scholarly journals FETAL INFECTIONS OPTIMIZATION OF PREGNANCY AND DELIVERY INTRODUCTION

2021 ◽  
Vol 74 (1) ◽  
pp. 28-34
Author(s):  
Nadiia V. Herevych ◽  
Olena A. Nochvina ◽  
Iryna M. Nikitina
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Growth Retardation ◽  
Ultrasound Examination ◽  
Parvovirus B19 ◽  
Main Group ◽  
Control Group ◽  
Close Monitoring ◽  
Pregnancy And Childbirth

The aim: Improving perinatal outcomes in pregnant women at high risk of intrauterine infection by developing diagnostic criteria and algorithms for managing pregnancy and childbirth. Materials and methods: The study of pregnancy and childbirth was conducted in 72 patients at high risk of IUI, which formed the main group. The control group consisted of 64 patients with a low infectious risk of IUI. Culture, bacterioscopic and biochemical methods were used to identify microorganisms. Peculiarities of infection in the examined women were investigated by determining the concentration of Ig M and IgG in the blood serum and performed polymerase chain reaction for measles virus, cytomegalovirus, parvovirus B19. Serum for the presence of specific immune globulins to these pathogens was examined by ELISA. Comprehensive ultrasound examination in B-mode was performed to determine the feto metry of the fetus and assess its development with the determination of the estimated mass, location, size and structure of the placenta, the amount of amniotic fluid. To determine the condition of the fetus, a Doppler study of blood flow in the uterine arteries, umbilical artery, middle cerebral artery of the fetus and venous duct. Results: Analyzing the course of this pregnancy in women of the studied groups threatened miscarriage and the threat of premature birth occurred in 24 (33.3%) cases, with signs of isthmic-cervical insufficiency were diagnosed in 13 (18.1%) patients. In the control group of patients, the threat of abortion was diagnosed in 15 (23.4%) patients. According to ultrasound examination, patients in the main group in 12 (16.7%) cases were diagnosed with fetal growth retardation, in 25 (34.7%) patients at high risk of IUI there were changes in the placenta, namely, hyper echogenic inclusions in the placenta occurred in 7 (9.7%) cases, dilation of the intervillous space in 8 (11.1%) cases, placental hyperplasia in 7 (9.7%) cases, polyhydramnios was diagnosed in only 5 (6), 9%) cases, with 1 (1.4%) acute polyhydramnios in patients with signs of acute respiratory viral infection during pregnancy. Conclusions: Women at high risk for IUI require close monitoring of the fetus due to the increased frequency of hemodynamic changes in uteroplacental-fetal circulation, including fetal-placental – 22.2% and the occurrence of intrauterine growth retardation. Women with suspected cytomegalovirus infection require determination of seroconversion; in case of immunologically confirmed infection, it is desirable to recognize PCR for cytomegalovirus in the amniotic fluid in order to determine further management and monitoring of this pregnancy.

Determination of clinical efficiency of deproteinized dialysate from blood of milk-fed calves after endoprosthetics in patients with ventral hernias

2020 ◽  
Vol 28 (3) ◽  
pp. 323-333
Author(s):  
Sergej V. Ivanov ◽  
Ilya S. Ivanov ◽  
Evgenij G. Obyedkov ◽  
Liliya P. Popova
Keyword(s):  
Abdominal Wall ◽  
Inflammatory Reaction ◽  
Inflammatory Process ◽  
Anterior Abdominal Wall ◽  
Dynamic Change ◽  
Main Group ◽  
Control Group ◽  
Surgical Department ◽  
Regeneration Stage

Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene. Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev. Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods. Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

scholarly journals Peculiarities of pregnansy and childbirth in patients with a burdened gynecological anamnesis

