VARIETY OF TUMOR MODELS FOR TESTING ANTITUM TREATMENT ACTIVITY OF SUBSTANCES IN MICE
Keyword(s):
Selection of tolerated and toxic doses, schemes of therapy for new anticancer drugs, assessment of its toxicity, pharmacokinetics, metabolism, study of the mechanism of action and tumor sensitivity are carried out using models of human tumors in mice. The review contains a diverse description of experimental models (transplantable, genetically engineered, humanized, autochthonous, orthotopic, heterotopic and metastatic) tumors using laboratory mice. The advantages, disadvantages, directions and specific features of the use of mouse models, their role in the study of mechanisms of action of antitumor drugs are considered on the examples of recent research.
2018 ◽
Vol 10
(446)
◽
pp. eaao2301
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2013 ◽
Vol 2013
(11)
◽
pp. pdb.top078774-pdb.top078774
◽
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