Labio-palatine Cleft, Morphological Substrate

2018 ◽  
Vol 69 (4) ◽  
pp. 1002-1005
Author(s):  
Cristian Romanec ◽  
Mariana Pacurar ◽  
Mioara Decusara ◽  
Monica Mihaela Scutariu ◽  
Delia Hinganu ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Congenital Abnormalities ◽  
Causative Factor ◽  
Common Type ◽  
Study Group ◽  
Disturbing Factor ◽  
Facial Region ◽  
Alveolar Cleft ◽  
Craniofacial Malformation ◽  
Functional Defects

Labio-palatin clefts are the most common type of craniofacial malformation encountered in practice and among the most common congenital abnormalities; it represent morphological and functional defects in newborns caused by genetically changes or environmental factors; those of the cervico-facial region have an increased incidence due to local embryological complexity and multifactorial etiology. The anomaly, with its variants, results from an inherent defect between the internal and external nasal buds, both from the frontal and upper maxillary bud. Labio-palatine clefts are characterized by a tissue deficiency as well as an abnormal disposition of the present tissues. It is believed that the labial clefts are consecutive to the lack of apoptosis of the ectoderm which envelops the internal maxillary and nasal buds, thus constituting a barrier to the fusion process of buds. Depending on the location and the extentension of the cleft, the labial cleft occurs, or the more frequent, the labial-alveolar cleft. The study group consisted of 22 patients with labio-palatine clefts, of which 16 boys (72.72%) and 6 girls (27.27%), who presented in the clinic for treatment. When the causative factor acts earlier, the clfet develops posteriorly, since mesodermization begins from the posterior to the anterior. The more disturbing factor acts, the greater the cleft. The increase in the incidence of labial-palatine cleft is believed to be mainly due to the increase in the number of women of older gestational age in women; women over 35 years of age have a double risk of having children with labio-palatine clefts, the risk being three times higher for mothers over the 39 years.

Distribution of lip and/or palate clefts types among children form Lodz during years 1981-2015

2018 ◽  
Vol 90 (3) ◽  
pp. 1-6
Author(s):  
Bogusław Antoszewski ◽  
Marta Fijałkowska
Keyword(s):  
Detailed Analysis ◽  
Clinical Picture ◽  
Cleft Lip ◽  
Common Type ◽  
Study Group ◽  
Body Side ◽  
Facial Clefts ◽  
Common Face

Introduction. Cleft lip and/or palate are the most common face malformations. Clinical picture of these anomalies is very variable. Cleft can include only lip and/or alveolus, palate or all of these structures can be clefted. Aim. The aim of this paper is to present all particular types of clefts, their relationship to sex and body side in the group of children from Lodz during the years 1981-2015. Material and method. The study group included 434 patients with facial clefts (218 males and 216 females) in the age between 4 weeks to 18 years. Results. In the analyzed group there were 181 palate clefts (41.7%), 156 lip and palate clefts (36%) and 97 lip clefts (22.3%). Detailed analysis of clefts types showed that isolated palate clefts are definitely more frequent in females than males (112 vs 69), while lip and palate clefts in boys than girls (96 vs. 60). Conclusions. During 35 years in children form Lodz the most common type of anomaly were palate clefts, followed by lip and palate clefts and the less frequent were lip clefts. Palate clefts are more common in girls, while lip and palate clefts in boys. Left-sided clefts are two times more common than right clefts.

scholarly journals Congenital Abnormalities in Cattle: Their Association with Hereditary and Environmental Factors

1962 ◽  
Vol 45 (12) ◽  
pp. 1493-1499 ◽  
Author(s):  
M.S. Herschler ◽  
N.S. Fechheimer ◽  
L.O. Gilmore
Keyword(s):  
Environmental Factors ◽  
Congenital Abnormalities

Assessment of the occurrence of upper limb injuries among female athletes training softball

2020 ◽  
Vol 1 (3) ◽  
pp. 11-20
Author(s):  
Tomasz RIDAN ◽  
Alan ZIMOWSKI ◽  
Grzegorz GŁĄB
Keyword(s):  
Upper Limb ◽  
Shoulder Joint ◽  
Female Athletes ◽  
Training Session ◽  
Common Type ◽  
Study Group ◽  
Limb Injuries

The aim of the study was to assess the occurrence of upper limb injuries among female athletes training softball. The study group consisted of 46 female players practicing softball in teams of the Polish Women's Softball League. The age of the respondents ranged from 14 to 35 years, with an average of 23.22 years. The study was based on the author's questionnaire, which was carried out at the turn of May and June 2016. The obtained data was processed with the use of the Excel 2007 spreadsheet. The study showed that the majority of the respondents suffered from injuries in the shoulder joint and the most common type of the damage was pulling the muscle. The injuries to the upper limb happened mainly during a training session. Contact with another subject was the most often mechanism of the injury during a match, and during a training session the injuries were sustained without contact.

