scholarly journals Uncommon diagnosis while studying dysphagia: advanced lung cancer.

2021 ◽  
Vol 44 (5) ◽  
pp. 190-192
Author(s):  
MM Díaz Alcázar ◽  
A García Robles ◽  
A Martín-Lagos Maldonado
Keyword(s):  
Lung Cancer ◽  
Advanced Lung Cancer ◽  
Endoscopia Digestiva ◽  
Cáncer De Pulmón

Resumen Varón de 65 años que consulta por disfagia progresiva acompañada de pérdida de peso. En tránsito esófago-gastro-duodenal se objetiva defecto de repleción en tercio medio esofágico, por lo que se realiza endoscopia digestiva alta que muestra a ese nivel estenosis esofágica franqueable con área de mucosa ulcerada y excavada. Se toman biopsias, cuyo estudio histológico sugiere carcinoma pulmonar de células pequeñas. El estudio se completa con tomografía computarizada, que visualiza conglomerado adenopático en mediastino que infiltra esófago y masa pulmonar en lóbulo inferior izquierdo. La disfagia puede complicar la evolución del 6-7% de los pacientes con cáncer de pulmón, sin embargo, no es habitual que sea la primera manifestación del tumor.

scholarly journals Experiencia Con Erlotinib Y Gefitinib En Pacientes Con Cáncer De Pulmón Avanzado Con Mutación Positiva En El Receptor De Factor De Crecimiento Epidérmico.

2019 ◽  
Vol 38 (2) ◽  
Author(s):  
Cristiane Martin ◽  
Erik Arauz ◽  
Alejandro Crismatt ◽  
Ruth Vergara
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egfr Mutations ◽  
Advanced Lung Cancer ◽  
First Line ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Cáncer De Pulmón ◽  
Epidermal Growth

<p><strong>[Experience with Erlotinib and Gefitinib in Patients with Advanced Lung Cancer With Positive Mutation In The Receptor of Epidermal Growth Factor]</strong></p><p><strong><br /></strong></p><div>Resumen<br />Introducción: Los inhibidores de tirosina cinasa (TKI) son el tratamiento estándar en Cáncer de pulmón avanzado con mutaciones del receptor de factor de crecimiento epidérmico (EGFR) y son superiores a quimioterapia en términos de supervivencia libre de progresión (PFS), tasas de respuesta y calidad de vida, sin embargo, hay pocos estudios comparando los diferentes TKI disponibles. Objetivos: como objetivo primario se comparó la PFS en pacientes tratados con TKI de primera generación en primera línea y el secundario fue analizar los factores asociados a Supervivencia Global (OS) en esta población. Metodología: Revisión retrospectiva de pacientes con Cáncer de pulmón avanzado con mutación positiva en EGFR tratados con Gefitinib o Erlotinib de 2011 a 2015, utilizando para el análisis de la PFS y OS el método de Kaplan-Meier Resultados: 80 pacientes con mutación en EGFR recibieron tratamiento para enfermedad metastásica, 34 sólo con TKI (42.5%), 45 con TKI y quimioterapia (56.3%) y 1 paciente sólo con Quimioterapia. De los pacientes que recibieron TKI, 30 recibieron Erlotinib con una PFS de 10.1 meses y 24 Gefitinib con una PFS de 7.8 meses sin diferencia significativa entre ambos (p=0.125). En cuanto a OS los factores asociados fueron el estado funcional y exposición a TKI y QT (p=0.035, p=0.009).</div><div>Conclusión: No hay diferencia significativa en PFS entre Erlotinib y Gefitinib en primera línea. Es importante exponer a aquellos pacientes con mutación en EGFR tanto a TKI como a quimioterapia para alcanzar una OS aceptable.</div><div> </div><div>Abstract<br />Tyrosine kinase inhibitors (TKI) are the standard treatment in advanced lung cancer with epidermal growth factor receptor (EGFR) mutations and are superior to chemotherapy in terms of progression-free survival (PFS), response rates and quality of life, however, there are few studies comparing the different TKI available. Objectives: the primary objective was to compare the PFS in patients treated with first-generation TKI in the first line and the secondary objective was to analyze the factors associated with Global Survival (OS) in this population. Methodology: Retrospective review of patients with advanced lung cancer with positive mutation in EGFR treated with Gefitinib or Erlotinib from 2011 to 2015, using the Kaplan-Meier method for the analysis of PFS and OS Results: 80 patients with mutation in EGFR received treatment for metastatic disease, 34 only with TKI (42.5%), 45 with TKI and chemotherapy (56.3%) and 1 patient with only chemotherapy. Of the patients who received TKI, 30 received Erlotinib with a PFS of 10.1 months and 24 Gefitinib with a PFS of 7.8 months without significant difference between them (p = 0.125). Regarding OS, the associated factors were functional status and exposure to TKI and QT (p = 0.035, p = 0.009).</div><div>Conclusion: There is no significant difference in PFS between Erlotinib and Gefitinib in the first line. It is important to expose those patients with EGFR mutation to both TKI and chemotherapy to achieve an acceptable OS.</div><p><strong><br /></strong></p><p> </p>

scholarly journals Experiencia en el manejo de pacientes con Cáncer de Pulmón Avanzado ALK+ en el Instituto Oncológico Nacional de Panamá.

