TNF Inhibitors and Periodontal Inflammation in Psoriatic Arthritis

2017 ◽  
Vol 68 (8) ◽  
pp. 1914-1918
Author(s):  
Codrina Ancuta ◽  
Eugen Ancuta ◽  
Rodica Chirieac ◽  
Carmen Anton ◽  
Zenaida Surlari ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Tnf Inhibitors ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Inflammatory Parameters ◽  
Periodontal Inflammation

The link between immune mediated rheumatic disorders and oral health, particularly periodontal disease, is widely accepted, based on shared immune and inflammatory processes as well as local (articular, gingival) damage mediated by similar pro-inflammatory cytokine and destructive mediators. We aimed to evaluate periodontal status in psoriatic arthritis (PsA) before and after 24-weeks treatment with TNF inhibitors and to identify potential relation between disease activity, inflammatory parameters, therapeutic response and chronic periodontitis. Patients were prospectively assessed according to a standard protocol comprising a complex rheumatologic (PsA activity, inflammatory prolife) and dental evaluation (plaque and gingival index, bleeding on probing, periodontal pocket depth, clinical attachment level). Up to one third PsA presented with moderate to severe periodontitis at baseline, with high prevalence of sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Higher levels of inflammatory parameters were described in the subset of PsA presenting with aggressive periodontal diseases, while significant correlation between dental pathology and CRP (p[0.05). A significant improvement in both PsA-related parameters and periodontal status was demonstrated after 24 weeks of anti-TNF therapy (p[0.05). Periodontal disease may develop in PsA and should be commonly evaluated, particularly patients with active disease. Benefits of TNF inhibitors, with significant response in articular and periodontal parameters, suggest common inflammatory pathways in both entities.

Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

2017 ◽  
Vol 68 (7) ◽  
pp. 1660-1664
Author(s):  
Cristina Iordache ◽  
Rodica Chirieac ◽  
Eugen Ancuta ◽  
Cristina Pomirleanu ◽  
Codrina Ancuta
Keyword(s):  
Ankylosing Spondylitis ◽  
Periodontal Disease ◽  
Systemic Inflammation ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Attachment Loss ◽  
Inflammatory Parameters ◽  
Periodontal Inflammation ◽  
The Impact

Although the relation between periodontitis (PD) and systemic disorders (e.g. cardiovascular diseases, diabetes and rheumatoid arthritis) is widely accepted, the association with ankylosing spondylitis (AS) is inconsistently mentioned. We prospectively examined the relationship between periodontal disease and AS, focusing on the rate and course of PD, factors associated with severity and the impact of anti-TNF-a treatment on inflammatory status. Standard assessments performed twice (week 0, week 24) included an extensive dental evaluation (plaque index, gingival index, bleeding on probing, periodontal pocket depth, clinical attachment loss), inflammatory parameters and AS activity scores (BASDAI, ASDAS-CRP). More than half of AS presented with impaired periodontal health at baseline (mild to moderate PD) meaning increased sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Significant positive correlation between presence and severity of PD, AS activity and systemic inflammation (CRP) was reported at baseline (p[0.05). A final analysis performed at 24 weeks revealed significant improvement in periodontal status, inflammatory parameters and AS activity, suggesting efficacy of TNF inhibitors directed not only against systemic, but also on local (articular, periodontal) inflammation (p[0.05). Patients with AS are at risk to develop periodontal disease, particularly those with high levels of systemic inflammation. Benefits of anti-TNFa therapy in the particular settings of AS patient and concomitant periodontal disease should be validated through further studies in larger cohorts.

scholarly journals Determinants of periodontitis according to the immunological and virological profiles of HIV-infected patients in Yaoundé, Cameroon

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Joseph Fokam ◽  
Buolikeze Kuoh Nji Geh ◽  
Samuel Martin Sosso ◽  
Desire Takou ◽  
Ezechiel Semengue Ngufack ◽  
...  
Keyword(s):  
Periodontal Diseases ◽  
Protective Role ◽  
Sub Saharan Africa ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Attachment Loss ◽  
Cd8 Cells ◽  
Reference Centre ◽  
Increased Risk

