DEVELOPMENT OF A SUBSYSTEM FOR DIAGNOSTICS OF GYNECOLOGICAL DISEASES BASED ON STATISTICAL AND SIMULATION MODELING

2021 ◽  
pp. 94-98
Author(s):  
Екатерина Ивановна Новикова ◽  
Анастасия Юрьевна Корниенко
Keyword(s):  
Differential Diagnosis ◽  
Mathematical Models ◽  
Simulation Modeling ◽  
Clinical Laboratory ◽  
Software Product ◽  
Gynecological Diseases ◽  
Medical Structure ◽  
Diagnostic Signs ◽  
Attending Physician ◽  
Probabilistic Nature

В статье рассматриваются методы кластерного и дискриминантного анализа для построения математических моделей диагностики гинекологических заболеваний. Гинекологические патологии занимают значительное место в структуре заболеваемости у женщин. Между тем, точная дифференциальная диагностика патологий зачастую бывает, невозможна, так как гинекологические заболевания носят вероятностный характер, большинство диагностических признаков выражаются качественными показателями, которые индивидуальны для каждой пациентки. Лечащему врачу приходится решать сложную задачу по анализу клинических, лабораторных и инструментальных признаков для постановки точного диагноза. С применением аппарата сетей Петри произведено построения модели дифференциальной диагностики гинекологических заболеваний. На основе полученных математических моделей, сформирована структура и информационно-программное обеспечение для системы диагностики гинекологических заболеваний в медицинских организациях. Внедрение разработанного программного продукта в медицинскую структуру позволит уменьшить вероятность врачебной ошибки, а также повысить эффективность и точность постановки диагноза пациенткам The article discusses the methods of cluster and discriminant analysis for constructing mathematical models for the diagnosis of gynecological diseases. Gynecological pathologies occupy a significant place in the structure of morbidity in women. Meanwhile, accurate differential diagnosis of pathologies is often impossible, since gynecological diseases are of a probabilistic nature, most of the diagnostic signs are expressed in qualitative indicators that are individual for each patient. The attending physician has to solve a complex task of analyzing clinical, laboratory and instrumental signs to make an accurate diagnosis. Using the apparatus of Petri nets, a model for the differential diagnosis of gynecological diseases was constructed. On the basis of the obtained mathematical models, the structure and information software for the system of diagnostics of gynecological diseases in medical organizations was formed. The introduction of the developed software product into the medical structure will reduce the likelihood of medical error, as well as increase the efficiency and accuracy of diagnosing patients

CLINICAL LABORATORY DIFFERENTIAL DIAGNOSIS OF ENCEPHALITIS, DISSEMINATED ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS IN CHILDREN

2017 ◽  
Vol 96 (4) ◽  
pp. 34-42
Author(s):  
N. V. Skripchenko ◽  
◽  
G. P. Ivanova ◽  
E. Y. Skripchenko ◽  
A. V. Surovtseva ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Differential Diagnosis ◽  
Clinical Laboratory

Clostridium botulinum and the Clinical Laboratorian: A Detailed Review of Botulism, Including Biological Warfare Ramifications of Botulinum Toxin

2004 ◽  
Vol 128 (6) ◽  
pp. 653-662 ◽  
Author(s):  
James G. Caya ◽  
Rashmi Agni ◽  
Joan E. Miller
Keyword(s):  
Health Care ◽  
Differential Diagnosis ◽  
Health Care Professionals ◽  
Clinical Laboratory ◽  
Therapeutic Approaches ◽  
Data Synthesis ◽  
Literature Searches ◽  
Pertinent Data ◽  
Prompt Diagnosis ◽  
Timely Treatment

Abstract Objective.—This review article is designed to thoroughly familiarize all health care professionals with the history, classification, epidemiology, clinical characteristics, differential diagnosis, diagnostic evaluation (including laboratory-based testing), treatment, and prognosis of botulism. It is especially targeted toward clinical laboratorians and includes a detailed enumeration of the important clinical laboratory contributions to the diagnosis, treatment, and monitoring of patients with botulism. Finally, the bioterrorism potential for botulism is discussed, with an emphasis on the clinical laboratory ramifications of this possibility. Data Sources.—Included medical periodicals and textbooks accessioned from computerized and manual medical literature searches. More than 1000 medical works published from the 1800s through 2003 were retrieved and reviewed in this process. Data Synthesis.—Pertinent data are presented in textual and tabular formats, the latter including 6 tables presenting detailed information regarding the clinical parameters, differential diagnosis, diagnostic studies, laboratory testing, and therapeutic approaches to botulism. Conclusions.—Because botulism is such a rare disease, a keen awareness of its manifestations and prompt diagnosis are absolutely crucial for its successful treatment. The bioterrorism potential of botulism adds further urgency to the need for all health care professionals to be familiar with this disease, its proper evaluation, and timely treatment; the need for such urgency clearly includes the clinical laboratory.

