scholarly journals Seroprevalence and Trends of HTLV-1/2 among Blood Donors of Santo Domingo, Dominican Republic, 2012-2017

Author(s):  
Emiliana Eusebio-Ponce ◽  
Francisco Javier Candel ◽  
Robert Paulino-Ramirez ◽  
Irene Serrano-García ◽  
Eduardo Anguita ◽  
...  

Objectives. Being a Caribbean country, the Dominican Republic is considered endemic for HTLV-1. Viral screening in blood banks is recommended for this blood borne infection. The purpose of this work is to analyze the seroprevalence and trends of HTLV-1/2 in the Dominican Republic blood donors; it is focused on Santo Domingo, the capital of the country, which has the largest blood donation activity. We also aim at comparing our findings with published data from neighboring countries. Patients and methods. We performed a retrospective cross-sectional study of 10 blood centers of Santo Domingo, which reported HTLV and the other blood-transmitted infections in full. They represent more than 40% of the province’s blood donations. Annual seroprevalence of HTLV-1/2, period prevalence (2012-2017), and time trend were determined. Results. A total of 352,960 blood donations were evaluated. The HTLV-1/2 period prevalence was 0.26% (929/352,960)(95% CI: 0.24–0.28%). We also found a marked predominance of replacement donation (90.4%) in comparison to voluntary contributions (9.6%). Therefore, this blood donor study may provide clues on the general prevalence of the infection. Conclusions. Seroprevalence of HTLV-1/2 in blood donors of Santo Domingo, Dominican Republic, showed a relatively low and steady trend in the studied period.

2017 ◽  
Vol 41 ◽  
pp. 1 ◽  
Author(s):  
Michael A Zingman ◽  
Amarilis Then Paulino ◽  
Matilde Peguero Payano

Objective. To further characterize chikungunya virus infection and its associated clinical manifestations, using a sample of university professors and staff in Santo Domingo, the Dominican Republic. Methods. A cross-sectional study with quota sampling by department was performed to obtain a convenience sample of professors (n = 736) and staff (n = 499) at the Universidad Autónoma de Santo Domingo. Surveys were used to collect demographic and infection data during the fall term of 2014. Univariate and bivariate analyses were carried out to quantify infection and clinical manifestation prevalence and to assess relationships of these outcomes with age, sex, and acute phase duration. Results. Of 1 236 participants, 49% reported infection (professors = 41%; staff = 61%). Of these, 53% also reported the presence of chronic effects, largely arthralgia (48%). Significant relationships were observed between reported infection and sex (P = 0.023), age (P < 0.001), and occupation (P < 0.001). More headache (P = 0.008) and edema (P < 0.001) in females, more headache (P = 0.005) in younger subjects, and more myalgia (P = 0.006) in those with longer acute symptoms were found. Additionally, more chronic arthralgia (P < 0.001; P = 0.003) and chronic edema (P < 0.001; P = 0.001) in females and older subjects, and more chronic myalgia (P = 0.041) and chronic edema (P = 0.037) in those with longer acute symptoms were observed. Conclusions. To the authors knowledge, this is the first population-based chikungunya prevalence study in the Dominican Republic, and the first to explore clinical manifestations in a university setting. The findings reflect results from studies following the 2005 – 2006 Reunion Island outbreak: prevalence of infection and chronic arthralgia, as well as associations with sex, age, and acute intensity. Longitudinal research can provide further insight into these effects.


2019 ◽  
Author(s):  
RAED FELIMBAN ◽  
Saeed Kabrah ◽  
Hadeel Al Sadoun ◽  
Raed Al Serihi