2020 ◽  
Vol 5 ◽  
pp. 5-10
Author(s):  
T. P. Andriichuk ◽  
A. Ya. Senchuk ◽  
V. I. Chermak
Keyword(s):  
Retrospective Study ◽  
High Risk ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Control Group ◽  
Careful Monitoring ◽  
Pregnancy And Childbirth ◽  
History Of ◽  
High Level ◽  
Adaptive Reactions

The objective: to study the features of pregnancy, childbirth, postpartum period, fetal status and newborns in patients with a history of chronic salpingo-оophoritis.Materials and methods. Conducted a retrospective study of 150 birth histories and neonatal development maps. All patients were divided into two groups. The main group includes 100 patients with chronic salpingo-оophoritis, for which they received anti-inflammatory treatment from 1 to 3 times before pregnancy. The control group included 50 pregnant women who did not suffer from chronic salpingo-оophoritis.Results. Our analysis of pregnancy, childbirth, fetal and neonatal status in women with chronic salpingo-оophoritis indicates that such patients have a complicated obstetric and gynecological and somatic history, which forms an unfavorable basic condition of organs and systems, imperfect adaptation to pregnancy, high risk of failure of adaptive reactions. The result is a violation of the formation and development of the mother-placenta-fetus system and, as a consequence, a high level of complications during pregnancy, childbirth and perinatal pathology.Conclusion. Patients suffering from chronic salpingo-oophoritis should be considered at high risk of possible complications during pregnancy and childbirth. This category of women needs quality preconception training and careful monitoring during pregnancy.

Primary Cardioprotection Reduces Mortality in Lymphoma Patients with Increased Risk of Anthracycline Cardiotoxicity, Treated by R-CHOP Regimen

Chemotherapy ◽  
2018 ◽  
Vol 63 (4) ◽  
pp. 238-245 ◽  
Author(s):  
Monika Długosz-Danecka ◽  
Alicja M. Gruszka ◽  
Sebastian Szmit ◽  
Agnieszka Olszanecka ◽  
Tomasz Ogórka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Overall Survival ◽  
High Risk ◽  
Cardiovascular Mortality ◽  
Control Group ◽  
Close Monitoring ◽  
Historical Cohort ◽  
Anthracycline Cardiotoxicity ◽  
Clinical Issue ◽  
Increased Risk

Background: Advances in anti-lymphoma therapy prolong overall survival, making late adverse effects, like doxorubicin-related cardiotoxicity, an even more important clinical issue. The effectiveness of cardioprotective strategies with close monitoring, angiotensin-converting enzyme inhibitors and/or β-blockers as well as liposomal doxorubicin are still unconfirmed in clinical practice. Methods: This study evaluated the role of a primary cardioprotection strategy in preventing cardiovascular mortality and heart failure occurrence in non-Hodgkin lymphoma (NHL) patients with a high risk of anthracycline cardiotoxicity. Thirty-five NHL patients were subjected prospectively to ramipril and/or bisoprolol at NHL diagnosis, before implementing doxorubicin-containing regimens. Additionally, patients with a diagnosis of asymptomatic/mild heart failure received the liposomal form of doxorubicin. The clinical outcome and frequency of all serious cardiac events were compared with the results in a historical cohort of 62 high-risk cases treated without primary cardioprotection. Results: NHL patients with a primary cardioprotection strategy did not experience cardiovascular deaths in contrast to the retrospective control group where cardiovascular mortality was 14.5% at 3 years (p < 0.05). Primary cardioprotection also decreased the frequency of new cardiotoxicity-related clinical symptoms (2.8 vs. 24.1%; p < 0.05) and prevented the occurrence of cardiac systolic dysfunction (0 vs. 8.5%, respectively; p < 0.05). Although the study was not planned to detect any survival benefit, it demonstrated a trend towards increased response rates (complete response 82 vs. 67%; p not significant) and prolonged survival (projected 5-year overall survival 74 vs. 60%; p < 0.05) for patients treated with primary cardioprotection. Conclusions: A primary personalized cardioprotection strategy decreases the number of cardiac deaths and may potentially prolong overall survival in NHL patients with increased risk of anthracycline cardiotoxicity.

