Biochemical Analysis of Mineral Metabolism and Central Bone Mineral Density in 157 Adult Women

This is a cross-sectional retrospective study of observational type. 157 menopausal subjects were included. A number of N1=89 were younger of 60 years old (also included) and a number of N2=68 were older than 60 years old. Median of age was of 55 years, respective 66 years.The biochemical parameters like total and ionic serum calcium, serum magnesium, and phosphorus between the two groups N1-N2 were similar (p]0.05).The median values of mentioned chemical elements were within normal limits.The bone turnover markers were not statistically significant different between N1 and N2. 25OHD was found deficient in both populations, irrespective of age. DXA- BMD and T-score N1-N2 difference was statistical significant for all the four central sites. Biochemical mineral parameters seem not to be influenced by the cut off of 60 years in menopausal women aged between 40 and 80 years. Yet, a large prevalence of hypovitaminosis D is identified regardless the age without secondary PTH raise. The statistical significant results are for BMD and T-score for all the four central sites.

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Blood Parathyrin and Mineral Metabolism Dynamics. A clinical analyze

Revista de Chimie ◽

10.37358/rc.18.10.6619 ◽

2018 ◽

Vol 69 (10) ◽

pp. 2754-2758

Author(s):

Lucretiu Radu ◽

Mara Carsote ◽

Ancuta Augustina Gheorghisan Galateanu ◽

Smaranda Adelina Preda ◽

Veronica Calborean ◽

...

Keyword(s):

Case Control Study ◽

Mineral Metabolism ◽

Lumbar Bone Mineral Density ◽

Urinary Calcium ◽

Mineral Density ◽

Cross Sectional ◽

X Ray ◽

Menopausal Women ◽

Ionic Calcium ◽

Control Study

Circulating parathyrin (PTH or parthormon) is increased in primary hyperparathyroidism (PHP) in association with high total/ionic calcium (T/I Ca) and others mineral metabolism anomalies. This is a clinical cross-sectional and case-control study analyzing these changes after PHP surgical correction in menopausal women. Baseline parameters were: mean age at diagnosis (59.63�9.6 years), TCa of 10.9�0.7 mg/dL, PTH of 138.02�59.36 pg/mL. Longitudinal data showed: final TCa p[0.00001, ICa p[0.00001, phosphorus p[0.0001, magnesium p=0.9, 24-h urinary calcium p=0.4, 25-hydroxycholecalciferol p=0.01, PTH p[0.00001. High circulating parathyrin values due to PHP normalized after surgery in addition to statistical significant changes of TCa, ICa, P, lumbar Bone Mineral Density provided by Dual-Energy X-Ray Absorptiometry; Mg and 24-h Ca might not be a marker of general mineral metabolism improvement.

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Osteoporosis in Surgical Menopause

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v6i1.8083 ◽

1970 ◽

Vol 6 (1) ◽

pp. 39-44 ◽

Cited By ~ 1

Author(s):

Farhana Kabir ◽

Nasim Jahan ◽

Nayma Sultana

Keyword(s):

Cross Sectional Study ◽

Control Group ◽

Mineral Density ◽

Cross Sectional ◽

Medical College ◽

T Score ◽

Estrogen Level ◽

Menopausal Women ◽

Microparticle Enzyme Immunoassay ◽

Group B

Background: Osteoporosis in both surgical and natural menopausal women are common health hazards all over the world. And the surgical menopausal women may have the greater chance of this disorder than those of natural menopausal women. Objective: To observe osteoporotic changes in both surgical and natural menopausal women in Bangladesh. Method: This Cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January 2010 to 31st December 2010. A total number of 60 female subjects were included in this study. Among them 30 surgical menopausal women age ranged from 45-55 years were included in the study group (Group B) and 30 natural menopausal women age ranged from 50-60 years were taken as control (Group A). All the menopausal women were selected from Out Patient Department (OPD) of Gynaecology and Obstetrics, Sir Salimullah Medical College and Mitford Hospital. Estimation of serum estrogen level by microparticle enzyme immunoassay (MEIA) method and T- score was obtained by Dual energy X-ray absorptiometry of both natural and surgical menopausal women were done. The statistical analysis was done by using appropriate method as applicable. Results: In this study T- score of both spinal and femoral neck bone were significantly (p<0.001) lower in surgical menopausal women than those of natural menopausal women. Again, mean serum estrogen level was significantly (p<0.001) lower in surgical menopausal women than that of natural menopausal women. Conclusion: The present study revealed that surgical menopausal women have greater chance of osteoporosis than those of natural menopausal women. Key words: Menopause; Bone mineral density; Osteoporosis. DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8083 J Bangladesh Soc Physiol. 2011 June; 6(1): 39-44