Abstract Background HIV infection is associated to different oral manifestations (including periodontal diseases), which have decreased with the advent of antiretroviral therapy (ART). Yet, the occurrence of periodontitis is still consistent among patients with HIV living in sub Saharan-Africa, with limited evidence on the driven factors and mitigating measures in these settings. We aimed at evaluating the occurrence of periodontitis and its associated immunological and virological factors in patients with HIV living in Yaoundé, Cameroon. Methods We included 165 (44 ART-naïve and 121 ART-experienced) patients > 18 years old attending the Yaoundé Central Hospital and the Chantal BIYA International Reference Centre, from January-April 2018. The periodontal status was assessed by measuring the clinical attachment loss, periodontal pocket depth, plaques index and gingival bleeding index. CD4+/CD8+ cells and viremia were measured using the fluorescence-activated cell sorting method (FACS Calibur) and the Abbott m2000 RT HIV-1 RNA kit respectively. A standard-questionnaire concerning participants’ medical records and oral hygiene methods was filled. Data was analyzed and p < 0.05 considered statistically significant. Results There was a significantly high prevalence of periodontitis in the ART-naïve (53.2%) compared to the ART-experienced group (37.3%), with a twofold increased risk of the ART-naïve population presenting with periodontitis than the ART-experienced population (OR 2.06, p = 0.03). More importantly, ART-naïve, patients with CD4 < 200 cells presented with higher risk of having periodontitis compared to those with higher CD4-values, with a threefold difference (OR 3.21). Worth noting, males presented with a higher risk of having clinical attachment loss (OR 6.07). There was no significant association between the occurrence of periodontitis and the CD8 (p = 0.45) or viremia (p = 0.10). Conclusion In the Cameroonian context, a considerable number of adults infected with HIV suffer from periodontitis regardless of their treatment profile. Nonetheless, ART-naïve patients have a higher risk, indicating the protective role of ART. Interestingly, severely immune-compromised patients and men are vulnerable to periodontitis, thereby highlighting the need for clinicians to refer patients for regular periodontal screening especially male patients and those with low CD4. Such measures could greatly improve the quality of life of the population living with HIV in Cameroon.

Periodontal status and salivary flow rate among diagnostic radiology department workers

2019 ◽  
Vol 31 (3) ◽  
pp. 17-20
Author(s):  
Ghadah N. Alhusaini ◽  
Ahlam T Mohammed
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Diagnostic Radiology ◽  
Periodontal Pocket ◽  
Control Group ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Significant Difference

Background: diagnostic radiology field workers are at elevated risk level for systemic and oral diseases like periodontal diseases. This study was aimed to estimate the periodontal condition and salivary flow rate among diagnostic radiology workers. Material and method: The sample for this study consisted of a study group radiographers (forty subjects) working for 5 years at least and control group consisted of nurses and laboratory workers away from radiation (forty subjects) in Baghdad hospitals. All the 80 subjects aged 30-40 year-old and looking healthy without systemic diseases. Plaque, gingival, periodontal pocket depth and clinical attachment loss indices were used for recording the periodontal conditions. Under standardized conditions, collection of unstimulated salivary samples was done and salivary flow rate was measured. Results: Although not significant statistically (p>0.01), analysis of the present study data showed that plaque and gingival indices were higher among radiographers. While periodontal pocket depth and clinical attachment loss were higher among radiographers than control group with statistically highly significant difference (p<0.01). On the other hand salivary flow rate was lower among radiographers than control group with statistically highly significant difference (p<0.01). Conclusions: Ionizing radiation affects salivary flow rate and this in turn will affect periodontal status.

scholarly journals Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1792
Author(s):  
João Botelho ◽  
Filipa Vicente ◽  
Laura Dias ◽  
André Júdice ◽  
Paula Pereira ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Self Report ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Epithelial Surface ◽  
Nutritional Parameters ◽  
Periodontal Status ◽  
Dietary Recall ◽  
The Past

