Laboratory-immunological diagnostics of complicated flow
of necrotic pancreatitis

Purpose of the study. Justify the additional laboratory and immunological possibilities of diagnosing the complications of necrotic pancreatitis. Materials and methods. A retrospective analysis of the case history of patients with edematous and necrotic pancreatitis has been carried out, and 1060 case histories have been analyzed. By special methods, 30 patients with acute pancreatitis were examined. Laboratory and immunological studies were carried out three times: 1 research – upon admission; 2 studies – on the 7th day; 3 studies – 14 days. Results. The conducted clinical researches and analysis of results allowed working out the method of diagnostics of local complications, based on quantitative estimation of level of lymphocytes. At level of lymphocytes up to 13% is very high probability of fluid collection development; from 13% to 25% - high probability; from 25% to 37% – moderate probability; above 37% – low probability of intra- and peripancreatic fluid collections. In general, a comparison of the dynamics of Ig subclasses showed that IgG1 and IgG3 tended to gradually increase. Conclusions. Among the laboratory parameters of the complicated course of necrotic pancreatitis, the most significant is the change in lymphocytes. The distribution of individual IgG subclasses suggests that severe necrotic forms overlap with a proven increase in the quantitative composition of IgG1 and IgG3, which is a confirmation of the pro inflammatory variant of the development of SIRS and requires correction of therapeutic tactics. Key words: necrotizing pancreatitis, complicated course, diagnostics.

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Benign extracerebral fluid collection in infancy as a risk factor for the development of de novo intracranial arachnoid cysts

Journal of Neurosurgery Pediatrics ◽

10.3171/2013.8.peds1399 ◽

2013 ◽

Vol 12 (6) ◽

pp. 555-564 ◽

Cited By ~ 12

Author(s):

Tobias A. Mattei ◽

Brandon J. Bond ◽

Deepak Sambhara ◽

Carlos R. Goulart ◽

Julian J. Lin

Keyword(s):

Risk Factor ◽

De Novo ◽

Multiple Logistic Regression Analysis ◽

Fluid Collection ◽

Arachnoid Cysts ◽

Ct Scans ◽

Delivery Mode ◽

History Of ◽

Fluid Collections ◽

Further Development

Object Intracranial arachnoid cysts are a relatively common benign intracranial pathology, accounting for as many as 0.75%–1% of nontraumatic CNS lesions. Although it has already been demonstrated that rupture of arachnoid cysts may lead to subdural hematomas/hygromas, no study to date has investigated benign extracerebral collection in infancy as a possible predisposing factor for further development of arachnoid cysts. Methods The authors performed a retrospective imaging and chart review of macrocephalic infants 12 months old or younger who were referred to neurosurgical care at OSF St. Francis Medical Center from 2003 to 2010, and who were diagnosed with benign extracerebral fluid collection in infancy on thin-slice (1-mm) head CT scans. Special attention was given to the investigation of risk factors for further development of de novo arachnoid cysts. Several epidemiological factors in the infants and mothers were analyzed, including gestational age at delivery, mode of delivery, mother's age at delivery, delivery complications, birth weight, age of macrocephaly development, degree of macrocephaly, family history of macrocephaly, prenatal and postnatal history of infection, fontanel status, presence of papilledema, previous history of head trauma, and smoking status. Imaging characteristics of the initial scans, such as location of subdural collection (frontal vs frontoparietal and frontotemporal) and presence of ventriculomegaly, were also evaluated. For those patients in whom arachnoid cysts were identified on subsequent CT scans, the size and location of the cysts were also analyzed. Results The authors identified 44 children with benign extracerebral fluid collection in infancy. From this group, over a mean follow-up of 13 months (range 6–13 months), 18 children developed intracranial arachnoid cysts (a 40.9% incidence of de novo development of arachnoid cysts), with 27.8% presenting with bilateral cysts. In the multiple logistic regression analysis, infants who presented with an extracerebral collection restricted to the bilateral frontal region were more likely to develop intracranial arachnoid cysts (p = 0.035) than those with collections involving the frontotemporal and frontoparietal regions (odds ratio [OR] = 5.73). Additionally, children with benign extracerebral fluid collections and plagiocephaly were more likely to develop intracranial arachnoid cysts (p = 0.043) than those without plagiocephaly (OR = 4.96). Conclusions This is the first report in the neurosurgical literature demonstrating that benign extracerebral fluid collections in infancy may constitute a significant risk factor for development of de novo arachnoid cysts. These findings support a 2-hit hypothesis for the development of arachnoid cysts, in which the combination of an embryological defect in arachnoid development followed by a second event leading to impairment of CSF fluid absorption in early childhood could lead to abnormal CSF dynamics and the consequent expansion of fluid collections in the intraarachnoid spaces.

