Sarcopenia and its Association with Geriatric Syndromes and Quality of Life in Older Indian Outpatients – A Cross-sectional Pilot Observational Study

2019 ◽  
Vol 15 (2) ◽  
pp. 66-74
Author(s):  
Sunny Singhal ◽  
Gevesh Chand Dewangan ◽  
Rishav Bansal ◽  
Ashish Datt Upadhyay ◽  
Sada Nand Dwivedi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Dual Energy ◽  
Stepwise Logistic Regression ◽  
Care Hospital ◽  
Geriatric Syndromes ◽  
Dxa Scan ◽  
X Ray ◽  
Increased Risk

Background: Despite the huge clinical impact of sarcopenia, there is very little to no data from Indian subcontinent regarding sarcopenia in older adults. We conducted this study to assess the frequency of sarcopenia in Indian older outpatients and its characteristics and associations with various geriatric syndromes and quality of life in Indian older adults. Methods: 100 participants above the age of 65 years were recruited from the outpatient department of Geriatric Medicine of a tertiary care hospital in India. Muscle mass, muscle strength and physical performance was measured by DXA scan (Dual Energy X-ray Absorptiometry), hand-held dynamometer and 4 m gait speed respectively. Sarcopenia was identified using an Asian working group for sarcopenia (AWGS) criteria. Many geriatric syndromes such as osteoporosis, dementia, depression and malnutrition were assessed using DXA scan (Dual Energy X-ray Absorptiometry), HMSE (Hindi Mental State Questionnaire), GDS-5 (Geriatric Depression scale – 5 item questionnaire) and MNA (Mini Nutritional Assessment) respectively. Quality of life was assessed using the OPQOL-brief questionnaire. Results: The preval nce of sarcopenia in our study population was 53% (49.3% in males, 61.3% in females). Hypothyroidism, neurological disease and osteoporosis were the only comorbidities found to be positively associated with sarcopenia. Among geriatric syndromes, nutrition and cognition were negatively associated with sarcopenia. Sarcopeniawas also negatively related to the quality of life. Multivariate stepwise logistic regression analysis showed that osteoporosis (OR: 5.43; 95% CI: 1.57-18.81; p-value: <0.01) was significantly associated with sarcopenia. Conclusion: Sarcopenia was common among Indian older outpatients with increased risk of geriatric syndromes and poor quality of life, therefore, a regular sarcopenia assessment may be considered in elderly patients.

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

Geriatric syndromes and quality of life in older adults with diabetes

2019 ◽  
Vol 19 (6) ◽  
pp. 518-524 ◽  
Author(s):  
Yi‐Ching Yang ◽  
Ming‐Hsing Lin ◽  
Chong‐Shan Wang ◽  
Feng‐Hwa Lu ◽  
Jin‐Shang Wu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Geriatric Syndromes

scholarly journals Biosocial and disease conditions affecting the quality of life among older adults in Eastern Nepal

2020 ◽  
Author(s):  
Uday Narayan Yadav ◽  
Tarka Bahadur Thapa ◽  
Sabuj Kanti Mistry ◽  
Saruna Ghimire ◽  
Godfred O. Boateng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Poor Quality ◽  
Chronic Obstructive ◽  
Cluster Sampling ◽  
Ageing Population ◽  
Increased Risk ◽  
Lower Likelihood

Abstract Background The ageing population in most low-and middle-income countries is accompanied by an increased risk of non-communicable diseases culminating in a poor quality of life. However, the factors accelerating this poor quality of life (QOL) have not been fully examined. Therefore, this study examined the factors influencing the quality of life of Nepali older adults.Methods Data from a previous cross-sectional study, conducted between January and April 2018 in eastern Nepal, was used. The analytical sample included 794 older adults aged ≥60 years, selected by a multi-stage cluster sampling approach. QOL was measured using the Older People’s Quality of Life tool; dichotomized as poor and good QOL. Other measures used included age, gender, ethnicity, religion, marital status, physical activity and chronic diseases such as osteoarthritis, cardiovascular disease, diabetes, chronic obstructive pulmonary disease (COPD), and depression. The factors associated with quality of life were examined using mixed-effects logistic regression.Results Seven in ten respondents (70.4%) reported a poor quality of life. At the bivariate level, increasing age, unemployment, intake of alcohol, lack of physical activity as well as osteoarthritis, COPD and depression were significantly associated with a lower likelihood of a good quality of life. The adjusted model showed that older age (AOR=0.50, p<0.05), the Christian religion (AOR=0.38, p<0.01), and being from an Indigenous, Dalit, or Madheshi background were associated with a lower likelihood of good quality of life. However, higher income of >Nrs 10,000 (AOR=3.34, p<0.001), daily physical activity (AOR=3.33, p<0.001), and the absence of osteoarthritis and depression were associated with a higher odds ratio of good quality of life.Conclusion The findings of this study echo the need to develop and implement policies aimed at improving the socio-cultural and disease conditions that catalyse poor quality of life in this population.