scholarly journals Determination of Zinc in Amniotic Fluid in Normal and High Risk Pregnancies

1983 ◽  
Vol 21 (6) ◽  
Author(s):  
U. Rösick ◽  
Erika Rösick ◽  
P. Brätter ◽  
G. Kynast
Keyword(s):  
High Risk ◽  
Amniotic Fluid

scholarly journals Ultrasound elastography capabilities in studying uterine cerviх state in pregnant women of high-risk group in the first trimester of pregnancy

2016 ◽  
Vol 97 (4) ◽  
pp. 656-661
Author(s):  
M G Tukhbatullin ◽  
K V Yanakova
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Chromosomal Abnormality ◽  
Chromosomal Abnormalities ◽  
Ultrasound Examination ◽  
Risk Group ◽  
First Trimester ◽  
High Risk Group ◽  
Control Group ◽  
Significant Difference

Aim. To study capabilities of quantitative elastographic study to assess the elasticity of the uterine cervix in women with a fetal chromosomal abnormality in the first trimester of pregnancy.Methods. 230 pregnant women of high-risk group at 11-13.6 weeks of pregnancy (parietal-coccygeal length 45-84 mm) were included in this study. The first group consisted of 213 women without fetal pathology. The second group included 17 women, in whose fetuses different chromosomal abnormalities were detected. In ultrasound examination of pregnant women in the I trimester of pregnancy, in addition to standard methods of examination, quantitative cervical elastography was performed.Results. According to results of quantitative elastography in 14 (82.35%) out of 17 pregnant women (second group) one or another degree of the cervical tissue softening was found, and 3 (17.64%) pregnant women with fetal chromosomal pathology had stiff cervix (all 3 cases with Down syndrome). In the control group in 10 (4.7%) of 213 pregnant women relatively soft cervix was identified, and in 203 (95.3%) women cervical density was higher than the myometrial density. A statistically significant difference between the indices of SWE-Ratio in groups was revealed. Quantitative elastography, as a diagnostic test predicting the risk of miscarriage due to chromosomal abnormalities, has a high sensitivity (84.38%) and even higher specificity (95.26%) of negative predictive value 97.57%.Conclusion. Quantitative elastography reveals a significant decrease in the cervical elasticity (softening) in pregnant women with fetal chromosomal abnormality in the I trimester of pregnancy, which allows us to recommend this method of ultrasound examination as an additional marker for early diagnosis of miscarriage due to fetal chromosomal abnormality.

scholarly journals ULTRASONOGRAPHIC DETERMINATION OF FETAL SEX -A STUDY ON 630 CASES IN BANGLADESH

2003 ◽  
Vol 40 (139) ◽  
pp. 128-133 ◽  
Author(s):  
G. M. Monawar Hosian ◽  
S R Milah ◽  
M Saha ◽  
A Begum
Keyword(s):  
Amniotic Fluid ◽  
Sex Determination ◽  
Twin Pregnancy ◽  
Ultrasound Examination ◽  
Female Child ◽  
Third Trimester ◽  
Singleton Pregnancy ◽  
Fetal Sex ◽  
Presentation Position

Ultrasound examination of the fetal perineal area was done in third trimester ofpregnancy to determine the fetal sex. We carried out ultrasound on 621 consecutiveobstetrics patients who attended these centers for obstetric causes referred by theirphysicians. Of them 612 had singleton pregnancy and 9 had twin pregnancy. Weattempted to determine the sex of all fetuses (n=630) based on demonstration of maleand female genitalia. In 585 pregnancies, fetal genitalia were well visualized – theaccuracy rate was thus 92.9%, while the rest 7.1% (n=45) could not be determinedwhich was limited by fetal presentation, position, volume of amniotic fluid and colonicgas. Among the correctly determined cases 384 (65.6%) were male and the rest 201(34.4%) were female. About 91% of the mother desired a male child in contrast toonly 3.1% of the mother who desired a female child prior to ultrasound examination.Interesting enough mothers welcoming female child were all multigravida with previousmale child/children. It needs to mention here that no primae mother welcomed femalechild. Some other aspects of prenatal sex determination have also been discussed inthisarticle.Key Words: Ultrasound, Fetal sex, Bangladesh

scholarly journals Improving of treatment of periodontal diseases in workers of the woodworking industry of the Chernivtsi region

