scholarly journals Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy

2019 ◽  
Vol 20 (4) ◽  
pp. 1-8
Author(s):  
Elbialy Elmorsy ◽  
Khalid Abouelnasr ◽  
Esam Mosbah ◽  
Adel Zaghloul
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Dose Rate ◽  
Serum Levels ◽  
The Other ◽  
Serum Concentrations ◽  
Randomized Controlled ◽  
Anesthetic Drugs ◽  
Post Surgery ◽  
Local Analgesics

Objective: To evaluate the effect of multimodal analgesic drugs for alleviation of pain accompanying laparo-ovariectomy in goat. Design: Randomized controlled experimental study. Animals: Sixteen goats ageing 8-18 months and weighing 20 kg on average. Procedures: The proposed site of laparotomy in all animals was infiltrated with lidocaine hydrochloride 1% 15 minutes before surgery started. The goats were allocated into four groups of four animals each; first group (L): animals received Lidocaine infltration , second group (PL): animals received Piroxicam at a dose rate of 5 mg/kg IM, third group (PPL): animals received Piroxicam and Propofol at a dose rate of (5 mg/kg and 6 mg/kg, respectively), and finally fourth group (PPBL): animals received Butorphanol at a dose rate of 0.1 mg/kg in addition to Piroxicam- Propofol . Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum concentrations of lactate, creatinine, blood urea nitrogen (BUN), interleukin-6 (IL-6), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined at baseline (15 minutes prior to surgery), directly after administration of the anesthetic agent, during surgery, and post-surgery at 30 minutes, 60 minutes, 120 minutes for 1-3 days postoperatively. Additionally, the analgesia score was monitored. Results: Heart rate, respiratory rate, Serum levels of IL 6, BUN and ALT decreased significantly in PPBL group compared to the other groups (P≤0.05). In addition, analgesia scores were significantly higher in PPBL group than the other groups (P≤0.05). Conclusion and clinical relevance: It could be concluded that the use of Propofol and Butorphanol in the analgesic protocol during laparo-ovariectomy in goats can alleviate stress and pain response and could therefore potentiate the effects of local analgesics.

scholarly journals The effect of adenotonsillectomy for childhood sleep apnoea on cardiorespiratory control

2016 ◽  
Vol 2 (2) ◽  
pp. 00003-2016 ◽  
Author(s):  
Mathias Baumert ◽  
Yvonne Pamula ◽  
James Martin ◽  
Declan Kennedy ◽  
Anand Ganesan ◽  
...  
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Obstructive Sleep Apnoea ◽  
Respiratory Sinus Arrhythmia ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Sinus Arrhythmia ◽  
Cardiorespiratory Control ◽  
Post Surgery ◽  
Obstructive Sleep

The efficacy of adenotonsillectomy for relieving obstructive sleep apnoea symptoms in children has been firmly established, but its precise effects on cardiorespiratory control are poorly understood.In 375 children enrolled in the Childhood Adenotonsillectomy Trial, randomised to undergo either adenotonsillectomy (n=194) or a strategy of watching waiting (n=181), respiratory rate, respiratory sinus arrhythmia and heart rate were analysed during quiet, non-apnoeic and non-hypopnoeic breathing throughout sleep at baseline and at 7 months using overnight polysomnography.Children who underwent early adenotonsillectomy demonstrated an increase in respiratory rate post-surgery while the watchful waiting group showed no change. Heart rate and respiratory sinus arrhythmia were comparable between both arms. On assessing cardiorespiratory variables with regard to normalisation of clinical polysomnography findings during follow-up, heart rate was reduced in children who had resolution of obstructive sleep apnoea syndrome, while no differences in their respiratory rate or respiratory sinus arrhythmia were observed.Adenotonsillectomy for obstructive sleep apnoea increases baseline respiratory rate during sleep. Normalisation of apnoea–hypopnoea index, spontaneously orviasurgery, lowers heart rate. Considering the small average effect size, the clinical significance is uncertain.

scholarly journals Chronic Exposure to Cadmium Disrupts the Adrenal Gland Activity of the NewtTriturus carnifex(Amphibia, Urodela)

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Flaminia Gay ◽  
Vincenza Laforgia ◽  
Ivana Caputo ◽  
Carla Esposito ◽  
Marilena Lepretti ◽  
...  
Keyword(s):  
Drinking Water ◽  
Adrenal Gland ◽  
Human Health ◽  
European Community ◽  
Chronic Exposure ◽  
Adrenocorticotropic Hormone ◽  
Serum Levels ◽  
The Other ◽  
Serum Concentrations ◽  
Ministry Of Health