2019 ◽  
Vol 38 (3) ◽  
Author(s):  
Taysser Alezza Sowley Delgado ◽  
Joel Moreno-Ríos ◽  
Ruth Vergara ◽  
Erik Arauz Romero
Keyword(s):  
Lung Cancer ◽  
Locally Advanced ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Phase Iii ◽  
Advanced Lung Cancer ◽  
First Line ◽  
Free Survival ◽  
Cáncer De Pulmón ◽  
Age Of Diagnosis

<p>[Experience in the Management of Patients with Advanced Lung Cancer Alk + at the National Oncology Institute of Panama.]</p><p><strong>Resumen</strong><br />Introducción: el rearreglo de ALK está presente en 3% - 7% de los pacientes con cáncer de pulmón avanzado. Los inhibidores de ALK constituyen el tratamiento de primera línea. El crizotinib fue el primer inhibidor aprobado. Metodología: Realizamos una revisión retrospectiva de los expedientes médicos de los pacientes con cáncer de pulmón ALK positivo desde febrero de 2014 hasta mayo de 2018. El objetivo era describir la incidencia, características clínico patológicas y determinar la supervivencia libre de progresión con el uso de crizotinib en primera línea. Resultados: De 406 pacientes evaluados, 26 resultaron positivos para ALK, obteniendo una incidencia de 6,4%. La edad media de diagnóstico fue 64 años (37 – 85) y 53,1% fueron mujeres. El 92,4% de los pacientes tenían ECOG 0 – 2. Un 43,2% con antecedente de tabaquismo. Todos los pacientes fueron diagnosticados con enfermedad al menos localmente avanzada y un 73,1% tenían enfermedad etapa IV. Al diagnóstico, 2 pacientes debutaron con metástasis cerebrales (10,3%) y ambos recibieron RTHC. Adenocarcinoma fue la histología predominante (96.3%). Un 86,9% de los pacientes iniciaron crizotinib de primera línea. La supervivencia libre de progresión fue 10.9 meses (IC 95% 7,69 – 14,12). Los efectos adversos más comunes fueron las náuseas, diarrea, disgeusia y transaminitis, en su mayoría G1. Sin toxicidad G3 o superior. La supervivencia global de los pacientes expuestos a crizotinib fue de 16.9 meses (IC 95% 11.29 – 21.50).<br /><br />Conclusión: Las características de los pacientes ALK positivo, así como la PFS asociada al crizotinib de primera línea en nuestra institución, es similar a la reportada en los estudios internacionales de fase III.<br /><br /><strong>Abstract</strong><br />Introduction: the rearrangement of ALK is present in 3% - 7% of patients with advanced lung cancer. ALK inhibitors constitute the first line treatment. Crizotinib was the first approved inhibitor. Methodology: We conducted a retrospective review of medical records of patients with ALK positive lung cancer from February 2014 to May 2018. The objective was to describe the incidence, clinical pathological characteristics and determine progression-free survival with the use of crizotinib First line. Results: Of 406 patients evaluated, 26 were positive for ALK, obtaining an incidence of 6.4%. The mean age of diagnosis was 64 years (37 - 85) and 53.1% were women. 92.4% of patients had ECOG 0-2. 43.2% had a history of smoking. All patients were diagnosed with at least locally advanced disease and 73.1% had stage IV disease. At diagnosis, 2 patients started with brain metastases (10.3%) and both received RTHC. Adenocarcinoma was the predominant histology (96.3%). 86.9% of patients started crizotinib first line. The progression-free survival was 10.9 months (95% CI 7.69 - 14.22). The most common adverse effects were nausea, diarrhea, dysgeusia and transaminitis, mostly G1. No toxicity G3 or higher. The overall survival of patients exposed to crizotinib was 16.9 months (95% CI 11.29 - 21.50). <br /><br />Conclusion: The characteristics of the positive ALK patients, as well as the PFS associated with the first line crizotinib in our institution, is similar to that reported in the international phase III studies.<br /><br /></p>

TP53 Exon 8 Mutations are Associated with Shorter Survival in Advanced Lung Cancer Patients

