scholarly journals Chemical Composition and Pharmacological Effects of Geopropolis Produced byMelipona quadrifasciata anthidioides

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Cintia Miranda dos Santos ◽  
Jaqueline Ferreira Campos ◽  
Helder Freitas dos Santos ◽  
José Benedito Perrella Balestieri ◽  
Denise Brentan Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chemical Composition ◽  
Antimicrobial Activities ◽  
Pharmacological Effects ◽  
Antimicrobial Drug Resistance ◽  
Gram Positive Bacteria ◽  
Microbial Infections ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis ofMelipona quadrifasciata anthidioidesand to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies ofS. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential ofM. q. anthidioidesgeopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.

scholarly journals Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC.: An In Vitro Comparative Study between Leaves, Stems, and Flowers

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1696 ◽  
Author(s):  
Souilem ◽  
Dias ◽  
Barros ◽  
Calhelha ◽  
Alves ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Bactericidal Effect ◽  
Antimicrobial Activities ◽  
Added Value ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

The present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa (Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS, correlating them with bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal effect against E. coli, while stems presented a higher cytotoxic activity and bactericidal effect against Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the presence of phenolic compounds was also verified. The obtained results bring added value to the studied plant species

Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)

2019 ◽  
Vol 70 (7) ◽  
pp. 2534-2537
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Antonia Poiata ◽  
Mihai Nichifor ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Ethylene Diamine ◽  
Chemical Characteristics ◽  
Gram Negative Bacteria ◽  
Pharmacological Effects ◽  
Physico Chemical ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

scholarly journals Effects of Hydroethanolic Extract of Adenia lobata (Jacq.) Engl. (Passifloraceae) on Nociception and Subsequent Anxiety-like Behavior: Both Anti-inflammatory and Antioxidant Approaches

2021 ◽  
pp. 10-22
Author(s):  
Pacôme Kouadio N’Go ◽  
Lazare Tehoua ◽  
Eric-Kevin Gbouhoury Bolou ◽  
Aicha Salamentou Touré ◽  
Antoine Némé Tako
Keyword(s):  
Oxidative Stress ◽  
Experimental Pain ◽  
Scientific Basis ◽  
Protein Thiol ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Stress Markers ◽  
Plus Maze ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

Aims: Adenia lobata (Jacq.) Engl. (Passifloraceae) is widely used in Ivorian traditional pharmacopeia to heal various chronic diseases, relieve headache and pain of gingiva inflammation, and facilitate labor. Here, we investigated the effects of hydroethanolic extract Adenia lobata (HEAL) on nociceptive pain and subsequent anxiety-like behavior. Materials and Methods: We used several experimental pain tests as the writhing, formalin and hot plate to evaluate both antinociceptive and anti-inflammatory actions of the extract. Anxiety related to nociception was tested with open field and elevated plus maze tests. Then, mice were sacrificed for assessing some oxidative stress markers.    Results: The extract of 30 mg/kg, p.o. reduced in the similar manner as reference peripheral drug salcylicacetic acid (ASA, 200 mg/kg, i.p.) the number of writhings induced by acid acetic. In both neurogenic and inflammatory phases of formalin test, the extract demonstrated an effective antinociceptive activity than ASA, but comparable to central analgesic tramadol (50 mg/kg, i.p). However, Adenia lobata reduced lesser thermal-induced pain than tramadol in hot plate test, but significantly compared to ASA. Furthermore, HEAL altered anxiety-like behavior in each case of the pain condition studied. Also, the extract showed the highest antioxidant activity by reduction oxide nitric (NO) and malondialdehyde (MDA), and increase non protein thiol (NP-SH) levels.     Conclusion: In conclusion, HEAL possesses antinociceptive and anti-inflammatory actions on peripheral and central mechanisms of pain. The phytochemicals components of the extract as alkaloids and flavonoids suggest to interact with the opioid system and combat the oxidative stress, respectively. Our findings provide scientific basis for the use of Adenia lobata in traditional medicine against pain and related diseases.

scholarly journals Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Christiane Schineider Machado ◽  
João Benhur Mokochinski ◽  
Tatiana Onofre de Lira ◽  
Fátima de Cassia Evangelista de Oliveira ◽  
Magda Vieira Cardoso ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Quality Standard ◽  
Antimicrobial Activities ◽  
Mato Grosso ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Chemical Profiles ◽  
Brazilian Propolis ◽  
First Time

The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing1H-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated.

scholarly journals Phytochemical Characterization and Bioactive Properties of Cinnamon Basil (Ocimum basilicum cv. ‘Cinnamon’) and Lemon Basil (Ocimum × citriodorum)

