RADIAL DIGNOSTICS OF LIQUID FOCAL LIVER FORMATIONS WITH THEIR IDENTIFICATION OF A COMMUNICATIONS WITH THE INTRAHEPATIC BILIARY DUCTS

Summary. The aim of the study is to improve radiological diagnosis and differential diagnosis of fluid focal formations of the liver and their communication with the intrahepatic bile ducts. Materials and methods. The article presents the results of radial diagnostics of drained liquid focal liver formations (non-parasitic cyst, hydatid cyst, abscess) in 182 patients over the past 8 years. Clinical laboratory methods, sonography, computer tomography, magnetic resonance imaging, laparoscopy, cytological and bacteriological examination of liquid from a cyst or liver abscess (in various combinations), statistical methods were used for the diagnostics. Results and discussion. 5 modified diagnostic methods have been applied, which made it possible to improve its accuracy and, at an early stage, to identify the communication of liquid formation with the intrahepatic biliary ducts. The characteristic radial criteria that correspond to various liquid focal liver formations are given. Conclusions. The use of a combination of imaging methods (MSCT, MRT, et al.) is necessary in difficult cases for the detection and differential diagnosis of fluid focal formations of the liver.

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The Rhinolith—A Possible Differential Diagnosis of a Unilateral Nasal Obstruction

Case Reports in Medicine ◽

10.1155/2010/845671 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 15

Author(s):

Detlef Brehmer ◽

Randolf Riemann

Keyword(s):

Differential Diagnosis ◽

Nasal Cavity ◽

Foreign Bodies ◽

Early Stage ◽

Diagnostic Techniques ◽

Nasal Discharge ◽

Rare Occurrence ◽

The Past ◽

Stage Of Development ◽

The Right

Rhinoliths are mineralised foreign bodies in the nasal cavity that are a chance finding at anterior rhinoscopy. Undiscovered, they grow appreciably in size and can cause a foul-smelling nasal discharge and breathing problems. Giant nasal stones are now a very rare occurrence, since improved diagnostic techniques, such as endoscopic/microscopic rhinoscopy, now make it possible to identify foreign bodies at an early stage of development. We report the case of a 37-year-old patient who, at the age of 5-6 years, introduced a foreign body, probably a stone, into his right nasal cavity. On presentation, he complained of difficulty in breathing through the right nostril that had persisted for the last 10 years. For the past four years a strong fetid smell from the nose had been apparent to those in his vicinity. Under general anaesthesia, the stone was removed in toto from the right nasal cavity. The possible genesis of the rhinolith is discussed, our case compared with those described in the literature, and possible differential diagnoses are considered.

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Diagnostic possibilities of investigation methods in acute destructive pancreatitis

Medical alphabet ◽

10.33667/2078-5631-2020-17-26-30 ◽

2020 ◽

pp. 26-30

Author(s):

A. V. Mamoshin ◽

A. V. Borsukov ◽

Y. V. Ivanov

Keyword(s):

Differential Diagnosis ◽

Clinical Laboratory ◽

Diagnostic Algorithm ◽

Diagnostic Methods ◽

Fine Needle ◽

Crystallographic Study ◽

Investigation Methods ◽

Pathological Focus ◽

Instrumental Methods ◽

Diagnostic Puncture

The article demonstrates the diagnostic effectiveness of clinical, laboratory and instrumental methods for the differentiation of clinical and morphological forms of acute destructive pancreatitis. The importance of such promising methods as minimally invasive multi-frequency bioimpedancemetry of the pathological focus, the crystallographic study of aspirate performed during fine-needle diagnostic puncture and differential diagnosis of exudative complications of acute destructive pancreatitis is shown. The results obtained determine the necessity of a comprehensive approach with the expansion of the diagnostic algorithm by using fine-needle diagnostic puncture. A comprehensive assessment of diagnostic methods significance can increase the effectiveness of differential diagnosis of clinical and morphological forms of destructive pancreatitis, thereby allowing to timely determinate the tactical position in the treatment of this category of patients.