We intended to verify the safety of the freshwater values established for cadmium by the European Community and the Italian Ministry of Health in drinking water (5 μg/L) and sewage waters (20 μg/L). Therefore, we chronically exposed the newtTriturus carnifexto 5 μg/L and 20 μg/L doses of cadmium, respectively, during 3 and 9 months and verified the effects on the adrenal gland. We evaluated the serum concentrations of adrenocorticotropic hormone (ACTH), corticosterone, aldosterone, norepinephrine, and epinephrine. During the 3-month exposure, both doses of cadmium decreased ACTH and corticosterone serum levels and increased aldosterone and epinephrine serum levels. During the 9-month exposure, the 5 μg/L dose decreased ACTH and increased aldosterone and epinephrine serum levels; the 20 μg/L dose decreased norepinephrine and epinephrine serum levels, without affecting the other hormones. It was concluded that (1) chronic exposure to the safety values established for cadmium disrupted the adrenal gland activity and (2) the effects of cadmium were related both to the length of exposure and the dose administered. Moreover, our results suggest probable risks to human health, due to the use of water contaminated by cadmium.

scholarly journals Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits

2018 ◽  
Vol 74 (10) ◽  
pp. 646-652 ◽  
Author(s):  
ABDULLAH KARASU ◽  
NURI ALTUG ◽  
LOGMAN ASLAN ◽  
BAHTIYAR BAKIR ◽  
NAZMI YUKSEK
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Hematological Parameters ◽  
The Other ◽  
Equal Treatment ◽  
Anesthesia Induction ◽  
Treatment Groups ◽  
Reference Limits ◽  
Hematological And Biochemical Parameters

The aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletamine-zolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p < 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable..

Hypothermia below 25 C for one day in the rat

1962 ◽  
Vol 17 (1) ◽  
pp. 107-109 ◽  
Author(s):  
Peter J. Connaughton ◽  
F. John Lewis
Keyword(s):  
Heart Rate ◽  
Survival Rate ◽  
Respiratory Rate ◽  
The Other ◽  
Body Temperatures ◽  
Adult Rats ◽  
Better Than

Adult rats were subjected to 24 hr of hypothermia at body temperatures below 25 C because of several characteristics which indicated that rats might withstand such a procedure better than dogs. Two groups were studied: in one the animals were enclosed in a poorly ventilated Lucite cylinder; the rats in the other group were merely wrapped in a cooling blanket. Those rats cooled while in a poorly ventilated enclosure had a significantly increased survival rate; factors which may have influenced this increased survival are discussed. The changes in hematocrit, respiratory rate, and heart rate parallel those observed previously in the dog subjected to the same procedure. Submitted on October 26, 1960

scholarly journals Percutaneous epidural adhesiolysis – treatment method for drug-resistant back pain

2021 ◽  
Author(s):  
Andrzej Zawadzki ◽  
Marta Zawadzka ◽  
Mateusz Maciej Węclewicz ◽  
Wojciech Skrobot ◽  
Wojciech Kloc
Keyword(s):  
Back Pain ◽  
Randomized Controlled Trials ◽  
Treatment Method ◽  
Controlled Trials ◽  
Drug Resistant ◽  
Randomized Controlled ◽  
Canal Stenosis ◽  
Anesthetic Drugs ◽  
Post Surgery ◽  
Experienced Physician

Introduction: Percutaneous epidural adhesiolysis (epidural decompressive neuroplasty, percutaneous epidural neuroplasty) is treatment method for drug-resistant back pain, including post-surgery syndrome, sciatica or spinal canal stenosis. Aim: To describe the method and outcomes of epidural adhesiolysis. Material and methods: The review of the literature on the topic of epidural adhesiolysis. Results and discussion: This procedure is usually performed in the lumbo-sacral part of the spine, although it can be also done in the cervical or thoracic parts as well. Its purpose is to administer anesthetic drugs, steroids, saline solution or hyaluronidase into the epidural space via one of the three approaches: caudal, interlaminar and transforaminal. The efficacy of epidural adhesiolysis was proven in numerous randomized controlled trials. Conclusions: The efficacy of epidural adhesiolysis was proven in numerous randomized controlled trials. When performed by an experienced physician, epidural adhesiolysis is a safe and effective method with infrequent adverse events.

scholarly journals Serum levels of interleukin-6 are not dependent on the kidney function

