scholarly journals Synthesis and Bioassay of Novel Quinozolins

2019 ◽  
Vol 17 (72) ◽  
pp. 129-138
Author(s):  
Yasmine Kadom. Al-Majedy
Keyword(s):  
Twist Angle ◽  
Antimicrobial Properties ◽  
Heat Of Formation ◽  
Gram Negative Bacteria ◽  
The Novel ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Ft Ir ◽  
Uv Visible

Novel Quinozolins were synthesized in a good yield through convert lacton to lactam and study the biological activity of the synthesized compounds. Quinozolins were characterized by elemental analysis, FT-IR and UV/visible spectra. The novel Quinozolins have been tested in vitro against (gram positive bacteria Staphylococcus aureus and against other gram negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus vulgaris; in order to assess their antimicrobial properties. Moreover, charge, bond length, bond angle, twist angle, heat of formation and steric energy were calculated by using of the ChemOffice program. The study indicates that these Quinozolins have high activity against tested bacteria. Based on the reported results, it may be concluded that the coumarin act as synthons for synthesis of new Quinozolins derivatives through the replacement of oxygen atom by nitrogen atom.

scholarly journals Synthesis, Characterization, Theoretical Crystal Structure, and Antibacterial Activities of Some Transition Metal Complexes of the Thiosemicarbazone (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed A. Al-Amiery ◽  
Yasmien K. Al-Majedy ◽  
Haziem Abdulreazak ◽  
Hussain Abood
Keyword(s):  
Metal Complexes ◽  
Twist Angle ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Heat Of Formation ◽  
Antibiotic Drugs ◽  
Visible Spectra ◽  
Ft Ir

Problem Statement. In Iraq like most third world countries, attempts discovered new antibiotic drugs derived from thiosemicarbazide and its metal complexes and developed the branch of applied in organic chemistry.Approach. New (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) was synthesized in a good yield by the reaction of pyrrolidone with thiosemicarbazide. Co(II), Ni(II), and Cu(II) complexes of (L) were prepared and characterized by FT-IR, UV/visible spectra,1HNMR, and CHN analyses. Moreover, charge, bond length, bond angle, twist angle, heat of formation, and steric energy were calculated by using of the ChemOffice program, and the DFT calculations for the complexes were done. The free ligand and its metal complexes were testedin vitroagainst several microorganisms (Staphylococcus aurous,E. coli,Proteus vulgaris,Pseudomonas, andKlebsiella pneumoniae) to assess their antimicrobial properties.Results. The study shows that these complexes have octahedral geometry; in addition, it has high activity against tested bacteria.Conclusion/Recommendations. Based on the reported results, it may be concluded that ligand acts as bidentate, neutral ligand, coordinating through one of the nitrogen and sulfur atoms.

scholarly journals Synthesis and Antibacterial Studies of Novel Phosphorus Ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione and its Metal Complexes with some Transition Metals

2010 ◽  
Vol 4 (2) ◽  
pp. 37-45
Author(s):  
Matheel D. Al-Sabti ◽  
Ahmed A. H. Al-Amiery ◽  
Thorria R. Marzoog ◽  
Yasmien K. Al-Majedy
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Cadmium Complex ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Number Of Microorganisms ◽  
Ft Ir ◽  
The Stability

This study involves the chemical synthesis of the novel ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione (DPDTT) by the reaction of 2-diphenylphosphino benzoic acid with absolute ethanol that yield ethyl 2-diphenylphosphino benzoate and by cyclization of this compound with thiosemicarbazide, DPDTT will be produced. The chelating complexes of this ligand with Cr(III), Co(II), Ni(II), Cu(II) and Cd(II) were also prepared and studied. The new complexes were characterized by FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. The stability for the prepared complexes was also measured using the density function theory and it was found that the cadmium complex is the most stable and the chromium complex is the least stable. Free ligand and its metal complexes have been tested in vitro against a number of microorganisms, like gram positive bacteria Staphylococcus aureus and gram negative bacteria E. coli, Proteus vulgaris, Pseudomonas and Klebsiella in order to assess their antimicrobial properties. All complexes showed considerable activity against all the studied bacteria.