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Management and outcome of spontaneous subaponeurotic fluid collections in infants: the Hospital for Sick Children experience and review of the literature

Journal of Neurosurgery Pediatrics ◽

10.3171/2016.4.peds1641 ◽

2016 ◽

Vol 18 (4) ◽

pp. 442-447 ◽

Cited By ~ 4

Author(s):

Shelly Wang ◽

James Drake ◽

Abhaya V. Kulkarni

Keyword(s):

English Language ◽

Fluid Collection ◽

Infectious Complications ◽

Unknown Etiology ◽

Laboratory Findings ◽

Imaging Characteristics ◽

History Of ◽

Sick Children ◽

Fluid Collections ◽

Age Range

OBJECTIVE Spontaneous subaponeurotic fluid collection (SSFC) is an uncommon and newly described entity of unknown etiology, observed in infants less than 1 year of age. The authors report on series of infants who presented to the Hospital for Sick Children (HSC) with SSFC, focusing on the natural history of this condition. METHODS Data from the Hospital for Sick Children were retrospectively reviewed for the period between January 2004 and June 2015. Patient age and sex, birth history, medical history, laboratory findings, and symptoms were reviewed. SSFC location, imaging characteristics, management, and outcome were also analyzed. A MEDLINE and Embase literature search was performed on the condition, yielding previously reported cases of SSFC in the English language. RESULTS Nine cases involving patients who presented with SSFC during the study period were identified. The patients were 4 male and 5 female infants (age range 5 weeks to 11 months). All cases of SSFC developed spontaneously over a period of days, and the infants had no history of injuries, trauma, or hair manipulation in the immediate period preceding the development of the subgaleal collections. Six patients underwent remote forceps- or vacuum-assisted instrumented births, although none of the patients developed scalp collections or skin discoloration immediately after birth. All of the cases were managed conservatively on an outpatient (6 cases) or inpatient (3 cases) basis. In 1 case, the size of the fluid collection fluctuated over 4 months, but in all of the cases, the collections resolved spontaneously without structural or infectious complications. CONCLUSIONS This is the largest series describing SSFC to date and summarizes 9 cases managed at a large academic neurosurgical center. Although the specific pathophysiology of SSFC remains unknown, in some cases the condition may be associated with a remote history of instrumented delivery. SSFC occurs spontaneously without immediate preceding trauma, and an extensive hematology or child abuse workup is not necessary. A conservative approach with outpatient follow-up is advocated.

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Step-up approach for acute infected necrotizing pancreatitis

Modern medical technologies ◽

10.34287/mmt.2(41).2019.21 ◽

2019 ◽

Vol 41 part 2 (2) ◽

pp. 29-34

Author(s):

O. I. Dronov ◽

I. O. Kovalska ◽

A. I. Gorlach ◽

T. V. Lubenets

Keyword(s):

