Coronavirus SARS-CoV-2 (COVID-19) and Companion Animal Pets

2020 ◽  
Author(s):  
W Jean Dodds
Keyword(s):  
Respiratory Infections ◽  
Middle Eastern ◽  
Spontaneous Mutation ◽  
Large Family ◽  
Dromedary Camel ◽  
High Morbidity ◽  
Enteric Infection ◽  
Enteric Infections ◽  
Transmissible Gastroenteritis ◽  
The 1960S

Coronaviruses belong to a large family of related viruses that can infect and cause diseases of the respiratory and gastrointestinal tracts of mammals and birds [1-8]. The human strains were first identified in the 1960s and were the cause of common colds, which could lead to bronchitis and pneumonia [1-3]. Coronaviruses are zoonotic microbes that can jump between species and are transmitted between animals and people [3,4]. For example, the Severe Acute Respiratory Syndrome Coronavirus (SARS -CoV) of 2003 was transmitted by civet cats to humans, and the Middle Eastern Respiratory Syndrome (MERS-Co-V) of 2012-2018 had the dromedary camel as an intermediate host [1,2]. The SARS-CoV-2 virus that causes COVID -19 disease of 2019-2020 is believed to have been transmitted by bats, and not as originally thought by some to have arisen from certain snakes and ant-eating pangolins [4-6].The beta-coronavirus (SARS-CoV-2) outbreak that began in the Wuhan area of China in late 2019 has 70% genetic similarity to SARS-CoV and 96% similarity to a bat coronavirus, or even to a chimera of the two viruses [9]. The current spread of COVID-19 disease is a result of human to human transmission [3,4]. Most symptoms are mild but they can develop into severe respiratory infections in elderly people and those with compromised immunity (e.g, cardiovascular and respiratory diseases, and diabetes) [3]. Importantly, SARS-CoV-2 infection of COVID-19 disease has been proven by gene sequencing to have evolved naturally as a mutation and was not a lab-constructed or purposely manipulated virus [9]. Regarding the alpha-coronaviruses of animals, the bovine and canine strains developed from a common ancestor in about 1950 [7,8]. These viruses were recognized in veterinary medicine to cause pathological conditions since the early 1970s. All have been intestinal (enteric) infections except for avian (mostly chicken) infectious bronchitis, which also targets the urogenital tract [7]. For dogs, there are two coronaviruses, the most common form that can cause mild gastrointestinal tract symptoms, and a different rare respiratory form [7].In cats, feline coronavirus is mainly a mild enteric infection, but it can undergo spontaneous mutation in some cats to cause feline infectious peritonitis (FIP) with high morbidity and mortality. In other species, the porcine coronavirus causes transmissible gastroenteritis, and both the bovine and porcine viruses cause diarrhea in young animals. Ferrets, rabbits, rats, and mice are also infected. In bats, the most closely related coronavirus diverged from SARS in 1986 [3,4].

Clinical Presentation, Quality of Care, Risk Factors and Outcomes in Women with Acute ST-Elevation Myocardial Infarction (STEMI): An Observational Report from Six Middle Eastern Countries

2019 ◽  
Vol 17 (4) ◽  
pp. 388-395 ◽  
Author(s):  
Abdulla Shehab ◽  
Khalid F. AlHabib ◽  
Akshaya S. Bhagavathula ◽  
Ahmad Hersi ◽  
Hussam Alfaleh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Quality Of Care ◽  
Middle East ◽  
Clinical Presentation ◽  
Middle Eastern ◽  
High Morbidity ◽  
Inhospital Mortality ◽  
Acute Stemi