scholarly journals Health-related Quality of Life (HRQOL) Decreases Independently of Chronic Conditions and Geriatric Syndromes in Older Adults With Diabetes: The Fujiwara-kyo Study

2014 ◽  
Vol 24 (4) ◽  
pp. 259-266 ◽  
Author(s):  
Satoko Nezu ◽  
Nozomi Okamoto ◽  
Masayuki Morikawa ◽  
Keigo Saeki ◽  
Kenji Obayashi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Chronic Conditions ◽  
Geriatric Syndromes ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Assessment of Sarcopenia and Obesity in Patients with Myasthenia Gravis Using Dual-Energy X-ray Absorptiometry: A Cross-Sectional Study

2021 ◽  
Vol 11 (11) ◽  
pp. 1139
Author(s):  
Che-Cheng Chang ◽  
Yen-Kung Chen ◽  
Hou-Chang Chiu ◽  
Jiann-Horng Yeh
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
Muscle Mass ◽  
Cross Sectional Study ◽  
Dual Energy ◽  
Sectional Study ◽  
Cross Sectional ◽  
X Ray ◽  
Composition Changes

Sarcopenia and obesity can negatively impact quality of life and cause chronic fragility, and are associated with neuromuscular diseases, including myasthenia gravis (MG). The long-term consequences of body composition changes in chronic MG remain unknown; we therefore evaluated changes in body composition, including sarcopenia, obesity, lean body mass, and the prevalence of sarcopenic obesity in patients. In this cross-sectional study, 35 patients with MG (mean age: 56.1 years) and 175 matched controls were enrolled. Body fat mass and skeletal muscle mass were measured using whole body dual-energy X-ray absorptiometry. Patients with MG exhibited a higher prevalence of obesity and higher android adiposity and total body fat percentage than those of controls. Although the prevalence of sarcopenia and sarcopenic obesity did not increase with age, there was a decrease in arm and android muscle mass in patients with MG compared with controls. Lower muscle mass percentages were correlated with increased age and MG severity, but not with corticosteroid use. Thus, MG is associated with increased risk for obesity and decreased muscle mass with aging, regardless of corticosteroid use. Therefore, accurate diagnosis of body composition changes in MG could facilitate the application of appropriate therapies to promote health, improve quality of life, and prevent fragility.

scholarly journals Physical Performance and Quality of Life in Older Adults: Is There Any Association between Them and Potential Drug Interactions in Polymedicated Octogenarians

2019 ◽  
Vol 16 (21) ◽  
pp. 4190 ◽  
Author(s):  
Verde ◽  
García de Diego ◽  
Chicharro ◽  
Bandrés ◽  
Velasco ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Drug Interactions ◽  
Physical Performance ◽  
Poor Quality ◽  
Potential Interaction ◽  
Cognitive Status ◽  
Community Dwelling ◽  
Increased Risk

Older adults are at increased risk of several cytochrome P450 (CYP) drug interactions that can result in drug toxicity, reduced pharmacological effect, and adverse drug reactions. This study aimed to assess the prevalence of potential CYP interactions referring to the most clinically relevant drugs and exploring the relationship between them and quality of life and physical performance in Spanish octogenarians. Institutionalized and community-dwelling octogenarians (n = 102) treated at three primary care centers, were recruited by a research nurse. Anthropometric measurements, chronic diseases, prescribed drugs, quality of life, physical performance, mobility skills, hand grip strength and cognitive status data were collected. Potential CYP drug-drug interactions (DDIs) were selected referring to the main CYP implicated in their metabolism. The 72.2% of recruited octogenarians presented potentially inappropriate CYP inhibitor-substrate or CYP inductor-substrate combinations. Analyzing the EuroQol Visual Analogue scale (EQ-VAS) results, patients with a potential CYP DDI perceived worse health status than patients without it (p = 0.004). In addition, patients with a potential CYP DDI presented worse exercise capacity, kinesthetic abilities, or mobility than those who didn’t present a potential interaction (p = 0.01, p = 0.047, and p = 0.02, respectively). To investigate and control factors associated with loss of muscle strength and poor quality of life, polypharmacy and DDIs could help institutions in the management of physical frailty.

scholarly journals Fuzzification Based Osteoporosis Prediction Model

2021 ◽  
Vol 10 (6) ◽  
pp. 28-31
Author(s):  
Shilpa Kumar ◽  
Shubangi D C
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Fuzzy Logic ◽  
Fuzzy Inference ◽  
Dual Energy ◽  
Literature Survey ◽  
Inference System ◽  
X Ray ◽  
The World

Osteoporosis is a disease in which bones become fragile and more likely to break. Osteoporosis can progress painlessly until it causes a bone fracture or a bone break. Dual Energy X-ray Absorptiometry (DEXA) is more costly and not accessible easily so we are using Fuzzy Inference system to predict osteoporosis. In this fuzzy logic, we collect risk factors and rules for osteoporosis and build a interface which take inputs and predicts if a person has osteoporosis. In the following Literature survey, we will take risk factors, rules, and ways to implement them. Around the world, 33% of women and 20% men over the age of 50 will suffer a fracture caused by Osteoporosis. Osteoporosis is a disease in which Bones become shallow and are fractured. If predicted before, quality of life will increase and severe surgery may be avoided.

