AGE-RELATED FEATURES OF THE PREVALENCE AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF THE EYE AND ITS ADNEXA (C69) WITH TAKING INTO ACCOUNT THE LOCALIZATION AND HISTOLOGICAL STRUCTURE: POPULATION STUDY

2020 ◽  
pp. 561-568
Author(s):  
В. М. Мерабишвили ◽  
Э. Н. Мерабишвили
Keyword(s):  
Cancer Registry ◽  
Malignant Tumors ◽  
Population Based ◽  
Federal State ◽  
Mortality Data ◽  
Histological Structure ◽  
North West ◽  
Similar Work ◽  
Age Related ◽  
First Time

Злокачественные новообразования глаза и его придаточного аппарата (С69) относятся к редким опухолям. До настоящего времени государственная статистика в России (ф. № 7) «Сведения о злокачественных новообразованиях» располагает данными только для расчета заболеваемости населения. Эти данные были включены в ф. № 7 по нашему предложению только с 2011 г. В 2018 г. мы впервые смогли располагать данными о заболеваемости населения по возрасту отдельно для мужчин и женщин, но только в целом по России. Такая возможность имеется и у каждого территориального ракового регистра. Расчет показателей одно-и пятилетней выживаемости больных по этой патологии осуществляется только нами по 10 административным территориям Северо-Западного федерального округа, где в феврале 2019 г. был нами сформирован первый в России Популяционный раковый регистр (ПРР) на уровне федерального округа с общим объемом базы данных более 1 млн наблюдений. Ранее аналогичные работы осуществлялись только на материалах ПРР Санкт-Петербурга. В настоящей работе впервые представлены особенности изменения структуры онкологической патологии глаза и его придаточного аппарата (С69) и расчеты пятилетней выживаемости по возрасту. К сожалению, Управление Федеральной службы государственной статистики относит патологию глаза (С69) к группе «прочие ЗНО» и не публикует данные о смертности. Вместе с тем, используя базу данных ПРР, нужно иметь в виду, что индекс достоверности учета (отношение числа умерших к числу впервые в жизни заболевших) по ЗНО глаза (С69) составляет около 0,50 % и постоянно снижается, а достоверность учета повышается. Malignant tumors of the eye and its adnexa (C69) are rare malignancies. To date state statistics in Russia (Form No. 7) have data only for estimating the incidence of the population. These data, at our proposal, were included in Form No. 7 only since 2011. In 2018 for the first time we were able to have data on the incidence of the population by age separately for men and women but only in Russia as a whole. The estimation of rates of a 1- and 5-year patient survival for this pathology is carried out only by us in the North-West Federal Region of Russia, where, in February 2019, we have formed the fi rst Population-based Cancer Registry (PCR) in Russia at the Federal Region’s level with a total database of more than 1 million cases. Previously similar work was conducted on the materials of the Population-based Cancer Registry of Saint-Petersburg. For the first time this work presents the features of data on changes in the structure of oncological pathology of the eye and its adnexa (C69) and estimations of a 5-year survival by age. Unfortunately the Office of the Federal State Statistics Service classifies the pathology of the eye (C69) as a group of «other malignant tumors» and does not publish mortality data. At the same time, using the PCR database, it must be borne in mind that index accuracy (the ratio of a number of deaths to a number of sick for the fi rst time in life) according to malignant tumors of the eye (C69) is about 0,50 % and is constantly decreasing.

scholarly journals Malignant neoplasms of the heart, prevalence, weather mortality, median survival and survival of patients, taking into account the stage of diseases, localization and histological structure of tumors

2020 ◽  
Vol 2 (3) ◽  
pp. 30-39
Author(s):  
Vakhtang M. Merabishvili
Keyword(s):  
Cancer Registry ◽  
Population Level ◽  
Federal District ◽  
Cancer Registries ◽  
Population Based ◽  
Malignant Neoplasms ◽  
Histological Structure ◽  
Cardiac Tumors ◽  
North West ◽  
The North

Malignant cardiac tumors are rare but dangerous tumors with a high mortality rate, not represented at the population level in any statistical collection. The study of its prevalence is possible only using the system of population cancer registries created in the world. Moreover, not at the regional level, only at the level of the federal district or the entire country. In 1993 we created the first in Russia Population-based Cancer Registry. In February 2019, it was possible to combine cancer registries of all 11 administrative territories of the North-West of Russia, with a population of more than 13 million inhabitants and a database of more than 1 million 100 thousand patients. It was only after the creation of the population cancer registry of the Northwestern Federal District that it became possible to study the patterns of prevalence and survival of patients in all tumor localizations, including, among other things, rare malignant cardiac tumors.