Background: Most of the available literature on ST-Elevated myocardial infarction (STEMI) in women was conducted in the developed world and data from Middle-East countries was limited. Aims: To examine the clinical presentation, patient management, quality of care, risk factors and inhospital outcomes of women with acute STEMI compared with men using data from a large STEMI registry from the Middle East. Methods: Data were derived from the third Gulf Registry of Acute Coronary Events (Gulf RACE-3Ps), a prospective, multinational study of adults with acute STEMI from 36 hospitals in 6 Middle-Eastern countries. The study included 2928 patients; 296 women (10.1%) and 2632 men (89.9%). Clinical presentations, management and in-hospital outcomes were compared between the 2 groups. Results: Women were 10 years older and more likely to have diabetes mellitus, hypertension, and hyperlipidemia compared with men who were more likely to be smokers (all p<0.001). Women had longer median symptom-onset to emergency department (ED) arrival times (230 vs. 170 min, p<0.001) and ED to diagnostic ECG (8 vs. 6 min., p<0.001). When primary percutaneous coronary intervention (PPCI) was performed, women had longer door-to-balloon time (DBT) (86 vs. 73 min., p=0.009). When thrombolytic therapy was not administered, women were less likely to receive PPCI (69.7 vs. 76.7%, p=0.036). The mean duration of hospital stay was longer in women (6.03 ± 22.51 vs. 3.41 ± 19.45 days, p=0.032) and the crude in-hospital mortality rate was higher in women (10.4 vs. 5.2%, p<0.001). However, after adjustments, multivariate analysis revealed a statistically non-significant trend of higher inhospital mortality among women than men (6.4 vs. 4.6%), (p=0.145). Conclusion: Our study demonstrates that women in our region have almost double the mortality from STEMI compared with men. Although this can partially be explained by older age and higher risk profiles in women, however, correction of identified gaps in quality of care should be attempted to reduce the high morbidity and mortality of STEMI in our women.

scholarly journals Evaluation of mobile real-time polymerase chain reaction tests for the detection of severe acute respiratory syndrome coronavirus 2

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chukwunonso Onyilagha ◽  
Henna Mistry ◽  
Peter Marszal ◽  
Mathieu Pinette ◽  
Darwyn Kobasa ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Real Time ◽  
Point Of Care ◽  
Middle Eastern ◽  
Turnaround Time ◽  
Cross Reactivity ◽  
Clinical Samples ◽  
Diarrhea Virus ◽  
Highly Sensitive ◽  
Transmissible Gastroenteritis

AbstractThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), calls for prompt and accurate diagnosis and rapid turnaround time for test results to limit transmission. Here, we evaluated two independent molecular assays, the Biomeme SARS-CoV-2 test, and the Precision Biomonitoring TripleLock SARS-CoV-2 test on a field-deployable point-of-care real-time PCR instrument, Franklin three9, in combination with Biomeme M1 Sample Prep Cartridge Kit for RNA 2.0 (M1) manual extraction system for rapid, specific, and sensitive detection of SARS-COV-2 in cell culture, human, and animal clinical samples. The Biomeme SARS-CoV-2 assay, which simultaneously detects two viral targets, the orf1ab and S genes, and the Precision Biomonitoring TripleLock SARS-CoV-2 assay that targets the 5′ untranslated region (5′ UTR) and the envelope (E) gene of SARS-CoV-2 were highly sensitive and detected as low as 15 SARS-CoV-2 genome copies per reaction. In addition, the two assays were specific and showed no cross-reactivity with Middle Eastern respiratory syndrome coronavirus (MERS-CoV), infectious bronchitis virus (IBV), porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis (TGE) virus, and other common human respiratory viruses and bacterial pathogens. Also, both assays were highly reproducible across different operators and instruments. When used to test animal samples, both assays equally detected SARS-CoV-2 genetic materials in the swabs from SARS-CoV-2-infected hamsters. The M1 lysis buffer completely inactivated SARS-CoV-2 within 10 min at room temperature enabling safe handling of clinical samples. Collectively, these results show that the Biomeme and Precision Biomonitoring TripleLock SARS-CoV-2 mobile testing platforms could reliably and promptly detect SARS-CoV-2 in both human and animal clinical samples in approximately an hour and can be used in remote areas or health care settings not traditionally serviced by a microbiology laboratory.

