Applied Successful Treatment of Two Main Post-COVID-19 Symptoms: Anosmia and Ageusia: A Novel Approach

2021 ◽  
Author(s):  
Majid Mohammed Mahmood
Keyword(s):  
Age Groups ◽  
Black Pepper ◽  
Health Conditions ◽  
Eye Drops ◽  
Pine Needle ◽  
Fluticasone Furoate ◽  
Novel Approach ◽  
Pharmaceutical Industries ◽  
Siberian Pine ◽  
Immunocompetent Patients

Patients recovering from COVID-19 occasionally reported anosmia (loss of smell) and ageusia (loss of taste). This paper aims to use medications to treat anosmia and ageusia in post-COVD-19 recovered patients. A total of 6391 recovered COVID-19 patients were invited to enroll in this study from all age groups, both genders and different health conditions (immunocompromised and immunocompetent patients). Clinical treatments of anosmia were done by application of Apisal nasal/eye drops (Amman Pharmaceutical Industries, Jordan), used 3 times a day to stimulate nasal epithelial lining cells. It can sensitize the nose then stimulate and induce smelling function. Responders were 2794 (43.72%) of patients who were cured and retained smelling (novel work). Next was application of Vicks inhaler nasal stick which consists of 125 mg menthol, 50 mg camphor and 10 mg Siberian pine needle oil used 3 times a day. Responders were 5884 (92.07%) within 5 days. A combination of Apisal and Vicks recorded 6186 (96.80%) cures. The rest, 205 non-responsive patients to above medications were prescribed Avamys (fluticasone furoate) 27.5 micrograms/spray, nasal spray suspension (GSK, UK), twice a day which gave 203 (99.02%) cures as this is a novel work. Clinical treatment of ageusia involved administration of A-Z vital caplets (Hansal, Germany), an excellent tonic (multivitamins and minerals) once a day for adults, while Pharmaton Kiddi syrup (Boehringer Ingelheim, Germany) was given to children. Hot spices included a mixture of equal volumes of black pepper, ginger, cinnamon, cloves and coriander (doses were not determined but little mixture powder was applied inside the mouth) were advised beside tonics to stimulate taste pads so as to gain its function back to normal. 6382 (99.80%) patients got their taste back to normal within 5 days and this is also a novel work. After massive success of these medications, they were circulated all over Arab homeland as well as expat Arabs across the world.

scholarly journals The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Karin Wildi ◽  
Samantha Livingstone ◽  
Chiara Palmieri ◽  
Gianluigi LiBassi ◽  
Jacky Suen ◽  
...  
Keyword(s):  
Age Groups ◽  
Geographical Location ◽  
High Morbidity ◽  
Shock State ◽  
Pharmacological Agents ◽  
New Approach ◽  
Novel Approach ◽  
Active Research ◽  
Targeted Medicine ◽  
Core Features

AbstractThe acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing pharmacological agents to treat ARDS, its mortality rate remains unaltered high and treatment is still only supportive. Over the years, there have been many attempts to identify meaningful subgroups likely to react differently to treatment among the heterogenous ARDS population, most of them unsuccessful. Only recently, analysis of large ARDS cohorts from randomized controlled trials have identified the presence of distinct biological subphenotypes among ARDS patients: a hypoinflammatory (or uninflamed; named P1) and a hyperinflammatory (or reactive; named P2) subphenotype have been proposed and corroborated with existing retrospective data. The hyperinflammatory subphenotyope was clearly associated with shock state, metabolic acidosis, and worse clinical outcomes. Core features of the respective subphenotypes were identified consistently in all assessed cohorts, independently of the studied population, the geographical location, the study design, or the analysis method. Additionally and clinically even more relevant treatment efficacies, as assessed retrospectively, appeared to be highly dependent on the respective subphenotype. This discovery launches a promising new approach to targeted medicine in ARDS. Even though it is now widely accepted that each ARDS subphenotype has distinct functional, biological, and mechanistic differences, there are crucial gaps in our knowledge, hindering the translation to bedside application. First of all, the underlying driving biological factors are still largely unknown, and secondly, there is currently no option for fast and easy identification of ARDS subphenotypes. This narrative review aims to summarize the evidence in biological subphenotyping in ARDS and tries to point out the current issues that will need addressing before translation of biological subohenotypes into clinical practice will be possible.