Percutaneous Drainage ◽

Clinical Laboratory ◽

Necrotizing Pancreatitis ◽

Fluid Collection ◽

Morphological Characteristics ◽

Treatment Method ◽

Multivariate Regression Analysis ◽

Second Step ◽

Percutaneous Catheter Drainage ◽

Fluid Collections

Purpose of the study. The role of interventional methods of the treatment of acute infected necrotic pancreatitis depending on the morphological characteristics of the disease was determined. Material and methods. In present prospective cohort study, we included 96 patients with acute infected necrotizing pancreatitis. All patients were stratified according to morphologic features. Stepup approach with following steps of interventions was applied: percutaneous drainage of infected fluid collections, increasing of drainages diameter and number of it and open or minimally invasive necrosectomy. Clinical, laboratory, and instrumental monitoring were the defining indicators for the stopping of the treatment or for the passing to the next step of the treatment. Results. At the first step 7 of 96 patients with superficial focal necrosis, a necrosis index of 2 points and a category D were successfully treated. Other 89 patients were passed to the second step of treatment, of which 23 patients with superficial subtotal necrosis, necrosis index of 2 points and category E were successfully treated. Another 66 patients had undergone a third step of treatment. A multivariate regression analysis was conducted that allowed to identify predictive factors of inefficiency of using of percutaneous drainage interventions (stages I and II) as a final stage of treatment: transmural subtotal or total necrotizing pancreatitis (OR = 1,58; 95% CI 1,03–3,88; p = 0,033); Necrosis index of 4 or more points (OR = 3.19, 95% CI 1.57–8.37; p = 0,003); heterogeneous peripancreatic fluid collection (OR = 4,15, 95% CI 1,49–5.19; p = 0,001); The CT-index of severity of acute pancreatitis of 7 or more points (OR = 1,89, 95% CI: 1,03–3,43; p = 0,029). Conclusion. Step-up approach showed following results: 7,3% patients were treated at the first step, 24% – at the second step. Third step of treatment was applied in 68,7% of patients, of witch 12,5% was treated with laparoscopic necrosectomy. Predictors of ineffectiveness of ultrasound guided percutaneous drainage as the final treatment method are: necrosis index of 4 or more, heterogeneous paripancreatic fluid collections, subtotal and transmural necrotizing pancreatitis. Keywords: infected pancreatic necrosis, stepup approach, percutaneous catheter drainage, uncontrolled infection, necrosectomy.

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HISTORY OF THE GOSNITI ESTABLISHMENT

Tekhnicheskiy servis mashin ◽

10.22314/2618-8287-2020-58-4-165-175 ◽

2020 ◽

Vol 4 (141) ◽

pp. 165-175

Author(s):

VYACHESLAV CHERNOIVANOV ◽

◽

VALENTIN LYALYAKIN

Keyword(s):

National Economy ◽

The State ◽

Advanced Technology ◽

Research Purpose ◽

Quantitative Composition ◽

Technical Documentation ◽

Agricultural Machinery ◽

History Of ◽

Electric Brake ◽

Testing Fuel

With the increase in the production of new machines, it was necessary to pay more attention to their repair and maintenance, expand research, create appropriate standards, and constantly update technical documentation. The pre-1953 repair laboratories were not powerful enough to solve the growing problems. In 1953, it was decided to establish The State Union Research Institute for the Repair and Operation of Tractors and Agricultural Machinery. (Research purpose) The research purpose is in describing the history of GOSNITI establishment, analyzing the tasks and results of the Institute's activities over the first decade. (Materials and methods) The article presents the base of the new Institute and its quantitative composition. The article describes the main objectives of the Institute and its activities. (Results and discussion) Work was carried out to create self-moving workshops for filling filters, electric brake stands, stands for testing fuel equipment, equipment for vibration contact surfacing. The calculations of the repair base for the regions were carried out. The article presents the list of works that were widely implemented in the national economy and the list of publications of technical documentation. GOSNITI was awarded the Order of the Red Banner of Labor by the decree of the Presidium of the Supreme Soviet of the USSR on May 25, 1967, for implementing the system and advanced technology for repairing cars. (Conclusions) The staff of the established Institute successfully completed the tasks set in the first decade.

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The Historical Role of Leviticus 25 in Naturalizing Anti-Black Racism

Religions ◽

10.3390/rel12080570 ◽

2021 ◽

Vol 12 (8) ◽

pp. 570

Author(s):

James W. Watts

Keyword(s):

Seventeenth Century ◽

Early Modern ◽

High Probability ◽

Middle Eastern ◽

American Colonies ◽

History Of ◽

Historical Role ◽

Permanent Property

Leviticus 25:39–46 describes a two-tier model of slavery that distinguishes Israelites from foreign slaves. It requires that Israelites be indentured only temporarily while foreigners can be enslaved as chattel (permanent property). This model resembles the distinction between White indentured slaves and Black chattel slaves in the American colonies. However, the biblical influence on these early modern practices has been obscured by the rarity of citations of Lev. 25:39–46 in sixteenth- and seventeenth-century sources about slavery. This article reviews the history of slavery from ancient Middle Eastern antiquity through the seventeenth century to show the unique degree to which early modern institutions resembled the biblical model. It then exposes widespread knowledge of Leviticus 25 in early modern political and economic debates. Demonstrating this awareness shows with high probability that colonial cultures presupposed the two-tier model of slavery in Leviticus 25:39–46 to naturalize and justify their different treatment of White indentured slaves and Black chattel slaves.