scholarly journals Pertanggungjawaban Pidana Pelaku Turut Serta Melakukan Pemerasan Dengan Ancaman Berdasarkan Putusan Nomor 672/PID.B/2020/PN.Tjk

Wajah Hukum ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 111
Author(s):  
Zainab Ompu Jainah ◽  
Anggalana Anggalana ◽  
Erlina B ◽  
Desta Fani Acbel ◽  
Sigit Pamungkas
Keyword(s):  
Environmental Factors ◽  
Research Method ◽  
Criminal Responsibility ◽  
Causative Factor ◽  
Empirical Approach ◽  
Economic Factors ◽  
Criminal Sanction ◽  
The Third ◽  
The Law

Extortion and threats are an act against the law and the perpetrator is obliged to take responsibility for his actions as regulated in the Extortion Law with Threats is a complaint offense so that the authorities can act if there is a complaint and the victim of Tuiuan from this research is to find out the causative factor and how the perpetrator's criminal responsibility.  As for the problem in this research are, what are the factors that led to the Criminal Act Committing 672 Pid B2020 PN Tjk?  How is the criminal responsibility of the perpetrator involved and exchanging extortion with threats?  The research method used in writing the Jumal of this research is a nomative juridical approach and an empirical approach. Based on the results of the research, the factors that cause perpetrators to commit extortion crimes with threats include economic factors, environmental factors and the third factor.  Where the role of the perpetrator is concerned, how the perpetrator does it, the weight of the mitigation side, the facts of the trial. so the perpetrator is responsible for his actions with a criminal sanction of imprisonment.

scholarly journals POLYHYDRAMNIOS

2010 ◽  
Vol 17 (04) ◽  
pp. 660-664
Author(s):  
SAADIA TARIQ ◽  
SADIA CHEEMA ◽  
ADEELA AHMAD ◽  
Naela Tarique
Keyword(s):  
Neonatal Outcome ◽  
Case Series ◽  
Causative Factor ◽  
Common Type ◽  
Antenatal Screening ◽  
Obstetrics And Gynaecology ◽  
Causative Factors ◽  
Study Results ◽  
Design Case ◽  
The Impact

Polyhydramnios is though an uncommon problem but very distressing for patient. Objectives: To locate the causative factors and neonatal outcome in polyhydramnios. Design: Case series. Setting: Department of Obstetrics and Gynaecology unit 1, Lahore General Hospital, Lahore. Period: From January 2004- December 2005. Subjects and Methods: Total 82 diagnosed cases of polyhydramnios in 3rd trimester were included in this study. Results: According to the results of this study polyhydramnios can occur in primigravida as well asmultigravida. Causative factor are mainly idiopathic after which the most important is fetal defects. Diabetes is also associated finding with polyhydramnios in 26.8% cases. The impact of polyhydramnios on neonatal outcome is that most of the babies were born without any significant effect. There were only 26 babies (31.5%) in which anomalies were present and neural tube defects were common. Conclusions: Idiopathicpolyhydramnio being the most common type. Improved prenatal and antenatal screening and early detection of congenital anomalies may help to minimize the morbidity of the patient.

scholarly journals Ontology of Variants of the Structure and Malformations of the Skull. Part II. Hereditary Syndromes

2021 ◽  
Vol 6 (3) ◽  
pp. 71-77
Author(s):  
T. V. Khmara ◽  
◽  
M. O. Ryznychuk ◽  
N. B. Kuzniak ◽  
S. P. Melnychuk ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Congenital Malformations ◽  
Developmental Disorders ◽  
Cleft Lip ◽  
Congenital Abnormalities ◽  
Chromosomal Abnormalities ◽  
Multiple Pregnancy ◽  
The Body ◽  
Craniofacial Anomalies ◽  
Hereditary Syndromes

