scholarly journals Gambaran histopatologi kanker payudara Periode Januari 2012 – Desember 2012

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Syendi Tanriono
Keyword(s):  
Breast Cancer ◽  
Gold Standard ◽  
Invasive Carcinoma ◽  
Histopathological Examination ◽  
Biological Tissues ◽  
Survey Method ◽  
Pathology Laboratory ◽  
Ductal Invasive Carcinoma ◽  
Diagnosis Of Cancer ◽  
Anatomical Pathology

Abstract: Cancer is a class of diseases characterized by uncontrolled cell division and the ability of these cells to invade other biological tissues, either by direct growth in adjacent tissue (invasion) or by migration of cells to distant sites (metastasis). There are several methods that can be used in diagnosis of cancer. But until now, the gold standard to diagnosis of cancer is histopathological examination. The examination can determine the type of both malignant and benign cancers. Currently, breast cancer is one of the most prevalent cancers in worldwide, and became the highest cause of death from the other cancers. That is why the research was conducted in order to find out an overview of breast cancer histopathology. This research is a descriptive retrospective survey method through data collection, analysis, and evaluation of the amount of histopathological examination of breast cancer patients in the Anatomical Pathology Laboratory Manado period January 2012- December 2012. Data collected through the analysis of 163 medical records description of breast cancer histopathological period of January 2012- December 2012 were selected from a total sampling methods. These results indicate that the description of breast cancer histopathology most commonly found in the Anatomical Pathology Laboratory Manado period January 2012- December 2012 were fibroadenomas were 62 cases ( 38.1 % ) and ductal invasive carcinoma followed by 49 cases ( 30.1 % ). Most women and the most common age group 40-49 years. Breast cancer histopathology most commonly found in the Anatomical Pathology Laboratory Manado period January 2012- December 2012 were fibroadenomas were 62 cases ( 38.1 % ) and ductal invasive carcinoma followed by 49 cases ( 30.1 % ).Key words: breast cancer, histopathology   Abstrak: Kanker merupakan segolongan penyakit yang ditandai dengan pembelahan sel yang tidak terkendali dan kemampuan sel-sel tersebut untuk menyerang jaringan biologis lainya , baik dengan pertumbuhan langsung di jaringan yang bersebelahan (Invasi) atau dengan migrasi sel ke tempat yang jauh (metastasis). Ada beberapa metode yang dapat digunakan dalam mendiagnosis kanker. Tetapi sampai sekarang yang menjadi gold standard dalam mendiagnosis kanker adalah pemeriksaan histopatologi. Dimana dalam pemeriksaan ini dapat menentukan jenis kanker baik ganas maupun jinak. Saat ini kanker payudara merupakan salah satu kanker yang paling banyak dijumpai diseluruh dunia, dan menjadi penyebab kematian tertinggi akibat kanker. Maka dari itulah penelitian ini dilakukan guna untuk mencari tahu gambaran histopatologi kanker payudara. Penelitian ini merupakan penelitian bersifat deskriptif dengan metode survey retrospektif melalui pengumpulan data, analisis, dan evaluasi jumlah hasil pemeriksaan histopatologi penderita kanker payudara di Laboratorium Patologi Anatomi Manado periode januari 2012-desember 2012. Pengumpulan data dilakukan melalui analisis pada 163 data rekam medis dari gambaran histopatologi kanker payudara periode januari 2012-desember 2012 yang dipilih dari metode total sampling. Hasil penelitian ini menunjukan bahwa gambaran histopatologi kanker payudara yang paling banyak ditemukan di Laboratorium Patologi Anatomi Manado periode januari 2012-desember 2012 adalah fibroadenoma sebanyak 62 kasus (38.1%) dan diikuti duktal karsinoma invasif sebanyak 49 kasus (30.1%). Terbanyak pada perempuan dan umur tersering golongan 40-49 tahun. Gambaran histopatologi kanker payudara terbanyak di Laboratorium Patologi Anatomi Manado periode januari 2012-desember 2012 adalah fibroadenoma sebanyak 62 kasus (38.1%) dan diikuti duktal karsinoma invasif sebanyak 49 kasus (30.1%). Kata kunci: kanker payudara, histopatologi

