scholarly journals Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting

2015 ◽  
Vol 133 (6) ◽  
pp. 488-494 ◽  
Author(s):  
Ozge Korkmaz ◽  
Hasan Yucel ◽  
Ali Zorlu ◽  
Ocal Berkan ◽  
Hakki Kaya ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Artery ◽  
Acute Pulmonary Embolism ◽  
Main Pulmonary Artery ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

ABSTRACT CONTEXT AND OBJECTIVE: The location of embolism is associated with clinical findings and disease severity in cases of acute pulmonary embolism. The level of gamma-glutamyl transferase increases under oxidative stress-related conditions. In this study, we investigated whether gamma-glutamyl transferase levels could predict the location of pulmonary embolism. DESIGN AND SETTING: Hospital-based cross-sectional study at Cumhuriyet University, Sivas, Turkey. METHODS : 120 patients who were diagnosed with acute pulmonary embolism through computed tomography-assisted pulmonary angiography were evaluated. They were divided into two main groups (proximally and distally located), and subsequently into subgroups according to thrombus localization as follows: first group (thrombus in main pulmonary artery; n = 9); second group (thrombus in main pulmonary artery branches; n = 71); third group (thrombus in pulmonary artery segmental branches; n = 34); and fourth group (thrombus in pulmonary artery subsegmental branches; n = 8). RESULTS : Gamma-glutamyl transferase levels on admission, heart rate, oxygen saturation, right ventricular dilatation/hypokinesia, pulmonary artery systolic pressure and cardiopulmonary resuscitation requirement showed prognostic significance in univariate analysis. The multivariate logistic regression model showed that gamma-glutamyl transferase level on admission (odds ratio, OR = 1.044; 95% confidence interval, CI: 1.011-1.079; P = 0.009) and pulmonary artery systolic pressure (OR = 1.063; 95% CI: 1.005-1.124; P = 0.033) remained independently associated with proximally localized thrombus in pulmonary artery. CONCLUSIONS : The findings revealed a significant association between increased existing embolism load in the pulmonary artery and increased serum gamma-glutamyl transferase levels.

scholarly journals Simultaneous Pulmonary Artery Pressure and Left Ventricle Stroke Volume Assessment Predicts Adverse Events in Patients With Pulmonary Embolism

2021 ◽  
Vol 10 (18) ◽  
Author(s):  
Hayaan Kamran ◽  
Essa H. Hariri ◽  
Jean‐Pierre Iskandar ◽  
Aditya Sahai ◽  
Ihab Haddadin ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Left Ventricle ◽  
Adverse Events ◽  
Pulmonary Artery ◽  
Stroke Volume ◽  
Acute Pulmonary Embolism ◽  
Systolic Pressure ◽  
Severity Index ◽  
Pulmonary Artery Systolic Pressure ◽  
Advanced Therapies

Background Certain echocardiographic parameters may serve as early predictors of adverse events in patients with hemodynamically compromising pulmonary embolism (PE). Methods and Results An observational analysis was conducted for patients with acute pulmonary embolism evaluated by a Pulmonary Embolism Response Team (PERT) between 2014 and 2020. The performance of clinical prediction algorithms including the Pulmonary Embolism Severity Index and Carl Bova score were compared using a ratio of right ventricle and left ventricle hemodynamics by dividing the pulmonary artery systolic pressure by the left ventricle stroke volume. The primary outcome of in‐hospital mortality, cardiac arrest, and the need for advanced therapies was evaluated by univariate and multivariable analyses. Of the 343 patients meeting the inclusion criteria, 215 had complete data. Pulmonary artery systolic pressure/left ventricle stroke volume was a clear predictor of the primary end point (odds ratio [OR], 2.31; P =0.005), performing as well or better than the Pulmonary Embolism Severity Index (OR, 1.43; P =0.06) or the Bova score (OR, 1.28; P =0.01). Conclusions This study is the first study to demonstrate the utility of early pulmonary artery systolic pressure/left ventricle stroke volume in predicting adverse clinical events in patients with acute pulmonary embolism. Pulmonary artery systolic pressure/left ventricle stroke volume may be a surrogate marker of ventricular asynchrony in high‐risk pulmonary embolism and should be prognostically evaluated.

