NUCLEAR DEGENERATION AS A BY-PRODUCT OF AGING AND ENVIRONMENT

2021 ◽  
pp. 10-12
Author(s):  
Monica Mehendiratta ◽  
Vidisha Vidisha ◽  
Vikash Kumar Singh ◽  
Shubhajit Roy ◽  
Aman Khurana
Keyword(s):  
Elderly Women ◽  
The Elderly ◽  
Cellular Level ◽  
Degenerative Changes ◽  
Genotoxic Effects ◽  
Exfoliated Cells ◽  
Toxic Environment ◽  
Nuclear Changes ◽  
Effects Of Aging ◽  
The Given

Background: The process of aging in the immediate toxic environment occurring in this Industrialized world is detrimental for human body. This is accelerating aging process and at the cellular level, the toxins present in environment are inducing chromosomal(micronuclei) and nuclear degenerative changes (karyorrhexis, karyolysis, pyknosis, condensed chromatin). The given study evaluates the effects of aging and environment on the chromosomal/nuclear degenerative changes, thus affecting the exfoliated cells collected from buccal mucosa. Methods: The sample included 86 healthy subjects divided into two groups according to age: 46 women aged above 60 years and 40 women of 20- 25 years of age. A questionnaire was prepared to retrieve all the data related to health and drug related history. Buccal smears were prepared and stained with both Papanicolaou and H&E stain. Hundred cells were counted from each slide to determine the number of micronuclei and other nuclear degenerative changes. Results: The number of micronuclei and other nuclear degenerative changes were signicantly higher among the elderly women (p<0.05) when compared with young women volunteers. Conclusion: Aging along with environmental factors appear to be detrimental in inducing mutagenic/ genotoxic effects at the cellular level. Cytological evaluation is clearly indicative of nuclear changes evident with aging.

scholarly journals Effects of age on the frequency of micronuclei and degenerative nuclear abnormalities

2016 ◽  
Vol 19 (4) ◽  
pp. 627-634 ◽  
Author(s):  
Gregory Alves Ferraz ◽  
Antônio de Oliveira Costa Neto ◽  
Eneida de Moraes Marcílio Cerqueira ◽  
José Roberto Cardoso Meireles
Keyword(s):  
Micronucleus Test ◽  
Genetic Material ◽  
The Elderly ◽  
Degenerative Changes ◽  
Men And Women ◽  
Exfoliated Cells ◽  
And Gender ◽  
Effects Of Aging ◽  
Interview Questionnaire ◽  
Main Factor

Abstract The effects of aging, gender and lifestyle factors on inducing chromosomal damage (micronuclei) and nuclear degenerative changes were assessed using the micronucleus test on exfoliated cells of the oral mucosa. The sample included 80 healthy subjects divided into four groups according to age and gender: men and women aged 19-29 years (M19, W19) and men and women aged over sixty years (M60, W60). An interview questionnaire was used to characterize the sample and to determine an index reflecting lifestyle (HLI). The frequency of micronuclei and nuclear degenerative changes was significantly higher among the elderly (p<0.001) and did not differ by gender among young people (p>0.05). The occurrence of micronuclei was similar among elderly men and women (p>0.10), but karyorrhexis and karyolysis were more frequent among men (p<0.005 and p<0.025, respectively), who also had a lower HLI than the other groups (p<0.0004). The results of the study indicate that age is the main factor associated with the induction of genetic material damage.

scholarly journals Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women

2015 ◽  
Vol 61 (4) ◽  
pp. 329-335
Author(s):  
Wilson de Melo Cruvinel ◽  
Danilo Mesquita Júnior ◽  
Júlio Antônio Pereira Araújo ◽  
Karina Carvalho Samazi ◽  
Esper Georges Kállas ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Mononuclear Cells ◽  
Elderly Women ◽  
The Elderly ◽  
Effector T Cells ◽  
T Cell Subsets ◽  
Healthy Elderly ◽  
T Cell Phenotypes ◽  
Effects Of Aging