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Familial Chylomicronemia Syndrome-Induced Acute Necrotizing Pancreatitis during Pregnancy

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1722173 ◽

2021 ◽

Vol 43 (03) ◽

pp. 220-224

Author(s):

Julia Cristina Coronado Arroyo ◽

Marcio José Concepción Zavaleta ◽

Eilhart Jorge García Villasante ◽

Mikaela Kcomt Lam ◽

Luis Alberto Concepción Urteaga ◽

...

Keyword(s):

Acute Pancreatitis ◽

Pancreatic Necrosis ◽

Clinical Course ◽

Necrotizing Pancreatitis ◽

Rare Condition ◽

Severe Hypertriglyceridemia ◽

Fetal Complications ◽

Acute Necrotizing ◽

History Of ◽

Important Objective

AbstractAcute pancreatitis is a rare condition in pregnancy, associated with a high mortality rate. Hypertriglyceridemia represents its second most common cause. We present the case of a 38-year-old woman in the 24th week of gestation with a history of hypertriglyceridemia and recurrent episodes of pancreatitis. She was admitted to our hospital with acute pancreatitis due to severe hypertriglyceridemia. She was stabilized and treated with fibrates. Despite her favorable clinical course, she developed a second episode of acute pancreatitis complicated by multi-organ dysfunction and pancreatic necrosis, requiring a necrosectomy. The pregnancy was ended by cesarean section, after which three plasmapheresis sessions were performed. She is currently asymptomatic with stable triglyceride levels. Acute pancreatitis due to hypertriglyceridemia represents a diagnostic and therapeutic challenge in pregnant women, associated with serious maternal and fetal complications. When primary hypertriglyceridemia is suspected, such as familial chylomicronemia syndrome, the most important objective is preventing the onset of pancreatitis.

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863 Peri-Implant Fluid Collection in Breast Reconstruction and Aesthetic Surgery

British Journal of Surgery ◽

10.1093/bjs/znab134.330 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

G Karagiannidis ◽

E Mallidis

Keyword(s):

Reconstructive Surgery ◽

Cell Lymphoma ◽

Breast Implant ◽

Fluid Collection ◽

Aesthetic Surgery ◽

Large Cell ◽

Inclusion Criteria ◽

Electronic Data Collection ◽

Fluid Collections ◽

Mean Time

Abstract Introduction Peri-implant fluid more than 6 months from surgery is a known complication of breast surgery.Differential diagnosis includes infection, inflammation,implant rupture and haematoma.Other than infection raised no concern until the identification of Breast Implant Associated Anaplastic Large Cell Lymphoma(BIA-ALCL). Method Retrospective electronic data collection for women 18 years or older who met the following inclusion criteria:(a)oncoplastic and/or cosmetic reconstructive surgery with placement of implant(b)peri-implant fluid collection after 6-36 months. Results In total,17 women with implants with a mean age of 56 years were included in the study.The mean time between reconstructive surgery and the peri-implant fluid collection was 23 months.The median peri-implant fluid collection size was 143 ml.14 of the 17 peri-implant fluid collections were benign.12 of 14 had polyurethane-coated textured implants.4 of the 17 were BIA-ALCL. Conclusions The current literature suggests that late peri-implant seromas arise from friction as the implant moves within the cavity and that this friction is increased with textured rather than smooth implants.In our unit 12/14 of the benign collections appeared in reconstructions with polyurethane implants.Furthermore,BIA-ALCL should always be considered in this situation and aspirate should be sent for cytology.Is this change in polyurethane implants a new entity?

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Jar-by-Jar: Curation Improvements to the Herpetology Collection at CUMNH

Biodiversity Information Science and Standards ◽

10.3897/biss.2.25853 ◽

2018 ◽

Vol 2 ◽

pp. e25853

Author(s):

Emily Braker

Keyword(s):