Marked Increase in Incident Gynecomastia: A 20-Year National Registry Study, 1998 to 2017

2020 ◽  
Vol 105 (10) ◽  
pp. 3134-3140 ◽  
Author(s):  
Trine Koch ◽  
Elvira V Bräuner ◽  
Alexander S Busch ◽  
Martha Hickey ◽  
Anders Juul
Keyword(s):  
Age Groups ◽  
Population Based ◽  
Incidence Rates ◽  
National Registry ◽  
Registry Study ◽  
Age Related ◽  
Danish Health ◽  
Increased Risk ◽  
National Patient ◽  
First Time

Abstract Context Gynecomastia, the proliferation of mammary glandular tissue in the male, is a frequent but little-studied condition. Available prevalence data are based on selected patient populations or autopsy cases with their inherent bias. Objective The objective of this work is to evaluate the age-related incidence and secular trends in gynecomastia in the general population. Design An observational, 20-year national registry study was conducted. Setting This population-based study used nationwide registry data. Participants Participants included all Danish males (age 0-80 years) with a first-time diagnosis of gynecomastia. Main Outcome Measures All Danish males (age 0-80 years) were followed up for incident diagnosis of gynecomastia in the Danish National Patient Registry from 1998 to 2017 using the International Codes of Diseases, 10th revision, and the Danish Health Care Classification System. Age-specific incidence rates were estimated. The hypothesis tested in this study was formulated prior to data collection. Results Overall, a total 17 601 males (age 0-80 years) were registered with an incident diagnosis of gynecomastia within the 20-year study period, corresponding to 880 new cases per year and an average 20-year incidence of 3.4 per 10 000 men (age 0-80 years). The average annual incidence was 6.5/10 000 in postpubertal males age 16 to 20 years and 4.6/10 000 in males age 61 to 80 years, with a respective 5- and 11-fold overall increase in these 2 age groups over the 20-year period. Conclusions The incidence of gynecomastia has dramatically increased over the last 20 years, implying that the endogenous or exogenous sex-steroid environment has changed, which is associated with other adverse health consequences in men such as an increased risk of prostate cancer, metabolic syndrome, type 2 diabetes, or cardiovascular disorders.

scholarly journals EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF THE BRAIN (C71). POPULATION-BASED STUDY

2020 ◽  
Vol 66 (5) ◽  
pp. 489-499
Author(s):  
Vakhtang Merabishvili ◽  
Kalyango Kennet ◽  
M. Valkov ◽  
Andrey Dyachenko
Keyword(s):  
Malignant Tumors ◽  
Cranial Nerves ◽  
Cancer Registries ◽  
Population Based ◽  
Malignant Neoplasms ◽  
Incidence And Mortality ◽  
Icd 10 ◽  
The Central Nervous System ◽  
First Time ◽  
The Brain

Malignant neoplasms of the brain (BMN) in accordance with the international classification of the diseases (ICD-10) belong to the rubric C71. However, in the world and Russia it is customary to understand this term as the entire block of localizations related to the brain - rubrics C70-71. The topographic codes C70 (meninges), C71 (brain) and C72 (spinal cord, cranial nerves and other parts of the central nervous system) make up a small proportion among MN in general. In addition, all the summary data WHO-IARC and Russia as a rule aggregate the CNS tumors under the three heading ICD - 10 (ICDO-3) C70-72. With the developments in Russia of the system of Population cancer registries, it became possible to study the patterns of dynamics of incidence and to calculate the survival rate of patients with malignant necrosis in each ICD-10 section. This study presents the population-based analysis of incidence and mortality from BMN using available sources and, for the first time in Russia, the analysis of the dynamics of the survival among the patients with BMN under the rubric C71 is performed.

scholarly journals Surveillance for Jordan Cancer Burden: Jordan Cancer Registry Data 2010-2014

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 241s-241s
Author(s):  
O. Nimri
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Cancer Registry ◽  
Cancer Control ◽  
Control Program ◽  
Population Based ◽  
Control Measures ◽  
Mortality Data ◽  
Cancer Data ◽  
Knowledge To Action