Peritoneal metastases in breast cancer patients: Differences in survival depending on histological subtype

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e12024-e12024
Author(s):  
Z. Atassi ◽  
D. Varga ◽  
K. Plotzki ◽  
C. Kurzeder ◽  
R. Kreienberg
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Invasive Carcinoma ◽  
Peritoneal Metastases ◽  
Breast Cancer Patients ◽  
Histologic Subtype ◽  
Cancer Subtypes ◽  
Ductal Invasive Carcinoma

e12024 Background: Distant spread from breast cancer is commonly found in bones, lungs, liver, and central nervous system. Metastatic involvement of peritoneum and retroperitoneum is unusual and unexpected. The aim of the study was to perform a comprehensive analysis of breast cancer patients with peritoneal metastases and to compare survivals depending on biological subtypes. Methods: 44 breast cancer pts with peritoneal metastases were detected out of a database of 2,500 breast cancer patients treated in one institution between 1995 and 2005. Clinical characteristics such as estrogen receptor and progesterone receptor as well as survivals were analized based on breast cancer subtypes. Results: Mean patient age was 54 years, 25 patients (56%) had ductal invasive carcinoma while 19 (44%) were diagnosed lobular invasive carcinoma. 30 (68%) patients had endocrine responsive tumors. A HER-2 percentage is not provided due to the lack of data before the year 2000. Median survival calculated from peritoneal metastases in histologic subgroups was as follows: Median progression free survival was 36.5 months for ductal invasive carcinoma, and 23.5 months for lobular invasive breast cancer. Median overall survival was 46 (Std 38.5) months for ductal invasive breast cancer and 32 (Std 54.5) months for lobular invasive breast cancer. Conclusions: Patients with peritoneal metastases are a heterogenous group with a different outcome. The histologic subtype seems to be an important predictive factor as lobular invasive breast cancer is associated with worsened progression free an overall survival rates. No significant financial relationships to disclose.

scholarly journals UTILIZATION OF 1% OF METHYLENE BLUE IN STAINING HISTOPATHOLOGICAL PREPARATIONS AT ANATOMIC PATHOLOGY LABORATORY

2020 ◽  
Vol 2 (2) ◽  
pp. 93-100
Author(s):  
Tri Rahmawati ◽  
Yadi Apriyadi ◽  
Mamay
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Methylene Blue ◽  
Cell Nuclei ◽  
Ionic Charge ◽  
Pathology Laboratory ◽  
Basic Dyes ◽  
Hematoxylin Eosin ◽  
Anatomical Pathology

Tissue staining using hematoxylin-eosin (HE) is a standard method of histopathological staining. The tissue staining is hampered when there is no hematoxylin reagent in laboratory. Therefore, other reagents are needed that can replace the use of hematoxylin. Methylene blue is a basic dyes that interact with cell nuclei which has a negative ionic charge of the tissue. It can be used as an alternative nuclei staining. This study aims to evaluate the use of 1% of methylene blue in cell nuclei staining in histopathological preparations. The research sample were 15 pathology preparations which were randomly selected including breast cancer, cervical cancer and ovarian cancer in the bank of sampel at anatomical pathology laboratory of RSUD Dr. Slamet Garut, Indonesia. The experiment showed that the methylene blue dyes yielded “worth” result (40%) and “poorly” result (60%). Further research can be carried out by modifying the pH of 1% of methylene blue reagent so that it can maximize the staining preparations results as good as those using hematoxylin.

scholarly journals 34. Anatomical Pathology And Histopathological Changes Of Ascaridia Galli In Layer Chicken

2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Muhammad Hambal ◽  
Rizki Efriyendi ◽  
Henni Vanda ◽  
Rusli Rusli
Keyword(s):  
Intestinal Mucosa ◽  
Histopathological Examination ◽  
Intestinal Lumen ◽  
Ascaridia Galli ◽  
Histopathological Changes ◽  
Pathology Laboratory ◽  
Treatment And Prevention ◽  
Layer Chicken ◽  
Relationship Of ◽  
Anatomical Pathology