Natural History ◽

Library Services ◽

Location Tracking ◽

University Of Colorado ◽

Routine Monitoring ◽

History Of ◽

Fluid Collections ◽

The University ◽

Collection Program

The University of Colorado Museum of Natural History (CUMNH) Herpetology Collection is comprised of over 65,000 fluid-preserved specimens representing over 2,500 taxa from more than 70 countries. Despite its active use, a history of irregular topping up schedules and a decades-long dearth in rehousing projects due to budgetary constraints left the collection in substandard conditions. A 2015 survey of roughly 10% of the collection revealed average ethanol concentrations far below desired levels, with only 15% of specimen jars surveyed containing optimal preservative strengths of 70% (+/- 2.5%). In Fall 2017, CUMNH secured an Institute of Museum and Library Services (IMLS) grant to holistically address shortcomings in the micro- and macro-storage environments within the Herpetology Collection. Program activities include jar-by-jar ethanol remediation using a digital density meter and a topping up algorithm proposed by Notton 2010, collection-wide replacement of faulty jars and lids, and installation of new static and mobile compactor shelving. Updates to nomenclature and a full specimen inventory including condition and location tracking in Arctos also fall within the project scope. This talk will cover progress thus far, our approaches to moving a collection in place, and systematic remedial topping up as a valuable counterpart to routine monitoring in fluid collections.

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Clusters of the Risk Markers and the Pattern of Premature Coronary Heart Disease: An Application of the Latent Class Analysis

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.707070 ◽

2021 ◽

Vol 8 ◽

Author(s):

Leila Jahangiry ◽

Mahdieh Abbasalizad Farhangi ◽

Mahdi Najafi ◽

Parvin Sarbakhsh

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Latent Class Analysis ◽

High Probability ◽

Latent Class ◽

Class Analysis ◽

Risk Markers ◽

History Of ◽

Opium Addiction ◽

The Mean

Background: Coronary heart disease (CHD) is the major cause of mortality in the world with a significant impact on the younger population. The aim of this study was to identify prematurity among patients with coronary artery bypass graft surgery (CABG) based on the clustering of CHD risk factors.Methods: Patients were recruited from an existing cohort of candidates for CABG surgery named Tehran Heart Center Coronary Outcome Measurement (THC-COM). A latent class analysis (LCA) model was formed using 11 potential risk factors as binary variables: cigarette smoking, obesity, diabetes, family history of CHD, alcohol use, opium addiction, hypertension, history of stroke, history of myocardial infarction (MI), peripheral vascular disease (PVD), and hyperlipidemia (HLP). We analyzed our data to figure out how the patients are going to be clustered based on their risk factors.Results: For 566 patients who were studied, the mean age (SD) and BMI of patients were 59.1 (8.9) and 27.3 (4.1), respectively. The LCA model fit with two latent classes was statistically significant (G2 = 824.87, df = 21, p < 0.0001). The mean (SD) age of patients for Class I and Class II was 55.66 (8.55) and 60.87 (8.66), respectively. Class I (premature) was characterized by a high probability of smoking, alcohol consumption, opium addiction, and a history of MI (P < 0.05), and class II by a high probability of obesity, diabetes, and hypertension.Conclusion: Latent class analysis calculated two groups of severe CHD with distinct risk markers. The younger group, which is characterized by smoking, addiction, and the history of MI, can be regarded as representative of premature CHD.

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Clinical profile of patients with pancreatitis

International Surgery Journal ◽

10.18203/2349-2902.isj20164702 ◽

2017 ◽

Vol 4 (2) ◽

pp. 534

Author(s):

MD. Shakeel ◽

Syed Shahid Irfan

Keyword(s):

Acute Pancreatitis ◽

Chronic Pancreatitis ◽

Dietary Habits ◽

Necrotizing Pancreatitis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Common Diagnosis ◽

History Of ◽

In The Beginning ◽

Alcoholic Liver Diseases

Background: Pancreatitis is an inflammatory process leading to abdominal pain, progressive destruction of the exocrine tissue and in some patients a loss of endocrine tissue as well. However owing to the tremendous reserve of pancreatic function, insufficiency may be at subclinical at least in the beginning of the disease.Methods: A cross sectional study was conducted which included the patients admitted with pancreatitis. For all the patients, meticulous records will be maintained regarding clinical features, family history of pancreatitis, alcohol intake, dietary habits, and stigmata of alcoholic liver diseases and by performing various investigations. 200 cases admitted, diagnosed to have pancreatitis.Results: The most common diagnosis was acute pancreatitis (48%) followed by chronic pancreatitis (12%), acute pancreatitis and pseudocyst (12%), acute on chronic pancreatitis (12%), necrotizing pancreatitis (8%) and acute pancreatitis with others (8%).Conclusions: Overall acute pancreatitis constituted 76%, chronic pancreatitis 12% and acute on chronic pancreatitis 12%.

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