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 369 ◽  
Author(s):  
Chaimae Majdi ◽  
Carla Pereira ◽  
Maria Inês Dias ◽  
Ricardo C. Calhelha ◽  
Maria José Alves ◽  
...  
Keyword(s):  
Thiobarbituric Acid ◽  
Positive Control ◽  
Thiobarbituric Acid Reactive Substances ◽  
Oxidative Hemolysis ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Derivatives Of

The aim of this work was to contribute to the knowledge on the chemical composition and bioactive properties of two species of the Ocimum genus, namely O. basilicum cultivar ’Cinammon’ and O. × citriodorum. For this purpose, samples of these plants grown in Portugal were evaluated for their composition in phenolic and volatile compounds, and the infusion and hydroethanolic extracts were assessed for their in vitro antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities. In total, the two basil samples showed the presence of seven caffeic acid and derivatives (dimers, trimers, and tetramers) and five flavonoids, mainly glycoside derivatives of quercetin. Despite some qualitative and quantitative differences, in both samples rosmarinic acid was the major phenolic compound, and linalool the predominant volatile compound. In general, the tested extracts provided relevant bioactive properties since both basil species showed higher antioxidant activity in Thiobarbituric Acid Reactive Substances (TBARs) and Oxidative Hemolysis Inhibition (OxHLIA) assays when compared with the positive control Trolox. Despite O. × citriodorum extracts showing slightly better activity against some strains, both types of extracts evidenced similar antimicrobial activity, being more active against Gram-positive bacteria. The extracts also revealed interesting cytotoxicity, particularly the O. × citriodorum hydroethanolic extract which was also the only one exhibiting anti-inflammatory activity.

scholarly journals Metformin and its anti-inflammatory and anti-oxidative effects; new concepts

2018 ◽  
Vol 8 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Ali Hasanpour Dehkordi ◽  
Abolfazl Abbaszadeh ◽  
Samareh Mir ◽  
Amin Hasanvand
Keyword(s):  
Oxidative Stress ◽  
Cellular Level ◽  
Stress Factors ◽  
Inflammatory Factors ◽  
New Concepts ◽  
Appropriate Treatment ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Oxidative Effects

Metformin is one of the oldest and commonly used blood sugar lowering drugs, having limited side effects and used as the first line treatment in patients suffering from diabetes mellitus. Moreover, various studies have emphasized on the anti-inflammatory and antioxidant role of metformin, with multiple mechanisms, which activation of AMPK by metformin has had a key role in many of them. During the searches on the internet websites of PubMed, Elsevier, Google Scholar, and Science Direct, 76 papers related to the anti-inflammatory and antioxidant role of metformin were selected and reviewed since 2003 to 2017. At the cellular level, metformin suppresses the inflammation in many cases and reduces or eliminates inflammatory factors mainly through dependent mechanisms and sometimes independent of AMPK at the cellular level and through other ways at the systematic levels. It is also effective in reducing the level of oxidative stress factors by regulating the antioxidant system of the cell. All evidence suggests the antioxidant and anti-inflammatory role of metformin in various conditions. Metformin can be an appropriate treatment option for many diseases, which inflammatory processes and oxidative stress play a role in their pathogenesis.

Study of Anti-oxidant, Anti-inflammatory, Genotoxicity, and Antimicrobial Activities and Analysis of Different Constituents found in Rhizome Essential Oil of Curcuma caesia Roxb., Collected from North East India

2020 ◽  
Vol 21 (5) ◽  
pp. 403-413 ◽  
Author(s):  
Manabi Paw ◽  
Roktim Gogoi ◽  
Neelav Sarma ◽  
Sudin K. Pandey ◽  
Angana Borah ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Allium Cepa ◽  
Antimicrobial Activities ◽  
Commercial Application ◽  
Diffusion Method ◽  
Ms Analysis ◽  
Allium Cepa Assay ◽  
Anti Inflammatory ◽  
Mic Value