scholarly journals Synthesizing, Structuring, and Characterizing Bioactivities of .Cr(III), La(III), and Ce(III) .Complexes with Nitrogen, Oxygen .and Sulpher donor bidentate Schiff base ligands

2021 ◽  
Vol 18 (4(Suppl.)) ◽  
pp. 1545
Author(s):  
Anaam M. Rasheed ◽  
Sinan M. M. Al-Bayati ◽  
Dr.Rehab A.M. Al-Hasani ◽  
Muna Ali Shakir
Keyword(s):  
Schiff Bases ◽  
Schiff Base Ligands ◽  
Minimal Inhibitory Concentrations ◽  
Gram Positive Bacteria ◽  
Physico Chemical ◽  
Visible Spectra ◽  
Ft Ir ◽  
Uv Visible ◽  
Anti Fungal

Two Schiff bases, namely, 3-(benzylidene amino) -2-thioxo-6-methyl 2,5-dihydropyrimidine-4(3H)-one (LS])and 3-(benzylidene amino)-6-methyl pyrimidine 4(3H, 5H)-dione(LA)as chelating ligands), were used to prepare some complexes of Cr(III), La(III), and Ce(III)] ions. Standard physico-chemical procedures including metal analysis M%, element microanalysis (C.H.N.S) , magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identify Metal (III) complexes and  Schiff bases (LS) and (LA). According to findings, a [Cr(III) complex] showed six coordinated octahedral geometry, while [La(III), and Ce(III) complexes]were structured with coordination number seven.  Schiff's bases and mineral complexes were examined in vitro to investigate potential inhibition against Gram-positive bacteria such as Pseudonomous aerugionosa and Gram-negative bacteria such as Staphylococcus aureus. The low concentration for inhibition has been also determined by studying the minimal inhibitory concentrations MIC .Antibiotics (Ampicillin, Amoxicillin) have been chosen to contrast their activity. Furthermore, Anti-fungal activity against two types of fungi ʺAspergillus flavusʺ and ʺPenicillum Spp.ʺ was studied for these compounds. The results of the antibacterial activity were better compared to the standard drugs.

scholarly journals Antimicrobial Studies of novel metal complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one

2009 ◽  
Vol 3 (2) ◽  
pp. 1-12
Author(s):  
Matheel D. Al-Sabti ◽  
Ahmed A. H. Al-Amiery ◽  
Yasmien K. Al-Majedy ◽  
Amel Ali
Keyword(s):  
Metal Complexes ◽  
Room Temperature ◽  
Antimicrobial Properties ◽  
Cadmium Complex ◽  
Antimicrobial Studies ◽  
Visible Spectra ◽  
Number Of Microorganisms ◽  
Ft Ir ◽  
Uv Visible

Chromium )III), cobalt (II), nickel (II), copper (II) and cadmium (II) complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone and 1-benzoyl-3-methyl-1H-pyrazol-5(4H)-one have been synthesized and characterized by elemental analysis, FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. Cadmium complex is expected to have tetrahedral structure while the other complexes are expected to have octahedral structure. The free ligands and their metal complexes have been tested in vitro against a number of microorganisms (Staphylococcus aurous, E.coli, Proteus vulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties.

scholarly journals In Vitro Antimicrobial Properties of Recombinant ASABF, an Antimicrobial Peptide Isolated from the NematodeAscaris suum

2000 ◽  
Vol 44 (10) ◽  
pp. 2701-2705 ◽  
Author(s):  
Hong Zhang ◽  
Shigenobu Yoshida ◽  
Tomoyasu Aizawa ◽  
Ritsuko Murakami ◽  
Masato Suzuki ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Minimum Bactericidal Concentration ◽  
Expression System ◽  
Antimicrobial Properties ◽  
Gram Negative Bacteria ◽  
Disulfide Bridges ◽  
Yeast Expression System ◽  
Gram Positive Bacteria ◽  
Low Ionic Strength

