scholarly journals Gambaran Profil Hematologi Dalam 24 Jam Pertama Pada Pasien Sepsis Di Unit Neonatus RSUD Dr. Pirngadi Medan Tahun 2017-2018

2021 ◽  
Vol 6 (2) ◽  
pp. 44-48
Author(s):  
Alpa Exaudi Siahaan ◽  
Johan Christian Silaen ◽  
Leo Simanjuntak
Keyword(s):  
Clinical Assessment ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Clinical Syndrome ◽  
Neonatal Unit ◽  
Cross Sectional ◽  
Early Management ◽  
Hematological Profile ◽  
Cross Sectional Design

Background: Neonatal sepsis is a clinical syndrome on infants aged 28 days or more. According to WHO data on 19th April 2018, estimated 3 million newborns and 1.2 million children suffer from sepsis globally every year. Hematological profile assessment can be used as a clinical guide to diagnose sepsis and early management of patients with early onset, especially in hospitals with limited facilities and the examination data can be obtained faster. Objective: This study was aimed to determine the hematological profile in sepsis patients in neonatal unit at RSUD Dr. Pirngadi Medan. Method: This research was a descriptive cross-sectional design. The research sample was selected by total sampling. Results: The results of the study were found from 74 neonates, 44 (59.5%) were male. Neonates with normal labor were 57 (78.1%) and survived 45 (60.8%). It was found that leukocytes (76.4%), neutrophils (60%), monocytes (87.9%), and hemoglobin (40.3%) were increased. Conclusion: The hematological profile can be used as a clinical assessment of sepsis at the first 24 hours on neonates. Hematological examination found an increased leukocytes, neutrophils, monocytes, and hemoglobin in neonatal sepsis patients at the first 24 hours.

scholarly journals ROLE OF IMMATURE/TOTAL NEUTROPHIL RATIO, LEUKOCYTE COUNT AND PROCALCITONIN IN DIAGNOSING NEONATAL SEPSIS

2018 ◽  
Vol 24 (2) ◽  
pp. 169
Author(s):  
I A Putri Wirawati1 ◽  
Aryati Aryati ◽  
A A Wiradewi Lestari
Keyword(s):  
Likelihood Ratio ◽  
Neonatal Sepsis ◽  
Leukocyte Count ◽  
Systemic Disease ◽  
Clinical Syndrome ◽  
Cross Sectional ◽  
Bacteria Growth ◽  
Long Time ◽  
Cross Sectional Design

Neonatal sepsis is a clinical syndrome of systemic disease, accompanied by bacteremia that occurs during infants in the first month of life. A late diagnosis might increase mortality. The presence of bacteria growth in blood cultures is a definitive diagnosis. Unfortunately, culture results are usually obtained of a long time. The study aimed to analyze sensitivity and specificity of the manual I/T ratio, automatic I/T ratio, leukocyte count and procalcitonin (PCT) to diagnose neonatal sepsis. This study used a cross-sectional design, from the NICU room in Sanglah General Hospital, Denpasar. There were 59 patients who met the study criteria. Along with blood culture as the gold standard in determining diagnosis of sepsis and with I/T ratio cut-off of 0.2, the sensitivity of manual I/T ratio was 69.2%, specificity 83.9%, PPV 63.9%, NPV 87% and likelihood ratio was 3.06. While the sensitivity of automatic I/T ratio was 47.6%, specificity 85.8%, PPV 55.1%, NPV 81.4% and likelihood ratio was 2.25. Based on the normal range of leukocyte count (9.1 - 34 x 103/μl), sensitivity of leukocyte count was 59%, specificity 71.5%, PPV 46.7%, NPV 80.9% and likelihood ratio was 1.59. With PCT cut-off 0.5 ng/mL, the obtained sensitivity of PCT was 64.3%, specificity 85.8%, PPV 64.3%, NPV 85.8% and likelihood ratio was 3.13. 

scholarly journals A comparison of neutrophil gelatinase-associated lipocalin and immature to total neutrophil ratio for diagnosing early-onset neonatal sepsis