2021 ◽  
Vol 106 (2) ◽  
pp. 28-35
Author(s):  
V. Batig ◽  
◽  
O. Tokar ◽  
I. Burdenyuk ◽  
◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Comparison Group ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Treatment And Prevention ◽  
Group A ◽  
Group B ◽  
Periodontal Indices

Goal. Improving the scheme of treatment and prevention of periodontal diseases in workers of the woodworking industry of Chernivtsi region, who in the process of professional activity have long-term contact with unfavorable factors of the production environment. Materials and methods. 70 workers of the woodworking industry with diagnosed chronic generalized periodontitis of the I degree were treated (35 people – the main group (A); 35 people – comparison group (B)), age – from 25 to 45 years. To compare the results of laboratory studies, an additional survey of 25 healthy individuals of the same age with an intact periodontium were conducted. They formed the control group (C). Clinical examination of patients was performed according to standart methods: subjective (complaints, medical history, life history) and objective (examination, periodontal indices, determination of the level of gingival attachment). Laboratory methods of research included determination of urease and lysozyme activity in saliva, degree of dysbiosis of oral cavity. As maintenance therapy, patients of the main group were prescribed the proposed composition DEPE. Results. After the treatment, a significant improvement in the hygienic status of patients in both groups was observed, but difference between groups A and B in the indicators of oral hygiene after treatment was no statistically significant (pA2–B2 > 0.05). There was a significant improvement in periodontal indices after treatment in patients of both groups (PMA index according to C. Parma, bleeding index according to Muhlemann in Cowell I. modification, Russell periodontal index, PSR-test), but the indicators in patients of the main group were significantly better – pA2–B2 < 0.05. In patients of the main group (A) the level of attachment loss decreased by 1.83 times, comparison group (B) – by 1.71 times. The difference in levels of attachment loss after treatment between groups A and B is statistically significant (pA2–B2 < 0.05). The activity of the enzyme urease in patients of the main group (A) and comparison group (B) after treatment was significantly reduced (pA1–A2 < 0.001, pB1–B2 < 0.001), but only in the main group it reached the level in the control group (C) (pA2–C > 0.05). The level of lysozyme after treatment was significantly increased in patients of both observation groups (pA1–A2 < 0.001, pB1–B2 < 0.001), and reached the level of lysozyme in patients of the control group (C) (pA2–C > 0.05, pB2–C > 0.05). The degree of oral dysbiosis in patients of the main group (A) was significantly reduced by 5.43 times (pA1–A2 < 0.001), and its difference from the degree of dysbiosis in patients of the control group (C) is statistically insignificant (pA2–C > 0.05 ). The degree of oral dysbiosis in patients of the comparison group (B) was significantly reduced by 3.04 times (pB1–B2 < 0.001), but still remained significantly different from oral dysbiosis in patients of the control group (C) (pB2–C < 0.05). Conclusion. The proposed pharmacological composition DEPE is an effective antiseptic solution and can be used in the phase of maintenance therapy to improve the treatment and prevention of periodontal disease in workers of woodworking industry. Key words: decamethoxine, propolis, ethonium, generalized periodontitis, woodworking industry.