Reflecting on perceived deinstitutionalization of gender‐biased employment practices in accountancy

2012 ◽  
Vol 9 (4) ◽  
pp. 300-336 ◽  
Author(s):  
Rosalind H. Whiting
Keyword(s):  
Organizational Change ◽  
Cultural Change ◽  
Sample Selection ◽  
Age Groups ◽  
Young Female ◽  
Human Resource Managers ◽  
Employment Practices ◽  
Content Type ◽  
Novel Approach ◽  
Chartered Accountants

PurposeThe purpose of this paper is to explore the changes in gender‐biased employment practices that it is perceived have occurred in New Zealand accountancy workplaces over the last 30 years, using Oliver's model of deinstitutionalization.Design/methodology/approachSequential interviewing was carried out with 69 experienced chartered accountants and three human resource managers, and at a later date with nine young female accountants.FindingsEvidence is presented of perceived political, functional and social pressures cumulatively contributing to deinstitutionalization of overt gender‐biased employment practices, with social and legislative changes being the most influential. Deinstitutionalization appears incomplete as some more subtle gender‐biased practices still remain in New Zealand's accountancy workplaces, relating particularly to senior‐level positions.Research limitations/implicationsThis study adds to understanding of how professions evolve. The purposeful bias in the sample selection, the small size of two of the interviewee groups, and the diversity in the interviewees' workplaces are recognized limitations.Practical implicationsIdentification of further cultural change is required to deinstitutionalize the more subtle gender‐biased practices in accountancy organizations. This could help to avoid a serious deficiency of senior chartered accountants in practice in the future.Originality/valueThis paper represents one of a limited number of empirical applications of the deinstitutionalization model to organizational change and is the first to address the issue of gender‐biased practices in a profession. The use of sequential interviewing of different age groups, in order to identify and corroborate perceptions of organizational change is a novel approach.

scholarly journals Vitamin E status in healthy population in Asia: a review of current literature

2019 ◽  
pp. 1-14
Author(s):  
Anku Malik ◽  
Manfred Eggersdorfer ◽  
Geeta Trilok-Kumar
Keyword(s):  
Vitamin E ◽  
Physiological State ◽  
Age Groups ◽  
Health Conditions ◽  
Healthy Population ◽  
Asian Countries ◽  
The Past ◽  
Conclusive Data ◽  
Vitamin E Status ◽  
Lipid Soluble Antioxidant

Abstract. Vitamin E is a lipid soluble antioxidant which mainly circulates as α-tocopherol in the human plasma. Its deficiency is associated with ataxia, neuropathy, anaemia and several other health conditions. Although substantial data on vitamin E status has been published worldwide, there is paucity of data on the extent of deficiency from most Asian countries, including India. Part of the problem is lack of validated biomarkers for vitamin E and no consensus on cut offs for defining deficiency and sufficiency. Thus, interpretation of the data on the vitamin E status is difficult. Limited available data from 31 studies on vitamin E status in healthy people from Asia, the most populated continent, has been collated for the purpose of this review. Broadly, the results suggest inadequate vitamin E status in most age groups, with the prevalence of deficiency reaching 67%, 80%, 56% and 72% in infants, children and adolescents, adults, elderly and pregnant women, respectively, based on varying cut offs. The findings are not surprising as both, vitamin E intakes and its status have not received too much attention in the past. Lack of conclusive data accentuates the need for more research on the vitamin E status across all age groups and to define age, gender and physiological state specific cut offs for vitamin E levels.

Neurotherapy Intervention: A novel approach of healing

2021 ◽  
Vol 2 (1) ◽  
pp. 28
Author(s):  
Saras Jyoti ◽  
Ram Gopal Parihar ◽  
Ajay Gandhi
Keyword(s):  
Nervous System ◽  
Complementary Medicine ◽  
Health Conditions ◽  
Holistic Treatment ◽  
Anatomy And Physiology ◽  
Root Cause ◽  
Alternative And Complementary Medicine ◽  
Novel Approach

Background: Neurotherapy is an alternative and complementary medicine originated in India. It is drugless holistic treatment founded and developed by Sh. Lajpatrai Mehra respectfully called “Guruji” by using ancient knowledge of ‘Nadi Vigyan’ (knowledge of nervous system), Ayureveda and principles of Anatomy and Physiology. Summary: t uses the finding of medical physiology but views them from a uniquely and refreshing approach, one that negates the use of medicines or drugs. Supported by basis of physiology, Dr. Lajpatrai Mehra (Guruji) has combined these palpations with symptoms and related them with various health conditions. Key message: The therapy acts on root-cause of the disease. It uncovers the root cause of the disease and cures the same in a sophisticated manner without the use of drugs or medication. It is simple therapy with potential to normalize or revive the functioning of the organs

Diagnoses of Chronic Health Conditions and Change in Subjective Age: The Moderating Role of Chronological Age