scholarly journals On the Non-Specific Stimulation of Agglutinins. With Especial Reference to the Enteric Fevers and Typhus Fever

1929 ◽  
Vol 28 (4) ◽  
pp. 418-448 ◽  
Author(s):  
A. Felix
Keyword(s):  
Qualitative Method ◽  
Published Data ◽  
Enteric Infection ◽  
Widal Test ◽  
Enteric Infections ◽  
The Difference ◽  
Specific Stimulation ◽  
Enteric Group ◽  
Typhus Fever ◽  
Stimulation Of

(1) The review of the published data furnishes additional evidence in support of the view that no technique whatsoever, Dreyer's technique included, based on the quantitative method of the agglutination reaction hitherto used, is capable of affording a differentiation between inoculation and infection agglutinins.(2) These techniques are concerned always exclusively in the demonstration of the labilotropic H agglutinins ofB. typhosusandB. paratyphosusA. and B. and it is the behaviour of these agglutinins that is the responsible factor in producing the phenomena.(3) In various febrile conditions in inoculated individuals these H agglutinins undergo a re-stimulation resulting in a curve of agglutination which is indistinguishable from that due to specific stimulation. The re-stimulation of the labilotropic inoculation agglutinins is of the same nonspecific character (i.e.heterologous) in the course of enteric infections as in the course of other febrile diseases.(4) The observation of this non-specific re-stimulation is independent of the technique used; living bacilli and suspensions preserved with phenol or formalin (Dreyer's technique included) do not in this respect behave differently.(5) The proposed qualitative method for the Widal test depends, in inoculated individuals, exclusively upon the behaviour of the stabilotropic O agglutinins. In their presence it is capable of affording the certain diagnosis of an enteric infection; in their absence the negative result of the test is not conclusive; if T.A.B. vaccine has been used it is only possible to diagnose enteric group without being able to differentiate typhoid from paratyphoid A. or B.; if T. vaccine has been used then A. or B. infection can be differentiated but not T.(1) The conclusions previously arrived at by means of the qualitative method of the Widal test were fully confirmed. By eliminating the labilotropic H agglutinins from any consideration—in the case of previously sensibilised individuals—agglutination due to the specific stimulation in active enteric infection can be distinguished definitely from that due to the nonspecific re-stimulation by various febrile diseases.(2) Normal and immune O agglutinins forB. typhosusandB. paratyphosusA. and B., as well as those forB. proteusX 19, are not liable to non-specific stimulation in the course of various febrile diseases.(3) One more of the supposed differences in nature between the Widal test and the Weil-Felix test is thereby eliminated.(4) The difference in the response to non-specific stimulation shown to exist in stabilotropic and labilotropic agglutination seems more likely to be one of degree than one in nature and needs further investigation.

scholarly journals Surveillance of influenza A H1N1 2009 among school children during 2009 and 2010 in São Paulo, Brazil

2012 ◽  
Vol 45 (5) ◽  
pp. 563-566 ◽  
Author(s):  
Sandra Baltazar Guatura ◽  
Aripuana Sakurada Aranha Watanabe ◽  
Clarice Neves Camargo ◽  
Ana Maria Passos ◽  
Sheila Negrini Parmezan ◽  
...  
Keyword(s):  
School Children ◽  
Influenza A ◽  
Respiratory Infections ◽  
Vaccination Campaign ◽  
Sao Paulo ◽  
Morbidity Rate ◽  
High Morbidity ◽  
São Paulo ◽  
High Morbidity Rate ◽  
Influenza A H1n1