SummaryIntroduction:aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency and function of these T cell subpopulations.Methods:peripheral blood mononuclear cells (PBMC) were obtained from 26 young (under 44 years old) and 18 elderly (above 80 years old) healthy women. T cell subpopulations were analyzed by flow cytometry.Results:elderly individuals had lower frequency of several activated effector T cell phenotypes as compared with young individuals: CD3+CD4+CD25+ (3.82±1.93 versus 9.53±4.49; p<0.0001); CD3+CD4+CD25+CD127+(2.39±1.19 versus 7.26±3.84; p<0.0001); CD3+CD4+CD25+ (0.41±0.22 versus 1.86±0.85, p<0.0001); and CD3+CD4+CD25highCD127+(0.06±0.038 versus 0.94±0.64, p<0.0001). Treg (CD3+CD4+CD25+CD127øFoxp3+) presented lower frequency in elderly individuals as compared to young adults (0.34±0.18 versus 0.76±0.48; p=0.0004) and its frequency was inversely correlated with age in the whole group (r=-0.439; p=0.013). The elderly group showed higher frequency of two undefined CD25øFoxp3+ phenotypes: CD3+CD4+CD25øFoxp3+(15.05±7.34 versus 1.65±1.71; p<0.0001) and CD3+CD4+CD25øCD127øFoxp3+(13.0±5.52 versus 3.51±2.87; p<0.0001).Conclusions:the altered proportion of different T cell subsets herein documented in healthy elderly women may be relevant to the understanding of the immunologic behavior and disease susceptibility patterns observed in geriatric patients.

Effects of Aging Process Exercise Program on Walking ability and Frailty of Elderly Women in Rural

2018 ◽  
Vol 27 (2) ◽  
pp. 1115-1126 ◽  
Author(s):  
Seul-Hee Lee ◽  
Ga-Ram Hong ◽  
Bong-Jo Kim ◽  
Eun-Hee Kim
Keyword(s):  
Aging Process ◽  
Elderly Women ◽  
Exercise Program ◽  
Walking Ability ◽  
Effects Of Aging

scholarly journals The effects of teaching methods of palliative care on life pattern of old women with chronic pain

2019 ◽  
Vol 29 (4) ◽  
Author(s):  
Elham Hesari ◽  
Zahra Sabzi ◽  
Shohreh Kolagari
Keyword(s):  
Chronic Pain ◽  
Palliative Care ◽  
Teaching Methods ◽  
Social Life ◽  
Educational Program ◽  
Elderly Women ◽  
Intervention Group ◽  
The Elderly ◽  
Old People ◽  
Life Pattern

Chronic pain is among problems of old people and causes changes in their life pattern and processes. Teaching palliative care can help old people suffering from chronic pain to live an active life. The aim of this research was to determine effects of educating of palliative care on life pattern of elderly women with chronic pain. The present study was a Quasi-experimental design with pre-test and post test was conducted on 30 elderly women suffering from chronic pain in 2018 in Iran. The Questionnaire for evaluating the Pattern of Life with Pain in the elderly was filled before the intervention, group educating of palliative care was carried out using an educational package, and the questionnaire was completed again immediately and one and three months after. The data was analyzed using mean, standard deviations, Fisher’s F test, and Greenhouse-Geisser and Bonferroni post-hoc test by employing SPSS- 16. Mean changes before teaching palliative care significantly differed from those of immediately and one and three months after the educational program (p = 0.0), (p = 0.004). There were significant differences between the stages of immediately and one month after the educational program and that of three months after it (p = 0.001), (p = 0.002). Concerning the personal life patterns, there were statistically significant differences between the stage immediately after the educational program and those before the intervention and three months after it (p = 0.005), (p = 0.000). Regarding the social life pattern, only the stage of one month after the educational program significantly differed from that of three months (p = 0.005). Mean growth in life pattern of the old women suffering from chronic pain in the stages after the intervention indicated the importance of and the necessity for palliative care during old age. Moreover, the success of this education three months after the educational program as compared to immediately and one month after it indicates that allocation of sufficient time plays a very important role in transferring information and in teaching methods of palliative care to old people.

scholarly journals The Road More Travelled: The Differential Effects of Spatial Experience in Young and Elderly Participants

2021 ◽  
Vol 18 (2) ◽  
pp. 709
Author(s):  
Antonella Lopez ◽  
Alessandro Germani ◽  
Luigi Tinella ◽  
Alessandro Oronzo Caffò ◽  
Albert Postma ◽  
...  
Keyword(s):  
Mental Representations ◽  
Spatial Relations ◽  
The Elderly ◽  
The Road ◽  
Socio Demographic Factors ◽  
Effects Of Aging ◽  
Coordinate Spatial Relations ◽  
Categorical Spatial Relations ◽  
The Relationship