2021 ◽  
Author(s):  
Anyah Prasad ◽  
Edward Alan Miller ◽  
Jeffrey A Burr ◽  
Kathrin Boerner
Keyword(s):  
Sense Of Self ◽  
Age Groups ◽  
Disease Diagnosis ◽  
Chronic Health Condition ◽  
Chronic Health Conditions ◽  
Health Conditions ◽  
Chronological Age ◽  
Subjective Age ◽  
Future Health ◽  
Chronic Health

Abstract Background and Objectives Health is a predictor of subjective age, and although inconclusive, the strength of this association is not uniform across different age groups. This study investigates if new diagnoses of chronic health conditions are associated with a change in subjective age and if chronological age moderates this relationship. Research Design and Methods Using data from the Health and Retirement Study, residualized change regression analysis was performed for a sample of 5,158 respondents older than 50 years to examine their subjective age in 2014 relative to that reported in 2010. The main predictor was the number of chronic health conditions newly diagnosed between 2010 and 2014. Chronological age in 2010 was the moderator. Results Results showed that each new diagnosis of a chronic health condition was significantly associated with a 0.68-year increase in subjective age reported in 2014, compared to subjective age reported in 2010. However, this increase in subjective age was attenuated by 0.05 years for each additional year in 2010 chronological age. Discussion and Implications According to Social and Temporal Comparison theories, people compare themselves to their age peers and earlier selves. Given expectations for better health at younger chronological ages, being diagnosed with chronic health conditions may have a stronger association with subjective age among middle-aged persons as compared to older persons. The findings suggest that subjective age may be used as a screening tool to predict how chronic disease diagnosis may influence peoples' sense of self, which in turn shapes future health.

scholarly journals The Association Between Health Conditions, Consciousness, Involvement, and Knowledge and Dietary Supplement Intake among University Students in South Korea

2019 ◽  
Vol 16 (20) ◽  
pp. 4028 ◽  
Author(s):  
Jinkyung Choi
Keyword(s):  
University Students ◽  
South Korea ◽  
Behavioral Intentions ◽  
Age Groups ◽  
The Elderly ◽  
Health Conditions ◽  
Intention To Purchase ◽  
Younger Age ◽  
The Future ◽  
Supplement Intake

Dietary supplements (DSs) are typically used by the elderly in a population, but younger age groups are increasingly purchasing these products. In consideration of this issue, the present study investigated the DS-related behaviors and general lifestyles of university students in South Korea. The health conditions, consciousness, involvement, and knowledge, as well as the future behavioral intentions, of DS users and non-users were determined and compared. A survey was administered to the respondents, and measurements were adapted and rephrased to suit the Korean context. Results showed that although the behaviors of DS users and non-users were characterized by similar patterns, significant differences in health involvement and future purchase were found between these groups. Health involvement influenced DSs buying intentions in the future, but no significant differences in the other variables were found. The findings suggested that university students take DSs regardless of their expectations about their efficacy and that their knowledge does not affect their intention to purchase such products.

scholarly journals Naturally occurring Piper plant amides potential in agricultural and pharmaceutical industries: perspectives of piperine and piperlongumine

2019 ◽  
Vol 62 (1) ◽  
Author(s):  
Hwang-Ju Jeon ◽  
Kyeongnam Kim ◽  
Yong-Deuk Kim ◽  
Sung-Eun Lee
Keyword(s):  
Review Paper ◽  
Folk Medicine ◽  
Black Pepper ◽  
Piper Nigrum ◽  
Agricultural Pests ◽  
Anticancer Properties ◽  
Naturally Occurring ◽  
Korean Traditional Medicine ◽  
Pharmaceutical Industries ◽  
Therapeutic Properties

Abstract Piperaceae plants consist of about 3600 species, of which about 2000 are Piper plants. Their habitat is distributed across pantropical regions. The representative plant is Piper nigrum, known as black pepper. These plants have been widely used in folk medicine in Korean traditional medicine. This review collected papers identifying and separating the amides obtained from these Piper plants, with a focus on Piper amides potential to control the production and growth of fungal strains that cause plant disease and their insecticidal properties against agricultural pests. Piper amide benefits include antiaflatoxigenic activities, antiparasitic activities, anticancer properties, antiplatelet activities, and anti-inflammatory activities, among other therapeutic properties for the treatment of human diseases. In addition, this review paper provides a total synthesis study on the mass production of Piper amides and their derivatives, with a formulation study for industrial use. This review paper is designed to help inform future studies on Piper amide applications.

scholarly journals Trends in total fat and fatty acid intakes and chronic health conditions in Korean adults over 2007–2015

2019 ◽  
Vol 22 (8) ◽  
pp. 1341-1350 ◽  
Author(s):  
SuJin Song ◽  
Jae Eun Shim ◽  
Won O Song
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
National Level ◽  
Age Groups ◽  
Chronic Health Conditions ◽  
Health Conditions ◽  
Chronic Health ◽  
Korean Adults ◽  
Distribution Ranges ◽  
Total Fat