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

2021 ◽  
pp. 39-40
Author(s):  
Avtar Singh Dhanju ◽  
Deepshikha Singla ◽  
Pashaura Singh ◽  
Ajay Chhabra ◽  
Sukhraj Kaur
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Coronary Syndrome ◽  
Healthy Control ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

scholarly journals HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Courtney E. Zola ◽  
Meredith S. Duncan ◽  
Kaku So-Armah ◽  
Kristina A. Crothers ◽  
Adeel A. Butt ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Cell Count ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
People Living With Hiv ◽  
Hiv Viral Load ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Hiv Coinfection ◽  
Hcv Coinfection

Abstract Hepatitis C virus (HCV) may increase pulmonary hypertension (PH) risk among people living with HIV (PLWH). Prior studies on this topic have been relatively small and examined selected populations. We determine whether HIV/HCV coinfection is associated with higher pulmonary artery systolic pressure (PASP) and prevalent echocardiographic PH. We performed a cross-sectional analysis of 6032 (16% HIV/HCV coinfected) Veterans Aging Cohort Study participants enrolled 4/1/2003–9/30/2012 with echocardiographic PASP measures. We performed multiple linear and logistic regression analyses to determine whether HIV/HCV mono- or co-infection were associated with PASP and PH compared to uninfected individuals. Individuals with HIV/HCV coinfection displayed a higher PASP than uninfected individuals ($$\widehat{\beta }$$ β ^ =1.10, 95% CI 0.01, 2.20) but there was no association between HIV/HCV coinfection and prevalent PH. Subset analyses examined HIV and HCV disease severity markers separately and jointly. Among PLWH, HCV coinfection ($$\widehat{\beta }$$ β ^ =1.47, 95% CI 0.26, 2.67) and CD4 + cell count ($$\widehat{\beta }$$ β ^ = − 0.68, 95% CI − 1.10, − 0.27), but not HIV viral load nor ART regimen, were associated with PASP. Among people with HCV, neither HIV coinfection nor HCV biomarkers were associated with PASP. Among US veterans referred for echocardiography, HIV/HCV coinfection was not associated with a clinically significant elevation in pulmonary pressure. Lower absolute CD4 + T-cell count was inversely associated with PASP which warrants further investigation in prospective studies.

scholarly journals A Single Imaging Modality in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism

2014 ◽  
Vol 2014 ◽  
pp. 1-10
Author(s):  
Hadice Selimoglu Sen ◽  
Özlem Abakay ◽  
Mehmet Güli Cetincakmak ◽  
Cengizhan Sezgi ◽  
Süreyya Yilmaz ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Artery ◽  
Risk Evaluation ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Pulmonary Artery Systolic Pressure ◽  
Risk Of Death ◽  
Prediction Of Mortality ◽  
Increased Risk ◽  
Acute Pe

Introduction. This study aimed to investigate the currency of computerized tomography pulmonary angiography-based parameters as pulmonary artery obstruction index (PAOI), as well as right ventricular diameters for pulmonary embolism (PE) risk evaluation and prediction of mortality and intensive care unit (ICU) requirement.Materials and Methods. The study retrospectively enrolled 203 patients hospitalized with acute PE. PAOI was calculated according to Qanadli score.Results. Forty-three patients (23.9%) were hospitalized in the ICU. Nineteen patients (10.6%) died during the 30-day follow-up period. The optimal cutoff value of PAOI for PE 30th day mortality and ICU requirement were found as 36.5% in ROC curve analysis. The pulmonary artery systolic pressure had a significant positive correlation with right/left ventricular diameter ratio (r=0.531,P<0.001), PAOI (r=0.296,P<0.001), and pulmonary artery diameter (r=0.659,P<0.001). The patients with PAOI values higher than 36.5% have a 5.7-times increased risk of death.Conclusion. PAOI is a fast and promising parameter for risk assessment in patients with acute PE. With greater education of clinicians in this radiological scoring, a rapid assessment for diagnosis, clinical risk evaluation, and prognosis may be possible in emergency services without the need for echocardiography.

scholarly journals Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

2020 ◽  
Vol 71 (1) ◽  
pp. 430-435
Author(s):  
Adriana Albu ◽  
Anca Moldovan ◽  
Cristian Petra ◽  
Ioana Para
Keyword(s):  
Visceral Adiposity ◽  
Skewed Distribution ◽  
Epicardial Fat ◽  
Abdominal Circumference ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Cardiovascular Morbidity And Mortality ◽  
Glutamyl Transferase

Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

Sign in / Sign up

Export Citation Format

Share Document