Our spatial mental representations allow us to give refined descriptions of the environment in terms of the relative locations and distances between objects and landmarks. In this study, we investigated the effects of familiarity with the everyday environment, in terms of frequency of exploration and mode of transportation, on categorical and coordinate spatial relations, on young and elderly participants, controlling for socio-demographic factors. Participants were tested with a general anamnesis, a neuropsychological assessment, measures of explorations and the Landmark Positioning on a Map task. The results showed: (a) a modest difference in performance with categorical spatial relations; (b) a larger difference in coordinate spatial relations; (c) a significant moderating effect of age on the relationship between familiarity and spatial relations, with a stronger relation among the elderly than the young. Ceteris paribus, the role of direct experience with exploring their hometown on spatial mental representations appeared to be more important in the elderly than in the young. This advantage appears to make the elderly wiser and likely protects them from the detrimental effects of aging on spatial mental representations.

scholarly journals Health-Related Quality of Life of Elderly Women with Fall Experiences

2021 ◽  
Vol 18 (15) ◽  
pp. 7804
Author(s):  
Jiyoung Song ◽  
Eunwon Lee
Keyword(s):  
Quality Of Life ◽  
Elderly Women ◽  
The Elderly ◽  
Basic Data ◽  
Health Related Quality ◽  
High Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

This study aimed to describe the health-related quality of life of elderly women with experience in fall treatment as well as to prepare basic data for the development of interventions to improve the quality of life for this group. The study was based on raw data from the 2019 Korea Community Health Survey. Using the SPSS program, the characteristics of the subjects were tested by frequency, percentage, and chi-square test. To establish the impact of fall experience on the health-related quality of life of elderly women, the OR and 95% CI were calculated using multiple logistic regression analysis. Of the 4260 people surveyed, 44.7% of the elderly women said they had a high quality of life, whereas 55.3% of the elderly women said they had a low quality of life. A younger age was associated with a better-rated health-related quality of life. Those who lived in a city and had a high level of education tended to describe a high quality of life. The quality of life was considered high by those who exercised, but low by those who were obese or diabetic. The results of this study can lead to a better understanding of the experiences of elderly women who have experienced falls, and they can be used as basic data for the development of related health programs.

scholarly journals Effects of Cognicise-Neurofeedback on Health Locus of Control, Depression, and Quantitative Electroencephalography Alpha Asymmetry in Elderly Women

2021 ◽  
Vol 11 (7) ◽  
pp. 899
Author(s):  
Heewook Weon ◽  
Jieun Yoo ◽  
Jumhwa Yu ◽  
Miso Park ◽  
Haekyoung Son
Keyword(s):  
Locus Of Control ◽  
Elderly Women ◽  
Health Locus Of Control ◽  
Cognitive Activity ◽  
The Elderly ◽  
Control Group ◽  
Quantitative Electroencephalography ◽  
Alpha Asymmetry ◽  
Post Test ◽  
Experimental Group

Background: With an increase in the aged population, there is a growing concern regarding the care of the elderly. This study aims to identify effects of cognicise-neurofeedback on health locus of control, depression, and quantitative electroencephalography (QEEG) alpha asymmetry in elderly women. Methods: A quasi-experimental control group pre-test–post-test design was used. Korean women aged 65 years or over at a senior welfare center were randomly allocated to the control (n = 12) or experimental (n = 19) groups from July to October 2019. The intervention consisted of cognicise (exercise with intensified cognitive activity) and neurofeedback twice a week for 10 weeks. The locus of control and depression were measured via self-reported questionnaires. QEEG alpha asymmetry was measured using BrainMaster. Results: Depression significantly decreased in the experimental group (t = 4.113, p = 0.001), while internality in the locus of control significantly decreased in the control group (t = 3.023, p = 0.012). On the other hand, QEEG alpha asymmetry index differences in F3-F4 between the pre-test and post-test were not significant in the experimental group (t = 0.491, p = 0.629) or control group (t = 0.413, p = 0.678). Conclusions: Due to the coronavirus disease (COVID-19) pandemic, contact between the elderly and healthcare workers in the clinical practice field has become more restricted. These findings can help decrease negative emotions among elderly women in the community based on an integrated neuroscientific approach.

Sign in / Sign up

Export Citation Format

Share Document