scholarly journals MANAGEMENT OF PREGNANCY AND DELIVERY IN WOMEN WITH CONGENITAL ANOMALIES OF FETAL DEVELOPMENT

2021 ◽  
pp. 333-336
Author(s):  
Diana Inshyna ◽  
Tetiana Fartushok
Keyword(s):  
Fetal Development ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
General Scheme ◽  
Positive Aspect ◽  
Pregnancy And Delivery

We represent results of the 20 women survey, who gave birth to children with congenital malformations of the fetus. It was found that pregnancy and delivery in these women are with complications. Presented a general scheme of women with congenital malformations of the fetus. An important positive aspect of this scheme is that the newborn passes to neonatologists and other specialists with established diagnosis, investigation and preliminary plan of treatment that is refined and adjusted in the dynamics.

scholarly journals Spectrum of Neonatal Surgical Problems in the Newborn: Incidence, Clinical Course, Immediate Outcome, Follow up Study in a Tertiary Care NICU

2019 ◽  
pp. 1-9
Author(s):  
K. G. Sachin ◽  
K. R. Sachin ◽  
H. Ramesh ◽  
Guru Prasad ◽  
Harsha Bullapur
Keyword(s):  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Population Control ◽  
Tertiary Care ◽  
Relevant Information ◽  
The United States ◽  
Physical Structure ◽  
Neonatal Deaths ◽  
Medical College

Background: A congenital anomaly may be defined in terms of physical structure as a malformation, an abnormality of physical structure or form usually found at birth or during the first few weeks of life. Congenital anomalies affect approximately 1 in 33 infants and result in approximately 3.2 million birth defect-related disabilities every year. Congenital anomalies or birth defects are relatively common, affecting 3% to 5% of live births in the United States (US) and 2.1% in Europe. Congenital anomalies account for 8% to 15% of perinatal deaths and 13% to 16% of neonatal deaths in India. Objectives: To provide an insight on the burden and types of surgical problems encountered in our NICU of Bapuji Child Health Institute & Research Center, JJM Medical College, Davangere, Karnataka, India and to study the incidence, clinical profile and outcome of surgical condition. Methodology: A total of 3820 babies were examined over a period of 2 years. The relevant information was documented on a semi-structured proforma and analysed. Results: Overall incidence of congenital malformations at birth was 24.8 per 1000 births. The GIT system (51.58%) was most commonly involved followed by respiratory system (26.32%). The incidence of congenital malformation was more in male babies than female babies. Increased frequency was seen in babies born to mothers between 26–30 years & primigravida. The factors which significantly increased the rate of congenital malformations were consanguinity in parents & bad obstetric history. Out of 95 cases, 72% got discharged normally, 18% died in NICU and 10% got discharged against medical advise. Conclusion: With emphasis on “small family” norms and population control it is necessary to identify malformations so that interventional programmes can be planned. Systematic clinical examination of newborns for early detection of anomalies that may warrant medical or surgical intervention. Accurate antenatal anomaly scan need to be done to identify major malformations and terminate the pregnancy.

Comparative characteristics of clinical and genetic relationships pathology amount of amniotic fluid and congenital malformations of the fetus

2015 ◽  
Vol 21 (31) ◽  
pp. 51-55
Author(s):  
Каркусова ◽  
Alla Karkusova
Keyword(s):  
Comparative Analysis ◽  
Amniotic Fluid ◽  
Genetic Relationship ◽  
Fetal Development ◽  
Congenital Malformations ◽  
Genetic Relationships ◽  
Case Histories ◽  
History Of ◽  
Genetic Consultation

A comparative analysis of clinical and genetic relationship pathology of amniotic fluid and congenital malformations during the study 12150 case histories of women aged 16 to 45 years. To identify the disease heritability amount of amniotic fluid and to establish relationships with congenital fetal development floggings calculation of direct and indirect correlations between them. Was used the estimation of the genetic community pathological content of the amniotic fluid and malformations, which amounted to 27.9% at oligohydramnios, at polyhydramnios - 25.8%, which allows women who have a history of pregnancy with abnormal content of amniotic fluid to send to the institution of medico-genetic consultation in order to get the recommendations for planning future pregnancies.

