Blood Parathyrin and Mineral Metabolism Dynamics. A clinical analyze

2018 ◽  
Vol 69 (10) ◽  
pp. 2754-2758
Author(s):  
Lucretiu Radu ◽  
Mara Carsote ◽  
Ancuta Augustina Gheorghisan Galateanu ◽  
Smaranda Adelina Preda ◽  
Veronica Calborean ◽  
...  
Keyword(s):  
Case Control Study ◽  
Mineral Metabolism ◽  
Lumbar Bone Mineral Density ◽  
Urinary Calcium ◽  
Mineral Density ◽  
Cross Sectional ◽  
X Ray ◽  
Menopausal Women ◽  
Ionic Calcium ◽  
Control Study

Circulating parathyrin (PTH or parthormon) is increased in primary hyperparathyroidism (PHP) in association with high total/ionic calcium (T/I Ca) and others mineral metabolism anomalies. This is a clinical cross-sectional and case-control study analyzing these changes after PHP surgical correction in menopausal women. Baseline parameters were: mean age at diagnosis (59.63�9.6 years), TCa of 10.9�0.7 mg/dL, PTH of 138.02�59.36 pg/mL. Longitudinal data showed: final TCa p[0.00001, ICa p[0.00001, phosphorus p[0.0001, magnesium p=0.9, 24-h urinary calcium p=0.4, 25-hydroxycholecalciferol p=0.01, PTH p[0.00001. High circulating parathyrin values due to PHP normalized after surgery in addition to statistical significant changes of TCa, ICa, P, lumbar Bone Mineral Density provided by Dual-Energy X-Ray Absorptiometry; Mg and 24-h Ca might not be a marker of general mineral metabolism improvement.

Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women

2018 ◽  
Vol 126 (09) ◽  
pp. 559-563 ◽  
Author(s):  
Zhong-Hua Xu ◽  
Xing Zhang ◽  
Hua Xie ◽  
Jin He ◽  
Wen-Chao Zhang ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Dual Energy ◽  
Complex Interaction ◽  
Mineral Density ◽  
X Ray ◽  
Control Study

Abstract Background As a novel adipokine, CTRP3 involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and adipose tissue via the secretion of adipokines. Aims A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women. Methods Serum levels of CTRP3 and osteocalcin were measured. Bone mineral density (BMD) was obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry. Results Serum CTRP3 level was lower in subjects with osteoporosis (76.7±22.1 ng/ml) than it in controls (89.4±22.5 ng/ml) (P<0.001). Meanwhile, the frequency of osteoporosis presented a significant decrease (66.4%, 53.9% and 35.9%, P<0.001), in the tertiles of serum CTRP3. Furthermore, serum CTRP3 witnessed an association with a lower risk of osteoporosis (adjusted odds ratio=0.973, 95% confidence interval [0.963–0.983], P<0.001). Lastly, serum CTRP3 level was positively correlated with femoral BMD (r=0.403, P<0.001), lumbar BMD (r=0.368, P<0.001), and HDL-C (r=0.118, P=0.022), among all participants after adjustment. Meanwhile, CTRP3 presented negative correlations with HOMA-IR (r=−0.136, P=0.008) and insulin (r=−0.192, P <0.001). Conclusions It shows that a decreased serum level of CTRP3 was independently associated with osteoporosis.

5-Hydroxytriptamine and Skeleton Influence Clinical Study

2018 ◽  
Vol 69 (9) ◽  
pp. 2438-2442
Author(s):  
Dana Maria Albulescu ◽  
Mara Carsote ◽  
Nina Ionovici ◽  
Adina Ghemigian ◽  
Mihaela Popescu ◽  
...  
Keyword(s):  
Venous Blood ◽  
Cross Sectional Study ◽  
Published Data ◽  
Mineral Density ◽  
Cross Sectional ◽  
X Ray ◽  
Menopausal Women ◽  
The Relationship ◽  
Circulating Levels ◽  
Serum Serotonin

5-hydroxytryptamine (5-HT) dually influences skeleton status through positive, indirect central effect and negative, direct, gut-associated impact. Circulating form is usually tested via venous blood sample. A limited number of clinical studies are published on this specific topic. We introduce a cross-sectional study on menopausal women with normal (N=29) and low bone mineral density (N=32) based on lumbar Dual-Energy X-Ray Absorptiometry (DXA) to whom serum serotonin was assessed and found no correlation with bone loss. This aspect confirms conflicting published data regarding the relationship between circulating levels and fracture risk assessment.

scholarly journals A cross-sectional case-control study of sexual dysfunction and associated depression in postmenopausal incontinent women.