Poor oral health in elite sport is a pressing issue, however little is known about the periodontal status of professional footballers. The aim of this study was to examine the prevalence of periodontitis in a group of professional footballers and its association with nutritional parameters and self-report non-traumatic injuries. Additionally, we assessed its association with anthropometric, dietary inflammatory load and self-reported muscular and/or articular injuries. Twenty-two professional footballers were evaluated at the beginning of the 2020–2021 season via full-mouth periodontal inspection, anthropometric measurements and the application of the dietary inflammatory index through a food intake measurement of 24 h dietary recall on two different days. Self-reporting non-traumatic muscular and articular injuries for the past 6 months were recorded from each athlete. Then we compared clinical measurements according to the periodontal status and we correlated age, periodontal and nutritional parameters. Overall, the prevalence of periodontitis was 40.9% and peri-implantitis was also observed. No significant differences were found regarding age or nutritional parameters according to the periodontal status. More non-traumatic muscular events in the past 6 months were found in the periodontitis group (55.6% vs. 38.4%), although the difference was non-significant. Both clinical attachment loss, periodontal pocket depth and the periodontal epithelial surface area revealed a significant moderate correlation with the percentage of fat mass, muscle mass, muscle mass index and total adipose folds. This group of professional footballers showed an alarming prevalence of periodontitis. Further studies shall examine whether periodontitis and periodontal treatment impact the performance of this group of athletes.

scholarly journals Relationship between BMI ≥25 and periodontal status: A case‒ control study

2019 ◽  
Vol 10 (2) ◽  
pp. 90-94
Author(s):  
Seyed Ali Banihashemrad ◽  
Kazem Fatemi ◽  
Taher Pakdel ◽  
Nahid Nasrabadi
Keyword(s):  
Demographic Data ◽  
Normal Weight ◽  
Periodontal Pocket ◽  
Control Group ◽  
Case Group ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Chi Squared ◽  
And Control

Background. Obesity is an important subject in both developed and developing countries. Obesity is a risk factor for many diseases, including cardiovascular diseases, hypertension and osteoarthritis. Periodontitis is a prevalent, chronic disease and multiple factors have been proposed to contribute to its progression. we aimed to compare the periodontal status of normalweight and obese individuals. Methods. In this study, we consecutively selected 100 patients (50 obese and overweight as the case group, based on body mass index [BMI], and 50 others with normal weight, as the control group) referred to the Periodontology Department of Mashhad Dental School. The demographic data of the participants were recorded, including age, gender, height and weight. The following periodontal parameters were assessed: periodontal pocket depth (PPD), clinical attachment level (CAL) and plaque index. Kolmogorov-Smirnov test, chi-squared test and independent t-test, as well as ANCOVA, were used to analyze data. Results. We found that the mean PPD was similar in the test and control groups (P=0.168). Moreover, CAL was not significantly different between the two groups (P=0.494). Conclusion. Our findings indicated that obesity and overweight do not seem to have an association with periodontal parameters such as periodontal pocket depth and clinical attachment loss. Further research is needed to evaluate this relationship.

scholarly journals Estimation of periodontal pocket surface area in small to medium dogs: a proof-of-concept study

2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Kazuya Tamura ◽  
Masako Tokuzen-Tai ◽  
Yasir Dilshad Siddiqui ◽  
Hitomi Tamura-Naito ◽  
Yoshiharu Nagahara ◽  
...  
Keyword(s):  
Body Weight ◽  
Periodontal Disease ◽  
Surface Area ◽  
Periodontal Pocket ◽  
Regression Equations ◽  
Serum Globulin ◽  
Pocket Depth ◽  
Epithelial Surface ◽  
Periodontal Inflammation ◽  
Systemic Health

Abstract Background Periodontal disease is the most common dental disease in dogs. Although the systemic effects of periodontal disease have not been clarified in veterinary science, it is necessary to evaluate the effects of periodontal disease in clinical trials in the future. There have been a few clinical attempts made, however, to assess the severity of periodontal inflammation and its impact on the systemic health of dogs. Meanwhile, in the field of dentistry for humans, the periodontal inflamed surface area (PISA) and periodontal epithelial surface area (PESA) have been used to quantitatively assess the degree of periodontal disease affecting a single tooth as well as the overall extent of periodontitis. Recent studies have also suggested the use of these assessments to examine the relationship between periodontal inflammation and systemic health. Results The estimation formula for a dog’s periodontal pocket surface area (PPSA), an alternative to PISA and PESA in humans, was established using body weight and periodontal pocket depth. Actual values were measured using extracted teeth from various dog breeds and sizes (2.3–25.0 kg of body weight) to obtain universal regression equations for PPSA. Altogether, 625 teeth from 73 dogs of 16 breeds were extracted and subsequently analyzed for morphological information. PPSA was measured in 61 dogs of 10 breeds with periodontal disease using the established estimation formulas, and the correlation between PPSA and preoperative blood chemistry data was analyzed accordingly. A strong correlation was found between PPSA and serum globulin (r = 0.71) while moderate correlations were found for C-reactive protein (r = 0.54) and serum albumin (r = -0.51). Conclusions Estimation formulas using body weight and the 6-point probing depth were established for determining PPSA. Direct correlations between PPSA and several blood test results were observed in the study sample. Taken together, these results suggest that PPSA could be useful for evaluating the effects of periodontitis on systemic conditions in dogs.