Background: This investigation was designed to evaluate the chemical composition, antioxidant, anti-inflammatory, genotoxicity, and antimicrobial activities of Curcuma caesia Roxb rhizome essential oil. Methods: Gas Chromatography/Mass Spectroscopy (GC/MS) analysis was performed to determine the chemical composition, standard antioxidative test DPPH assay, reducing power assay, in vitro antiinflammatory activity (egg albumin denaturation, protease inhibitory assay) by using standard methods. Similarly, antimicrobial activity was tested using the disc diffusion method, minimum inhibitory concentration ability (MIC); while to test genotoxicity, Allium cepa assay was used. Results: GC/MS analysis revealed eucalyptol (28.55%), epicurzerenone (19.62%), and camphor (21.73%) as the major components of C. caesia rhizome essential oil. Potent antioxidant (IC50= 48.08±0.003 μg/mL), anti-inflammatory (IC50= 121.7±0.0013 μg/mL), and antimicrobial activities of the essential oil were recorded better than the standard drugs Fluconazole for fungus and Ciprofloxacin for bacteria. The essential oil also possessed a strong antibacterial effect against two tested bacterial strains B. subtilis and B. cereus with 7.5 μg/mL MIC value, while for fungal strains the essential oil was most effective against S. cereviaceae with an MIC value of 2.5 μg/mL. All the data were recorded in triplicates. Allium cepa assay revealed minor genotoxicity with mitotic index, MI= 27.70%; chromosome aberration, A= 1.1% of C. caesia rhizome essential oil. Conclusion: C. caesia rhizome essential oil possesses potent antioxidant, anti-inflammatory, and antimicrobial properties with negligible genotoxicity. Hence, the present study is highly significant for the utilization of rhizome of C. caesia, a high-value ethnopharmacological plant for advanced R & D and commercial application.

scholarly journals Essential Oil of Galinsoga Parviflora Leaves from Colombia

2010 ◽  
Vol 5 (11) ◽  
pp. 1934578X1000501
Author(s):  
Jorge A. Pino ◽  
Mauricio Gaviria ◽  
Juana Quevedo-Vega ◽  
Laura García-Lesmes ◽  
Clara E. Quijano-Celis
Keyword(s):  
Staphylococcus Aureus ◽  
Chemical Composition ◽  
Essential Oil ◽  
Bacillus Cereus ◽  
Volatile Compounds ◽  
Antimicrobial Activities ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Leaf Oil

The chemical composition of the volatile compounds from the leaves of Galinsoga parviflora Cav. (Asteraceae) from Colombia was studied by GC and GC/MS. Eighty-eight volatile compounds were identified, of which the major ones were (Z)-3-hexen-1-ol (21.7%), β-caryophyllene (12.4%), and 6-demethoxy-ageratochrome (14%). The leaf oil presented antimicrobial activities against the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus.

scholarly journals PEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 464
Author(s):  
Alessio Filippo Peritore ◽  
Ramona D’Amico ◽  
Marika Cordaro ◽  
Rosalba Siracusa ◽  
Roberta Fusco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Signs ◽  
Neutrophil Infiltration ◽  
Sirtuin 1 ◽  
Positive Staining ◽  
Related Factor ◽  
Nuclear Factor ◽  
Protective Effects ◽  
Inflammatory Processes ◽  
Anti Inflammatory

Palmitoylethanolamide (PEA) has well-known anti-inflammatory effects. However, PEA does not possess an antioxidant ability. A comicronized formulation of ultramicronized PEA (um-PEA) and polydatin (Pol) PEA/Pol, a biological precursor of resveratrol with antioxidant activity, could have protective effects on oxidative stress produced by inflammatory processes. We evaluated the effects of a comicronized PEA/Pol 10 mg/kg (9 mg of um-PEA+1 mg of polydatin) in a model of Dinitrobenzene sulfonic acid (DNBS)-induced colitis. Ulcerative colitis was induced in mice by intrarectally injection of DNBS (4 mg in 100 µL of 50% ethanol per mouse). Macroscopic and histologic colon alterations and marked clinical signs were observed four days after DNBS and elevated cytokine production. The myeloperoxidase (MPO) activity assessed for neutrophil infiltration was associated with ICAM-1 and P-selectin adhesion controls in colons. Oxidative stress was detected with increased poly ADP-ribose polymerase (PARP) and nitrotyrosine positive staining and malondialdehyde (MDA) levels in inflamed colons. Macroscopic and histologic alterations minimized by oral PEA/Pol, as well as neutrophil infiltration, inflammatory cytokine release, MDA, nitrotyrosine, PARP and ICAM-1, and P-selectin expressions. The mechanism of action of PEA/Pol could be related to the sirtuin 1/nuclear factor erythroid 2-related factor 2 (SIRT-1/Nrf2) pathway and nuclear factor (NF)-κB. PEA/Pol administration inhibited NF-κB and increased SIRT-1/Nrf2 expressions. Our results show that PEA/Pol is capable of decreasing inflammatory bowel disease (IBD) DNBS-induced in mice.

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