INTRODUCTION: Influenza A H1N1 2009 is associated with a high morbidity rate among children around the world, including Brazil. This survey was conducted on samples of symptomatic children (< 12 years) to investigate the influenza virus as the etiological agent of respiratory infections in a day care school in a health facility during the first and second pandemic wave of H1N1 (2009-2010) in São Paulo, Brazil. METHODS: Influenza infections were determined by real-time PCR in 34% (47/137) of children with a median age of 5 years (8 months - 12 years), from June to October 2009 and in 16% (14/85) of those with median age of 6 years (1-12 years), from March to November 2010. RESULTS: In general, most positive cases (64%) occurred in children aged 5-12 years, this age group was significantly the most affected (39.8%, p = 0.001, OR = 8.3, CI 95% 1.9-36.9). Wheezing was reported by 31% (19/61) and dyspnea by 23% (14/61) of the studied patients. An outbreak of influenza H1N1 with an attack rate of 35.7% among children (median age 6 years) was documented in April 2010, before the vaccination campaign against the pandemic virus was extended for children up to 5 years in Brazil. CONCLUSIONS: Therefore, the study reinforces the recommendation to immunize school children to reduce the incidence of the disease.

scholarly journals NOSOCOMIAL INTESTINAL SYNDROME IN CHILDREN: FREQUENCY, STRUCTURE, TREATMENT TACTICS

2019 ◽  
Vol 21 (5) ◽  
pp. 272-278
Author(s):  
Yulia V. Maltseva ◽  
T. A. Kuznetsova
Keyword(s):  
Nosocomial Infection ◽  
Respiratory Infections ◽  
Clinical Manifestations ◽  
Negative Attitude ◽  
Hospital Treatment ◽  
Expert Assessment ◽  
Enteric Infection ◽  
Significant Difference ◽  
Hospital Patients ◽  
Hospital Acquired

The problem of nosocomial infections (IUI) is relevant in all countries of the world, both industrialized and developing. According to American and European authors, 91-94% of all cases of nosocomial diarrhea are caused by viruses, most often by rotavirus due to high contagiousness. The official statistics on nosocomial acute intestinal infections in the Russian Federation are understated and incomplete. Due to the immediacy of the problem of hospital-acquired enteric infection, there was conducted a retrospective review of 3098 charts of hospital patients (form 003/у) aged from 0 months to 17 years, who admitted the acute respiratory diseases unit during the period of three years. According to the results of an expert assessment of the case histories of children with acute respiratory pathology, the admission of nosocomial infection was noted in 26.9% of cases (834 patients), with more than half of the cases in children of the first 3 years of life 83.3% (695 patients). There is no significant difference in the clinical manifestations of nosocomial infection, depending on the main respiratory disease. The overlay of the hospital-acquired enteric infection increases the duration of hospitalization, polypharmacy, economic expenses. Moreover, it shapes parents’ negative attitude toward their children’s hospital treatment. It is expected, that the differential approach to hospital admission of only severe pediatric patients in boxes, if possible, and rotavirus enteritis immunization will promote the drop in the enteric superinfection frequency at the acute respiratory infections units.

scholarly journals Specific therapy and emergency prevention of flu

2021 ◽  
pp. 116-123
Author(s):  
Wassili M. Delyagin
Keyword(s):  
Influenza A ◽  
Respiratory Infections ◽  
Age Groups ◽  
Antiviral Drug ◽  
Risk Groups ◽  
Diagnostic Methods ◽  
High Morbidity ◽  
Low Birth Weight Infants ◽  
Food Treatment ◽  
Number Of Patients