Background: Cancer registry is an important tool for any successful cancer control program. The cancer-related data from Jordan was vague scarcity. This, urged scholars to set up the first and only population-based cancer registry in Jordan. Which did the Ministry of Health and the Middle East Cancer Consortium (MECC) established it jointly. The registry started to collect data from cases of cancer referred to the treatment and diagnostic facilities throughout the country to improve cancer reporting in the country and define the size of the cancer problem and the pattern of cancer in Jordan; distribution of cancer by geographical locations; age; gender; type and cancer sites for both Jordanians and non-Jordanians. Strategy/Tactics: The Jordan Cancer Registry (JCR) collects cancer data in passive and active methods of case finding, the collected data coded by means of ICD_O3. Quality control measures applied, and the data stored and computerized using CanReg_4 and CanReg_5; then analyzed statistically. World standard population for age adjustment and standardization to facilitate national and international comparison and contrast. Outcomes: Incidence of the most common cancers among Jordanians, distributed by site, age, gender, and geographically for the period 2010-2014. The leading cancer among adults, males was colorectal (11.9%) followed by lung (11.7%), leukemia (9.1%), urinary bladder (8.9%) and prostate (8.1%). While among female cancers are breast (34.4%), colorectal (9.4%); leukemia (6.7%); lymphomas (5.8%) and thyroid (5.3%). Childhood cancers were about (4.9%) of all cancers; leukemia was 1st (34.8%) followed by brain and CNS (20.9%) and lymphomas (17.5%). Whereas the most recent mortality data showed lung is responsible for (21.03%) deaths among males followed by colorectal (11.0%) and leukemia (8.02%). Among females breast deaths (26.8%); colorectal (9.3%) and leukemia (7.2%). What was learned: Knowledge to action, based on the JCR data, Jordan started the Jordan Breast Cancer Program for early detection and screening of breast cancer. We are looking forward starting early detection for colorectal cancer soon.

scholarly journals Cancer incidence estimation from mortality data: a validation study within a population-based cancer registry

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel Redondo-Sánchez ◽  
Miguel Rodríguez-Barranco ◽  
Alberto Ameijide ◽  
Francisco Javier Alonso ◽  
Pablo Fernández-Navarro ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Time Series ◽  
Cancer Registry ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Goodness Of Fit ◽  
Smoothing Splines ◽  
Population Based ◽  
Mortality Data ◽  
Incident Cases

Abstract Background Population-based cancer registries are required to calculate cancer incidence in a geographical area, and several methods have been developed to obtain estimations of cancer incidence in areas not covered by a cancer registry. However, an extended analysis of those methods in order to confirm their validity is still needed. Methods We assessed the validity of one of the most frequently used methods to estimate cancer incidence, on the basis of cancer mortality data and the incidence-to-mortality ratio (IMR), the IMR method. Using the previous 15-year cancer mortality time series, we derived the expected yearly number of cancer cases in the period 2004–2013 for six cancer sites for each sex. Generalized linear mixed models, including a polynomial function for the year of death and smoothing splines for age, were adjusted. Models were fitted under a Bayesian framework based on Markov chain Monte Carlo methods. The IMR method was applied to five scenarios reflecting different assumptions regarding the behavior of the IMR. We compared incident cases estimated with the IMR method to observed cases diagnosed in 2004–2013 in Granada. A goodness-of-fit (GOF) indicator was formulated to determine the best estimation scenario. Results A total of 39,848 cancer incidence cases and 43,884 deaths due to cancer were included. The relative differences between the observed and predicted numbers of cancer cases were less than 10% for most cancer sites. The constant assumption for the IMR trend provided the best GOF for colon, rectal, lung, bladder, and stomach cancers in men and colon, rectum, breast, and corpus uteri in women. The linear assumption was better for lung and ovarian cancers in women and prostate cancer in men. In the best scenario, the mean absolute percentage error was 6% in men and 4% in women for overall cancer. Female breast cancer and prostate cancer obtained the worst GOF results in all scenarios. Conclusion A comparison with a historical time series of real data in a population-based cancer registry indicated that the IMR method is a valid tool for the estimation of cancer incidence. The goodness-of-fit indicator proposed can help select the best assumption for the IMR based on a statistical argument.

scholarly journals Epidemiologic Pattern of Cancer in Kathmandu Valley, Nepal: Findings of Population-Based Cancer Registry, 2018

2021 ◽  
pp. 443-452
Author(s):  
Ranjeeta Subedi ◽  
Meghnath Dhimal ◽  
Atul Budukh ◽  
Sandhya Chapagain ◽  
Pradeep Gyawali ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Control Strategies ◽  
Cancer Control ◽  
Population Based ◽  
Public Health Issue ◽  
Kathmandu Valley ◽  
Community Health Volunteers ◽  
Female Community Health Volunteers ◽  
Adjusted Incidence Rate ◽  
First Time