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CLINICAL LABORATORY DIFFERENTIAL DIAGNOSIS OF ENCEPHALITIS, DISSEMINATED ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS IN CHILDREN

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2017-96-4-34-42 ◽

2017 ◽

Vol 96 (4) ◽

pp. 34-42

Author(s):

N. V. Skripchenko ◽

◽

G. P. Ivanova ◽

E. Y. Skripchenko ◽

A. V. Surovtseva ◽

...

Keyword(s):

Multiple Sclerosis ◽

Differential Diagnosis ◽

Clinical Laboratory

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On the effect of the periodicity of diagnostic measurements on improving the reliability of high-voltage transformers

Safety and Reliability of Power Industry ◽

10.24223/1999-5555-2019-12-1-18-21 ◽

2019 ◽

Vol 12 (1) ◽

pp. 18-21

Author(s):

V. A. Tikhonov

Keyword(s):

Service Life ◽

High Voltage ◽

Chromatographic Analysis ◽

Aluminum Industry ◽

Early Stage ◽

Diagnostic Methods ◽

Transformer Oil ◽

Operating Voltage ◽

Dissolved Gases ◽

The Aluminum Industry

The influence of the periodicity of diagnostic measurements on the operational state of high-voltage transformers is considered. Examples of defects of switching devices of converter transformers and methods for their detection are given. The rationale for the importance of recognition of defects at an early stage of their occurrence is given. The influence of the multiplicity of overvoltages on the service life of converter transformers in the aluminum industry is investigated. Based on the analysis of the service life of converter transformers of one of the powerful aluminum plants, where 83% of converter transformers have exhausted their standard service life, it is shown that in 40% of cases it would be possible to avoid their failures, with timely detection and elimination of emerging defects. Examples of defects of OLR (on-load regulators) of converter transformers and methods for their detection are given. The importance of recognition of defects at an early stage of their occurrence is substantiated. A method for chromatographic analysis of dissolved gases in transformer oil has been developed for the qualitative determination of defects and ways to eliminate them. Examples of diagnostics of converter transformers at operating voltage and working load are given, providing the best quality operational characteristics of converter transformers. The periodicity of diagnostic measurements and the reduction of defects and failures has been substantiated. The question of diagnosing the state of the converter transformer TDNP-40000/10 at an enterprise of the aluminum industry is investigated. Currently, diagnostic methods are being developed based on chromatographic analysis of dissolved gases in transformer oil. The presented method of evaluating the operating parameters of transformers allows for the safe operation of high-voltage transformers and enables to increase the reliability of the power supply scheme of aluminum industry plants.

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HPV-associated cervical diseases: screening, methods of examination, principles of treatment

GYNECOLOGY ◽

10.26442/20795696.2019.3.190595 ◽

2019 ◽

Vol 21 (3) ◽

pp. 6-8

Author(s):

Vera N Prilepskaya

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Cancer Prevention ◽

Mortality Rates ◽

Diagnostic Methods ◽

Screening Methods ◽

The Past ◽

Associated Diseases ◽

Principles Of Treatment ◽

Cervical Diseases

This article presents information about modern principles of diagnosis and treatment of HPV-associated diseases. Behind cervical cancer morbidity and mortality rates over the past 10 years increase significantly. Examination and observation of patients with human papillomavirus persistence of highly oncogenic types is important a link in cancer prevention. The article presents diagnostic methods, treatment of cervical diseases, as well as the possibility of pharmacotherapy in HPV-associated diseases.

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‘Higher then to her no bookes doe reach’

10.1093/oso/9780198816720.003.0002 ◽

2018 ◽

Author(s):

Martha Vandrei

Keyword(s):

Early Stage ◽

Deep Understanding ◽

Contemporary Philosophy ◽

James I ◽

Historical Method ◽

The Past ◽

Classical World ◽

Material Evidence ◽

Do So

This chapter and the following both draw the reader into seventeenth-century understandings of the past, and of Boudica in particular, and makes clear that in a time before disciplines, writers of ‘history’ were erudite commentators, immersed in political thought, the classical world, and contemporary ideas, as well as in drama, poetry, and the law. Chapter 1 shows the subtleties of Boudica’s place in history at this early stage by giving sustained attention to the work of Edmund Bolton (1574/5–c.1634), the first person to analyse the written and material evidence for Boudica’s deeds, and the last to do so in depth before the later nineteenth century. Bolton’s distaste for contemporary philosophy and his loyalty to James I were highly influential in determining the way the antiquary approached Boudica and her rebellion; but equally important was Bolton’s deep understanding of historical method and the strictures this placed on his interpretive latitude.