scholarly journals A retrospective study to assess and correlate maternal periodontal status with term of pregnancy and weight of newborn

2017 ◽  
Vol 6 (10) ◽  
pp. 4589
Author(s):  
Mayuri N. Jain ◽  
Girish Suragimath ◽  
Siddhartha A. Varma ◽  
Sameer Anil Zope ◽  
Ashwini S. R.
Keyword(s):  
Body Mass Index ◽  
Retrospective Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Body Mass ◽  
Periodontal Diseases ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status

Background: Periodontitis is an inflammatory disease affecting the tooth supporting structures; studies have shown that it also affects the systemic health and conditions like pregnancy. With this background the present retrospective study was conducted to assess and correlate periodontal status of pregnant women with their pregnancy outcome.Methods: A total of 150 pregnant women two days postpartum were examined for periodontal status using following parameters: Oral hygiene index- simplified (OHI-S), modified gingival index (MGI), probing pocket depth (PPD) and clinical attachment loss (CAL). The level of education, body mass index (BMI), gestational age and weight of the baby were recorded and correlated with the periodontal status.Results: Out of 150 women, 83 (55.3%) women suffered from gingivitis and 67 (44.7%) had periodontitis. The incidence of preterm low birth weight babies was seen in 65 (43.33%) women. Body mass index, education level and periodontal disease were significantly associated with preterm low birth weight infants.Conclusions: A significant association was found between periodontitis and preterm low birth infants. The promotion of early detection and treatment of periodontal diseases in women before and during pregnancy will be beneficial. This will minimize the cost of post natal care and morbidity in the new born.

Topical oral 1-tetradecanol complex in the treatment of periodontal diseases in cats

2019 ◽  
Vol 21 (12) ◽  
pp. 1141-1148 ◽  
Author(s):  
Fernanda Maria Lopes Kubitza ◽  
James Mudie George Anthony
Keyword(s):  
Placebo Group ◽  
Periodontal Disease ◽  
Periodontal Diseases ◽  
Oral Treatment ◽  
Treatment Protocol ◽  
Test Group ◽  
Tissue Destruction ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Treatment And Prevention

ObjectivesThe aim of this study was to evaluate the outcomes of the treatment of chronic periodontal disease with an oral application of tetradecanol complex (1-TDC) in cats.MethodsThe test group (n = 9) received 1-TDC (525 mg per gel capsule/day) and the placebo group (n = 4) received olive oil (0.25 ml per gel capsule/day) for 6 weeks.ResultsOral treatment with 1-TDC resulted in significant reductions in all parameters of clinical periodontal disease except tooth mobility at 6 weeks. The 1-TDC group exhibited a statistically significant reduction in pocket depth, clinical attachment loss, gingival index and bleeding on probing after treatment at 6 weeks, whereas the placebo group did not show any significant change.Conclusions and relevanceChronic inflammation associated with periodontal diseases leads to periodontal tissue destruction. As a result, modulation of the host response has been included in the treatment protocol for periodontal diseases. Fatty acids present anti-inflammatory properties and are being investigated for use in the treatment and prevention of progressive periodontal diseases.

scholarly journals Periodontal status and salivary flow rate among diagnostic radiology department workers

2019 ◽  
Vol 31 (2) ◽  
pp. 32-35
Author(s):  
Ghadah N. Alhusaini ◽  
Ahlam T Mohammed
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Diagnostic Radiology ◽  
Periodontal Pocket ◽  
Control Group ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Significant Difference