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Bone density and bone turnover markers in patients with epilepsy on chronic antiepileptic drug therapy

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302007000300016 ◽

2007 ◽

Vol 51 (3) ◽

pp. 466-471 ◽

Cited By ~ 16

Author(s):

Carolina A.M. Kulak ◽

Victória Z.C. Borba ◽

Carlos Eduardo Silvado ◽

Luciano de Paola ◽

Markus J. Seibel ◽

...

Keyword(s):

Type I Collagen ◽

Mineral Metabolism ◽

Cross Sectional Study ◽

Type I ◽

Mineral Density ◽

Cross Sectional ◽

Bone Specific Alkaline Phosphatase ◽

Hip Bmd ◽

Turnover Markers ◽

Patients With Epilepsy

In this comparative, cross-sectional study, we evaluated 55 patients with epilepsy on chronic use of antiepileptic drugs (AED); [(38 females and 17 males, 35 ± 6 years (25 to 47)] and compared to 24 healthy subjects (17 females/7 males). Laboratorial evaluation of bone and mineral metabolism including measurements of bone specific alkaline phosphatase (BALP) and carboxyterminal telopeptide of type I collagen (CTX-I) were performed. Bone mineral density (BMD) was measured by DXA. BALP and CTX-I levels did not differ significantly between the groups. CTX-I levels were significantly higher in patients who were exposed to phenobarbital (P< 0.01) than those who were not. Patients presented BMD of both sites significantly lower than the controls (0.975 ± 0.13 vs. 1.058 ± 0.1 g/cm²; p= 0.03; 0.930 ± 0.1 vs. 0.988 ± 0.12 g/cm²; p= 0.02, respectively). Total hip BMD (0.890 ± 0.10 vs. 0.970 ± 0.08 g/cm²; p< 0.003) and femoral neck (0.830 ± 0.09 vs. 0.890 ± 0.09 g/cm²; p< 0.03) were significantly lower in patients who had been exposed to phenobarbital, in comparison to the non-phenobarbital users. In conclusion, patients on AED demonstrate reduced BMD. Among the AED, phenobarbital seems to be the main mediator of low BMD and increases in CTX-I.

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Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.77.6.376 ◽

2007 ◽

Vol 77 (6) ◽

pp. 376-381 ◽

Cited By ~ 12

Author(s):

de Souza Genaro ◽

de Paiva Pereira ◽

de Medeiros Pinheiro ◽

Szejnfeld ◽

Araújo Martini

Keyword(s):

Vitamin D ◽

Mineral Metabolism ◽

Sodium Intake ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Mineral Density ◽

Cross Sectional ◽

Serum Vitamin D ◽

Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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BMD status of Postmenopausal Women in relation with BMI: A study with 93 cases

Bangladesh Journal of Nuclear Medicine ◽

10.3329/bjnm.v17i2.28200 ◽

2016 ◽

Vol 17 (2) ◽

pp. 138-141

Author(s):

Samira Sharmin ◽

Mabubul Haque ◽

Syedur Rahman Miah ◽

Md Mahbub Ur Rahman ◽

Jasmine Ara Haque ◽

...

Keyword(s):