Learning of the biotope of maternity pathways of pregnant women with olygohydramnios

2018 ◽  
pp. 81-83
Author(s):  
I. Basiuha ◽  
Keyword(s):  
Pregnant Women ◽  
Genital Herpes ◽  
Pathogenic Bacteria ◽  
Enteric Bacteria ◽  
Main Group ◽  
Gardnerella Vaginalis ◽  
Control Group ◽  
Amniotic Fluid Index ◽  
Urogenital Infections

The article focuses on clinical-statistical analyses of microbiocenosis of maternity pathways of women with oligohydramnios, which will enable the usage of etiotropic mediator aimed at reducing of the frequency of fetus and newborn’s infecting. The objective: to learn the biotope of vaginal environment in the process of pregnancy complicated by oligohydramnios. Materials and methods. There were observed 120 pregnant women with oligohydramnios at gestation term of 27–29 weeks (the main group). 30 women with physiological pregnancy process constituted the control group. Oligohydramnios was diagnosed on the basis of complex examination of pregnant women at the term of 27–29 weeks with the help of standard determination of amniotic fluid index. All the women underwent bacterioscopic and bacteriological examination and detection of antigens to: chlamydia, ureaplasma, mycoplasma, virus of genital herpes, cytomegalic virus. Results. In the main group of women there was diagnosed ureaplasmosis, Gardnerella vaginalis, chlamydiosis, trichomoniasis, Candida albicans, more than half of women had increased concentration of pathogenic bacteria (staphylococcus epidermidis, aureus, saprophyticus, enteric bacteria, enterococcus faecalis), genital herpes, cytomegalovirus. Most of the representatives of the main group had bacterial infection of genital tract (69.17%), and complex bacterial-viruses infection (30.83%). Conclusion. Results of the research show that pregnant women with urogenital infections, inflammations of pelvic organs complicated by obstetrical – gynecological anamnesis should be referred to the group of high risk in reference to the development of oligohydramnios. Key words: pregnancy, microbiocenosis of vulva, oligohydramnios, infections.

Pregnancy and childbirth with Shereshevsky–Turner syndrome, established at 12 years of age

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 90-92
Author(s):  
Evgeny S. Mikhaylin ◽  
Lada A. Ivanova ◽  
Mariya M. Shilo ◽  
Igor V. Berlev
Keyword(s):  
High Risk ◽  
In Vitro Fertilization ◽  
Cesarean Section ◽  
Growth Retardation ◽  
Gonadal Dysgenesis ◽  
Personal Observation ◽  
Vitro Fertilization ◽  
Pregnancy And Childbirth ◽  
Donor Egg

The article presents a personal observation of the course of pregnancy and childbirth in a patient with a typical form of gonadal dysgenesis (ShereshevskyTurner syndrome, karyotype 45,X0/46,XY in the ratio of clones 1:1). The diagnosis was established at 12 years of age during an examination for growth retardation and lack of signs of puberty. Given the presence of a 46,XY clone in the karyotype, a high risk of malignization of dysgenetic gonads, laparoscopy and gonadectomy were performed at 12 years of age. Pregnancy occurred after preparation of the endometrium with estrogens and progestogens, as a result of the first in vitro fertilization attempt with a donor egg and her husbands sperm, occurred against the background of hormonal support with the threat of termination of pregnancy and hypercoagulation. At 34 weeks, there was a premature detachment of placenta, in connection with which she was delivered by cesarean section.

Outcomes of pregnancy and childbirth for the fetus and newborn in case of untimely discharge of amniotic fluid

1986 ◽  
Vol 67 (6) ◽  
pp. 455-456
Author(s):  
T. G. Suleimanova
Keyword(s):  
Fluid Flow ◽  
Statistical Analysis ◽  
Amniotic Fluid ◽  
Control Group ◽  
Study Group ◽  
Pregnancy And Childbirth ◽  
Term Births ◽  
Further Development

To date, the question of the effect of untimely amniotic fluid discharge on the birth act, fetal condition and further development of the newborn has not been solved. We performed a clinical and statistical analysis of 564 term births. Premature amniotic fluid flow occurred in 117 (20.7%) women in the study group and timely flow in 447 (control group).

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