ABSTRACT ASABF is a CSαβ-type antimicrobial peptide that contains four intramolecular disulfide bridges (Y. Kato and S. Komatsu, J. Biol. Chem. 271:30493–30498, 1996). In the present study, a recombinant ASABF was produced by using a yeast expression system, and its antimicrobial activity was characterized in detail. The recombinant ASABF was active against all gram-positive bacteria tested (7 of 7; minimum bactericidal concentration [MBC], 0.03 to 1 μg/ml) exceptLeuconostoc mesenteroides, some gram-negative bacteria (8 of 14; MBC, >0.5 μg/ml), and some yeasts (3 of 9; MBC >3 μg/ml). Slight hemolytic activity (4.2% at 100 μg/ml) against human erythrocytes was observed only under low-ionic-strength conditions. Less than 1 min of contact was enough to kill Staphylococcus aureus ATCC 6538P. The bactericidal activity against S. aureus was inhibited by salts.

Biogenic Gold Nanoparticles and its Antibacterial Activities: Houttuynia Cordata Leaf Extract

2014 ◽  
Vol 1051 ◽  
pp. 392-397
Author(s):  
T.V.M. Sreekanth ◽  
In Yong Eom
Keyword(s):  
Gold Nanoparticles ◽  
Leaf Extract ◽  
Antibacterial Activities ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Houttuynia Cordata ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Uv Visible

Gold nanoparticles (AuNPs) can be prepared in a number of chemical techniques, which are not environmentally friendly. Biosynthesis of nanoparticles by plant extracts is currently under exploitation. In this work, we describe an eco-friendly technique for green synthesis of AuNPs from AuCl4 solution using the Houttuynia cordata leaf extract as reducing agent. The AuNPs were characterized using UV-Visible spectroscopy, SEM, TEM, FTIR and AFM. The UV-Visible spectra indicate a strong plasma resonance that is located at 535 nm. The antibacterial activity of AuNPs was performed on various gram positive and gram negative bacteria. The AuNPs showed more inhibitory activity on gram negative than gram positive bacteria.

scholarly journals Antimicrobial potential of eucalyptus oil and lemongrass oil alone and in combination against clinical bacteria in planktonic and biofilm mode

2021 ◽  
Vol 6 (2) ◽  
pp. 21
Author(s):  
Iram Liaqat ◽  
Amna Asgar
Keyword(s):  
Essential Oils ◽  
Antimicrobial Properties ◽  
Klebsiella Pneumonia ◽  
Gram Negative Bacteria ◽  
High Antimicrobial Activity ◽  
Gram Positive Bacteria ◽  
Natural Substances ◽  
Volatile Products ◽  
Different Strains

The use of natural substances has been trending from past few years. In recent years, the synthetic products obtained from plants have gained immense importance. Essential oils and volatile products obtained from plants are the source of food flavoring, aroma products and fragrance industries. Their use is also common to cure different ailments such as cancer, skin problems and nosocomial infections. Vast research has shown the antimicrobial properties of essential oils obtained from plants. Essential oils of lemongrass and eucalyptus have antiviral, antibacterial, antioxidant and insecticidal characteristics. Lemongrass and eucalyptus oils shows their antibacterial activity towards Gram positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria such as Escherichia coli and Klebsiella pneumonia. Combination of these oils also depicts high antimicrobial activity against different strains of bacteria. This review highlights the use of essential oils of lemongrass and eucalyptus for their in vitro antimicrobial properties against different bacteria in planktonic and biofilm mode. Mode of action by which the oil shows its inhibitory activity will be discussed. Susceptibility shown by different bacteria towards these essential oils and their components will be described

scholarly journals Preparation of New Biologically Active and Water Soluble Dyes: Characterization, Aggregation and Extraction of Metal Ions from Solutions