Lumbar Spine ◽

Femoral Neck ◽

Postmenopausal Women ◽

Lumbar Vertebrae ◽

The Body ◽

Mineral Density ◽

Cross Sectional ◽

T Score ◽

Minimal Trauma ◽

The Mean

Objectives: Low bone mass is a common disorder in elderly population which predisposes to fracture with minimal trauma. This study was performed to find out the association between the Body Mass Index (BMI) and Bone Mineral Density (BMD) in postmenopausal women.Materials and Methods: This cross sectional study was carried out at Institute of Nuclear Medicine and Allied Sciences Comilla and Mitford, Dhaka over a period of 12 months from January 2013 to December 2013. A total 93 postmenopausal women were enrolled for this study. All postmenopausal women underwent a BMD scan of femoral neck and lumbar vertebrae using a Dual Energy X-ray Absorptiometry (DEXA). Participants were categorized into three groups according to their age and BMI. BMD were expressed base on T-score according to WHO criteria. The relation among BMI, age and BMD were assessed.Results: The results of this study showed that the mean age of the study group was 57.13±7.49 years with range of 46 to 75 years. The most postmenopausal women were in age group 55-65years. The mean BMI of the study subjects were 24.18±5.08 kg/m2 with a range of 15.62 to 36.20 kg/m2. Among 93 subjects osteopenia was greater at lumbar spine (45.2%) with T-score mean±SD-1.83±0.33 and osteoporosis at femoral neck (51.6%) with T-score mean ±SD-3.36±-0.67. Pearsons correlation coefficient test showed inverse relationship between age and BMD both lumbar spine (r = -0.301, p = 0.003) and femoral neck (r = -0.303, p=0.003) whereas the positive relation between BMI and BMD both at lumbar spine (r=0.338, p=0.001) and femoral neck (r =0.343, p=0.001). These showed that with advancing age, BMD decreases and the risk of osteoporosis increases and with increasing BMI, BMD increases and risk of osteoporosis decreases.Conclusion: The findings of this study portrait that aging and low BMI are risk factors associated with bone loss. So preventive measure should be taken for high risk post menopausal women.Bangladesh J. Nuclear Med. 17(2): 138-141, July 2014

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Study of prevalence of osteoporosis in males of above 40 years age group attending SMS Hospital, Jaipur

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20172883 ◽

2017 ◽

Vol 3 (4) ◽

pp. 837

Author(s):

Parwez Qureshi ◽

R. C. Meena ◽

Jakir Husain ◽

Gaurav Deshwar ◽

Vineet Maheshwari ◽

...

Keyword(s):

Vitamin D ◽

Dietary Habits ◽

Good Control ◽

Age Group ◽

Mineral Density ◽

Cross Sectional ◽

T Score ◽

Vitamin D Levels ◽

Study Population ◽

Prevalence Of Osteoporosis

Background: Whenever osteoporosis is discussed, the focus is on women; men are far less likely to receive a diagnosis of osteoporosis or osteoporotic fracture because of considerable gaps in knowledge on male osteoporosis. The aim and objectives were to study the prevalence of osteoporosis in males of above 40 year age group attending SMS Hospital Jaipur & to explore the influence of various modifiable and non-modifiable risk factors on BMD.Methods: Study Location: SMS Medical College and Hospital, Jaipur. Study design: Hospital based cross sectional study. Study period: April 2015 to December 2016. Sample Size: 200. Work up: After taking ethical clearance and informed verbal consent, demographic and clinical details were noted along with S- calcium, Vitamin D and bone mineral density assessment. Osteoporosis was defined as T score ≤−2.5 bone mass −1 to −2.5 and normal as >−1. Data thus collected was analysed with help of SPSS 22.0 through frequency, percentages, Mean, SD and ANOVA.Results: Prevalence of osteopenia and osteoporosis in the study population was 28.5% and 11.5%. Age wise maximum prevalence was in the age group 71-80 years (31.81%). Prevalence of osteoporosis was more among Muslim community 20.83%, more in low socio economic group (BPL). T score of study population was -0.3705±1.41. The mean BMI, S-Calcium, Vitamin D levels and T score values among osteopenic and osteoporotic patients were statistically highly significant when compared to patients without osteo-penic/porotic changes (p<0.05).Conclusions: Osteoporosis is a silent killer and prevention is better than cure as prevention requires simple steps such as good dietary habits, active life style, good control of systemic disorders, reduced intake of tobacco and alcohol.

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Longterm Antiepileptic Therapy and Bone Health: Implications for Patients with Brain Tumors

Acta Medica Academica ◽

10.5644/ama2006-124.303 ◽

2021 ◽

Vol 49 (1, 2, 3) ◽

pp. 23

Author(s):

Admir Mehičević ◽

Nevena Mahmutbegović ◽

Ibrahim Omerhodžić ◽

Enra Mehmedika Suljić

Keyword(s):

