucose and L-lactate measurements, and AG and SID calculations. The data were analyzed through repeated measures ANOVA. The IS caused mild acidifying effect by increasing Cl- and decreasing plasma SID. In contrast, the TS induced mild and transient hypochloremia without changes in acid-base balance. Hyperglycemia was present at the end of the TS infusion and reversed 6 hours later. The horses did not exhibit any clinical changes. We concluded that TS is an option for fluid therapy in horses.

scholarly journals Isoflurane-induced acidosis depresses basal and PGE2-stimulated duodenal bicarbonate secretion in mice

2007 ◽  
Vol 292 (3) ◽  
pp. G899-G904 ◽  
Author(s):  
Markus Sjöblom ◽  
Olof Nylander
Keyword(s):  
Base Excess ◽  
Ringer Solution ◽  
Bicarbonate Secretion ◽  
Acid Base Balance ◽  
Acid Base ◽  
In Vivo Experiments ◽  
Arterial Blood ◽  
Blood Ph ◽  
Base Balance

When running in vivo experiments, it is imperative to keep arterial blood pressure and acid-base parameters within the normal physiological range. The aim of this investigation was to explore the consequences of anesthesia-induced acidosis on basal and PGE2-stimulated duodenal bicarbonate secretion. Mice (strain C57bl/6J) were kept anesthetized by a spontaneous inhalation of isoflurane. Mean arterial blood pressure (MAP), arterial acid-base balance, and duodenal mucosal bicarbonate secretion (DMBS) were studied. Two intra-arterial fluid support strategies were used: a standard Ringer solution and an isotonic Na2CO3 solution. Duodenal single perfusion was used, and DMBS was assessed by back titration of the effluent. PGE2 was used to stimulate DMBS. In Ringer solution-infused mice, isoflurane-induced acidosis became worse with time. The blood pH was 7.15–7.21 and the base excess was about −8 mM at the end of experiments. The continuous infusion of Na2CO3 solution completely compensated for the acidosis. The blood pH was 7.36–7.37 and base excess was about 1 mM at the end of the experiment. Basal and PGE2-stimulated DMBS were markedly greater in animals treated with Na2CO3 solution than in those treated with Ringer solution. MAP was slightly higher after Na2CO3 solution infusion than after Ringer solution infusion. We concluded that isoflurane-induced acidosis markedly depresses basal and PGE2-stimulated DMBS as well as the responsiveness to PGE2, effects prevented by a continuous infusion of Na2CO3. When performing in vivo experiments in isoflurane-anesthetized mice, it is recommended to supplement with a Na2CO3 infusion to maintain a normal acid-base balance.

Changes in blood acid-base balance parameters and coagulation profile during diarrhea in calves

2013 ◽  
Vol 16 (3) ◽  
pp. 543-549 ◽  
Author(s):  
P. Sobiech ◽  
W. Rękawek ◽  
M. Ali ◽  
R. Targoński ◽  
K. Żarczyńska ◽  
...  
Keyword(s):  
Control Group ◽  
Thrombin Time ◽  
Acid Base Balance ◽  
Acid Base ◽  
Blood Samples ◽  
Coagulation Profile ◽  
At Iii ◽  
Base Balance ◽  
Diarrheic Calves ◽  
D Dimer

Abstract The purpose of this study was to investigate possible alterations in acid-base balance parameters and the coagulation profile in neonatal diarrheic calves. Twenty neonatal diarrheic and 20 clinically healthy neonatal calves aged between 1 week to 10 days were used. All blood samples were taken on the third day from the onset of diarrhea symptom. Venous blood samples were collected from each animal to determine platelet numbers, pH, pCO2, pO2, HCO3-, BE, O2SAT, ctCO2 and electrolytes (K+, Na+ and Cl-). Plasma samples were collected from each animal for the measurement of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), the concentrations of fibrinogen, D-dimer and the activity of antithrombin III (AT III). Blood pH (7.19), BE (-10.6 mmol/l), HCO3 - (25.15 mmol/l), pO2 (3.33 kPa), O2SAT (24.12 %) were significantly lower and serum concentration of K+ (6.55 mmol/l) was significantly higher in diarrheic calves. These changes indicate the state of uncompensated metabolic acidosis with accompanying hyperkalemia. TT (32.05s) and APTT (39.9s) values were more prolonged in calves with diarrhea than in the control group. D-dimer (587.25 μg/l) concentrations were significantly increased while a visible drop in AT III (103.75%) activity and platelets counts (598 x109/l) were observed in diarrheic group of calves. The results suggest that a consumptive type of disseminated intravascular coagulation (DIC) developed in diarrheic calves.

scholarly journals Acid-base balance in acute ethylene glycol poisoning in rats treated with fomepizole

2014 ◽  
Vol 83 (1) ◽  
pp. 29-36
Author(s):  
Jędrzej Przystanowicz ◽  
Barbara Zielińska-Psuja ◽  
Joanna Kowalówka-Zawieja ◽  
Karina Sommerfeld
Keyword(s):  
Single Dose ◽  
Ethylene Glycol ◽  
Base Excess ◽  
Gas Analysis ◽  
Acid Base Balance ◽  
Bicarbonate Concentration ◽  
Acid Base ◽  
Balance Disorders ◽  
Blood Ph ◽  
Base Balance

Introduction. Ethylene glycol (EG) is relatively nontoxic but undergoes a multi-step oxidation to toxic metabolites, aldehydes and acids. The accumulation of organic acids, mainly glycolates, leads to the development of profound, life-threatening metabolic acidosis. A key therapy is an antidotal treatment with fomepizole (4-MP), the inhibitor of the first step of EG biotransformation enzyme, alcohol dehydrogenase.Aim. The aim of the study was to demonstrate the efficacy of fomepizole in the prevention of acid-base balance disorders in acute ethylene glycol poisonings in rats.Material and methods. Adult male Wistar rats were given EG (p.o.) with single (i.p.) or multiple (p.o.) doses of 4-MP (EG 3830 and 5745 mg/kg, respectively, 4-MP in single dose of 10 mg/kg or 15 mg/kg followed by 10 mg/kg every 12 hours). Blood gas analysis was performed and blood pH, bicarbonate concentration and base excess were evaluated.Results and conclusions. The single dose of 4-MP was effective in preventing a decrease in blood pH, bicarbonate concentration and base excess during the entire experimental period (pH 7.35 vs 7.21 at hour 12, bicarbonate concentration 27.2 vs 18.3 mmol/dm3 at hour 8, base excess 1.8 vs -8.2 mmol/dm3 at hour 18). The multiple administration of 4-MP started 2 hours after EG poisoning resulted in rapid restoration of proper values of acid- -base balance parameters. Fomepizole is highly efficacious in restraining the acid-base balance disorders which are concomitant with acute ethylene glycol poisonings.

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