scholarly journals Potential Beneficial Effects of Probiotics on Human Migraine Headache: A Literature Review

2017 ◽  
Vol 2 (20;2) ◽  
pp. E251-E255
Author(s):  
Yong-Hai Sun
Keyword(s):  
Literature Review ◽  
Gut Microbiota ◽  
Brain Function ◽  
Migraine Headache ◽  
Large Scale ◽  
Gastrointestinal Diseases ◽  
Gastrointestinal Disorders ◽  
Efficacy And Safety ◽  
Positive Effects ◽  
The Relationship

Background: Recent studies have shown that migraine headache is often associated with concomitant gastrointestinal diseases. There is a higher prevalence of headaches in patients with gastrointestinal disorders. These associations between migraine and gastrointestinal disorders suggest a potential link to a bidirectional modulation of gut microbiota and brain function. The underlying working mechanistic links between migraine and gastrointestinal diseases may include increased intestinal epithelial permeability and inflammation. Objective: This review presents an overview of the relationship between gut microbiota and brain function, especially with regard to migraine headache. Study Design: Literature review. Setting: Anesthesia and Operation Center, Department of Anesthesiology, Chinese PLA General Hospital. Methods: The present investigation included a PubMed search using the following terms: migraine headache, gut microbiota, brain function, and probiotics. Results: In this literature review, we mainly discussed the relationship between gut microbiota and brain function, especially with regard to migraine headache. The potential effects of probiotics supplement on migraine headache were also included. Limitations: There is limited evidence from clinical studies of the positive effects of probiotics in patients with migraine headache. Large-scale randomized, placebo-controlled clinical trials are warranted to evaluate the clinical efficacy and safety of probiotics in patients with migraine headache. Conclusions: Similar to migraine headache, disorders of the brain involving depression and anxiety have been demonstrated to be associated with increased gut permeability. An improvement in gut microbiota and reduction of inflammation can have positive effects on strengthening gut and brain function. Moreover, it can be inferred that probiotics may have a beneficial effect on the frequency and severity of migraine headache attacks. Large-scale randomized, placebo-controlled studies are warranted in the future to evaluate the clinical efficacy and safety of probiotics in patients with migraine headache. Key words: Migraine headache, gut microbiota, brain function, probiotics

Investigating Diseases and Chemicals in COVID-19 Literature with Text Mining (Preprint)

2020 ◽  
Author(s):  
Amir Karami ◽  
Brandon Bookstaver ◽  
Melissa Nolan
Keyword(s):  
Text Mining ◽  
Literature Review ◽  
Topic Modeling ◽  
Large Scale ◽  
Clinical Manifestations ◽  
International Health ◽  
Research Papers ◽  
Strategic Plans ◽  
Funding Agencies ◽  
The Relationship

BACKGROUND The COVID-19 pandemic has impacted nearly all aspects of life and has posed significant threats to international health and the economy. Given the rapidly unfolding nature of the current pandemic, there is an urgent need to streamline literature synthesis of the growing scientific research to elucidate targeted solutions. While traditional systematic literature review studies provide valuable insights, these studies have restrictions, including analyzing a limited number of papers, having various biases, being time-consuming and labor-intensive, focusing on a few topics, incapable of trend analysis, and lack of data-driven tools. OBJECTIVE This study fills the mentioned restrictions in the literature and practice by analyzing two biomedical concepts, clinical manifestations of disease and therapeutic chemical compounds, with text mining methods in a corpus containing COVID-19 research papers and find associations between the two biomedical concepts. METHODS This research has collected papers representing COVID-19 pre-prints and peer-reviewed research published in 2020. We used frequency analysis to find highly frequent manifestations and therapeutic chemicals, representing the importance of the two biomedical concepts. This study also applied topic modeling to find the relationship between the two biomedical concepts. RESULTS We analyzed 9,298 research papers published through May 5, 2020 and found 3,645 disease-related and 2,434 chemical-related articles. The most frequent clinical manifestations of disease terminology included COVID-19, SARS, cancer, pneumonia, fever, and cough. The most frequent chemical-related terminology included Lopinavir, Ritonavir, Oxygen, Chloroquine, Remdesivir, and water. Topic modeling provided 25 categories showing relationships between our two overarching categories. These categories represent statistically significant associations between multiple aspects of each category, some connections of which were novel and not previously identified by the scientific community. CONCLUSIONS Appreciation of this context is vital due to the lack of a systematic large-scale literature review survey and the importance of fast literature review during the current COVID-19 pandemic for developing treatments. This study is beneficial to researchers for obtaining a macro-level picture of literature, to educators for knowing the scope of literature, to journals for exploring most discussed disease symptoms and pharmaceutical targets, and to policymakers and funding agencies for creating scientific strategic plans regarding COVID-19.