scholarly journals Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract

2017 ◽  
Vol 29 (1) ◽  
pp. 36-50 ◽  
Author(s):  
Amelie T. van der Ven ◽  
Asaf Vivante ◽  
Friedhelm Hildebrandt
Keyword(s):  
Urinary Tract ◽  
Vesicoureteral Reflux ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Renal Agenesis ◽  
Incomplete Penetrance ◽  
Variable Expressivity ◽  
Genetic Causes ◽  
Shed Light ◽  
Lines Of Evidence

Congenital anomalies of the kidneys and urinary tract (CAKUT) comprise a large spectrum of congenital malformations ranging from severe manifestations, such as renal agenesis, to potentially milder conditions, such as vesicoureteral reflux. CAKUT causes approximately 40% of ESRD that manifests within the first three decades of life. Several lines of evidence indicate that CAKUT is often caused by recessive or dominant mutations in single (monogenic) genes. To date, approximately 40 monogenic genes are known to cause CAKUT if mutated, explaining 5%–20% of patients. However, hundreds of different monogenic CAKUT genes probably exist. The discovery of novel CAKUT-causing genes remains challenging because of this pronounced heterogeneity, variable expressivity, and incomplete penetrance. We here give an overview of known genetic causes for human CAKUT and shed light on distinct renal morphogenetic pathways that were identified as relevant for CAKUT in mice and humans.

Prevalence and Forms of Congenital Anomalies in Twins Born in Pomeranian District During the Period from 1.07.1997 to 31.12.1998

1998 ◽  
Vol 47 (3-4) ◽  
pp. 255-259 ◽  
Author(s):  
T. Zimoń ◽  
M. Walczak ◽  
J. Fydryk ◽  
A. Materna-Kiryluk ◽  
J. Mejnar-towicz ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Congenital Malformations ◽  
Multiple Pregnancy ◽  
Multiple Pregnancies ◽  
Singleton Pregnancy

AbstractThe authors have analysed the frequency and structure of congenital anomalies in children born in the Pomeranian district in the period from 01.07.1997 to 31.12.1998. Among a total of 28.361 births in that area, 748 (2.64%) were affected by congenital anomalies. Among 28.361 births, 620 (2.18%) were from multiple pregnancies. 23 (3.71%) among births from multiple pregnancies were affected by congenital malformations. The prevalence rate of inborn anomalies in births from multiple pregnancy in our area were higher (3.71%) in comparison to births from singleton pregnancy (2.61%). It implies that children born from multiple pregnancy are at higher risk of developing congenital anomalies.

Congenital Anomalies in Twins in Aberdeen and Northeast Scotland

1983 ◽  
Vol 32 (1) ◽  
pp. 31-35 ◽  
Author(s):  
G. Corney ◽  
I. MacGillivray ◽  
D.M. Campbell ◽  
B. Thompson ◽  
J. Little
Keyword(s):  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Statistical Significance ◽  
Mz Twins

Data with regard to the proportion of congenital malformations found at birth are presented from a survey of 657 pairs of twins of known zygosity and placentation delivered in Aberdeen and Northeast Scotland between 1968 and 1979. There was an excess of malformed individuals from monozygotic (MZ) pairs, but this did not reach statistical significance. The possible effect of monochorionic placentation in the causation of malformations in MZ twins in general is discussed. It seems that this type of placentation may be of less causative importance than has been previously suggested.

scholarly journals Association of other congenital anomalies in children with cleft lip and palate: a prospective hospital based observational study

2019 ◽  
Vol 6 (3) ◽  
pp. 1059
Author(s):  
Padmasani Venkat Ramanan ◽  
Rajesh Balan ◽  
Jyotsna Murthy ◽  
Syed Altaf Hussain
Keyword(s):  
Congenital Anomaly ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Associated Anomalies ◽  
Live Births ◽  
Associated Malformations ◽  
Syndrome Association