Abstract Background: This study aimed to assess knowledge about and attitude towards blood donation among students at the Faculty of Applied Medical Sciences at King Abdulaziz University. In Saudi Arabia, the shortage of blood donors is a major challenge in blood banks. This could be due to low levels of community knowledge and unfavorable attitudes. Methods: A community-based cross-sectional study was conducted between November 2017 and July 2018. A total of 350 students were randomly selected and interviewed using a well-structured and validated electronic self-administered questionnaire. Results: Among the 350 students, the mean age was 22; 345 (98.5%) of the students were Saudi Arabian. Ninety-three (26.6%) of the students had a prior experience of blood donation, while 257 (73.4%) had never donated blood before. Three-hundred-forty-nine (99.8%) of the students had a good attitude towards blood donation. The majority (86.9%) of the students had good knowledge about blood donation, while 13.1% had poor knowledge. Of the 350 students, 240 (68.6%) strongly agreed that increasing blood donation awareness could increase blood donations. Thirty-five (15.1%) of students strongly agreed that donating blood causes anemia and 54 (15.4%) strongly agreed with the statement: “Blood donation can transmit diseases”. Conclusion: These results reflect a strong positive knowledge about and attitude towards blood donations. The negative responses from students provide a platform for a future campaign that should recruit donors and motivate them to donate blood.


2018 ◽  
Vol 25 (08) ◽  
pp. 1245-1251
Author(s):  
Mustansar Billah ◽  
Syed Muhammad Raza Shah ◽  
Muhammad Mujtaba Hashir

Objectives: To determine the frequency of HBV and HCV among blood donorscoming voluntarily at the blood bank of Ibne- Siena hospital and research centre, Multan,Pakistan, to ascertain the disease burden in the community for their future prevention andcontrol. Study Design: It was a descriptive, cross- sectional study on blood units donated byhealthy individuals coming voluntarily for blood donation, and willing to get their blood testedfor HBV, HCV. Setting: Community medicine department of Multan medical and dental collegeMultan, and blood bank of affiliated tertiary hospital, Ibn-e- Siena hospital Multan. Period: Sixmonths period from Jan 2016 to June 2016. Materials and Methods: Data of the blood donorswas collected. Present study was based on previous well maintained records of hospital bloodbank. During the reported period, a total of 1195 blood donors attended the blood bank, andthey all were screened for HBsAg and anti-HCV. SPSS- 16 was used to analyze the data, fordetermination of frequencies of Hepatitis- B, and C according to the age and gender. Results:Total numbers of blood donors were 1195. 1191 were males, and 4 were females. All thefemales were negative for both HBV, and HCV. Males positive for HBV were 18 (1.5 %), andthose Positive for HCV were 27 (3.2%).


2021 ◽  
Vol 1 (4) ◽  
pp. 383-393
Author(s):  
Sari Rahmada Mulyani ◽  
Aditya Aditya ◽  
Festy Ladyani Mustofa ◽  
Zulfian Zulfian

ABSTRACT: PREVALENCE OF POSITIVE HBsAg BETWEEN VOLUNTARY BLOOD DONATIONS AND REPLACEMENT BLOOD DONATIONS AT PMI UTD LAMPUNG PROVINCE 2019-2020 Background: The risk of transmission of HBV infection through blood transfusion depends on many things, including the prevalence of disease in the community, the recipient's immune status, the number of donors per unit of blood, and the effectiveness of the screening used. The main disease transmission will occur during the window period, which is a period immediately after infection in which the donor's blood has been infected but the screening result is still negative.Objective: To determine the prevalence of positive HBsAg between voluntary blood donations and replacement blood donations at the PMI UTD in Lampung Province in 2019-2020. Methodology: The type of research used in this research is quantitative descriptive with cross-sectional design. The sample used in this study were blood donors at UTD PMI Lampung Province in 2019-2020.Results: The prevalence of voluntary blood donation with positive HBsAg in 2019 was obtained as many as 70 people (33.65%) while the prevalence of replacement blood donors with positive HBsAg in 2019 was obtained as many as 8 people (16%). Then, the prevalence of positive HBsAg voluntary blood donors in 2020 was found to be 138 people (66.35%) while the prevalence of positive HBsAg blood donors in 2020 was 42 people (84%).Conclusion: There is a difference in the prevalence of both voluntary blood donors and replacement blood donors between 2019 and 2020. and the prevalence of HBsAg positive in blood donors is different every year. Keywords: Blood Transfusion, Volunteer, Replacement, HBsAg  INTISARI: PREVALENSI HBsAg POSITIF ANTARA DONOR DARAH SUKARELA DENGAN DONOR DARAH PENGGANTI DI UTD PMI PROVINSI LAMPUNG TAHUN 2019-2020 Latar Belakang: Risiko penularan pada infeksi HBV melalui transfusi darah bergantung pada banyak hal, antara lain yaitu adanya prevalensi penyakit pada masyarakat, status imun resipien, jumlah donor tiap unit darah dan keefektifan skrining yang di gunakan. Penularan penyakit yang utama akan timbul pada saat window period, yaitu suatu periode segera terjadi setelah terinfeksi dimana darah donor sudah terinfeksi tetapi hasil skrining masih negative.Tujuan: Mengetahui Prevalensi HBsAg Positif Antara Donor Darah Sukarela Dengan Donor Darah Pengganti Di UTD PMI Provinsi Lampung Tahun 2019-2020.Metodologi: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan desain cross sectional. Sampel yang digunakan pada penelitian ini adalah pendonor darah di UTD PMI Provinsi Lampung tahun 2019-2020.Hasil: Prevalensi donor darah sukarela dengan HBsAg positif pada tahun 2019 didapatkan sebanyak 70 orang (33,65%) sementara prelavensi donor darah pengganti dengan HBsAg positif pada tahun 2019 didapatkan sebanyak 8 orang (16%). Lalu, prevalensi donor darah sukarela dengan HBsAg positif pada tahun 2020 didapatkan sebanyak 138 orang (66,35%) sementara untuk prevalensi donor darah pengganti dengan HBsAg positif pada tahun 2020 didapatkan sebanyak 42 orang (84%).Kesimpulan: Terdapat perbedaan prevalensi baik donor darah sukarela maupun donor darah pengganti antara tahun 2019 dengan tahun 2020. Dan prevalensi HBsAg Positif pada donor darah berbeda-beda setiap tahun. Kata Kunci     : Donor Darah, Sukarela, Pengganti, HBsAg