2016 ◽  
Vol 56 (2) ◽  
pp. 107
Author(s):  
Rocky Wilar ◽  
Dasril Daud ◽  
Suryani As’ad ◽  
Dwi Bahagia Febriani ◽  
Mina Mina
Keyword(s):  
Early Diagnosis ◽  
Sensitivity And Specificity ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
High Sensitivity ◽  
Clinical Syndrome ◽  
Cross Sectional ◽  
Predictive Values ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Background Neonatal sepsis is a clinical syndrome caused by the invasion of microorganisms into the bloodstream. Early diagnosis of early-onset neonatal sepsis (EONS) is difficult. Laboratory tests with high sensitivity and specificity are needed in order to make early diagnoses in newborns.Objective To compare the sensitivity and specificity of neutrophil gelatinase-associated lipocalin (NGAL) and immature to total (IT) neutrophil ratio for the diagnosis of early-onset neonatal sepsis.Methods This observational study with cross-sectional design was conducted in the Neonatology Division, Prof. R. D. Kandou General Hospital from November 2012 to April 2014. Consecutive sampling was applied. There were 103 newborns with suspected EONS who fulfilled the inclusion criteria. Complete blood counts, blood cultures, as well as NGAL and IT ratio measurements were performed.Results NGAL was not significantly more sensitive than IT ratio [80.4% vs. 67.3%, respectively; (P=0.058)]. However, NGAL had lower specificity than IT ratio (27.7% vs. 50.0%, respectively; P=0.016). The positive predictive values (57.0% vs. 64.9%, respectively; P=0.176), and negative predictive values (54.2% vs. 52.6%, respectively; P=0.451) were similar in both diagnostic tests.Conclusion Immature to total neutrophil (IT) ratio has higher specificity compared to NGAL for early diagnosis of EONS. However, the difference in sensitivity between the two test is not statistically significant.

THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Marselli Widya Lestari ◽  
Tri Wahyuni Bintarti
Keyword(s):  
Uric Acid ◽  
Nutritional Status ◽  
Gouty Arthritis ◽  
Extracellular Fluid ◽  
Boarding School ◽  
Clinical Syndrome ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Cross Sectional Design

Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly

scholarly journals Identification of Candida Species on The Skin of Diabetes Mellitus Patients

2018 ◽  
Vol 1 (1) ◽  
pp. 11-18
Author(s):  
OK. Muhammad Al Hafiz ◽  
Rina Amelia ◽  
Nelva Karmila Jusuf
Keyword(s):  
Diabetes Mellitus ◽  
Candida Species ◽  
Clinical Syndrome ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
The Public ◽  
Slide Culture ◽  
Agar Media ◽  
Cross Sectional Design ◽  
Observational Descriptive Study

Intertriginous candidiasis is a type of candidiasis which the lesion lies in the folds of the armpit, groin, intergluteal, folding of the breast, between the fingers or the toes, glans penis, and the umbilicus. One of the risk factors for intertriginous candidiasis is diabetes mellitus (DM). DM is a typical clinical syndrome characterized by the presence of hyperglycemia which is caused by deficiency or the decrease of insulin effectivity. Fungal infection of the skin with Candida species becomes easier in patients with immunocompromised conditions such as DM patients. Objective: To identify the Candida species in DM patient's skin. Method: This research is an observational descriptive study with cross sectional design. This research identifies Candida species from 30 DM patients at The Public Health Center Sentosa Baru Medan who met the inclusion and exclusion criteria by skin scraping with KOH 10% and slide culture. Results: The location of the rash was found in the crotch folds 63.3% and in the intergluteal 36.7%. All samples (100%) showed positive fungus structure with KOH 10% examination. On the examination of slide culture with Saboraoud Dextrose Agar media and identification of slide colony with Corn Meal Agar medium as many as 60% Candida spesies was found with overall species are Candida albicans.

scholarly journals THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI

2019 ◽  
Vol 3 (1) ◽  
pp. 41-46
Author(s):  
Marselli Widya Lestari ◽  
Tri Wahyuni Bintarti
Keyword(s):  
Uric Acid ◽  
Nutritional Status ◽  
Gouty Arthritis ◽  
Extracellular Fluid ◽  
Boarding School ◽  
Clinical Syndrome ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Cross Sectional Design

Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly.

scholarly journals Early neonatal sepsis: prevalence, complications and outcomes in newborns with 35 weeks of gestational age or more

2022 ◽  
Vol 40 ◽  
Author(s):  
Juliana Fernandes de Camargo ◽  
Jamil Pedro de Siqueira Caldas ◽  
Sérgio Tadeu Martins Marba
Keyword(s):  
Hospital Discharge ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Descriptive Analysis ◽  
Neonatal Unit ◽  
Cross Sectional ◽  
Live Births ◽  
Early Onset Sepsis ◽  
Discharge Status ◽  
Early Neonatal Sepsis