Background: Cleft lip and palate is a common congenital anomaly affecting approximately 1 in 700 live births in south Asia. It is often associated with syndromes and other malformations but the exact incidence of these in Asians is not known. The present study was carried out to determine the association of other congenital anomalies in children with cleft.Methods: The study was carried out in the patients attending the Cleft centre of our Hospital. They were examined for other major external congenital malformations and syndrome association.  Where ever relevant, appropriate investigations were done.Results: Of the total of 2367 children examined, 262 (11.06%) had congenital malformations.  Among the non-syndromic children, 9% had associated malformations.  The commonest was congenital heart disease (1.4%) following by genitourinary and skeletal anomalies.  The highest number of anomalies was seen in patients with cleft palate alone (24.89%). 1.4% patients had identifiable syndromes.Conclusions: The study emphasizes the need for a thorough examination of all children with cleft.  The overall lower incidence of syndromic clefts and associated anomalies in present study suggests that other etiological factors may be involved in our country.

scholarly journals Gastric and esophageal duplications in children

2020 ◽  
Vol 15 (4) ◽  
pp. 110-113
Author(s):  
M.A. Aksel'rov ◽  
◽  
V.N. Evdokimov ◽  
V.V. Svazyan ◽  
T.V. Sergienko ◽  
...  
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Gastrointestinal Tract ◽  
Anal Canal ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Clinical Manifestations ◽  
Clear Understanding ◽  
Gastric Duplication ◽  
Esophageal Duplication

Considerable attention is currently being paid to the diagnosis and treatment of gastric malformations complicated by its obstruction. This can be attributed to stable incidence of these disorders among other congenital anomalies of the gastrointestinal tract and no clear understanding of the causes and mechanisms underlying the development of this pathology. Gastrointestinal duplications are rare congenital malformations that differ significantly in their appearance, location, size, and clinical manifestations. Their incidence is 1 case per 4,500 autopsies. Duplications can be cystic and diverticular (tubular) and can be located in any part of the gastrointestinal tract from the root of the tongue to the anal canal. The small intestine is affected most frequently, while duplications of the rectum, duodenum, and esophagus are exceedingly rare. In this article, we report two cases of gastrointestinal duplications in children treated using surgery. Key words: neonate, obstruction, developmental malformations, gastric duplication, esophageal duplication, case report

scholarly journals Prevalence, Pattern and Outcome of Congenital Malformations among Neonates Seen at a Tertiary Health Institution in Yenagoa

2021 ◽  
pp. 1-10
Author(s):  
I. I. Tunde-Oremodu ◽  
O. A. Okosun ◽  
U. Idholo ◽  
A. S. Ujuanbi ◽  
K. K. Odinaka ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Chromosomal Abnormalities ◽  
Data Entry ◽  
Interval Data ◽  
Favourable Outcome ◽  
Neonatal Unit ◽  
Chromosomal Anomalies ◽  
Surgical Interventions

Background: Congenital malformations (CM) are significant causes of childhood morbidity and mortality impacting negatively on the affected family’s emotional and financial life. It also results in an enormous burden on a nation’s health and socio-economic systems. However, few studies on CM have emanated from developing countries including Nigeria and specifically from Yenagoa, Bayelsa State which is located in the oil rich Niger Delta region. We therefore analyzed the prevalence, pattern and outcome of management of babies with CM seen at the Neonatal unit (SCBU) of the Federal Medical Centre, Yenagoa. This could be used as evidence for policy makers to develop and implement CM surveillance, prevention and supportive programs. Methods: This was a descriptive observational study of all neonates with CM admitted into the Special Care Baby Unit (SCBU) over a one year period from 1st February 2017 to 31st January 2018. Identification and confirmation of congenital anomalies was done by physical examination, diagnostic investigations and surgical interventions. The conditions were classified organ and system-wise except for the chromosomal abnormalities. The prevalence and pattern of defects were determined, while factors related to the outcome of the anomalies were calculated with odds ratio and 95% confidence interval. Data entry and analysis were performed using excel and SPSS version 22. Results: Among the 502 newborn admissions during the study period, congenital anomalies were found in 61 newborns, giving a prevalence rate of 12.2% with a female preponderance of 55.7%. The commonest CM were those related to the cardiovascular system (47.5%) followed by the digestive system (32.8%) then musculoskeletal system (19.7%). The mean duration of care was 9.7± 9.0 days with mortality of 30.5% recorded at that period. Babies with CM affecting the cardiovascular system and chromosomal anomalies were less likely to survive although these relationships were not statistically significant (p > 0.05). However, duration of care showed a statistically significant relationship with outcome as babies who spent one day and less in the neonatal unit  had  reduced odds of a favourable outcome (OR – 0.07). An increased odd of survival (OR – 2.09) was seen in babies with only one congenital birth defect. Conclusion: A high prevalence of Congenital malformations in newborns was demonstrated in this study. This has highlighted the need for a well-designed surveillance, prevention and supportive hospital, State and National programme for affected babies and their families.