2018 ◽  
Author(s):  
Yutao Liu ◽  
Fang Xu ◽  
Yubo Wang ◽  
Qingchen Wu ◽  
Buhai Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Advanced Lung Cancer ◽  
Lung Cancer Patients

scholarly journals A population-based analysis of spirometry use and the prevalence of chronic obstructive pulmonary disease in lung cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sophie Corriveau ◽  
Gregory R. Pond ◽  
Grace H. Tang ◽  
John R. Goffin
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Early Stage ◽  
Advanced Lung Cancer ◽  
Public Healthcare ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Early Stage Disease ◽  
Morbidity Score

Abstract Background Chronic obstructive pulmonary disease (COPD) and lung cancer are associated diseases. COPD is underdiagnosed and thus undertreated, but there is limited data on COPD diagnosis in the setting of lung cancer. We assessed the diagnosis of COPD with lung cancer in a large public healthcare system. Methods Anonymous administrative data was acquired from ICES, which links demographics, hospital records, physician billing, and cancer registry data in Ontario, Canada. Individuals age 35 or older with COPD were identified through a validated, ICES-derived cohort and spirometry use was derived from physician billings. Statistical comparisons were made using Wilcoxon rank sum, Cochran-Armitage, and chi-square tests. Results From 2002 to 2014, 756,786 individuals were diagnosed with COPD, with a 2014 prevalence of 9.3%. Of these, 51.9% never underwent spirometry. During the same period, 105,304 individuals were diagnosed with lung cancer, among whom COPD was previously diagnosed in 34.9%. Having COPD prior to lung cancer was associated with lower income, a rural dwelling, a lower Charlson morbidity score, and less frequent stage IV disease (48 vs 54%, p < 0.001). Spirometry was more commonly undertaken in early stage disease (90.6% in stage I-II vs. 54.4% in stage III-IV). Conclusion Over a third of individuals with lung cancer had a prior diagnosis of COPD. Among individuals with advanced lung cancer, greater use of spirometry and diagnosis of COPD may help to mitigate respiratory symptoms.

scholarly journals BIOMARKER TESTING FOR PEOPLE WITH ADVANCED LUNG CANCER IN ENGLAND

2021 ◽  
pp. 100176
Author(s):  
Jana B. Adizie ◽  
Judith Tweedie ◽  
Aamir Khakwani ◽  
Emily Peach ◽  
Richard Hubbard ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Advanced Lung Cancer ◽  
Biomarker Testing

scholarly journals Expanded human NK cells from lung cancer patients sensitize patients’ PDL1−negative tumors to PD1-blockade therapy

2021 ◽  
Vol 9 (1) ◽  
pp. e001933
Author(s):  
Sophie M Poznanski ◽  
Tyrah M Ritchie ◽  
Isabella Y Fan ◽  
Abdullah El-Sayes ◽  
Ana L Portillo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Microenvironment ◽  
Nk Cells ◽  
Tumor Regression ◽  
Checkpoint Inhibitors ◽  
Combined Treatment ◽  
Death Receptor ◽  
High Rate ◽  
Advanced Lung Cancer ◽  
Pd1 Blockade

Lung cancer remains the leading cause of cancer death worldwide despite the significant progress made by immune checkpoint inhibitors, including programmed death receptor-1 (PD1)/PD ligand 1 (PDL1)-blockade therapy. PD1/PDL1−blockade has achieved unprecedented tumor regression in some patients with advanced lung cancer. However, the majority of patients fail to respond to PD1/PDL1 inhibitors. The high rate of therapy non-response results from insufficient PDL1 expression on most patients’ tumors and the presence of further immunosuppressive mechanisms in the tumor microenvironment. Here, we sensitize non-responding tumors from patients with lung cancer to PD1-blockade therapy using highly cytotoxic expanded natural killer (NK) cells. We uncover that NK cells expanded from patients with lung cancer dismantle the immunosuppressive tumor microenvironment by maintaining strong antitumor activity against both PDL1+ and PDL1− patient tumors. In the process, through a contact-independent mechanism involving interferon γ, expanded NK cells rescued tumor killing by exhausted endogenous TILs and upregulated the tumor proportion score of PDL1 across patient tumors. In contrast, unexpanded NK cells, which are susceptible to tumor-induced immunosuppression, had no effect on tumor PDL1. As a result, combined treatment of expanded NK cells and PD1-blockade resulted in robust synergistic tumor destruction of initially non-responding patient tumors. Thus, expanded NK cells may overcome the critical roadblocks to extending the prodigious benefits of PD1-blockade therapy to more patients with lung cancer and other tumor types.

Sign in / Sign up

Export Citation Format

Share Document