2020 ◽  
Author(s):  
TANUDEEP KAUR ◽  
RAJESH KUMARI ◽  
JAI BHAGWAN SHARMA ◽  
KAVITA PANDEY ◽  
BHARTI UPPAL ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Sexual Dysfunction ◽  
Female Sexual Dysfunction ◽  
Case Control Study ◽  
Case Control ◽  
Cross Sectional ◽  
Coital Incontinence ◽  
Menopausal Women ◽  
Control Study ◽  
Indian Scenario

Background: Female sexual dysfunction (FSD) has higher prevalence in postmenopausal women especially with urinary incontinence (UI) and coital incontinence (CI). This study was attempted as there is dearth of literature to quantify FSD, CI and depression in UI women and their correlation with each other especially in Indian scenario. Aim: Aim of this study was to determine the prevalence of FSD, CI and depression in postmenopausal UI women. Material and Methods: Cross-sectional case control study of 100 menopausal women with previously diagnosed UI with matching controls over period of 3 months were analyzed for the prevalence of FSD, CI and depression using validated questionnaires like Female Sexual Function Index (FSFI) and Primary Health Questionnaire 9 (PHQ 9). Statistical Analysis was performed using SPSS version 19.0. Results: UI is independently associated with FSD, CI and depression (p < 0.001) with prevalence of 100%, 83%, and 100% respectively for cases versus 5%, 6%, and 4% respectively for controls. FSD and CI are also independently associated with depression (p < 0.001). Combined FSD with UI and CI with UI are also significantly associated with depression. Conclusion: UI is independently associated with FSD, CI and depression. FSD and CI are also independently associated with depression. UI is the major determinant of depression in those with both FSD and UI or CI and UI. Keywords: Female sexual dysfunction (FSD), urinary incontinence (UI), coital incontinence (CI), depression, sexual health

scholarly journals Biochemical Analysis of Mineral Metabolism and Central Bone Mineral Density in 157 Adult Women

2019 ◽  
Vol 69 (12) ◽  
pp. 3565-3568
Author(s):  
Edwin Sever Bechir ◽  
Mara Carsote ◽  
Mihaela Jana Tuculina ◽  
Marilena Bataiosu ◽  
Ionela Teodora Dascalu ◽  
...  
Keyword(s):  
Chemical Elements ◽  
Mineral Metabolism ◽  
Serum Magnesium ◽  
Hypovitaminosis D ◽  
Adult Women ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score ◽  
Menopausal Women ◽  
Turnover Markers

This is a cross-sectional retrospective study of observational type. 157 menopausal subjects were included. A number of N1=89 were younger of 60 years old (also included) and a number of N2=68 were older than 60 years old. Median of age was of 55 years, respective 66 years.The biochemical parameters like total and ionic serum calcium, serum magnesium, and phosphorus between the two groups N1-N2 were similar (p]0.05).The median values of mentioned chemical elements were within normal limits.The bone turnover markers were not statistically significant different between N1 and N2. 25OHD was found deficient in both populations, irrespective of age. DXA- BMD and T-score N1-N2 difference was statistical significant for all the four central sites. Biochemical mineral parameters seem not to be influenced by the cut off of 60 years in menopausal women aged between 40 and 80 years. Yet, a large prevalence of hypovitaminosis D is identified regardless the age without secondary PTH raise. The statistical significant results are for BMD and T-score for all the four central sites.

scholarly journals Evaluation of Bone Density in Ankylosing Spondylitis Patient on Biologic Agents in Erbil City Case Control Study

2021 ◽  
Vol 20 (2) ◽  
pp. 82-93
Author(s):  
Mohammed Ibrahim Rasul ◽  
◽  
Shwan Kader Media
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Bone Density ◽  
Body Mass ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Mineral Density ◽  
X Ray ◽  
Control Study