Congenital abnormalities occur in 2-3% of all children and about 1% have hereditary syndromes or multiple malformations. About 30% of all cases have a cleft lip or palate. Genetic factors such as chromosomal abnormalities and gene mutations cause about 15% of congenital abnormalities; exogenous environmental factors cause about 10% of defects; a combination of genetic and environmental factors (multifactorial inheritance) cause 20-25%; multiple pregnancy causes 0.5-1% of congenital abnormalities. Craniofacial anomalies represent an important pediatric problem. They are among the leading causes of infant mortality and morbidity. Craniofacial anomalies mainly affect the development of the skull and facial bones. These defects range from mild to severe, which can be life-threatening and require immediate surgical intervention. Examination of patients with congenital cranial pathology is of particular importance, since a correct diagnosis can often be established only by taking into consideration all stigmas and malformations. The onset of pathology occurs during ontogenesis: normal embryonic development is disturbed under the influence of exogenous and endogenous factors, to which the body is particularly sensitive during critical periods. The consequences of various endogenous and exogenous factors are disruption of growth and development of the organism and occurrence of congenital malformations as an independent unit or occurrence of hereditary syndromes as a set of certain symptoms. Craniofacial syndromes can be divided into several groups. They are most often accompanied by premature fusion of cranial sutures (craniosynostosis) and syndromes with cleft formation. The most frequent syndromes in this group are: Crouzon syndrome, suture synostosis, microsomia, cerebral anomalies and midface clefts. These developmental disorders can lead to a variety of health consequences, namely affecting these patients’ respiratory health, appearance, brain development, hearing, vision, bite, speech, and mental development. Congenital malformations of the skull bones can be related to genetic mutations and environmental factors. Conclusion. Based on the analysis of the literature, a brief clinical characterization of the most common hereditary syndromes accompanied by cerebral and facial skull deformities is given, the type of inheritance and the gene mutation that causes these disorders are indicated

scholarly journals Faktor Penyebab Siswa tidak dapat Menyelesaikan Soal Materi Limit Fungsi Aljabar

2020 ◽  
Vol 4 (2) ◽  
pp. 134
Author(s):  
Syintia Dewi Ananta Shinta Dewi ◽  
Yenita Roza ◽  
M. Maimunah
Keyword(s):  
Environmental Factors ◽  
Psychological Factors ◽  
Algebraic Function ◽  
Causative Factor ◽  
Learning Models ◽  
Physiological Factors ◽  
Limit Problems ◽  
The Subject ◽  
Academic Year ◽  
Algebraic Limit

Indikasi banyaknya jumlah siswa yang tidak dapat menyelesaikan soal limit fungsi aljabar yang diberikan di kelas XI MAN 1 Pekanbaru, menggambarkan adanya permasalahan siswa. Penelitian ini bertujuan untuk menganalisis faktor penyebab siswa tidak menyelesaikan soal limit fungsi aljabar, khususnya siswa di kelas XI SMA/MA. Metode penelitian yang digunakan adalah penelitian deskriptif kualitatif. Subjek pada penelitian ini adalah 22 orang siswa kelas XI IIS 4 MAN 1 Pekanbaru tahun pelajaran 2019/2020. Instrumen yang digunakan dalam penelitian ini adalah angket untuk mengetahui faktor penyebab siswa tidak menyelesaikan soal limit fungsi aljabar berupa faktor fisiologis, faktor psikologis, faktor materi, faktor lingkungan sekolah, faktor lingkungan keluarga, dan faktor lingkungan masyarakat. Hasil analisis menunjukkan bahwa faktor terbesar yang menyebabkan siswa tidak menyelesaikan soal materi limit fungsi aljabar yaitu faktor materi (50%) dan yang paling sedikit adalah faktor fisiologis (18%). Hasil penelitian ini dapat menjadi rujukan bagi guru untuk dapat lebih menekankan konsep limit fungsi dalam bentuk akar dengan menggunakan strategi dan model pembelajaran yang sesuai dengan karakteristik siswa dan kebutuhan materi.Students' Causative Factor Unable to Solve The Algebraic Limit Function’s ProblemsAbstractThe indication that many of the students were not able to solve the  algebraic function limit’s  problems given in class XI MAN 1 Pekanbaru, it pointed out that there were some student's problem. This research aims to analyze the factors that caused many of the students were not able to solve the  algebraic function limit’s  problems, especially students in class XI SMA/MA. The method used in this research was descriptive qualitative research. The subject of this research were 22 students of class XI IIS 4 MAN 1 Pekanbaru in the academic year 2019/2020. The instrument used in this research was a questionnaire to determine the factors caused students were not able to solve the algebraic function limit problems in the form of physiological factors, psychological factors, topic factors, school environmental factors, family environmental factors, and community environmental factors. The analysis results showed that the biggest factor caused students were not able to solve the problems about algebraic function limit was the topic factors (50%) and the least factor was the physiological factors (18%). The results of this study can be a reference for teachers to be able to emphasize the concept of limit functions in the form of roots by using strategies and learning models that are in accordance with student characteristics and material needs.