Serum Alpha Fetal Protein in a Three Year Old Child with Hepatoma

1976 ◽  
Vol 62 (4) ◽  
pp. 407-414 ◽  
Author(s):  
Yehuda Shoenfeld ◽  
Albert I. Pick ◽  
Sarah Schreibman ◽  
Helena Kessler ◽  
Moshe Dintzman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Differential Diagnosis ◽  
Surgical Procedure ◽  
Tumor Recurrence ◽  
Clinical Laboratory ◽  
Sharp Decrease ◽  
Normal Serum ◽  
Primary Hepatocellular Carcinoma ◽  
X Ray

A 3 year old child with primary hepatocellular carcinoma and high AFP concentrations is described. Following hemihepatectomy, a sharp decrease and return to normal of serum AFP concentrations indicated the completeness of the surgical procedure. Repeat-normal serum AFP concentrations (less than 19 ng/ml), found during a three year follow-up, correlated well with the absence of clinical, laboratory and x-ray evidence of tumor recurrence. The differential diagnosis of abnormal AFP concentrations in childhood is discussed, and the importance of the AFP assay in the follow-up of post-hemihepatectomy patients for the assessment of the completeness of the surgical procedure, the prognosis, and the early detection of tumor recurrence is stressed.

Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis

Rheumatology ◽  
2020 ◽  
Vol 59 (12) ◽  
pp. 3798-3806 ◽  
Author(s):  
Denis Poddubnyy ◽  
Henning Weineck ◽  
Torsten Diekhoff ◽  
Imke Redeker ◽  
Nino Gobejishvili ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Back Pain ◽  
Axial Spondyloarthritis ◽  
Clinical Laboratory ◽  
Lower Percentage ◽  
Imaging Features ◽  
Lower Prevalence ◽  
Sacroiliac Joints ◽  
Mri Characteristics ◽  
Osteitis Condensans Ilii

Abstract Objectives Osteitis condensans ilii (OCI) has become an important differential diagnosis for axial spondyloarthritis (axSpA). The objective of this matched case–control study was to investigate demographic, clinical, laboratory and MRI characteristics of OCI as compared with axial spondyloarthritis (axSpA). Methods A total of 60 patients diagnosed with OCI were included in the final analysis. From 27 of these patients, MRIs of the sacroiliac joints were available. OCI patients were matched with a 1:1 ratio by back pain duration to patients with definite axSpA in order to compare clinical, laboratory and MRI characteristics. Results The OCI patients were nearly all females (96.7 vs 46.7%), had a significantly lower prevalence of inflammatory back pain (39.5 vs 88.9%), a significantly lower percentage of HLA-B27 positives (35.2 vs 80.0%) and a lower prevalence of the majority of other SpA features as compared with axSpA patients. Interestingly, there was no difference in the prevalence of osteitis in the sacroiliac joints (92.6 vs 85.2% in OCI and axSpA, respectively, P = 0.44), but there was a difference in the prevalence of erosions (7.4 vs 66.7%, respectively, P = 0.0001). In addition, in OCI nearly all lesions were localized in the anterior part of the sacroiliac joints while in axSpA lesions were localized predominantly in the middle part of the joint (for osteitis: 96 vs 4% in OCI and 28.6 vs 71.4% in axSpA; P = 0.0002 for the inter-group difference). Conclusion Clinical and imaging features of OCI compared with axSpA are described that should help in differential diagnosis.

Mathematical Models for the Differential Diagnosis of Various Forms of Pyelonephritis by Expert Systems in Urology

2020 ◽  
Vol 53 (6) ◽  
pp. 437-439
Author(s):  
N. А. Korenevskiy ◽  
G. V. Siplivyi ◽  
D. S. Rodionov ◽  
T. N. Govorukhina ◽  
V. V. Dmitrieva
Keyword(s):  
Differential Diagnosis ◽  
Expert Systems ◽  
Mathematical Models

Primary and Secondary Central Nervous System Vasculitis

2012 ◽  
Vol 27 (11) ◽  
pp. 1448-1459 ◽  
Author(s):  
Peter Gowdie ◽  
Marinka Twilt ◽  
Susanne M. Benseler
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Clinical Laboratory ◽  
Early Recognition ◽  
Brain Diseases ◽  
Neurological Deficits ◽  
Healthy Children ◽  
Central Nervous System Vasculitis ◽  
Secondary Central Nervous System