Background: Ankylosing spondylitis is a chronic autoimmune inflammatory disease, mostly affect young men. Reduced bone density is the most common complication in ankylosing spondylitis, since reduced bone density occurs in most of the patients. Assessment of bone density in the early stages of the disease by using X- ray absorptiometry is essential. Objective: To determine and evaluate the bone mineral density of ankylosing spondylitis patients compared healthy to control group. Patients and Methods: This is a cross-sectional case control study of 50 patients with ankylosing spondylitis according to the Modified New York criteria and 50 healthy control group. The data were collected including socio demographic information of all patients (age, gender, medical history); systemic diseases type of biology treatment, using supplements, duration of ankylosing spondylitis, regular exercise, and smoking. The body mass index was calculated. Bone mineral density of the lumbar spine (L1-L4), and the left femoral neck were measured by using a dual energy x-ray absorptiometry. Statistical analysis was done by using a statistical package for social sciences (SPSS) version 22; Fisher’s exact, and Student’s t tests were used to compare two means. A p value of ≤ 0.05 was considered statistically significant. Results: The prevalence of osteoporosis and osteopenia among patients group according to T-spine score were 12% and 42% respectively, compared with 0% and 26% respectively among the control group (p= 0.002) which was statistically significant. According to the T-left femur none patients group and the control group had osteoporosis, but 46% of the cases had osteopenia, compared with 8% of the controls which was statistically significant. There was a significant but non-consistent association between the disease duration and the osteoporosis, and osteopenia in spine and femur. The prevalence of osteopenia and osteoporosis in the spine and femur were highest among those with low body mass index. Conclusion: Osteoporosis and osteopenia are common among patients with ankylosing spondylitis. In the early stage of disease osteoporosis can occur. The osteoporosis of the spine is more common than in the femur. Osteoporosis related to the duration of the diseases and body mass of the patient.

scholarly journals The impact of clothing style on bone mineral density among post menopausal women in Morocco: a case-control study

2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Fadoua Allali ◽  
Siham El Aichaoui ◽  
Bouchra Saoud ◽  
Houda Maaroufi ◽  
Redouane Abouqal ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Case Control Study ◽  
Case Control ◽  
Mineral Density ◽  
Clothing Style ◽  
Menopausal Women ◽  
Post Menopausal ◽  
The Impact ◽  
Control Study

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

scholarly journals Prevalence of Balance Impairment and Factors Associated with Balance among Patients with Stroke. A Cross Sectional Retrospective Case Control Study

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 320
Author(s):  
Fayaz Khan ◽  
Mohamed Faisal Chevidikunnan
Keyword(s):  
Case Control Study ◽  
Binary Logistic Regression ◽  
Berg Balance Scale ◽  
Case Control ◽  
Knee Extensors ◽  
Retrospective Case ◽  
Cross Sectional ◽  
Balance Impairment ◽  
Factors Associated ◽  
Control Study

Stroke is a major cause of disability worldwide, and balance impairments are common disabling factors in patients with stroke, leading to falls. Thus, the study objectives were as follows: (i) To find the prevalence of balance impairment among patients with stroke. (ii) To find out the factors associated with balance impairment in patients with stroke. This cross-sectional retrospective case control study involved eighty-one post stroke patients with a mean age of 58.36 ± 14.06, recruited from six hospitals, who underwent an assessment of balance, walking speed, depression and isometric strength of the ankle and knee. These patients were later categorized into subjects with good balance (<45) in the Berg balance scale (BBS) and those with poor balance (≥45), as cases and controls, to assess the factors associated with balance impairment using binary logistic regression. The prevalence of balance impairment among patients with stroke was 48.1%. The reduction in power of knee flexors (OR = 0.858), knee extensors (OR = 0.880) and ankle dorsiflexors (OR = 0.820) was found to be significantly associated with balance impairment, along with speed (OR = 1.187 (95% CI = 1.100, 1.280)), depression (OR = 1.331 (95% CI = 1.055–1.679)) and activities of daily living (OR = 0.313 (95% CI = 0.150–0.650)). In summary, around half of the patients with stroke exhibited balance impairments, with females being more prone.

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