This study aimed to determine the anatomical pathology and histopathological, and their relationship of the ascaridiosis caused by Ascaridia galli worms infection that have been found in layer chickens after necropsy, thus facilitating the diagnosis, treatment, and prevention of ascaridiosis. This study used 1 dead chicken from the Lambaro traditional market, Ingin Jaya District, Aceh Besar Regency. The sample was taken to the Pathology Laboratory, Faculty of Veterinary Medicine, Syiah Kuala University for dissected and observed in anatomical pathology changes, then histopathological preparations were made to observe histopathological changes. Data were obtained then analyzed descriptively and presented in the form of images. The results of anatomical pathology examination in chickens infected with ascaridiosis were found the Ascaridia galli worms infestation in the intestinal lumen with moderate infestation rates and focal area of hemorrhage in the intestinal mucosa. Then, histopathological examination were found desquamation of villous epithelium, hemorrhage in the intestinal mucosa, inflammatory cell infiltration, and proliferation of cryptic cells caused by A. galli worms infection. Based on the results of the examination concluded that there is an association between anatomical and histopathological pathology findings, namely hemorrhage in the intestine.

scholarly journals Concurrent Bowen’s Disease of the Nipple and Breast Cancer

2020 ◽  
Vol 13 (3) ◽  
pp. 1410-1414
Author(s):  
Kei Yamaguchi ◽  
Ryoichi Matsunuma ◽  
Toko Kumeta ◽  
Sae Imada ◽  
Ryosuke Hayami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Squamous Cell Carcinoma ◽  
Carcinoma In Situ ◽  
Histopathological Examination ◽  
Careful Examination ◽  
Bowen’S Disease ◽  
Ipsilateral Breast ◽  
Surgical Specimen ◽  
Bowen's Disease

Bowen’s disease is a squamous cell carcinoma in situ that commonly develops on the trunk, arms, or legs and has not spread beyond the top layer of skin. It seldom develops on the nipple. We report a patient who presented with Bowen’s disease of the nipple and had a concurrent breast cancer identified in the ipsilateral breast after careful examination. Histopathological examination of the surgical specimen after mastectomy confirmed the diagnoses.

scholarly journals SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Dongquan Chen ◽  
Yufeng Li ◽  
Lizhong Wang ◽  
Kai Jiao
Keyword(s):  
Breast Cancer ◽  
Expression Profile ◽  
Heart Development ◽  
Invasive Carcinoma ◽  
Patient Survival ◽  
The Cancer Genome Atlas ◽  
Breast Cancer Patients ◽  
Genomic Expression ◽  
Cancer Genome Atlas ◽  
Public Datasets

Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients’ survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

scholarly journals Breast Thermograms Asymmetry Analysis using Gabor filters

2021 ◽  
Vol 309 ◽  
pp. 01109
Author(s):  
Priyanka Yadlapalli ◽  
Madhavi K Reddy ◽  
Sunitha Gurram ◽  
J Avanija ◽  
K Meenakshi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Cost Effective ◽  
Gabor Filters ◽  
Support Vector ◽  
Svm Classifier ◽  
Infrared Thermal Imaging ◽  
Younger Women ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer

Women are far more likely than males to acquire breast cancer, and current research indicates that this is entirely avoidable. It is also to blame for higher death rates among younger women compared to older women in nearly all developing nations. Medical imaging modalities are continuously in need of development. A variety of medical techniques have been employed to detect breast cancer in women. The most recent studies support mammography for breast cancer screening, although its sensitivity and specificity remain suboptimal, particularly in individuals with thick breast tissue, such as young women. As a result, alternative modalities, such as thermography, are required. Digital Infrared Thermal Imaging (DITI), as it is known, detects and records temperature changes on the skin’s surface. Thermography is well-known for its non-invasive, painless, cost-effective, and high recovery rates, as well as its potential to identify breast cancer at an early stage. Gabor filters are used to extract the textural characteristics of the left and right breasts. Using a support vector machine, the thermograms are then classified as normal or malignant based on textural asymmetry between the breasts (SVM). The accuracy achieved by combining Gabor features with an SVM classifier is around 84.5 percent. The early diagnosis of cancer with thermography enhances the patient’s chances of survival significantly since it may detect the disease in its early stages.