Biosocial and disease conditions is associated with good quality of life among older adults in Eastern Nepal

2020 ◽  
Author(s):  
Uday Yadav ◽  
Tarka Bahadur Thapa ◽  
Sabuj Kanti Mistry ◽  
Saruna Ghimire ◽  
Godfred O. Boateng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Poor Quality ◽  
Chronic Obstructive ◽  
Cluster Sampling ◽  
Ageing Population ◽  
Increased Risk ◽  
Lower Likelihood

Abstract Background The ageing population in most low-and middle-income countries is accompanied by an increased risk of non-communicable diseases culminating in a poor quality of life. However, the factors accelerating this poor quality of life (QOL) have not been fully examined. Therefore, this study examined the factors influencing the quality of life of Nepali older adults. Methods Data from a previous cross-sectional study, conducted between January and April 2018 in eastern Nepal, was used. The analytical sample included 794 older adults aged ≥60 years, selected by a multi-stage cluster sampling approach. QOL was measured using the Older People’s Quality of Life tool; dichotomized as poor and good QOL. Other measures used included age, gender, ethnicity, religion, marital status, physical activity and chronic diseases such as osteoarthritis, cardiovascular disease, diabetes, chronic obstructive pulmonary disease (COPD), and depression. The factors associated with quality of life were examined using mixed-effects logistic regression. Results Seven in ten respondents (70.4%) reported a poor quality of life. At the bivariate level, increasing age, unemployment, intake of alcohol, lack of physical activity as well as osteoarthritis, COPD and depression were significantly associated with a lower likelihood of a good quality of life. The adjusted model showed that older age (AOR=0.50, p<0.05), the Christian religion (AOR=0.38, p<0.01), and being an Indigenous, Dalit, or Madheshi were associated with a lower likelihood of good quality of life. However, higher income of >Nrs 10,000 (AOR=3.34, p<0.001), daily physical activity (AOR=3.33, p<0.001), and the absence of osteoarthritis and depression were associated with a higher odds of good quality of life. Conclusion The findings of this study echo the need to develop and implement policies aimed at improving the socio-cultural and disease conditions that catalyse poor quality of life in this population.

Problems and fall risk determinants of quality of life in older adults with increased risk of falling

2014 ◽  
Vol 15 (5) ◽  
pp. 579-587 ◽  
Author(s):  
Sang-I Lin ◽  
Ku-Chou Chang ◽  
Hsuei-Chen Lee ◽  
Yi-Ching Yang ◽  
Jau-Yih Tsauo
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Fall Risk ◽  
Risk Of Falling ◽  
Increased Risk ◽  
Risk Determinants

scholarly journals Effects of adolescence-onset hypogonadism on metabolism, bone mineral density and quality of life in adulthood

2015 ◽  
Vol 28 (9-10) ◽  
Author(s):  
Friederike I.W. Tam ◽  
Angela Huebner ◽  
Lorenz C. Hofbauer ◽  
Julia Rohayem
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
General Population ◽  
Medical Care ◽  
Hormone Replacement ◽  
Dual Energy ◽  
Z Score ◽  
Mineral Density ◽  
X Ray

AbstractIn a cross-sectional study of 54 patients with adolescence-onset hypogonadism (33 females, 21 males; age range: 19–40 years), medical care, quality of life, and health status were assessed. Most patients had received adequate medical care with short cumulative periods of interruption of hormone replacement. The prevalence of the metabolic syndrome was 27% in females and 19% in males. In comparison to the general population, females had both a lower bone mineral density (dual-energy X-ray absorptiometry, Z-score=−0.8, p<0.001) and a higher prevalence of obesity (age 19–29 years: study population 35%, general population 4%). The body fat percentage (dual-energy X-ray absorptiometry) was significantly elevated (age 19–29 years: females Z-score=+1.8, p<0.001, males Z-score=+2.4, p=0.001). Quality of life (SF-36) was normal. Despite adequate treatment, patients with early-onset hypogonadism are prone to develop signs and symptoms consistent with inadequate hormone replacement. A successful transition from pediatric to adult medicine seems important to optimize treatment outcomes.

Sign in / Sign up

Export Citation Format

Share Document