Institutional Capital on Trade Marketing and Environmentally-Sustainable Development Policy Making

2020 ◽  
pp. 34-66
Author(s):  
José G. Vargas-Hernández
Keyword(s):  
Sustainable Development ◽  
Literature Review ◽  
Development Policy ◽  
Policy Making ◽  
Research Model ◽  
Environmentally Sustainable ◽  
Positive Effects ◽  
Institutional Capital ◽  
The Relationship

The aim of this study is to critically analyze the implications in terms of the relationship between cooperation, conflict, and institutional capital, as well as their interactions with trade marketing and environmentally sustainable development policy making under the framework of NAFTA. The methodology is based on a literature review aimed to create a relationship between the analytical variables in order to obtain a research construct. This research model is used to critically analyze the implications in terms of cooperation and conflict relationships as institutional capital and their interactions with trade marketing and environmentally sustainable development policy making. It is concluded that, although the existence of NAFTA is severely questioned, its institutional capital has positive effects on the implications of trade-marketing; however, environmentally sustainable development proves to be conflictive and highly contentious, although some positive effects are developing.

scholarly journals Efficacy and Safety of Hou Gu Mi Xi on Spleen Qi Deficiency in Patients with Nonorganic Gastrointestinal Disorders: Protocol for a Multicenter, Randomized, Placebo-Controlled Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Xiaofan Chen ◽  
Heyun Nie ◽  
Wenjun Liu ◽  
Xu Zhou ◽  
Jianhua Nie ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Gastrointestinal Diseases ◽  
Ethics Committee ◽  
Gastrointestinal Disorders ◽  
Evidence Based ◽  
Research Model ◽  
Efficacy And Safety ◽  
Medical Treatments ◽  
Study Population ◽  
Double Blinded

Background. There is a worldwide epidemic of nonorganic gastrointestinal disorders (NOGDs), which are a class of disorders that cause various discomforts and ultimately progress into organic gastrointestinal diseases. Because of the unsatisfactory efficacy of Western medical treatments, traditional Chinese medicine (TCM) is becoming a promising complementary and alternative treatment to manage NOGDs. Objectives. To investigate the efficacy and safety of Hou Gu Mi Xi (HGMX), a newly developed dietary TCM formula, on the syndrome of spleen qi deficiency (SQD) in patients with NOGDs. Methods/Design. This study is a multicenter, randomized, double-blinded, parallel, and placebo-controlled trial that will last for 2 years. All qualified subjects with NOGDs and SQD will be included. The study population will be divided into the HGMX and placebo groups. To assess the efficacy of HGMX, we will mainly focus on changes in SQD symptoms scored by a Spleen Qi Deficiency Symptoms Grading and Quantifying Scale and evaluate changes in gastrin-17, the negative Helicobacter pylori conversion rate, body weight, body mass index, and gastroscopy findings. The safety of HGMX will be assessed by recording adverse events (AEs), severe AEs, treatment-related AEs and withdrawal due to AEs. Discussion. This trial is part of our study series that intends to validate the potential of HGMX in the management of chronic gastrointestinal diseases. This series of RCTs is the first committed to the evaluation of a dietary TCM formula and will hopefully establish an evidence-based clinical research model for dietary TCM formulas. Ethics. The protocol was approved by Ethics Committee of five research hospitals and was registered in Clinicaltrials.gov (NCT03019042).

scholarly journals Relationship Stability and Supply Chain Performance for SMEs: From Internal, Supplier, and Customer Integration Perspectives