scholarly journals Gut microbiome investigation in celiac disease: from methods to its pathogenetic role

2020 ◽  
Vol 58 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Lucia Sacchetti ◽  
Carmela Nardelli
Keyword(s):  
Celiac Disease ◽  
Environmental Factors ◽  
Gut Microbiome ◽  
Large Body ◽  
Causative Factor ◽  
Individual Variability ◽  
Culture Methods ◽  
Pathogenetic Role ◽  
Culture Independent ◽  
Host Microbe Interactions

AbstractOur body is inhabited by a variety of microbes (microbiota), mainly bacteria, that outnumber our own cells. Until recently, most of what we knew about the human microbiota was based on culture methods, whereas a large part of the microbiota is uncultivable, and consequently previous information was limited. The advent of culture-independent methods and, particularly, of next-generation sequencing (NGS) methodology, marked a turning point in studies of the microbiota in terms of its composition and of the genes encoded by these microbes (microbiome). The microbiome is influenced predominantly by environmental factors that cause a large inter-individual variability (~20%) being its heritability only 1.9%. The gut microbiome plays a relevant role in human physiology, and its alteration (“dysbiosis”) has been linked to a variety of inflammatory gut diseases, including celiac disease (CD). CD is a chronic, immune-mediated disorder that is triggered by both genetic (mainly HLA-DQ2/DQ8 haplotypes) and environmental factors (gluten), but, in recent years, a large body of experimental evidence suggested that the gut microbiome is an additional contributing factor to the pathogenesis of CD. In this review, we summarize the literature that has investigated the gut microbiome associated with CD, the methods and biological samples usually employed in CD microbiome investigations and the putative pathogenetic role of specific microbial alterations in CD. In conclusion, both gluten-microbe and host-microbe interactions drive the gluten-mediated immune response. However, it remains to be established whether the CD-associated dysbiosis is the consequence of the disease, a simple concomitant association or a concurring causative factor.

scholarly journals Fluctuating Asymmetry in Ground Beetles (Coleoptera, Carabidae) and Conditions of Its Manifestation

Symmetry ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1475
Author(s):  
Sukhodolskaya Raisa ◽  
Saveliev Anatoliy ◽  
Mukhametnabiev Timur ◽  
Eremeeva Natalia
Keyword(s):  
Environmental Factors ◽  
Data Base ◽  
Fluctuating Asymmetry ◽  
Anthropogenic Impact ◽  
Ground Beetles ◽  
Disturbing Factor ◽  
One Dimensional ◽  
Landscape Features ◽  
Species Specific ◽  
Vast Area

Fluctuating asymmetry (FA) is used to reveal environmental or genetic stress, but the results of some studies are inconsistent. We aimed to give some explanations of possible controversial conclusions, when FA was employed. We measured FA (one dimensional and one meristic traits) in the recognized bioindicators—ground beetles (Coleoptera, Carabidae). Beetles were sampled in a vast area (four provinces of Russia with the spectrum of the studied sites, which differed in anthropogenic impact, vegetation, and landscape features). On the basis of such measurements (4673 specimen) we created a data base. Subsequent ANOVA showed, that FA was species-specific (out of six species investigated it was expressed in five ones), sex-biased (males had higher levels of FA), and were affected practically by all environmental factors. Besides significant species–sex and factors–sex interactions were found. So, when employing FA as an indicator of stress, overall biological and ecological variation in species-indicator must be investigated before. Sometimes FA (or its absence) may not be due to pollution or another disturbing factor, but be the result of the effect of unaccounted but FA determinative factors.

scholarly journals Advances of Genomic Medicine in Psoriatic Arthritis

2022 ◽  
Vol 12 (1) ◽  
pp. 35
Author(s):  
Carlos M. Laborde ◽  
Leyre Larzabal ◽  
Álvaro González-Cantero ◽  
Patricia Castro-Santos ◽  
Roberto Díaz-Peña
Keyword(s):  
Psoriatic Arthritis ◽  
Environmental Factors ◽  
Early Diagnosis ◽  
Inflammatory Arthritis ◽  
Structural Damage ◽  
Genomic Medicine ◽  
Common Type ◽  
Screening Tools ◽  
Genetic And Environmental Factors ◽  
Existing Data

Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible structural damage, there are no adequate screening tools for this purpose, and there are no clear markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and heterogeneous, where genetic and environmental factors converge to trigger inflammatory events and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex and not completely understood. In this review, we describe the existing data in PsA in order to highlight the need for further research in this disease to progress in the knowledge of its pathobiology and to obtain early diagnosis tools for these patients.

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