Influenza A and B epidemics, occasionally pandemics, are characterized by high morbidity and mortality rates. In most cases, an uncomplicated disease ends with recovery, but unfavorable outcomes, up to lethal, are possible, especially in premature, low birth weight, infants and young children, old people, pregnant and postpartum women, with chronic diseases, immunocompromised, receiving salicylates and anticoagulants. The use of modern diagnostic methods allows early detection of patients with influenza, distinguishing them from the total number of patients with respiratory infections. This allows you to optimize the timing of the examination, avoid unnecessary prescription of antibiotics, and timely prescribe specific chemotherapy and chemoprophylaxis. During epidemics, in the presence of an epidemiological history, the conclusion of the clinician is decisive for the diagnosis. Vaccination is an excellent method of preventing or relieving the flu. However, in case of an unfavorable course of the disease, in risk groups, in closed groups, it is recommended to use chemotherapy, pre-exposure or post-exposure chemoprophylaxis. Numerous studies have proven the effectiveness of the use of the drug oseltamivir, a specific blocker of the virus neuraminidase. As a result, its replication stops. The drug does not complicate the vaccination, it can be used in vaccinated people, in all age groups, is available in different dosages, and can be used with food. Treatment for uncomplicated influenza lasts 5 days. In certain situations, chemoprophylaxis and chemotherapy with the specific antiviral drug oseltamivir can help control influenza outbreaks in certain populations.

scholarly journals Monostrain and multistrain probiotics for respiratory diseases in children

2020 ◽  
Vol 4 (11) ◽  
pp. 698-704
Author(s):  
E.S. Dzottsoeva ◽  
◽  
A.V. Gorelov ◽  
◽  
Keyword(s):  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Lactobacillus Rhamnosus ◽  
Human Organism ◽  
High Morbidity ◽  
Acute Respiratory Infections ◽  
Bifidobacterium Lactis ◽  
Impaired Performance ◽  
Vital Functions ◽  
Multistrain Probiotics

Acute respiratory infections (ARIs) in children are common conditions characterized by high morbidity. ARIs account for up to 75% of all cases of antibiotic use. Dysbiosis results in the impaired performance of vital functions, i.e., digestion, synthesis, colonization resistance, and the regulation of immune system. Probiotics are one of the effective tools to affect the composition of gut microbiota and to restore its metabolic activity. Probiotics, their effects on human organism, and their use in various diseases have received an enormous attention. Meanwhile, the use of antibiotics and the etiological diversity of ARIs account for the lack and irrationality of extensive preventive measures (as in flu) and raise the interest in non-specific prophylaxis. Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. Lactis BB-12 are well-studied strains. Lactobacillus plantarum LP01 and LP02, Lactobacillus rhamnosus LR04 and LR05, and Bifidobacterium lactis BS01 used as monostrain probiotics are also of interest. Multistrain probiotics are gaining traction. However, these probiotics are understudied and require more attention. KEYWORDS: microbiome, monostrain probiotics, multistrain probiotics, acute respiratory infections, antibiotic-associated diarrhea, antibiotic-associated syndrome, Lactobacillus rhamnosus, Bifidobacterium lactis. FOR CITATION: Dzottsoeva E.S., Gorelov A.V. Monostrain and multistrain probiotics for respiratory diseases in children. Russian Medical Inquiry. 2020;4(11):698–704. DOI: 10.32364/2587-6821-2020-4-11-698-704.

Hospital Infections

2012 ◽  
Author(s):  
E Patchen Dellinger ◽  
Heather L. Evans ◽  
Erik G. Van Eaton
Keyword(s):  
Nosocomial Infections ◽  
Respiratory Infections ◽  
Hospital Infections ◽  
Postoperative Fever ◽  
Algorithmic Approach ◽  
Risk Detection ◽  
Mediastinal Infection ◽  
Enteric Infections ◽  
Device Associated Infection ◽  
Tract Infections

