scholarly journals Study on the Release and Bioevaluations of Green Silver Nanoparticles Entrapped Inside Polymer-based Nanovesicles

2018 ◽  
Vol 55 (4) ◽  
pp. 696-699
Author(s):  
Maria Proks ◽  
Florin Borcan ◽  
Adelina Cheveresan ◽  
Iulia Pinzaru ◽  
Bogdan Almajan Guta ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Surface Charge ◽  
Release Rate ◽  
Noble Metals ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Herbal Extracts ◽  
Good Thermal Stability ◽  
Toxicological Effects ◽  
Invasive Techniques

The drug carriers represent a very important and modern pathway used to increase the therapeutic efficacy of the natural active substances. Nano-sized assemblies of noble metals and herbal extracts represent very simple, cheap, biologically and ecologically friendly synthesis. The main aims of this study were to obtain polyurethane nanovesicles containing silver nanoparticles and to evaluate their release rate. The vesicles� sizes, homogeneity and surface charge were studied using a Cordouan Technol. Zetasizer, while the thermal behaviour was assessed by DSC. UV-Vis measurements were done to evaluate the release rate. Toxicological effects were studied by non-invasive techniques on human skin. The results suggest the obtaining of homogenous polyurethane nanovesicles between 80 and 95 nm, with positive surface charge, very good thermal stability and a prolonged release. The non-irritation potential recommends these vesicles as a safe carrier for different herbal extracts.

scholarly journals Comparative Characterization of Birch Bark Extracts Encapsulated Inside Polyurethane Microstructures

2018 ◽  
Vol 55 (3) ◽  
pp. 385-388 ◽  
Author(s):  
Florin Borcan ◽  
Marius Preda ◽  
Livia Cristina Borcan ◽  
Iulia Pinzaru ◽  
Sorin Florescu ◽  
...  
Keyword(s):  
Surface Charge ◽  
Birch Bark ◽  
Organosulfur Compounds ◽  
Dsc Analysis ◽  
Good Thermal Stability ◽  
Safe Delivery ◽  
Non Invasive ◽  
Natural Extracts ◽  
Invasive Techniques

The phytotherapy is based on the consume of fruits, vegetables and medicinal plants; they contain mixtures of bioactive chemical substances (carotenoids, phenolic acids, flavonoids, coumarins, tannins, organosulfur compounds) with synergic effects on the treatment of diseases. Nano- and micro-carriers are very useful drug delivery systems which can improve the transmembrane transfer of natural extracts. In the present study, betulin and two birch bark extracts were encapsulated inside polyurethane microstructures. Structures� size, homogeneity and surface charge were studied using a Zetasizer, while DSC analysis was involved to assay structures� thermal behavior. Irritation effects were monitored by non-invasive techniques on human skin. The results indicate the obtaining of structures with size around 200-250 nm, with a positive surface charge and a very good thermal stability. The non-irritation potential recommends these structures as a safe delivery system used for natural extracts.

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2351
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Release Rate ◽  
Composite System ◽  
Methyl Blue ◽  
Burst Release ◽  
Fluorescein Sodium ◽  
Photothermal Conversion ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

scholarly journals Current Strategies for Noble Metal Nanoparticle Synthesis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Giyaullah Habibullah ◽  
Jitka Viktorova ◽  
Tomas Ruml
Keyword(s):  
Noble Metal ◽  
Noble Metals ◽  
Drug Carriers ◽  
Industrial Applications ◽  
Metal Nanoparticle ◽  
Noble Metal Nanoparticles ◽  
Synthesis Methods ◽  
Gold And Silver Nanoparticles ◽  
Diverse Range ◽  
The Past

AbstractNoble metals have played an integral part in human history for centuries; however, their integration with recent advances in nanotechnology and material sciences have provided new research opportunities in both academia and industry, which has resulted in a new array of advanced applications, including medical ones. Noble metal nanoparticles (NMNPs) have been of great importance in the field of biomedicine over the past few decades due to their importance in personalized healthcare and diagnostics. In particular, platinum, gold and silver nanoparticles have achieved the most dominant spot in the list, thanks to a very diverse range of industrial applications, including biomedical ones such as antimicrobial and antiviral agents, diagnostics, drug carriers and imaging probes. In particular, their superior resistance to extreme conditions of corrosion and oxidation is highly appreciated. Notably, in the past two decades there has been a tremendous advancement in the development of new strategies of more cost-effective and robust NMNP synthesis methods that provide materials with highly tunable physicochemical, optical and thermal properties, and biochemical functionalities. As a result, new advanced hybrid NMNPs with polymer, graphene, carbon nanotubes, quantum dots and core–shell systems have been developed with even more enhanced physicochemical characteristics that has led to exceptional diagnostic and therapeutic applications. In this review, we aim to summarize current advances in the synthesis of NMNPs (Au, Ag and Pt).