2019 ◽  
Vol 31 (6) ◽  
pp. 1398-1404
Author(s):  
NEDRA TOUJ ◽  
ABDULLAH SULAIMAN AL-AYED ◽  
NACEUR HAMDI
Keyword(s):  
Azo Dye ◽  
Water Soluble ◽  
Biologically Active ◽  
Gram Negative Bacteria ◽  
Dpph Radical ◽  
Gram Negative ◽  
Ic50 Values ◽  
Ft Ir ◽  
Uv Visible

The synthesis of metallo-phthalocyanines complexes (M = Co, Ni, Cu, Zn) containing azo dye were described in this study. The metallophthalocyanines have been supported by elemental analysis, UV-visible, FT-IR and NMR. The aggregation of phthalocyanine compounds was investigated in different solvents and concentrations. The newly synthesized metallophthalocyanines possess modest antibacterial activity against various Gram-positive and Gram-negative bacteria. Moreover, these complexes have been tested as antioxidant and presented remarkable activities by two different in vitro chemical assays. They were able to reduce DPPH % radical with IC50 values ranging from 3.8 to 7.5 μmol L-1 and some of them also reduced ABTS % radical cation.

scholarly journals Synthesis and Preliminary Biological Activity Evaluation of New N- Substituted Phthalimide Derivatives

2020 ◽  
Vol 29 (1) ◽  
pp. 247-252
Author(s):  
Halah A. Sahib ◽  
Mohammed H. Mohammed
Keyword(s):  
Antimicrobial Activity ◽  
Methyl Ester ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Bacteria And Fungi ◽  
Phenylalanine Methyl Ester

A A new series of bases of Schiff (H2-H4) derived from phthalic anhydrideweresynthesized. These Schiff bases were prepared by the reaction of different amines (tyrosine methyl ester, phenylalanine methyl ester, and isoniazid) with the phthalimide derived aldehyde with the aid of glacial acetic acid or triethylamine ascatalysts. All the synthesized compounds were characterized by (FT-IR and 1HNMR) analyses and were in vitro evaluated for their antimicrobial activity against six various kinds of microorganisms. All the synthesized compounds had been screened for their antimicrobial activity against two Gram-positive bacteria “Staph. Aureus, and Bacillus subtilis”, two Gram-negative bacteria “Escherichia coli, and Klebsiella pneumoniae”, and two fungi species “Candida tropicalis and Candida albicans” using concentrations of 62.5, 125 and 250 µg\mLof derivative in dimethyl sulfoxide(DMSO). All the synthesized compounds showed no activity at all against Gram-positive bacteria, for Gram-negative bacteria and fungi they showed moderate or no activity except compound H1revealedhigh antifungal activityagainstCandida tropicalisat concentrations 125 and 250 µg\ mL. Keywords: Schiff base, phthalic anhydride, antimicrobial.  

Synthesis, Spectral and Antimicrobial Investigation of 2-(Naphthalenel-ylamino)-2- Phenylacetonitrile and 1, 10-Phenanthroline with Five Divalent Transition Metal Ions

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Mohammed Al-Amery1 ◽  
Ashraf Saad Rasheed ◽  
Dina A. Najeeb
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Gram Negative Bacteria ◽  
Magnetic Studies ◽  
Gram Positive Bacteria

Five new mixed ligand metal complexes have been synthesized by the reaction of divalent transition metal ions (Hg, Ni, Zn, Cu and Cd) with 2-(naphthalen-l-ylamino)-2-phenylacetonitrile (L1 ) and 1,10-phenanthroline (L2). The coordination likelihood of the two ligands toward metal ions has been suggested in the light of elemental analysis, UV-Vis spectra, FTIR, 1H-NMR, flam atomic absorption, molar conductance and magnetic studies. Results data suggest that the octahedral geometry for all the prepared complexes. Antibacterial examination of synthesized complexes in vitro was performed against four bacterias. Firstly, Gram-negative bacteria namely, Pseudomonas aerugin and Escherichia. Secondly, Gram-positive bacteria namely, Bacillus subtilis, Staphylococcuaurouss. Results data exhibit that the synthesized complexes exhibited more biological activity than tetracycline pharmaceutical.

Sign in / Sign up

Export Citation Format

Share Document