Mathematics ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1902
Author(s):  
Tsu-Ming Yeh ◽  
Fan-Yun Pai ◽  
Liang-Chuan Wu
Keyword(s):  
Supply Chain ◽  
Large Scale ◽  
Environmental Uncertainty ◽  
Past Research ◽  
Supply Chain Integration ◽  
Supply Chain Performance ◽  
Relationship Stability ◽  
Moderation Effect ◽  
Positive Effects ◽  
The Relationship

This study examined the relationship between supply integration and relationship stability and the relationship between relationship stability and performance; furthermore, the moderation effect of environmental uncertainty on supply chain integration and relationship stability was analyzed. The subjects are typical small and medium-sized enterprises (SMEs) in developing countries that focus on niche markets to compete with large-scale manufacturers. Questionnaires were distributed to manufacturers to collect empirical data; in total, 566 valid samples were gathered. The results indicate that supply chain integration has positive effects on relational stability and that relational stability has positive effects on supply chain performance. Relational stability is a mediator between supply chain integration and supply chain performance. The contingency effects of environmental uncertainty on the relationships between internal integration and relational stability were determined in this research. This research framework extended past research on supply chain management; part of the research explored the relationship between supply chain integration and different measures of supply chain performance, as well as whether uncertainty affects supply chain integration and supply chain performance.

Relationship between country brand and internationalization: a literature review

2019 ◽  
Vol 27 (7) ◽  
pp. 2148-2165 ◽  
Author(s):  
Maria Gabriela Montanari ◽  
Janaina de Moura Engracia Giraldi ◽  
Simone Vasconcelos Ribeiro Galina
Keyword(s):  
Literature Review ◽  
International Markets ◽  
Country Image ◽  
Entry Modes ◽  
Content Type ◽  
Positive Effects ◽  
Positive Attitudes ◽  
Country Brand ◽  
Quantitative Descriptive ◽  
The Relationship

Purpose The purpose of this paper is to explain a possible relationship between the country brand and internationalization topics, searching in the literature the possible connections between them. Design/methodology/approach An integrative literature review of the past 15 years of research (2003–2017) was acquired using the well-known databases Web of Science and Scopus. Findings Studies linking country brand and internationalization are new, often quantitative, descriptive and focused on emerging markets. In terms of content, it was shown first that a country brand, when well-managed, is not only essential to attract foreign direct investment into the country, but it can also help the outflows of investments. Referring specifically to outflows of foreign investment, internationalization affects the country brand, generating positive attitudes toward the brand in international markets. However, it is also affected by the country brand because the country image influences the entry modes of business and the country of origin affects the performance of multinationals abroad. Research limitations/implications With the strengths and deficiencies of a body of literature exposed in this paper, a better understanding of the topic through synthesis can be provided. Practical implications Findings show that internationalization can influence country brand and country image. The internationalization process might positively affect the attitude toward a place brand. In terms of country image, when a company rebranding is entering international markets, it can integrate the brand of its products with the country brand and its image, generating positive effects in relation to brand in the new market. However, this relationship is not clear and should be explored by new studies. Originality/value This paper contributes both to the literature through an overview of the relationship between the two topics and a research agenda for future studies; and to governments and companies by providing information that enables them to become more competitive in the international market.

Institutional Capital on Trade-Marketing and Environmentally Sustainable Development Policy Making

2019 ◽  
Vol 3 (2) ◽  
pp. 1-21
Author(s):  
José G Vargas-Hernández
Keyword(s):  
Sustainable Development ◽  
Literature Review ◽  
Development Policy ◽  
Policy Making ◽  
Research Model ◽  
Environmentally Sustainable ◽  
Positive Effects ◽  
Institutional Capital ◽  
The Relationship

The aim of this study is to critically analyze the implications in terms of the relationship between cooperation, conflict, and institutional capital, as well as their interactions with trade marketing and environmentally sustainable development policy making under the framework of NAFTA. The methodology is based on a literature review aimed to create a relationship between the analytical variables in order to obtain a research construct. This research model is used to critically analyze the implications in terms of cooperation and conflict relationships as institutional capital and their interactions with trade-marketing and environmentally sustainable development policy making. It is concluded that, although the existence of NAFTA is severely questioned, its institutional capital has positive effects on the implications of trade-marketing; however, environmentally sustainable development proves to be conflictive and highly contentious, although some positive effects are developing.