AbstractObjectiveTo investigate trends in total fat and fatty acid intakes and chronic health conditions among Korean adults over nine years between 2007 and 2015.DesignCross-sectional, observational study using a stratified, multistage probability sampling design at a national level. Intakes of total fat and fatty acids were estimated from 24 h dietary recalls by sex and age groups. Trends of total fat and fatty acid intakes were determined by multiple linear regression after adjusting for covariates. Trends in age-standardized prevalence of obesity, hypercholesterolaemia and hypertriacylglycerolaemia were examined by sex.SettingKorea.ParticipantsPopulation data of 47749 healthy adults (aged ≥19 years) derived from the Korea National Health and Nutrition Examination Survey between 2007 and 2015.ResultsOver the survey period, daily intakes of energy and total, saturated, monounsaturated, polyunsaturated, n-3 and n-6 fats (grams and percentage of energy (%E)) increased steadily. In all sex and age groups, significant increases were seen in SFA intake from 9·9 g (4·7 %E) to 12·0 g (5·3 %E) and in MUFA intake from 9·9 g (4·6 %E) to 13·3 g (5·8 %E). The prevalence of hypercholesterolaemia increased from 10·7 to 17·9 % over the same period.ConclusionsIn Korean adults, total fat, SFA and other fatty acids have been increasing along with the prevalence of hypercholesterolaemia. This information can help set adequate macronutrient and fatty acid distribution ranges in developing population-specific preventive strategies against diet-related illness.

scholarly journals A Novel Approach for Bone Age Assessment using Deep Learning

2021 ◽  
pp. 67-75
Author(s):  
Nishan B. Poojary ◽  
Prathamesh G. Pokhare ◽  
Pratik P. Poojary ◽  
Charmi D. Raghavani ◽  
Dr. Jayashree Khanapuri
Keyword(s):  
Transfer Learning ◽  
Age Groups ◽  
Bone Age ◽  
Absolute Error ◽  
Assessment Model ◽  
Age Assessment ◽  
Male And Female ◽  
Novel Approach ◽  
Proposed Model ◽  
Bone Age Assessment

In this paper, we propose a detailed approach to create a Bone age assessment model. Bone age assessment is a common medical practice in the assessment of child development, who are less than 18 years of age. In this proposed model, the Xception architecture is being used for transfer learning. Using feature extraction and transfer learning, the pre-trained convolutional neural network were custom trained. The dataset used for training the model is obtained from the Kaggle RNSA Bone Age dataset containing 12811 male and female bone images of different age groups. Finally, we were able to attain a mean absolute error (MAE) of 8.175 months in male and female patients, which aligns with our initial goal of achieving MAE in under a year.

scholarly journals Probiotic Biofilm: A Novel Approach to Produce a New Generation of Probiotics and Probiotic Foods

2021 ◽  
Author(s):  
Zeinab Rezaei ◽  
Amir Salari ◽  
Saeid Khanzadi
Keyword(s):  
Lactobacillus Rhamnosus ◽  
Fourth Generation ◽  
Protection Method ◽  
Novel Approach ◽  
Gastrointestinal Conditions ◽  
Natural Protection ◽  
Pharmaceutical Industries ◽  
New Generation ◽  
Number Of Bacteria

Abstract Background Probiotic biofilm is considered a new version of an advanced natural protection method recently placed on researchers’ agenda as the fourth generation of probiotics. In several studies, probiotic biofilms have been produced exclusively in the bacterial culture medium, but in this study, the biofilm of Lactobacillus plantarum PTCC 1745 and Lactobacillus rhamnosus PTCC 1637 were formed in food (milk) and evaluated for the first time. Methods The biofilm was produced in milk then was transferred to yogurt in whole and crushed forms to be tested in real conditions as probiotic bacteria carriers. Survival was assessed for 21 days as well as gastrointestinal conditions. Results Results demonstrate that the number of bacteria in biofilm did not change significantly during 21 days of refrigerated storage. In contrast, planktonic bacteria was decreased by about 2.8 log simultaneously. Another significant result is that the biofilm could appropriately protect the bacteria in the stomach and intestine simulated conditions. So, no significant reduction was observed in the number of bacteria during 120 min, but planktonic cells were destroyed after 30 min. Conclusions In conclusion results indicated that L. plantarum and L. rhamnosus could form a very desirable and strong biofilm in vitro and milk that can have a good protective effect on yogurt’s probiotic survival process and storage. Therefore, the probiotic biofilm technique can introduce a new generation of probiotics to the food and pharmaceutical industries

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