2021 ◽  
Vol 8 (29) ◽  
pp. 2615-2619
Author(s):  
Indu Pachampully Kumaran ◽  
Archana K.A ◽  
Meena Dharmadas ◽  
Sasikala Nadanganan ◽  
Anu Kumar B ◽  
...  

BACKGROUND Even in the presence of sufficient voluntary blood donors, the need of blood is not met yet. We wanted to evaluate the causes that hinder the smooth functioning of well-maintained blood transfusion services (BTS). METHODS This is a population based cross-sectional study conducted among blood donors from voluntary outreach blood donation camp for period of one year. Total 1536 blood donors from 32 blood donation camps were subjected to study for the sociodemographic characteristic and their knowledge of blood donation. Statistical analysis of data was done using Microsoft Excel, analysed using statistical package for social sciences (SPSS) ver.16 software. RESULTS A total of 32 blood donation camps were conducted during the study period that provided 1536 donors. In most of the camps, male donors (75 %) were more than female donors. Donors of age group of 30 to 39 years (43.9 %) were more when compared to others. Donors those who were married accounted for 79.9 %. Blood donors of Hindu religion (53 %) were more. CONCLUSIONS The main hindrance for blood donor motivation is lack of knowledge. Literacy and chance to mingle in society have a positive effect on blood donor motivation. Targeting of effective donor motivation, recruitment, and retention were attained by conducting awareness classes, seminars, workshops, and visual communication modalities. KEYWORDS World Health Organization, Altruistic Blood Donor, Blood Transfusion Services, Transfusion Transmitted Infections, Blood Components and Plasma Derivatives, Director General of Health Services (DGHS), National Blood Transportation Council (NBTC)


2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Adelbert B. James ◽  
Cassandra D. Josephson ◽  
Marta I. Castillejo ◽  
George B. Schreiber ◽  
John D. Roback

Background. The explosive growth of Hispanics in the US makes this population a significant and untapped source for blood donation. Methods. A cross-sectional study was performed to evaluate blood donation behaviors and demographics of foreign-born and US-born Hispanic donors between 2006 and 2009 in metropolitan Atlanta, GA, USA. Bivariate analyses and multivariate logistic regression were used to assess factors associated with foreign-born donors. Results. 5,119 foreign-born and 11,841 US-born Hispanics donated blood. Foreign-born Hispanic donors were more likely than US-born donors to be blood group O (57.6% versus 52.0%; P<.001) and more frequent donors (2.2 versus 2.0; P<.001). Cuban-born donors had the highest rates of return donation (63.2%). In contrast, Mexicans, the most prevalent subpopulation among foreign-born Hispanic donors (31.8%), had the lowest rates of return donation (42.0%). Conclusions. The heterogeneity found among Hispanic donors in this study is valuable for the design of recruitment strategies to increase blood donations.