ABSTRACT Objective: To analyze the incidence, complications, and hospital discharge status in newborns with ≥35 weeks of gestational age with early neonatal sepsis. Methods: This is a cross-sectional, retrospective study. Cases of early-onset sepsis registered from January 2016 to December 2019 in neonates with gestational age of 35 weeks or more were reviewed in a level III neonatal unit. The diagnoses were performed based on the criteria by the Brazilian Health Regulatory Agency (Anvisa), and the episodes were classified according to microbiological classification and site of infection. The following complications were evaluated: shock, coagulation disorders, and sequelae of the central nervous system. The conditions at hospital discharge were also assessed. The collected data were analyzed with the descriptive analysis. Results: In the period, early neonatal sepsis occurred in 46 newborns, corresponding to 1.8% of all newborns admitted to the neonatal unit, with a prevalence of 4/1,000 live births. Culture confirmed sepsis ocurred in three patients (0.3/1,000 live births), with the following agents: S. pneumoniae, S. epidermidis and S. agalactiae. As to site of infection, there were 35 cases of primary bloodstream infection, seven cases of pneumonia and four cases of meningitis. Most patients (78.3%) had at least one risk factor for sepsis, and all were symptomatic at admission. There were no deaths. Complications occurred in 28.2% of the cases, especially shock (10 cases – 21.7%). Conclusions: The prevalence of proven early neonatal sepsis was low. Despite the common occurrence of complications, there were no deaths.

scholarly journals Differences in levelFms-Like Tyrosine Kinase-1 (sFlt-1), soluble Endoglin (s-Eng), and Placental Growth Factor (PIGF) between Early Onset Preeclampsia and Late Onset Preeclampsia

2018 ◽  
Vol 3 (2) ◽  
pp. 11
Author(s):  
Lita Nafratilova ◽  
Yusrawati Yusrawati ◽  
Irza Wahi
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Intrinsic Factors ◽  
Significant Difference ◽  
The Difference ◽  
Cross Sectional Design ◽  
Early Onset Preeclampsia

Early Onset Preeclampsia (EO-PE) is preeclampsia that develops before 34 weeks 'gestation, caused by intrinsic factors, while Late Onset Preeclampsia (LO-PE) is preeclampsia that develops after 34 weeks' gestation due to extrinsic and maternal factors. There is an increased production of antiangiogenic factors (sFlt-1, s-Eng and PIGF) contribute to pathophysiology of preeclampsia.This study aims to measure the difference of sFlt-1, sEng, PIGF levels between EO-PE and LO-PE. This was an observational study with cross sectional design conducted at Dr. M. Djamil, TK Hospital. III dr. Reksodiwiryo and Biomedical Laboratory FK Unand Padang from August 2017 to August 2018. The sample of this study were 26 severe preeclampsia women : 13 (EO-PE)  and 13 (LO-PE), selected using consecutive sampling. Levels of sFlt-1, sEng, PIGF were examined using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using unpaired t test and Mann-Whitney Test. Results shown that serum levels of sFlt-1 and sEng in (EO-PE)  were 9.51 ± 0.71 ng / L, 1.44 ± 0.06 ng / mL, 5.79 ± 0.42 ng / mL while in PEAL it was 8, 89 ± 0.78 ng / mL, 1.35 ± 0.14 ng / mL, 6.72 ± 0.76. There were a significant difference with a value of p <0.05. The conclusion of this study is that the levels of sFlt-1 and sEng are higher in (EO-PE)  than(LO-PE)and PIGF levels was lower in (EO-PE) compared to (LO-PE)

Abstract P174: Early Onset Parental Hypertension is Associated With Hypertension Status of Their Offspring

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Yongwoo Jeon ◽  
Hyeon Chang Kim ◽  
Hyungseon Yeom ◽  
Dahye Jeon ◽  
Jee-Seon Shim ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Least Square ◽  
High Risk Population ◽  
Onset Age ◽  
Asian Countries ◽  
Hypertension Status ◽  
Cross Sectional ◽  
Prospective Cohorts ◽  
Cross Sectional Design

Background: Family history is a important risk factor for hypertension (HT), however impacts of parental early onset versus late onset on offspring’s HT has not been explored yet in Asian countries. Methods and Results: We analyzed 1,524 participants from two Korean prospective cohorts in cross-sectional design. Early onset was defined as onset before age of 55 and participants were categorized according to parental hypertension(PH) status; “No PH”, “late onset PH” and “early onset PH”. Logistic regression was conducted to compare risks of HT on parental, maternal and paternal HT status. Participants’ HT onset age was compared using least-square means. Overall prevalence of HT was 25.7% (392/1,524) and that of “early onset PH” group was 33.7% (98/291). This group conferred an OR of 3.83 (95% CI, 2.67-5.54) for HT. The onset age of HT was earliest in this group (48.2 years; 95% CI, 47.3-49.2). Conclusions: Early onset HT in parents was associated with high HT prevalence in offspring and also with their onset age. Therefore, for applying early prevention and intervention to the high risk population, it would be beneficial to identify whether individuals had early onset PH.

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