PURPOSE Although cancer is an important and growing public health issue in Nepal, the country lacked any population-based cancer registry (PBCR) until 2018. In this study, we describe the establishment of the PBCR for the first time in Nepal and use the registry data to understand incidence, mortality, and patterns of cancer in the Kathmandu Valley (consisting of Kathmandu, Lalitpur, and Bhaktapur districts), which comprises 10.5% of the estimated 29 million population of Nepal in 2018. MATERIALS AND METHODS The PBCR collects information from facilities and communities through the active process. The facilities include cancer or general hospitals, pathology laboratories, hospice, and Ayurvedic centers. In the communities, the field enumerators or female community health volunteers collected the data from the households. In addition, the Social Security and Nursing Division under the Department of Health Services, which provides subsidy for cancer treatment of underprivileged patients, was another major source of data. The collected data were verified for residence, accuracy, and completeness and then entered and analyzed using CanReg5 software. RESULTS In the Kathmandu Valley, the PBCR registered 2,156 new cancer cases with overall age-adjusted incidence rate for all cancers of 95.7 per 100,000 population (95.3 for males and 98.1 for females). The age-adjusted mortality rate for males was 36.3 (n = 365) and for females 27.0 (n = 305) per 100,000 population. We found that the commonest cancers in males were lung and stomach, whereas in females, they were breast and lung cancer. Gallbladder cancer was among the top five common cancers in both sex. CONCLUSION These findings provide a milestone to understand the cancer burden in the country for the first time using the PBCR and will be helpful to develop and prioritize cancer control strategies.

METHODOLOGICAL APPROACHES TO THE ANALYSIS OF THE ACTIVITIES OF THE CANCER SERVICE ON THE BASIS OF THE FORMS OF STATE REPORTING AND THE DATABASE OF THE POPULATION CANCER REGISTER OF THE NORTHWESTERN FEDERAL DISTRICT. PART 1

2019 ◽  
Vol 65 (5) ◽  
pp. 653-663
Author(s):  
A. Belyaev ◽  
V. Merabishvili
Keyword(s):  
Malignant Tumors ◽  
Objective Assessment ◽  
Relative Survival ◽  
Federal District ◽  
The State ◽  
International Standards ◽  
Federal State ◽  
Cancer Service ◽  
Morbidity Data ◽  
First Time

The assessment of the state of the cancer service should be carried out on a reliable basis, which can be greatly helped by the established system of Population cancer registers (DB PRR), which is not fully used at present for the analysis of its activities. In the northwestern Federal district for the first time in Russia fully formed DB PRR, collected more than 1 million cases of malignant tumors for a comprehensive study of its condition. The analysis of these materials forms the basis of our research. The purpose of the article is to present a set of analytical criteria for an objective assessment of the activities of cancer services on the example of the regional PRR NWFD of the Russian Federation. The analysis of survival of patients in the NWFD according to international standards will be presented in the next article (part II). Materials and methods. Materials for the study selected data from the official statements of f.№7 and the Federal state statistics service And for the first time in Russia complete database PRR NWFD. Classical methods of statistical analysis are used. Results. Established for 7 years, the growth of cancer incidence in the northwestern Federal district by 10.3% in standardized indicators and a decrease in mortality of the population of the northwestern Federal district by 9% in the same indicators. For the first time the comparison of morbidity data on f.№7 and DB PRR at the level of the Federal district. The calculation of the index of reliability of accounting is carried out, its positive dynamics is shown. Median survival rate of patients with NWFD was calculated. Dynamics of 1-year and 5-year observed and relative survival of cancer patients was calculated. The conducted research has shown expediency of wide use for the analysis of activity of oncological service of data of DB PRR in addition to statistical collections of Management of Federal service of the state statistics about population and number of the died. Data f.№7 it is advisable to use as operational reporting.