Bio-fabricated silver nanoparticles preferentially targets Gram positive depending on cell surface charge

2016 ◽  
Vol 83 ◽  
pp. 548-558 ◽  
Author(s):  
Debasis Mandal ◽  
Sandeep Kumar Dash ◽  
Balaram Das ◽  
Sourav Chattopadhyay ◽  
Totan Ghosh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Cell Surface ◽  
Surface Charge ◽  
Gram Positive ◽  
Cell Surface Charge

A Microporous Chitosan/Collagen Composite Encapsulated Small Tube of Nanoporous Anodic Aluminum Oxide for Long-Acting Drug Release

2015 ◽  
Author(s):  
Bao-Ying Lee ◽  
Ching-Wen Li ◽  
Gou-Jen Wang
Keyword(s):  
Drug Release ◽  
Aluminum Oxide ◽  
Release Rate ◽  
Anodic Aluminum Oxide ◽  
Drug Carriers ◽  
Anodic Aluminum ◽  
Release Device ◽  
Nanoporous Anodic Aluminum Oxide ◽  
Long Acting ◽  
Nanoporous Anodic Aluminum

This study aims to develop a long-acting and implantable drug release device that can well control the release rate and concentration of the loaded drug. The proposed long-acting and implantable drug release device consists of a tubular nanoporous anodic aluminum oxide (AAO) and the microporous chitosan/collagen composite encapsulated inside it. The nanopore size of the AAO tube can be arranged by the anodization parameters to adjust the release rate and concentration, while the microporous chitosan/collagen composite can provide the device with a long-acting release property. Fabrication results indicated that the AAO tube has a uniform pore arrangement with pore size around 50 nm. And the synthesized microporous chitosan/collagen composites composites containing 90% of chitosan had the highest moisture content; therefore were used as the drug carriers. Release experiments demonstrate that the proposed long-acting drug release device had released only less than 60% of the loading drug at the 16th release day.

scholarly journals Нелинейное поглощение растворов метиленового голубого в присутствии плазмонных наночастиц с различным поверхностным зарядом

2020 ◽  
Vol 128 (9) ◽  
pp. 1380
Author(s):  
А.П. Русинов ◽  
М.Г. Кучеренко
Keyword(s):  
Methylene Blue ◽  
Silver Nanoparticles ◽  
Mathematical Models ◽  
Surface Charge ◽  
Light Absorption ◽  
Nonlinear Absorption ◽  
Nonlinear Optical ◽  
Optical Nonlinearity ◽  
Dye Molecules ◽  
Gold And Silver Nanoparticles

By continuous-pump Z-scanning, the nonlinear light absorption of aqueous and alcohol solutions of methylene blue was studied. It was shown that the mechanisms of optical nonlinearity of these solutions vary depending on the dye concentration and type of solvent. The dependence of the amplitude of nonlinear absorption of dye molecules on the concentration and sign of the surface charge of gold and silver nanoparticles in solution is revealed. Mathematical models of optical nonlinearity for concentrated and diluted solutions of dye molecules are considered; in the latter case, the influence of plasmon nanoparticles on the nonlinear optical characteristics of methylene blue solutions is taken into account

scholarly journals Chronic Effects of Silver Nanoparticles on Micro-Crustacean Daphnia lumholtzi

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Tran Thanh Thai ◽  
Pham Thanh Luu ◽  
Ngo Xuan Quang ◽  
Dao Thanh Son
Keyword(s):  
Silver Nanoparticles ◽  
Chronic Toxicity ◽  
Exposure Period ◽  
Control Treatment ◽  
Reproduction Rate ◽  
Daphnia Lumholtzi ◽  
Multiple Generations ◽  
Toxicological Effects ◽  
Chronic Effects ◽  
And Control

This study aimed to enhance our insight on the potential toxicological effects of silver nanoparticles (AgNPs)  into the aquatic environment. To investigate the chronic toxicity of nanoparticles, freshwater micro-crustacean Daphnia lumholtzi was exposed to different concentrations of 0.2, 0.5 µg/l AgNPs, and control, for 21 days. Toxicological endpoints at different growing stages such as the maturation and reproduction were recorded. The reproduction rate of D. lumholtzi exposed to both AgNPs concentrations (0.2 and 0.5 µg/l ) was significantly lower than that of control. In turn, the maturation exposed to both AgNPs concentrations was not significantly different from the control treatment. This result indicates that AgNPs (with a concentration lower than 0.5 µg/l) did not have an adverse effect on the maturation of D. lumholtzi, but AgNPs with a concentration higher than 0.2 caused a toxic effect on the reproduction rate of D. lumholtzi during 21 days of the exposure period. In conclusion, the present results showed that AgNPs have toxic effects on D. lumholtzi and it has the potential to use as good freshwater aquatic zooplankton for assessment on the toxicity of nanomaterials in tropics. The future study should pay more attention to the effect of AgNPs on survival, growth rate, and multiple generations of daphnids to better understand the effects of nanoparticles in general and AgNPs in particular.

Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo

2019 ◽  
Vol 36 (8) ◽  
pp. 1900174 ◽  
Author(s):  
Rinea Barbir ◽  
Walter Goessler ◽  
Marija Ćurlin ◽  
Vedran Micek ◽  
Mirta Milić ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protein Corona ◽  
Toxicological Effects
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