Nosocomial infections are a threat to all hospitalized patients. They can increase morbidity, mortality, length of stay, and costs and occur in almost every body site. This review features an algorithmic approach to the risk, detection, and treatment of nosocomial infections. Respiratory infections include pneumonia, tracheitis or tracheobronchitis, paranasal sinusitis, and otitis media. Operative site or injury-related infections include those occurring in wounds, the intra-abdominal space, methicillin-resistant Staphylococcus aureus (MRSA), empyema, posttraumatic meningitis, osteomyelitis, and sternal and mediastinal infection. A review of intravascular device--associated infection focuses on catheter-related bacteremia and its management. Catheter-associated urinary tract infections (UTIs) and enteric infections are also considered. Enteric infections and transfusion-associated infections are covered in depth, reviewing the most important recent advances and studies. A discussion of postoperative fever addresses the magnitude and incidence of hospital infections, UTIs, and catheter duration and pathogens typically involved and considers the associated costs and the risks of acquiring a nosocomial infection. This review contains 5 figures, 1 table,1 algorithm, and 292 references.

scholarly journals Minimum Determinants of Transmissible Gastroenteritis Virus Enteric Tropism Are Located in the N-Terminus of Spike Protein

Pathogens ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 2 ◽  
Author(s):  
Carlos M. Sanchez ◽  
Alejandro Pascual-Iglesias ◽  
Isabel Sola ◽  
Sonia Zuñiga ◽  
Luis Enjuanes
Keyword(s):  
Sialic Acid ◽  
Transmissible Gastroenteritis Virus ◽  
High Morbidity ◽  
S Protein ◽  
Binding Domains ◽  
Gastroenteritis Virus ◽  
Sialic Acid Binding ◽  
Transmissible Gastroenteritis ◽  
Enteric Tract

Transmissible gastroenteritis virus (TGEV) is an enteric coronavirus causing high morbidity and mortality in porcine herds worldwide, that possesses both enteric and respiratory tropism. The ability to replicate in the enteric tract directly correlates with virulence, as TGEVs with an exclusive respiratory tropism are attenuated. The tissue tropism is determined by spike (S) protein, although the molecular bases for enteric tropism remain to be fully characterized. Both pAPN and sialic acid binding domains (aa 506–655 and 145–155, respectively) are necessary but not sufficient for enteric tract infection. Using a TGEV infectious cDNA and enteric (TGEV-SC11) or respiratory (TGEV-SPTV) isolates, encoding a full-length S protein, a set of chimeric recombinant viruses, with a sequential modification in S protein amino terminus, was engineered. In vivo tropism, either enteric, respiratory or both, was studied by inoculating three-day-old piglets and analyzing viral titers in lung and gut. The data indicated that U655>G change in S gene (S219A in S protein) was required to confer enteric tropism to a respiratory virus that already contains the pAPN and sialic acid binding domains in its S protein. Moreover, an engineered virus containing U655>G and a 6 nt insertion at position 1124 (Y374-T375insND in S protein) was genetically stable after passage in cell cultures, and increased virus titers in gut by 1000-fold. We postulated that the effect of these residues in enteric tropism may be mediated by the modification of both glycosaminoglycan binding and S protein structure.

Mainstreaming Middle East Gender Research: Promise or Pitfall?

2001 ◽  
Vol 35 (1) ◽  
pp. 15-23
Author(s):  
Ruth Roded
Keyword(s):  
Middle East ◽  
Middle Eastern ◽  
Feminist Movement ◽  
Gender Research ◽  
Quantitative Studies ◽  
Cultural Life ◽  
Major Subject ◽  
The Status ◽  
The 1960S ◽  
New Research

From The Advent Of Middle Eastern Studies, the ‘status of the Muslim woman’ was a major subject of interest, not to say fascination. Women in Middle Eastern society were depicted as invisible, downtrodden figures, whiling away their time in harems, ignorant of anything but the most frivolous matters, and prone to childlike behavior. A handful of outstanding, unique women were portrayed either as ideal paragons or as evil shrews.In the wake of the feminist movement of the 1960s, Middle Eastern ‘women’s history’ gradually began to modify these stereotypes. During the last two decades, new research has revealed the varied roles women have played in the economic, social, and cultural life of the Middle East. Quantitative studies of economic records have produced provocative findings on the ownership and management of property by women.

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