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Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol

BMJ Open ◽

10.1136/bmjopen-2018-023850 ◽

2018 ◽

Vol 8 (10) ◽

pp. e023850

Author(s):

Catherine S Wall ◽

Rose S Bono ◽

Rebecca C Lester ◽

Cosima Hoetger ◽

Thokozeni Lipato ◽

...

Keyword(s):

Clinical Laboratory ◽

Subjective Effects ◽

Latin Square ◽

Abuse Liability ◽

Smoke Inhalation ◽

Nicotine Concentration ◽

The Past ◽

The Usa ◽

Behavioural Economic ◽

Scientific Meetings

IntroductionIn the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Flavourings may mask the taste of tobacco and enhance smoke inhalation, influencing toxicant exposure and abuse liability among novice tobacco users. Using clinical laboratory methods, this study investigates how flavour availability affects measures of abuse liability in young adult cigarette smokers. The specific aims are to evaluate the effect of cigar flavours on nicotine exposure, and behavioural and subjective measures of abuse liability.Methods and analysesParticipants (projected n=25) are healthy smokers of five or more cigarettes per day over the past 3 months, 18–25 years old, naive to cigar use (lifetime use of 50 or fewer cigar products and no more than 10 cigars smoked in the past 30 days) and without a desire to quit cigarette smoking in the next 30 days. Participants complete five laboratory sessions in a Latin square design with either their own brand cigarette or a session-specific Black & Mild cigar differing in flavour (apple, cream, original and wine). Participants are single-blinded to cigar flavours. Each session consists of two 10-puff smoking bouts (30 s interpuff interval) separated by 1 hour. Primary outcomes include saliva nicotine concentration, behavioural economic task performance and response to various questionnaire items assessing subjective effects predictive of abuse liability. Differences in outcomes across own brand cigarette and flavoured cigar conditions will be tested using linear mixed models.Ethics and disseminationThe Virginia Commonwealth University Institutional Review Board approved the study (VCU IRB: HM20007848). Dissemination channels for study findings include scientific journals, scientific meetings, and policy briefs.Trial registration numberNCT02937051.

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A large ovarian steroid cell tumor‐not otherwise specified with a unique combination of benign and malignant features as a challenging cause of oligomenorrhea and hirsutism in a 21‐year‐old Syrian female: a case report

BMC Women s Health ◽

10.1186/s12905-021-01244-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Sawsan Ismail ◽

Munawar Hraib ◽

Rana Issa ◽

Thanaa Alassi ◽

Zuheir Alshehabi

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Virgin Female ◽

Cell Tumor ◽

Diagnostic Methods ◽

Unique Combination ◽

Ovarian Steroid ◽

Not Otherwise Specified ◽

Steroid Cell Tumor ◽

Rare Category

Abstract Background Ovarian steroid cell tumors represent a rare category of sex cord-stromal tumors that constitute less than 0.1% of all ovarian tumors. These neoplasms are classified into three main subtypes according to the cell of origin: Leidyg cell tumors, stromal luteomas, and steroid cell tumors not otherwise specified (SCTs-NOS). The latter subtype is defined as a neoplasm of an uncertain lineage that mostly affects middle-aged women, whereas it’s rare in younger ages. Case presentation We report a case of a 21-year-old virgin female who presented to our hospital with complaints of mild abdominal pain, hirsutism, and oligomenorrhea for more than a year. Before her current admission, the patient had attended an external gynecologic clinic where she had been prescribed oral contraceptives to regulate her periods. Nevertheless, on presentation to our institution, physical examination revealed abdominal tenderness with a palpable pelvic mass and mild hirsutism in the thigh. Ultrasonography demonstrated a large left ovarian mass measuring 154 × 104 mm, and compressing the uterus. Therefore, a unilateral salpingo-oophorectomy was performed, and interestingly, pathologic examination of the large aforementioned mass alongside with immunohistochemical correlation revealed the diagnosis of a large ovarian steroid cell tumor-not otherwise specified with a unique combination of benign and malignant features. Conclusions Although ovarian steroid cell tumors represent a rare category, they must be considered in the differential diagnosis for mild virilization symptoms in young females due to the importance of early diagnosis and management. In this manuscript, we aimed to present the first case report from Syria that highlights the crucial role of detailed morphological examination for challenging cases despite the difficulties in differential diagnosis, and the absence of ancillary techniques. Furthermore, we managed to discuss a brief review of diagnostic methods, histological characteristics, and treatment recommendations.