1992 ◽  
Vol 1 (3) ◽  
pp. 197-199 ◽  
Author(s):  
L. Nässberger
Keyword(s):  
Molecular Weight ◽  
Kidney Function ◽  
Interleukin 6 ◽  
Serum Levels ◽  
The Other ◽  
Serum Concentrations ◽  
Complement Protein ◽  
Protein Factor ◽  
Stimulatory Factor ◽  
Reduced Kidney Function

Interleukin-6, also named B-cell stimulatory factor, is a glycoprotein with a molecular weight of 26 kDa. Increased serum levels of interleukin-6 (IL-6) are found in several disease conditions. We investigated the importance of a deteriorated kidney function upon IL-6 serum concentrations. No relation was found between serum levels of IL-6 and s-creatinine, r = 0.004. On the other hand, the serum concentration of complement protein factor D and soluble IL-2 receptor showed a good correlation to s-creatinine, r = 0.92 and 0.79, respectively. In conclusion, serum levels of IL-6 are not dependent upon a reduced kidney function.

Serum levels of estrogens and of five 'steroid sensitive' proteins in early normal pregnancy

1988 ◽  
Vol 118 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Lottie Skjöldebrand Sparre ◽  
Jan Brundin ◽  
Anders Carlström ◽  
Bo von Schoultz ◽  
Kjell Carlström
Keyword(s):  
Serum Levels ◽  
Normal Pregnancy ◽  
The Other ◽  
Sex Hormone Binding Globulin ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Protein Levels ◽  
Physiological Regulator ◽  
Steroid Sensitive ◽  
Estradiol 17Β

Abstract. Serum concentrations of sex hormone binding globulin (SHBG), pregnancy associated α2-glycoprotein (α2-PAG), caeruloplasmin (Cp), α1-antitrypsin (α1-At) and transferrin (Tf), unconjugated and total estrone, and unconjugated estradiol-17β were measured twice at a 4–5 week interval in 43 cases of early normal pregnancy (gestational weeks 6–19). Significant correlations between estrogen and protein levels in the total material were observed for all proteins except for Tf. However, within 2-week intervals of pregnancy, significant correlations were obtained only in certain intervals between estrogens on one hand and SHBG, Cp and α1-At on the other. Significant correlations between rates of increase of estrogens and of proteins were obtained only at certain occasions for SHBG, Cp, Tf and α1-At. The results indicate that, although estrogens may have a modulatory function in 'steroidsensitive' protein synthesis, they are probably not the main physiological regulator.

scholarly journals The effect of spinal manipulative therapy and home stretching exercises on heart rate variability in patients with persistent or recurrent neck pain: a randomized controlled trial

2021 ◽  
Vol 29 (1) ◽  
Author(s):  
Anders Galaasen Bakken ◽  
Andreas Eklund ◽  
David M. Hallman ◽  
Iben Axén
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Neck Pain ◽  
Intervention Group ◽  
Spinal Manipulative Therapy ◽  
The Other ◽  
Control Group ◽  
Manipulative Therapy ◽  
Randomized Controlled ◽  
Stretching Exercises

Abstract Background Persistent or recurrent neck pain is, together with other chronic conditions, suggested to be associated with disturbances of the Autonomic Nervous System. Acute effects on the Autonomic Nervous System, commonly measured using Heart Rate Variability, have been observed with manual therapy. This study aimed to investigate the effect on Heart Rate Variability in (1) a combination of home stretching exercises and spinal manipulative therapy versus (2) home stretching exercises alone over 2 weeks in participants with persistent or recurrent neck pain. Methods A randomized controlled clinical trial was carried out in five multidisciplinary primary care clinics in Stockholm from January 2019 to April 2020. The study sample consisted of 131 participants with a history of persistent or recurrent neck. All participants performed home stretching exercises daily for 2 weeks and were scheduled for four treatments during this period, with the intervention group receiving spinal manipulative therapy in addition to the home exercises. Heart Rate Variability at rest was measured at baseline, after 1 week, and after 2 weeks, with RMSSD (Root mean square of successive RR interval differences) as the primary outcome. Both groups were blinded to the other group intervention. Thus, they were aware of the purpose of the trial but not the details of the “other” intervention. The researchers collecting data were blinded to treatment allocation, as was the statistician performing data analyses. The clinicians provided treatment for participants in both groups and could not be blinded. A linear mixed-effects model with continuous variables and person-specific random intercept was used to investigate the group-time interaction using an intention to treat analysis. Results Sixty-six participants were randomized to the intervention group and sixty-five to the control group. For RMSSD, a B coefficient of 0.4 (p value: 0.9) was found, indicating a non-significant difference in the regression slope for each time point with the control group as reference. No statistically significant differences were found between groups for any of the Heart Rate Variability indices. Conclusion Adding four treatments of spinal manipulation therapy to a 2-week program of daily stretching exercises gave no significant change in Heart Rate Variability. Trial Registration: The trial was registered 03/07/2018 at ClinicalTrials.gov, registration number: NCT03576846. (https://pubmed.ncbi.nlm.nih.gov/31606042/)