Vitamin D ◽

Brain Tumors ◽

Bone Health ◽

Monotherapy Group ◽

Z Score ◽

Mineral Density ◽

Cross Sectional ◽

Antiepileptic Agents ◽

T Score ◽

Significant Difference

Objective. The objective of our study was to investigate the effects of carbamazepine (CBZ) and lamotrigine (LTG) treatment on bone metabolism in epileptic patients.Patients and Methods. A cross-sectional study was performed on normal controls (N=30) and 100 patients with symptomatic epilepsy caused by a primary brain tumor, divided into two groups according to the treatment: LTG monotherapy group (N=50) and CBZ monotherapy group (N=50). For each participant serum levels of 25-OHD and osteocalcin (OCLN) were measured, and bone mineral density (BMD) was evaluated by the dual-energy X-ray absorptiometry method.Results. There was no statistically significant difference in the average values of vitamin D in serum between the CBZ and LTG groups (Vitamin D CBZ 17.03±}12.86 vs. Vitamin D LTG 17.97±}9.15; F=0.171, P=0.680). There was no statistically significant difference in the average values of OCLN between the CBZ and LTG groups (OCLN CBZ 26.06±}10.87 vs. OCLN LTG 27.87±}28.45; F=0.171, P=0.674). The BMD value was lower in both groups using antiepileptic agents compared to the controls, but when comparing the CBZ group to the LTG group, a statistically significant difference was only observed for the Z score (T-score CBZ: 0.08±} 1.38 vs. T-score LTG: 0.37±} 1.02; F=1.495, P=0.224; Z score CBZ: -0.05±}1.17 vs. Z. Score CBZ: 0.38±}0.96; F=4.069, P=0.046) (Table 3).Conclusion. The choice of antiepileptic agents for treating seizures in patients with brain tumors should be carefully evaluated in relation to their impact on bone health. These patients could benefit from supplementation and regular measurement of biochemical markers of bone turnover and BMD.

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Bone Mineral Density Assessment by DXA vs. QCT in Postmenopausal Females with Central Obesity

Current Aging Science ◽

10.2174/1874609812666190912155525 ◽

2020 ◽

Vol 13 (2) ◽

pp. 153-161

Author(s):

Lejla Milisic ◽

Sandra Vegar-Zubovic ◽

Amina Valjevac ◽

Suada Hasanovic-Vučković

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Proximal Femur ◽

Central Obesity ◽

Quantitative Computed Tomography ◽

Normal Weight ◽

Mineral Density ◽

Cross Sectional ◽

T Score

Objectives: Although Dual-energy X-ray Absorptiometry (DXA) is gold standard for osteoporosis diagnosis, several reports have shown discordant T-score values measured by Quantitative Computed Tomography (QCT) and DXA especially in obese subjects, but it is still not clear whether BMD measurement by two modalities is affected by overall obesity or central obesity in postmenopausal females. Therefore, the aims of this study were to compare BMD and T-scores by DXA and QCT and to evaluate whether these two osteoporosis assessment modalities yield different T-score values in postmenopausal females with obesity and central obesity. Methods: This cross-sectional study enrolled 44 postmenopausal females, referred for osteoporosis screening. Anthropometric indices (BMI-body mass index, WC-waist circumference and ICOindex of central obesity) were measured and females underwent an assessment of bone mineral density by DXA and QCT. Results: Lumbar Spine (LS) T-score values were observed to be significantly lower by DXA compared to qCT in females with BMI >25 kg/m2, (-1.9±1.5 vs. -2.3±1.2; p=0.039), in females with WC>88 cm(-1.9±1.5 vs. -2.4±1.2; p=0.008) and in females with ICO>0.5(-1.96±1.4 vs. -2.5±1.2; p=0.004). However, in normal-weight females and in those without central obesity, LS T-scores by DXA were not different than qCT. DXA at lumbar spine and proximal femur revealed osteoporosis in 47.7% and 11.4% respectively, while QCT detected osteoporosis in 61.4% of females (p<0.001). Measures of central obesity; ICO and WC were not associated with QCT bone mineral density (BMD) (r=0.14 and r=0.21, respectively), but were positively associated with both DXALS BMD (r=0.29 and r=0.31; p<0.05) and DXA proximal femur BMD (r=0.41 and r=0.44; p<0.01). Conclusion: Our results suggest that obesity is associated with lower T-scores by DXA compared to QCT. Caution is needed when assessing osteoporosis status in obese postmenopausal females. However, further studies with larger sample size are needed to confirm the findings.

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Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802011000300004 ◽

2011 ◽

Vol 129 (3) ◽

pp. 139-145 ◽

Cited By ~ 9

Author(s):

Daniela Fodor ◽

Cosmina Bondor ◽

Adriana Albu ◽

Laura Muntean ◽

Siao-pin Simon ◽

...