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Update and clinical management of anti-DNA auto-antibodies

Advances in Laboratory Medicine / Avances en Medicina de Laboratorio ◽

10.1515/almed-2021-0008 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Concepción González Rodríguez ◽

MªBelén Aparicio Hernández ◽

Inmaculada Alarcón Torres

Keyword(s):

Lupus Erythematosus ◽

Analytical Methods ◽

Clinical Laboratory ◽

Meta Analysis ◽

Laboratory Methods ◽

Wide Variability ◽

Diagnostic Usefulness ◽

Dna Antibodies ◽

Editorial Review

Abstract Objectives Anti-deoxyribonucleic acid (DNA) antibodies in the clinical laboratory are intimately linked to the diagnosis and monitoring of systemic lupus erythematosus (SLE); however, the characteristics of the analytical methods and the properties of the antibodies themselves are heterogeneous. To review the definition and properties of anti-double-stranded anti-DNA (anti-dsDNA) antibodies, the adequacy of analytical methods, and the clinical requirements for this biomarker. Content Through PubMed we searched the existing literature with the terms anti-dsDNA, editorial, review, guideline, meta-analysis and SLE. The last search, anti-dsDNA and SLE restricted to the last two years. Information was expanded through related articles and those published in official state bodies related to anti-dsDNA and SLE. Summary Clinical laboratory methods for anti-dsDNA analysis and their characteristics are analyze. The clinical utility of anti-dsDNA in its diagnostic, clinical association and follow-up aspects of SLE is reviewed. Outlook There is wide variability in analytical methods and deficits in standardization persist. They are part of the current SLE classification criteria and are used as markers in the follow-up of the disease. Their diagnostic usefulness improves when they are determined in antinuclear antibody (ANA)-positive patients. In follow-up, quantification is of interest, preferably with the same analytical method (given the deficits in standardization).

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The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma

Cancers ◽

10.3390/cancers13153740 ◽

2021 ◽

Vol 13 (15) ◽

pp. 3740

Author(s):

Chunye Zhang ◽

Ming Yang

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Cancer ◽

Fatty Liver ◽

Early Stage ◽

Primary Liver Cancer ◽

Treatment Options ◽

Underlying Mechanism ◽

Diagnostic Methods ◽

T Cell Therapy ◽

Nonalcoholic Fatty Liver

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, followed by cholangiocarcinoma (CCA). HCC is the third most common cause of cancer death worldwide, and its incidence is rising, associated with an increased prevalence of obesity and nonalcoholic fatty liver disease (NAFLD). However, current treatment options are limited. Genetic factors and epigenetic factors, influenced by age and environment, significantly impact the initiation and progression of NAFLD-related HCC. In addition, both transcriptional factors and post-transcriptional modification are critically important for the development of HCC in the fatty liver under inflammatory and fibrotic conditions. The early diagnosis of liver cancer predicts curative treatment and longer survival. However, clinical HCC cases are commonly found in a very late stage due to the asymptomatic nature of the early stage of NAFLD-related HCC. The development of diagnostic methods and novel biomarkers, as well as the combined evaluation algorithm and artificial intelligence, support the early and precise diagnosis of NAFLD-related HCC, and timely monitoring during its progression. Treatment options for HCC and NAFLD-related HCC include immunotherapy, CAR T cell therapy, peptide treatment, bariatric surgery, anti-fibrotic treatment, and so on. Overall, the incidence of NAFLD-related HCC is increasing, and a better understanding of the underlying mechanism implicated in the progression of NAFLD-related HCC is essential for improving treatment and prognosis.

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