SUPPRESSION OF SERUM LEVELS OF LUTEINIZING HORMONE BY SHORT- AND LONG-LOOP NEGATIVE FEEDBACK IN OVARIECTOMIZED WOMEN

1979 ◽  
Vol 80 (3) ◽  
pp. 353-356 ◽  
Author(s):  
A. MIYAKE ◽  
T. AONO ◽  
T. KINUGASA ◽  
O. TANIZAWA ◽  
K. KURACHI
Keyword(s):  
Serum Level ◽  
Negative Feedback ◽  
Intramuscular Injection ◽  
Serum Levels ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
The Other ◽  
Serum Concentrations ◽  
Short Loop ◽  
Control Injection

The suppressive effects of short- and long-loop negative feedback on serum levels of LH were assessed after administration of human chorionic gonadotrophin (HCG) and conjugated oestrogens. Fourteen ovariectomized women were injected intravenously with 5 mg conjugated oestrogens, eight of these patients were also given an intramuscular injection of 10 000 i.u. HCG 8 h later, while the other six patients were given a control injection of 0·9% saline. The serum levels of LH decreased by similar amounts in both groups of women. Thirteen other ovariectomized women were initially injected with 10 000 i.u. HCG, i.m., seven of these patients were also given an i.v. injection of 5 mg conjugated oestrogens 8 h later, while the remaining six patients received a control injection of 0·9% saline. The results showed that conjugated oestrogens could further suppress the serum level of LH which had been reduced by prior HCG treatment. In six ovariectomized women who received i.m. saline injections at the start of the experiment and 8 h later, the serum levels of LH did not change significantly. It is concluded that the suppression of the serum concentrations of LH by long-loop negative feedback after administration of 5 mg conjugated oestrogens is greater than that by short-loop negative feedback after treatment with 10 000 i.u. HCG.

Cardiorespiratory variables of the six-minute walking test of women submitted to bariatric surgery.

2014 ◽  
Vol 12 ◽  
pp. 158
Author(s):  
Fabiana Sobral Peixoto-Souza ◽  
Letícia Baltieri ◽  
Dirceu Costa ◽  
Camila Piconi-Mendes ◽  
Irineu Rasera-Junior ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Heart Rate ◽  
Oxygen Saturation ◽  
Respiratory Rate ◽  
Functional Capacity ◽  
Lower Limbs ◽  
Walking Test ◽  
Post Surgery

Introduction: It's known that bariatric surgery provides an improvement in the functional capacity and cardiorespiratory performance. However, most of these studies are limited to the distance walked during the 6MWT as a function of the functional capacity. Objective: The goal of this study was to evaluate the functional capacity and cardiorespiratory responses of women with morbid obesity, applying the six-minute walk test before and 6 months after bariatric surgery. Method: Prospective and observational study in which 14 women with morbid obesity submitted to Roux-en-Y gastric derivation were studied. The volunteers performed made the six-minute walking test (6MWT) before and six months after surgery gastric bypass. The distance walked and the blood pressure were registered as well as the subjective sensation of dyspnea and exhaustion of the lower limbs. In addition, the heart rate, oxygen saturation and respiratory rate were registered at the beginning, during and the end of the 6MWT. Results: An increase in the distance walked was observed 6 months post-surgery (588.92 ± 34.81m) as compared to the preoperative distance (516.28 ± 50.91m). Regarding to the cardiorespiratory variables, which included the heart rate (HR), blood pressure (BP), peripheral oxygen saturation (SatO2), respiratory rate (RR) and sensation of dyspnea, there was a decrease in the systolic and diastolic blood pressures during the recovery period of the 6MWT. There was no statistical difference in the other variables analyzed. Conclusion: the bariatric surgery and the following weight loss provided improvements in the functional capacity and blood pressure values during recovery from the exercise.

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