Author(s):  
Dr. Sheikh Saiful Islam Shaheen ◽  
Dr. Md. Ashraful Hoque ◽  
Dr. Jannatul Ferdous

Background: Cytomegalovirus (CMV) infection is a matter for concern among blood bank professionals and blood transfusion recipient, especially in cases of transfusion to neonates and immunocompromised patients. Objective: The aim of the study was to investigate the seroprevalence of cytomegalovirus with the purpose of determining routine CMV screening for donors. Method: A descriptive cross sectional study was carried out in the Department of Transfusion Medicine in Bangabandhu Sheikh Mujib Medical University from January 2017 to December 2017. A total of 150 blood donors were selected by convenient sampling technique. Result: The seroprevalence of cytomegalovirus is 91% for IgG and 4% for IgM. Association was found in between IgG and age,sex.In case of age anti-CMV-IgG,c2= 26.5, t = 9.49; c2> t (Association Exists),for sex anti-CMV-IgG: df = 1, CI = 95%, c2= 17.8, t = 3.84; c2> t (Association Exists)Anti-CMV-IgM: df = 1, CI = 95%, c2= 10.7, t = 3.84; c2> t (Association Exist). This study was undertaken to find out seroprevalence of Cytomegalovirus among blood donors in the department of transfusion medicine. The incidence of cytomegalovirus is 91.3% for IgG and 4% for IgM. Most of the IgG positive subjects were in 38-47 years and for IgM were in 28-37 years. It was observed that seroprevalence of CMV was more in female (94.9% in case of IgG& 6.8% in IgM). It was observed that the highest prevalence of IgG was 3out of 3 (100%)in illiterate and that of IgM was 1 out of 3(33.33%) in illiterate level of education. In conclusion it was found that seroprevalence of cytomegalovirus was 91.3% for IgG and 4% for IgM. Association was found in between IgG & age, sex. Conclusion: Prospective blood donors should be screened for CMV most especially for immunocompromised recipients. Leucoreduced blood products from CMV seronegative donors should be given to preterm neonates, infants as this will prevent transfusion associated perinatal CMV disease. There should be more campaign and awareness on provision of voluntary blood donation for CMV negative blood. Program should be made to create awareness in the community on the significant impact of CMV infection on health.


2021 ◽  
Author(s):  
Pei Pei Tan ◽  
Chee Tao Chang ◽  
Jernih Abdul Rahman ◽  
Sabariah Mohd Noor

Abstract BackgroundIn Malaysia, blood supply relies mainly on non-remunerated blood donors. This study aimed to assess the satisfaction and experience of blood donors during the blood donation process and their intention to return for donation in future.Materials and MethodsThis was a cross-sectional study conducting using a self-administered questionnaire among blood donors. Study was conducted in a tertiary referral hospital and two mobile sites in the Perak state of Malaysia. The questionnaire was initially developed in the Malay language with 5-point Likert scale. The questionnaire comprised of three domains: i) sociodemographic characteristics ii) donor’s satisfaction towards staff iii) donors’ experience and satisfaction towards the donation process. ResultOf the 400 questionnaires distributed, 369 (92.3%) were analysed. The mean age of the donors was 35.98±10.67 years. Most of the donors were male (75.1%), of Malay ethnicity (60.2%) and regular donors (65.6%). Majority of the blood donors reported high satisfaction towards the interviewer (99.0%), blood taking skill of the staff (97.5%), politeness and friendliness of the staff (99.5%) and communication with the staff (98.9%). Minority of the blood donors expressed dissatisfaction towards the parking spaces (13.4%), refreshment (0.8%), and the blood donation operation hours (0.8%). Generally, the respondents had high overall satisfaction level (99.2%) and high intention to donate blood again in the future (98.9%). Conclusion Blood donors in the current study were highly satisfied towards the staff and blood donation process. Translation of high intention to return for donation to actual donation behaviour require further exploration in future studies.