MICROBES INSIDE OUR BODIES: CASUAL COMPANIONS, OR PREREQUISITE FOR OUR SURVIVAL? OR WHY PROBIOTICS ARE NEEDED IN INFANT FORMULAE

2020 ◽  
Vol 99 (6) ◽  
pp. 163-171
Author(s):  
S.E. Ukraintsev ◽  
◽  
E.A. Kornienko ◽  
L.I. Kafarskaya ◽  
M.I. Dubrovskaya ◽  
...  
Keyword(s):  
Literature Review ◽  
Lactobacillus Reuteri ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Effective Prevention ◽  
Symbiotic Relationships ◽  
Positive Effects ◽  
Infant Formulae ◽  
Prevention And Treatment ◽  
Evolutionary Aspects

This literature review describes evolutionary aspects of the formation of relationships between microorganisms and the human body. The formation of symbiotic relationships, which resulted in the formation of a holobiont, is discussed. Separate chapter of the article is dedicated to describing positive effects of Lactobacillus reuteri DSM 17938 strain for human health, including effective prevention and treatment of functional gastrointestinal disorders in infants.

The Potential of Medicinal Plants as Galactagogue in Indonesia: A Review from Medical Perspective

2021 ◽  
Vol 14 (3) ◽  
pp. 1595-1612
Author(s):  
Astrid Feinisa Khairani ◽  
Teuku Muhammad Adzdzikri ◽  
Shafa Tasya Menggala ◽  
Muhammad Hasan Bashari ◽  
Enny Rohmawaty ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Breast Milk ◽  
Medicinal Plants ◽  
Literature Review ◽  
Common Factor ◽  
World Health ◽  
Efficacy And Safety ◽  
Positive Effects ◽  
The World ◽  
Medical Perspective

The World Health Assembly's target in exclusive breastfeeding has not been achieved. The most common factor contributing to this problem is the perceived insufficient production of breast milk, leading to the inability to give breastmilk to her child. Milk production can be increased using some ways, such as herbal galactagogue. This article aimed to review the effectiveness of some medicinal plants as galactagogues. This study uses a literature review approach by using several sources selected based on the criteria that have been set by researchers. Based on thirteen literature, herbs reviewed in this article showed positive effects as a galactagogue. Evidence regarding its efficacy and safety is scarce. Additionally, few clinical trials exist to justify its effectiveness. Further clinical trials are needed to support these findings.

scholarly journals ‘Living in the community’ the pros and cons: A systematic literature review of the impact of deinstitutionalisation on people with intellectual and psychiatric disabilities

2018 ◽  
Vol 20 (1) ◽  
pp. 83-116 ◽  
Author(s):  
Femmianne Bredewold ◽  
Margot Hermus ◽  
Margo Trappenburg
Keyword(s):  
Literature Review ◽  
Intellectual Disabilities ◽  
Systematic Literature Review ◽  
Large Scale ◽  
Family Members ◽  
Institutional Care ◽  
People With Disabilities ◽  
Target Groups ◽  
Positive Effects ◽  
The Impact

Summary How did deinstitutionalisation affect the lives of people with intellectual disabilities and people with a psychiatric background? This paper contains a systematic literature review on the consequences of deinstitutionalisation for the target groups, their social network and society at large. PubMed and Online Contents were searched from 2004 till February 2016. Inclusion criteria were (1) article describes (a) consequence(s) of deinstitutionalisation, (2) in Western countries and (3) the target group(s) include people with psychiatric or intellectual disabilities. Sixty-one papers were found and analysed to establish positive, negative or mixed results. Findings The positive effects pertain to the quality of life of people with disabilities after deinstitutionalisation. They learned adaptive skills and receive better care. Negative effects relate to more criminal behaviour by the target groups, victimisation of the target groups and physical health issues. Life for the most severely afflicted people with disabilities deteriorated when they moved to smaller group homes in the community. Mixed effects were also found. It is not clear whether deinstitutionalisation leads to real inclusion in the community. It is equally unclear whether it is cheaper than large-scale institutional care. Only a few studies investigate the effects on family members but some show they are overburdened. Applications Social workers catering for people with disabilities should pay attention to risks for their health and safety and keep an eye on family members. Those who are asked to advise on deinstitutionalisation should consider that this may not benefit the most severely afflicted.

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