Protective Effects of Persimmon Leaf and Fruit Extracts against Acute Ethanol-Induced Hepatotoxicity

The study was aimed to evaluate the protective effects of alcoholic extracts of Strawberry and Blueberry fruits [AESF and AEBF] in acute pancreatitis in rats. Treatment groups received AESF and AEBF at doses of 200 and 400 mg/kg for 7 days with prior injections of L-arginine on 5th day. Biochemical parameters were estimated in serum and pancreatic tissue samples. Histopathological studies and DNA fragmentation assay were carried out in isolated pancreatic tissue. The results of the study indicated that treatment of AESF and AEBF exhibited a significant dose dependent protective effect. Upon the treatment, anti-oxidant enzymes were significantly (*pless than 0.05) increased. Biochemical results were correlated with the histopathological findings. In addition, the DNA fragmentation assay showed an intact DNA in pancreatic cells of treated groups. In conclusion, berry fruit extracts exerted a potential protective effect against L-arginine induced damage in rat pancreas, at least in part, due to its antioxidant properties.

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Protective effects of zinc sulfate and l-lysine on acute ethanol toxicity in mice

Environmental Research ◽

10.1016/0013-9351(79)90039-2 ◽

1979 ◽

Vol 19 (1) ◽

pp. 112-120 ◽

Cited By ~ 6

Author(s):

Ijaz S. Jamall ◽

John E. Mignano ◽

Vincent D. Lynch ◽

Jesse H. Bidanset ◽

Ceasar Lau-Cam ◽

...

Keyword(s):

Zinc Sulfate ◽

Protective Effects ◽

Ethanol Toxicity ◽

Acute Ethanol

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Hepatic and Renal Protective Effects of Annona muricata Leaf and Fruit Extracts on Ehrlich Ascites Carcinoma in Mice

Zagazig Veterinary Journal ◽

10.21608/zvjz.2019.12593.1040 ◽

2019 ◽

Vol 47 (3) ◽

pp. 234-247

Author(s):

Ahmad Hassan ◽

Lames Osman ◽

Mohammed Abd ElMoneim ◽

Atef Abd ElBaky

Keyword(s):

Ehrlich Ascites Carcinoma ◽

Protective Effects ◽

Annona Muricata ◽

Fruit Extracts ◽

Ehrlich Ascites

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Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/9920379 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Jing Liu ◽

Chao Yang ◽

Zhigui Wu ◽

Jianguo Pei ◽

Yao Chen ◽

...

Keyword(s):

Ulcerative Colitis ◽

Chemical Components ◽

Protective Agent ◽

Protective Effects ◽

Trinitrobenzenesulfonic Acid ◽

Fruit Extracts ◽

Gardenia Jasminoides ◽

Tnf Α ◽

Ameliorative Effect ◽

Gardenia Jasminoides Ellis

Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. Therefore, GFE can be a promising protective agent of colitis that deserves further investigation.

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Protective effects of Sasa veitchii extract on acute ethanol‐induced hepatotoxicity in mice

Traditional & Kampo Medicine ◽

10.1002/tkm2.1245 ◽

2020 ◽

Vol 7 (2) ◽

pp. 78-84

Author(s):

Hiroki Yoshioka ◽

Sarah Tominaga ◽

Mai Nishikawa ◽

Yoshimi Ichimaru ◽

Tohru Maeda ◽

...

Keyword(s):

Protective Effects ◽

Sasa Veitchii ◽

Acute Ethanol

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Neuroprotective Effect of Cudrania tricuspidata Fruit Extracts on Scopolamine-Induced Learning and Memory Impairment

International Journal of Molecular Sciences ◽

10.3390/ijms21239202 ◽

2020 ◽

Vol 21 (23) ◽

pp. 9202

Author(s):

Seung-Cheol Jee ◽

Kwang Min Lee ◽

Min Kim ◽

Yoo-Jung Lee ◽

Soee Kim ◽

...

Keyword(s):

Ache Activity ◽

Biological Activities ◽

Neuroprotective Effect ◽

Neuronal Cell ◽

Protective Effects ◽

Gene Expressions ◽

Differentiation Markers ◽

Neuroprotective Effects ◽

Cudrania Tricuspidata ◽

Fruit Extracts

Cudrania tricuspidata has diverse biological activities, such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. This study investigated the protective effects of C. tricuspidata fruit extracts (CTFE) against scopolamine (SCO)-induced neuron impairment. The neuroprotective effects of CTFE on SCO-induced memory dysfunction were confirmed in mice using the Barnes maze test. The results showed that co-treatment of SCO and CTFE increased the stay time in the target zone compared with SCO treatment alone. Similarly, the results obtained by the fear conditioning test revealed that SCO-CTFE co-treatment induced the freezing action time under both the contextual fear condition and the cued fear condition compared with SCO treatment alone. Moreover, we showed that CTFE reduced the SCO-induced acetylcholinesterase (AChE) activity, thereby increasing the acetylcholine concentration in mice hippocampal tissues. Consistent with the improvement of memory and recognition function in vivo, our in vitro results showed that CTFE induced cAMP response element binding protein (CREB) and extracellular regulated kinase 1/2 (ERK1/2) activity in PC12 cells and reduced SCO-induced AChE activity. In addition, the microarray results of the hippocampal tissue support our data showing that CTFE affects gene expressions associated with neurogenesis and neuronal cell differentiation markers such as spp1 and klk6. Overall, CTFE exerts a neuroprotective effect via regulation of the CREB and ERK1/2 signaling pathways and could be a therapeutic candidate for neurodegenerative diseases.

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