scholarly journals Major Congenital Malformations Among The Newborns in BSMMU Hospital

1970 ◽  
Vol 40 (1) ◽  
pp. 7-12 ◽  
Author(s):  
K Fatemaq ◽  
F Begum ◽  
N Akter ◽  
SMM Zaman
Keyword(s):  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Cross Sectional Study ◽  
Obstetrics And Gynecology ◽  
Sectional Study ◽  
Cross Sectional ◽  
The World ◽  
Major Congenital Malformations ◽  
Medical University ◽  
Recorded Diagnosis

Congenital anomalies make an important contribution to infant mortality and they remain a leading cause of death in many countries of the world. Many babies also died in our country due to congenital anomalies. So this study was done to find out proportion, types of congenital anomalies at birth and immediate outcome of anomalous neonates. This cross sectional study was carried out in the department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital Shahbagh, Dhaka during the period January 2007 to December 2007. All the women giving birth to babies with congenital anomalies during this period were included. Types of congenital anomalies in neonates were recorded. Diagnosis of congenital anomalies was based on ultrasonography and clinical evaluation of the newborn was done by experienced neonatologist. During the study period 1630 patients delivered, of which 60 had congenitally malformed babies making the occurance of 3.68%. Neural tube defect was found to be the commonest (33.33%) type of anomaly. Among the most frequent NTD was hydrocephalus. DOI: http://dx.doi.org/10.3329/bmj.v40i1.9955 BMJ 2011; 40(1): 7-12

scholarly journals A dicephalus calf: anatomical, pathological and radiographic aspects

2021 ◽  
Vol 14 (1) ◽  
pp. 33-39
Author(s):  
Tiago Peixoto ◽  
◽  
Lorena Ribeiro ◽  
Múcio Mendonça ◽  
Ana Souza ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Thoracic Spine ◽  
Fetal Development ◽  
Congenital Malformations ◽  
Animal Species ◽  
Morphological Changes ◽  
Brain Structures ◽  
Bone Changes ◽  
Aortic Arches ◽  
The Right

Congenital malformations are morphofunctional abnormalities of tissues and organs that can occur during embryonic or fetal development in all animal species. Among these, dicephalus is characterized by the development of an individual with two heads and two necks, due to the total duplication of facial, cranial, and brain structures. Reports of dicephalus in cattle are scarce and do not normally emphasize radiographic and bone anatomy characteristics. The objective was to describe a case of a stillborn dicephalus calf. The duplication of the head, brain, neck, and two thoracic vertebral columns, isolated from each other, with 13 vertebrae each was verified radiographically. There were 13 pairs of ribs, the ones on the right side articulated with the thoracic spine on the right and the left ones with the spine on the left. Caudally at T13, there was only one lumbar spine, sacral and coccygeal. In the ventrodorsal projection, L1, L2, L3, and L6 had the shape of a butterfly (suggestive of hemivertebrae). At necropsy, in addition to craniocervical and spinal morphological changes, collapsed lungs, duplication of the heart with anastomosis between the aortic arches of the hearts, and duplication of the upper digestive tract were observed. Additionally, there was arthrogryposis of the pelvic limbs. Corpse maceration, followed by the skeletal assembly, showed the bone changes previously observed and confirmed the suspicion of hemivertebrae.

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