MALIGNANT TUMORS OF THE COLON IN BELARUS AND NORTHWEST FEDERAL DISTRICT OF THE RUSSIAN FEDERATION

2017 ◽  
Vol 63 (1) ◽  
pp. 28-37
Author(s):  
Vakhtang Merabishvili ◽  
Aleksey Okeanov ◽  
Pavel Moiseev ◽  
Alesya Yevmenenko ◽  
Igor Krasilnikov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Malignant Tumors ◽  
Federal District ◽  
Cancer Registries ◽  
Population Based ◽  
The State ◽  
High Rate ◽  
Published Data ◽  
North West ◽  
The Russian Federation

Background: Colon cancer (CC) refers to a group of malignant tumors (MT) with a high rate of morbidity increase. In Russia, only from 2000 to 2014 the standardized incidence rate has increased from 12.9 to 16.6 0/0000, or by 28.7% among males, and from 10.8 to 13.10/0000, or by 21.9 % among females. In the Republic of Belarus (RB) the level of CC incidence has increased from 12.0 to 18.0 0/0000 (by 50%) among males and from 9.0 to 13.40/0000 (by 44.4%) among females. In the City of Minsk the level of CC incidence was highest in 2000 and 2014 and has increased by 33.5%, while in St. Petersburg it was lower than in a number of regions of the North-West Federal District of the Russian Federation (NWFD RF) and has decreased by 8.8% for 15 years. Purpose of the study: To present a comparative evaluation of the main analytical rates of CC morbidity, its mortality and the state of contemporary diagnosis in RB and NWFD RF. Materials and methods: The basis of this work consisted of materials of population-based cancer registries databases of RB and NWFD RF. Also there were used published data to compare the basic parameters. For the estimation of the rates there were used the traditional methods. Standardized rates were estimated on the basis of the world standard population structure. Cartograms were prepared on the basis of the methodology of geographic information systems (GIS). Analysis of obtained data: There was performed a precise analysis of population-based data on CC, including particularly the 4th sign of ICD-10 and identified a number of patterns of CC incidence at present stage. Conclusion: CC incidence increases in Russia, North-West Federal District of the Russian Federation and in Republic of Belarus. Registering rates and the state of cancer control have improved at all comparable administrative territories. It primarily concerns such parameters as morphological verification level, early diagnosis, one-year lethality and others. Comparative monitoring and a study of experience in various administrative territories and countries with the best rates could be useful for planning effective anti-cancer programs.

scholarly journals Epidemiology, index of accuracy, histological structure, year-by-year lethality and survival of patients with malignant melanoma. Population study – part I

2020 ◽  
Vol 66 (6) ◽  
pp. 630-637
Author(s):  
Vakhtang Merabishvili ◽  
Elvira Merabishvili
Keyword(s):  
Malignant Melanoma ◽  
Cancer Registry ◽  
Russian Federation ◽  
Cancer Incidence ◽  
Malignant Tumors ◽  
Basal Layer ◽  
Federal District ◽  
District Level ◽  
Histological Structure ◽  
The Russian Federation

Malignant melanoma of the skin (MMS) is one of the many types of skin tumors that consists of three layers – the epidermis, dermis and hypoderma. MMS develops from melanocyte cells located in the basal layer of the epidermis and producing the pigment melanin. The melanocyte is a dangerous and vindictive cell, it remembers all sunburns and accumulates them. It is the melanin that gives the skin a brown hue as a result of insolation. It also determines the skin color of African-Americans. Birthmarks are also examples of a cluster of melanocytes. In the structure of cancer incidence in economically developed countries, MMS occupies a fairly modest place, but over the past 30 – 40 years, there has been an unfavorable trend. In Russia, MMS is not even among the top ten main localities of malignant tumors, its even smaller share in the overall structure of malignant tumors in Russia was in the 80s of the XX century. Until 1982, state reporting did not provide a set of data on the MMS in the USSR and in Russia, including. At our suggestion, in 1982, the Ministry of health of the USSR decided to allocate a separate line in the state reporting for malignant tumors. In this study, along with assessing the prevalence of MMS in the world and Russia, we focused on the in-depth development of materials for the North-Western Federal district, mainly based on data from the established population cancer registry (PCR). For many years, the analysis of cancer incidence and survival of patients with malignant tumors was carried out by us on the basis of the PCR of St. Petersburg. In February 2019, the first cancer registry at the Federal district level appeared in Russia – PCR of the NWFD of the Russian Federation. As of 01.02.2019, the PCR of the NWFD of the Russian Federation had more than 1 million cases of malignant tumors (1,067,661), including more than 20,000 (21,428) with MMS (2.0%). The PI on the Federal district level allows for in-depth development of the dynamics of localization and histological structure of malignant tumors fourth sign of ICD–10 to study the characteristics of prevalence and survival of patients malignant tumors in any part of the localization structures (lips, ear, trunk, upper and lower extremities, etc.) that cannot be done on the basis of public reporting, and provide analysis of survival of patients of any localization.

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