scholarly journals Karakteristik Klinikopatologik Pasien Kanker Payudara dengan Metastasis Tulang di RSUP Sanglah pada Tahun 2014 - 2018

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Putu Krishna B. S. Putra ◽  
I Wayan J. Sumadi ◽  
Ni Putu Sriwidyani ◽  
IG Budhi Setiawan
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Invasive Carcinoma ◽  
Molecular Subtype ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Luminal B ◽  
Histopathological Type

Abstract: Breast cancer is the most common cancer in woman. Metastasis often occurs especially to the bones. This study was aimed to determine the characteristics of breast cancer patients with bone metastasis. This was a descriptive study with a cross-sectional design. Samples were 46 breast cancer patients with bone metastasis recorded at Sanglah Hospital from 2014 until 2018. Data of pathological examination archives of Oncology Surgery Division Medical Faculty of Udayana University/Sanglah General Hospital were used to obtain the clinicopathological characteristics of metastatic breast cancer patients based on age, lateralization, histopathological type, and tumor molecular subtype. The results showed that most cases of metastatic breast cancer were aged 40-49 years as many 21 patients (45.7%), minimal difference in lateralization between right breast as many 22 patients (47.8%) and left breast 23 patients (50%). The most common histopathological type was invasive carcinoma of no special type as many 34 patients (73.9%). The most common tumor subtype was the luminal B subtype as many 21 patients (45.7%). In conclusion, most patients of breast cancer with bone metastasis were 40-49 years old, invasive carcinoma of no special type, molecular subtype of luminal B, and no significant difference between lateralization to the right and left breast.Keywords: breast cancer, bone, metastasis, clinicopathological caharacteristics Abstrak: Kanker payudara merupakan jenis kanker yang paling sering dijumpai pada wanita. Metastasis sering terjadi terutama pada tulang. Penelitian ini bertujuan untuk mengetahui karakteristik pasien kanker payudara dengan metastasis tulang di RSUP Sanglah Denpasar. Jenis penelitian ialah deskriptif dengan desain potong lintang. Sampel penelitian ialah 46 pasien kanker payudara dengan metastasis tulang yang tercatat di RSUP Sanglah tahun 2014-2018. Data diambil dari arsip hasil pemeriksaan patologi di Subdivisi Bedah Onkologi, Departemen/Kelompok Staf Medis (KSM) Bedah Fakultas Kedokteran Universitas Udayana (FK UNUD)/RSUP Sanglah untuk mendapatkan karakteristik klinikopatologi pasien kanker payudara metastasis tulang berdasarkan usia, lateralisasi, tipe histopatologik, dan subtipe molekuler tumor. Hasil penelitian menunjukkan kasus terbanyak terjadi pada rentang usia 40-49 tahun sebanyak 21 orang (45,7%), dengan lateralisasi tidak jauh berbeda antara payudara kanan sebanyak 22 orang (47,8) dan kiri sebanyak 23 orang (50%). Tipe histopatologik yang lebih sering ditemukan yaitu invasive carcinoma of no special type sebanyak 34 orang (73,9%). Subtipe molekuler yang paling banyak ditemukan ialah subtipe luminal B sebanyak 21 orang (45,7%). Simpulan penelitian ini pasien kanker payudara dengan metastasis tulang berada pada rentang usia 40-49 tahun, invasive carcinoma of no special type, subtipe molekuler luminal B. dan lateralisasi payudara kanan dan kiri tidak jauh berbeda.Kata kunci: kanker payudara, metastasis, tulang, karakteristik klinikopatologik

Sign in / Sign up

Export Citation Format

Share Document