Author(s):  
Le Chang ◽  
Wanghen Hou ◽  
Lei Zhao ◽  
Yali Zhang ◽  
Yanbin Wang ◽  
...  

Objectives The prevalence of antibodies to SARS-CoV-2 among blood donors in China remains unknown. To reveal the missing information, we investigated the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang of China. Design Cross-sectional study Setting Three blood centers, located in the central, south and north China, respectively, recruiting from January to April 2020. Participants 38,144 healthy blood donors donated in Wuhan, Shenzhen and Shijiazhuang were enrolled, who were all met the criteria for blood donation during the COVID-19 pandemic in China. Main outcome measures Specific antibodies against SARS-CoV-2 including total antibody (TAb), IgG antibody against receptor-binding domain of spike protein (IgG-RBD) and nucleoprotein (IgG-N), and IgM. Pseudotype lentivirus-based neutralization test was performed on all TAb-positive samples. In addition, anonymous personal demographic information, including gender, age, ethnicity, occupation and educational level, and blood type were collected. Results A total of 519 samples from 410 donors were confirmed by neutralization tests. The SARS-CoV-2 seroprevalence among blood donors was 2.29% (407/17,794, 95%CI: 2.08% to 2.52%) in Wuhan, 0.029% (2/6,810, 95%CI: 0.0081% to 0.11%) in Shenzhen, and 0.0074% (1/13,540, 95%CI: 0.0013% to 0.042%) in Shijiazhuang, respectively. The earliest emergence of SARS-CoV-2 seropositivity in blood donors was identified on January 20, 2020 in Wuhan. The weekly prevalence of SARS-CoV-2 antibodies in Wuhan's blood donors changed dynamically and were 0.08% (95%CI: 0.02% to 0.28%) during January 15 to 22 (before city lockdown), 3.08% (95%CI: 2.67% to 3.55%) during January 23 to April 7 (city quarantine period) and 2.33% (95%CI: 2.06% to 2.63%) during April 8 to 30 (after lockdown easing). Female and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among donors in Wuhan. Conclusions The prevalence of antibodies to SARS-CoV-2 among blood donors in China was low, even in Wuhan city. According to our data, the earliest emergence of SARS-CoV-2 in Wuhan's donors should not earlier than January, 2020. As most of the population of China remained uninfected during the early wave of COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.


2021 ◽  
pp. 1-8
Author(s):  
Max Esefeld ◽  
Ariane Sümnig ◽  
Ulf Alpen ◽  
Hans Jörgen Grabe ◽  
Andreas Greinacher

<b><i>Background:</i></b> Previous studies suggest that blood donation impacts blood donors’ psychological state, with either positive or negative effects, such as feeling more energetic or more exhausted. It has not yet been described how long these effects last. <b><i>Materials and Methods:</i></b> This prospective cohort study consisted of a qualitative and a quantitative part: (1) Psychological characteristics which changed after blood donation were identified by structured interviews of regular whole blood donors (<i>n</i> = 42). Based on this, a questionnaire addressing 7 psychological dimensions was established. (2) The psychological state of 100 blood donors was assessed after blood donation by applying the questionnaire 15–30 min before and during donation, as well as 15–30 min, 6 h, 24 h, 72 h, 1 week, and 8 weeks after donation. The resulting changes were summarized to a score. Furthermore, potential correlations of the score with pre-donation blood pressure, hemoglobin, or body mass index were calculated. <b><i>Results:</i></b> Seven items were identified which changed in at least 25% of blood donors (mood, concentration, satisfaction, resilience, spirit of initiative, physical well-being, energy level). In the 100 blood donors, the well-being score increased (positive effects, <i>n</i> = 23), showed minor changes (<i>n</i> = 53), or decreased (negative effects, <i>n</i> = 24). The positive effects lasted for about 1 week and the negative effects for 3 days. <b><i>Conclusion:</i></b> While the frequency of psychological effects following blood donation identified by our study was comparable to others, the changes of the psychological state in our donors were traceable for a longer period than previously acknowledged.


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