Background: diagnostic radiology field workers are at elevated risk level for systemic and oral diseases like periodontal diseases. This study was aimed to estimate the periodontal condition and salivary flow rate among diagnostic radiology workers. Material and method: The sample for this study consisted of a study group radiographers (forty subjects) working for 5 years at least and control group consisted of nurses and laboratory workers away from radiation (forty subjects) in Baghdad hospitals. All the 80 subjects aged 30-40 year-old and looking healthy without systemic diseases. Plaque, gingival, periodontal pocket depth and clinical attachment loss indices were used for recording the periodontal conditions. Under standardized conditions, collection of unstimulated salivary samples was done and salivary flow rate was measured. Results: Although not significant statistically (p>0.01), analysis of the present study data showed that plaque and gingival indices were higher among radiographers. While periodontal pocket depth and clinical attachment loss were higher among radiographers than control group with statistically highly significant difference (p<0.01). On the other hand salivary flow rate was lower among radiographers than control group with statistically highly significant difference (p<0.01). Conclusions: Ionizing radiation affects salivary flow rate and this in turn will affect periodontal status.

scholarly journals The correlation between immunoexpression of estrogen receptor and the severity of periodontal disease

2010 ◽  
Vol 43 (3) ◽  
pp. 117
Author(s):  
Yuliana Mahdiyah Da’at Arina ◽  
S. Sunardhi Widyaputra ◽  
Koeswadji Koeswadji
Keyword(s):  
Risk Factors ◽  
Estrogen Receptor ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Estrogen Receptor Α ◽  
Periodontal Pocket ◽  
Periodontal Tissue ◽  
Pocket Depth ◽  
Periodontal Status ◽  
Menopausal Women

Background: The decreased level of estrogen during menopause may be one of the risk factors of periodontal disease. The influence of estrogen to periodontal tissue disturbance is mediated by the presence of estrogen receptor on tissue. The precise mechanism how the estrogens mediate this effect is still unclear. Purpose: The aim of this study was to determine the correlation between estrogen receptor α and ß on the periodontal pocket of women who had severe chronic periodontitis measured based on the periodontal pocket depth. Methods: Twenty four periodontitis patients from menopausal and productive women according to the criteria were examined upon her periodontal status and immunoexpression of estrogen receptor α and ß on their periodontal pocket wall. Results: The result showed that in the menopausal and productive women, immunoexpression of estrogen receptor α and ß was not correlated with the periodontal pocket depth (p>0.05). However, the pocket depth seemed to show higher correlation with immunoexpression of estrogen receptor α than that with estrogen receptor ß, r=0.37 vs. r=0.12 for menopausal women, and r=41 vs. r=0.11 for productive women. Conclusion: It was concluded that no significant correlation was found between the estrogen receptor and periodontal pocket depth both on menopausal and productive women, presumed that estrogen has little role in the severity of periodontitis based on periodontal pocket depth. However, the estrogen receptor α has valuable effect on the severity of periodontal disease more than the estrogen receptor ß.Latar belakang: Berkurangnya kadar estrogen pada masa menopause merupakan salah satu faktor resiko penyakit periodontal. Peran estrogen dalam kerusakan jaringan periodontal dimediatori oleh reseptor estrogen α dan ß yang terdapat dalam jaringan. Akan tetapi, mekanisme estrogen mempengaruhi efek ini sampai saat ini masih belum jelas. Tujuan: Penelitian ini bertujuan untuk menentukan korelasi antara reseptor estrogen pada poket periodontal wanita menopause penderita periodontitis kronis dengan keparahan periodontitis yang ditentukan berdasarkan kedalaman poket. Metode: Dilakukan pemeriksaan status periodontal dan immunoekspresi reseptor estrogen α dan ß pada dinding poket periodontal dari 24 wanita menopause dan belum menopause penderita periodontitis yang sesuai dengan kriteria yang telah ditetapkan. Hasil: Hasil mendapatkan bahwa immunoekspresi reseptor estrogen α dan ß tidak berkorelasi dengan kedalaman poket periodontal wanita menopause dan belum menopause (p>0,05). Meskipun demikian, kedalaman poket periodontal tampak lebih berkorelasi dengan reseptor estrogen α daripada dengan reseptor estrogen ß, dengan nilai r=0,37 vs r=0,12 pada wanita menopause, dan r=0,41 vs r=0,11 pada wanita belum menopause. Kesimpulan: Dapat disimpulkan bahwa tidak terdapat korelasi yang signifikan antara reseptor estrogen dan kedalaman poket periodontal wanita menopause dan belum menopause sehingga diduga bahwa estrogen mempunyai sedikit pengaruh pada keparahan periodontitis. Meskipun demikian, reseptor estrogen α tampak lebih berperan terhadap keparahan penyakit periodontal dibandingkan reseptor estrogen ß.

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