Keyword(s):

Lumbar Spine ◽

Femoral Neck ◽

Postmenopausal Women ◽

Atherosclerotic Plaque ◽

Vertebral Fractures ◽

Mineral Density ◽

Cross Sectional ◽

T Score ◽

Osteoporotic Vertebral Fractures ◽

The Relationship

CONTEXT AND OBJECTIVES: Controversy exists regarding the relationship between atherosclerosis and osteoporosis. The aim of this study was to determine the relationship between intima-media thickness (IMT) of the common carotid artery (CCA), presence of calcified atherosclerotic plaques and bone mineral density (BMD) evaluated by dual energy X-ray absorptiometry (DXA), in postmenopausal women. DESIGN AND SETTING: Cross-sectional study at Second Internal Medicine Clinic, Cluj-Napoca, Romania. METHODS: We studied the IMT (left and right CCA and mean IMT) and T-score (lumbar spine L2-L4, femoral neck and total hip) in 100 postmenopausal women (mean age 64.5 years). The presence of calcified atherosclerotic plaque and osteoporotic vertebral fractures was also noted. RESULTS: IMT in the left and right CCA and mean IMT were significantly associated with T-score measured for the lumbar spine L2-L4, femoral neck and total hip, with lower T-score, in the osteoporotic group than in the normal and osteopenic groups (P < 0.05). IMT had a significantly negative correlation with the lumbar spine T-score and femoral neck T-score; and mean IMT with lowest T-score. Mean IMT (P < 0.001), high blood pressure (P = 0.005) and osteoporotic vertebral fractures (P = 0.048) showed statistical significance regarding the likelihood of developing atherosclerotic plaque. CONCLUSIONS: In women referred for routine osteoporosis screening, the relationship between CCA, atherosclerosis and osteoporosis can be demonstrated using either cortical or trabecular BMD. Vertebral fractures may be considered to be a likelihood factor for atherosclerotic plaque development.

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Fractures, Bone Mineral Density, and Final Height in Craniopharyngioma Patients with a Follow-up of 16 Years

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgz279 ◽

2020 ◽

Vol 105 (4) ◽

pp. e1397-e1407 ◽

Cited By ~ 1

Author(s):

Selveta S van Santen ◽

Daniel S Olsson ◽

Marry M van den Heuvel-Eibrink ◽

Mark Wijnen ◽

Casper Hammarstrand ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Bone Health ◽

Final Height ◽

Z Score ◽

Mineral Density ◽

Childhood Onset ◽

Cross Sectional ◽

T Score

Abstract Context Pituitary hormonal deficiencies in patients with craniopharyngioma may impair their bone health. Objective To investigate bone health in patients with craniopharyngioma. Design Retrospective cross-sectional study. Setting Dutch and Swedish referral centers. Patients Patients with craniopharyngioma (n = 177) with available data on bone health after a median follow-up of 16 years (range, 1-62) were included (106 [60%] Dutch, 93 [53%] male, 84 [48%] childhood-onset disease). Main outcome measures Fractures, dual X-ray absorptiometry-derived bone mineral density (BMD), and final height were evaluated. Low BMD was defined as T- or Z-score ≤-1 and very low BMD as ≤-2.5 or ≤-2.0, respectively. Results Fractures occurred in 31 patients (18%) and were more frequent in men than in women (26% vs. 8%, P = .002). Mean BMD was normal (Z-score total body 0.1 [range, -4.1 to 3.5]) but T- or Z-score ≤-1 occurred in 47 (50%) patients and T-score ≤-2.5 or Z-score ≤-2.0 in 22 (24%) patients. Men received less often treatment for low BMD than women (7% vs. 18%, P = .02). Female sex (OR 0.3, P = .004) and surgery (odds ratio [OR], 0.2; P = .01) were both independent protective factors for fractures, whereas antiepileptic medication was a risk factor (OR, 3.6; P = .03), whereas T-score ≤-2.5 or Z-score ≤-2.0 was not (OR, 2.1; P = .21). Mean final height was normal and did not differ between men and women, or adulthood and childhood-onset patients. Conclusions Men with craniopharyngioma are at higher risk than women for fractures. In patients with craniopharyngioma, a very low BMD (T-score ≤-2.5 or Z-score ≤-2.0) seems not to be a good predictor for fracture risk.

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