Central nervous system vasculitis is an increasingly recognized inflammatory brain disease causing devastating neurological deficits and psychiatric manifestations in previously healthy children. Primary central nervous system vasculitis represents an isolated inflammatory attack targeting the cerebral vessels. In contrast, in children with secondary central nervous system vasculitis, an underlying condition can be identified. The spectrum of childhood primary and secondary central nervous system vasculitis is rapidly expanding, as is the differential diagnosis including nonvasculitic inflammatory brain diseases and noninflammatory vasculopathies. Early recognition, rapid diagnostic evaluation, and initiation of treatment have led to improved morbidity and mortality. This review focuses on clinical, laboratory, and neuroimaging characteristics of the distinct subtypes of primary childhood central nervous system vasculitis, reports the etiology of secondary central nervous system vasculitis, provides an overview of the differential diagnosis, and reviews the current approaches in treatment.

scholarly journals RADIAL DIGNOSTICS OF LIQUID FOCAL LIVER FORMATIONS WITH THEIR IDENTIFICATION OF A COMMUNICATIONS WITH THE INTRAHEPATIC BILIARY DUCTS

2021 ◽  
pp. 40-45
Author(s):  
I. P. Vakulenko ◽  
V. V. Khatsko ◽  
O. Ye. Kuzmenko ◽  
V. N. Voytyuk ◽  
V. M. Fominov ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Laboratory ◽  
Early Stage ◽  
Diagnostic Methods ◽  
Laboratory Methods ◽  
The Past ◽  
Intrahepatic Bile Ducts ◽  
Biliary Ducts ◽  
Cyst Hydatid ◽  
Difficult Cases

Summary. The aim of the study is to improve radiological diagnosis and differential diagnosis of fluid focal formations of the liver and their communication with the intrahepatic bile ducts. Materials and methods. The article presents the results of radial diagnostics of drained liquid focal liver formations (non-parasitic cyst, hydatid cyst, abscess) in 182 patients over the past 8 years. Clinical laboratory methods, sonography, computer tomography, magnetic resonance imaging, laparoscopy, cytological and bacteriological examination of liquid from a cyst or liver abscess (in various combinations), statistical methods were used for the diagnostics. Results and discussion. 5 modified diagnostic methods have been applied, which made it possible to improve its accuracy and, at an early stage, to identify the communication of liquid formation with the intrahepatic biliary ducts. The characteristic radial criteria that correspond to various liquid focal liver formations are given. Conclusions. The use of a combination of imaging methods (MSCT, MRT, et al.) is necessary in difficult cases for the detection and differential diagnosis of fluid focal formations of the liver.

scholarly journals DIFFERENTIAL DIAGNOSIS OF STERILE AND I NFECTED PANCREONECROSIS

2021 ◽  
pp. 31-35
Author(s):  
V. V. Boyko ◽  
V. M. Lykhman ◽  
A. O. Merkulov ◽  
D. O. Myroshnychenko ◽  
S. V. Tkach ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Differential Diagnosis ◽  
Pancreatic Necrosis ◽  
Clinical Laboratory ◽  
Practical Importance ◽  
Modern Medicine ◽  
Infectious Complications ◽  
Infected Pancreatic Necrosis ◽  
Septic Complications ◽  
Great Practical Importance

Summary. Introduction. The search for objective methods for diagnosing the form and severity of acute pancreatitis, accurate prediction and timely prevention of infectious complications in this surgical pathology is of great practical importance for modern medicine. Materials and methods. According to clinical, morphological and bacteriological data, groups of patients were selected. The first group included 33 patients with sterile pancreatic necrosis (SP), the second group consisted of 29 patients with infected pancreatic necrosis (IP). Results and discussion. The program of differential diagnosis of sterile and infected pancreatic necrosis with calculation of the index of differential diagnosis (IDD) for each clinical-laboratory and instrumental indicator used in this system is developed. The development and evaluation of diagnostic possibilities of the method of verification of purulent-septic complications of acute pancreatitis and the transition of a sterile form of pancreatic necrosis to an infected one was carried out. Conclusions. The use of the developed method of diagnosis of sterile and infected pancreatic necrosis with the calculation of the index of differential diagnosis allowed in 93% of cases to distinguish sterile pancreatic necrosis from infected and timely determine the scope and tactics of treatment.

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